FOOD CHEMISTRY
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2024
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IF 8.5
Shaoxuan Yu,Geyu Pang,Shiyang Li,Shengjuan Lv,Zhengpeng Wei,Jinmei Wang,Haifang Xiao,Lanlan Zhu
Zein-fucoidan nanoparticles (ZFNPs) as an excellent colloidal delivery system for bioactive compounds, such as curcumin (CUR), show a great application potential in the food industry. Herein, various amount of ZFNPs, ZFNPs loaded with CUR (CZFNPs) and free CUR were added into golden threadfin bream ( Nemipterus virgatus ) surimi to explore their impacts on the gel properties. Dynamic rheological tests showed that storage modulus (G') and loss modulus (G") of surimi gels with the additive amount of ZFNPs and CZFNPs under 0.8 % significantly increased and their loss tangent (tan δ) slightly reduced during thermal gelation, indicating stronger networks and better structural configuration. Puncture test and textural profile analysis confirmed the improvements in breaking force, hardness, chewiness and gumminess of surimi gels. Furthermore, 0.8 % of ZFNPs and CZFNPs induced conformational changes of surimi proteins from α-helix to β-sheet and random coil, and then facilitating the cross-link between proteins. Low-field nuclear magnetic resonance revealed that ZFNPs and CZFNPs promoted the redistribution of water in surimi gel networks, converting more free water to tightly bounded water, and thus increasing the water holding capacity. However, the addition of equivalent amount of CUR caused detrimental to surimi gel properties. In conclusion, ZFNPs and CZFNPs conferred better gel properties and nutritional characteristics to surimi gels, and this study provided a theoretical basis for the development of high-quality surimi products.
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JOURNAL OF MOLECULAR LIQUIDS
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2025
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IF 5.2
Ziyin Yang,Shengbin Zeng,Jiayao Tang,Linghuan Yang,Bei Jin
The potential of dual protein–polyphenol supramolecular complexes for constructing delivery systems based on high internal phase Pickering emulsions (HIPPEs) is significant, yet the underlying mechanism has not been fully revealed. This study systematically investigated hybrid supramolecular complexes fabricated through physical processing techniques such as ultrasound (US) and high pressure (HP), integrating sunflower-walnut protein hydrolysates (SW) with naringenin (Nar) as novel stabilizers for oil-in-water HIPPEs. While physical treatments effectively enhanced SW emulsification capacity through particle size reduction, interfacial tension decrease, and wettability increase, particularly under US treatment, the physical field (US and HP) has limited effectiveness in improving the emulsion’s cream stability. The synergistic application of physical processing and naringenin complexation induced SW structural unfolding, facilitating the adsorption and anchoring of SW at the oil–water interface. Compared to the SW-Nar (US), SW-Nar (HP) generated emulsions with smaller droplets, reinforced viscoelastic networks, and improved curcumin bioaccessibility. In vitro digestion induced SW-Nar complexes interfacial structural unfolding, hydrophobic exposure, and α-helix-to-β-sheet transition, enhancing emulsification and micelle formation via strengthened hydrogen bonds and hydrophobic interactions, particularly in SW-Nar (HP). These findings collectively establish SW-Nar-stabilized HIPPEs as advanced delivery platforms for lipophilic bioactives, with system performance critically dependent on supramolecular interfacial microstructure modulated by physical processing methods.
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CELL PROLIFERATION
·
2018
·Vol. 51
·期 6
·e12486
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IF 4.936
Yuedi Yang,Zhongbing Huang,Ximing Pu,Guangfu Yin,Lei Wang,Fabao Gao
Objective Five-year survival rate at early lung tumour was about 70%; however, its early diagnosis rate was still at a low level, so the enhancement of diagnosis level for early lung tumour is the key factor to increase the survival rate. Diagnosis and therapy of early lung tumour are still challenged. Methods The magnetic nanochains (NCs) with biocompatibility and transverse relaxivity (r 2 = 231 Fe mmol l −1 s −1 ) were fabricated through a co-precipitation method in the assistance of dextran, and then, linked with chlorotoxin (CTX) and curcumin (Cur) via the PEGylation and carbodiimide technique (named as CTX-NCs-Cur). Results The results of cell test indicated that CTX-conjugated NCs could obviously target non–small-cell lung cancer cells and limit their growth. The in vivo results of magnetic resonance imaging and fluorescence imaging indicated that the CTX-NCs-Cur significantly targeted the tumour site and enhanced images contrast of the small-size tumour. Moreover, the results of everyday tail-vein injection confirmed that CTX-NCs-Cur could significantly limit the growth of early tumour, due to blocking Cl ion channels from CTX-NCs-Cur-MMP-2 composite and intracellular ROS increase from Cur treatment. Conclusions We provided a mechanism about the effect of CTX-NCs-Cur on the targeting and limiting early tumour, and these results indicated the application foreground of CTX-NCs-Cur in tumour diagnosis and therapy.
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2021
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IF 4.384
Ziqing Wang,Wenwen Mu,Pengxiao Li,Guoyun Liu,Jie Yang
Curcumin was reported as an anti-inflammatory agent. However, curcumin's poor bioavailability limited its clinical utility. Here, thirty ortho -substituted mono-carbonyl curcumin derivatives, containing acetone, cyclopentanone, cyclohexanone or 4-piperidione ( N H, N -methyl or N -acrylyl) moieties replacing β-diketone moiety of curcumin, were investigated for anti-inflammatory activity. Two active ortho -trifluoromethoxy-substituted 4-piperidione-containing derivatives 22 and 24 owned good cell uptake ability, and displayed excellent anti-inflammatory activity in both lipopolysaccharide-induced Raw264.7 macrophages and a dextran sulfate sodium (DSS)-induced mouse model of colitis . They inhibited the production of nitric oxide , reactive oxygen species , malonic dialdehyde and cyclooxygenase-2; and the expression of pro-inflammatory cytokines interleukin-1β, tumor necrosis factor-α and myeloperoxidase ; the phosphorylation of mitogen-activated protein kinases; and the nucleus translocation of p65. What's more, 22 or 24 oral administered reduced the severity of clinical symptoms of ulcerative colitis (body weight and disease activity index), and reduced obviously DSS-induced colonic pathological damage (the colon length and histopathology analysis). These results suggested that ortho -trifluoromethoxy-substituted 4-piperidione-containing mono-carbonyl curcumin derivatives 22 and 24 were potential anti-inflammatory agents; and offered the important information for design and discovery of more potent anti-inflammatory drug candidates.
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TALANTA
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2025
·
IF 6.1
Zhenxing Guo,Fang Xu,Longfei Su,Qiang Cheng,Liqiang Xu,Guoping Sheng
Fluorescence methods hold great potential for arsenate (As(V)) detection in food safety. However, the development of environmentally friendly and sustainable fluorescence indicators remains at an early stage. Herein, we develop a novel fluorescence sensing platform for As(V) detection. Curcumin (Cur), a plant-derived, non-toxic, and environmentally friendly food additive. Owing to its excellent fluorescent properties, it was used as a green fluorescent indicator in this study. Cerium dioxide nanoparticles (CeO 2 NPs) were synthesized via a green hydrothermal method and then assembled with Cur to form the CeO 2 @Cur fluorescent probe. The detection of As(V) was achieved through an adsorption-desorption mechanism, where As(V) displaces Cur from the CeO 2 surface, thereby restoring its fluorescence. Based on this mechanism, the probe exhibited a linear response (R 2 = 0.991) to As(V) concentrations within the range of 0.10-30.00 μM, with a low detection limit of 25.83 nM. Furthermore, by integrating smartphone-based RGB analysis of fluorescence images, a portable platform was constructed for the on-site detection of As(V). This work thus offers a promising strategy for sustainable and practical solution for As(V) detection in food and environmental samples.
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BIOMATERIALS
·
2025
·
IF 12.9
Fang Zhang,Bingbing Zhao,Keqiang Lu,Xueping Zeng,Zikun Wang,Wei Chen,Yunyun Zhou,Juanjuan Peng,Lingzhi Zhao
Oxidative stress and fibrosis are core drivers of post-myocardial infarction dysfunction. Conventional therapies predominantly address either acute oxidative damage or chronic fibrosis, lacking strategies that concurrently target the two interconnected processes. Here, a microenvironment-responsive nanomedicine delivering nitric oxide (NO) and curcumin specifically to the infarcted heart is presented (named C@Si-NM). Constructed from glutathione-sensitive cyclic nitrate-trimethylene carbonate-polyethylene glycol block copolymer micelles crosslinked with silica, the system releases both NO and the encapsulated curcumin upon encountering elevated glutathione levels at the infarction site. In cardiomyocytes, NO suppresses the opening of mitochondrial permeability transition pore, inhibiting the release of reactive oxygen species, while curcumin directly acts as an antioxidant. In fibroblasts, NO inhibits the TGF-β/Smad pathway and curcumin downregulates the production of TGF-β, jointly suppressing fibrosis. The combined nanomedicine C@Si-NM significantly improved cardiac function in a rat model of MI after four weeks of treatment, resulting in an ejection fraction of 74 %. This value approached the normal range of 81 % and was superior to the outcomes observed with NO monotherapy at 62 % or curcumin monotherapy at 63 %. This strategy effectively mitigates both oxidative damage and fibrosis, bridging the gap between acute and chronic therapeutic interventions of myocardial infarction.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Bingqing Huang,Qianyi Hu,Guoguang Zhang,Jinmei Zou,Peng Fei,Zhenjiong Wang
This study successfully grafted caffeic acid and 3,4-dihydroxybenzoic acid into chitosan through a coupling reaction, yielding grafting ratio of 8.93 % for caffeic acid grafted chitosan (CA-GC) and 9.15 % for 3,4-dihydroxybenzoic acid grafted chitosan (DHB-GC) at an optimal concentration of 4 mmol phenolic acids. The characterization of modified chitosans through ultraviolet visible spectrometer (UV–vis), Fourier transform infrared spectrometer (FTIR), proton nuclear magnetic resonance ( 1 H NMR), and x-ray photoelectron spectrometer (XPS) confirmed the successful grafting of phenolic acids. In the subsequent step of emulsion preparation, confocal laser scanning microscope images confirmed the formation of O/W (oil-in-water) emulsions. The phenolic acid-grafted chitosans exhibited better emulsification properties compared to native chitosan, such as reduced droplet size, more uniform emulsion droplet distribution, increased ζ-potential, and enhanced emulsifying activity and stability. Moreover, the modified chitosans demonstrated increased antioxidant activities (evidenced by DPPH and β-carotene assays) and displayed greater antimicrobial effects against E. coli and S. aureus . Its efficacy in curcumin encapsulation was also notable, with improved encapsulation efficiency, sustained release rates, and enhanced storage and photostability. These findings hint at the potential of modified chitosans as an effective emulsifier.
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JOURNAL OF CLUSTER SCIENCE
·
2024
·
IF 2.7
Luo Honghuan,Chen Menglan,Song Fangxiang,Cai Xiaoqin,Yan Yibing,Li Tingxian,Songye Li,Li Yan
Zeolitic imidazolate framework-8 (ZIF-8) is a promising material for drug delivery, but its poor stability limits its wide application. In this work, homogeneous dodecahedral ZIF-8 was prepared by the room-temperature solution stirring method, and to improve the stability of ZIF-8, ZIF-8@mSiO 2 and DZIF-8 (ZIF-8 after calcination) @PMO composites with the core-shell structure were obtained using mesoporous silica (mSiO 2 ) and periodic mesoporous organic silica (PMO) coatings. Folic acid-coupled chitosan (CS-FA) was modified on nanoparticles, and curcumin (CUR) was used as a model anti-tumor drug to obtain the drug delivery systems with targeting and pH stimulation response: ZIF-8@mSiO 2 @CUR@CS-FA and DZIF-8@PMO@CUR@CS-FA, which exhibited good dispersion and high drug loading capability. In addition, we used the MTT assay to assess the cytotoxicity of the drug-carrying systems and selected human cervical cancer cells (Hela) as model cells. The results of the in vitro experiments suggested that the final CUR-loaded drug delivery systems had significantly increased anticancer efficiency compared with the free drug CUR, which improved the therapeutic effect of the hydrophobic CUR on tumors. In conclusion, the pH-responsive nanocarriers provided potential for the targeted delivery of anticancer medication, resulting in a platform for drug-controlled release and cancer therapy.
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Mengdi Qin,Guangshuai Zhang,Peixu Zhao,Genyang Ye,Mo Li,Xiwei Jiang,Xiaohong Liu,Qiang Fu,Zhonggui He
Thiol-modified hyaluronic acid (HASH) improves zein nanoparticles (ZNPs) stability by disulfide bonding with zein. However, the effect of the degree of thiol substitution in HASH on the stability of the ZNPs remains unclear. In this study, HASH with 1%, 3%, and 5% degrees of thiol substitution was synthesized and used as stabilizers to prepare three composite NPs. The pH and salt ion stability of the composite NPs increased with increasing degree of thiol substitution, which improved the antioxidant and anti-inflammatory capacities of the composite NPs. Interestingly, when the degree of thiol substitution exceeded 3%, the physical stability of composite NPs did not improve further. Our results revealed the relationship between the degree of thiol substitution in HASH and the stability of ZNPs, and provided the optimal degree of thiol substitution. These findings provided important information for improving the physical stability of ZNPs and contributed to the development of a delivery system for natural actives.
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INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Bin Zhang,Yanlong Zhong,Peng Luo,Xiaolong Yu,Shaorong Huang,Xiaoyong Zhang,Xiaowei Yang
Osteoporosis is a metabolic bone disorder characterized by a reduction in bone mass and strength, which in turn leads to an increased likelihood of fracture. Although natural compounds show promising potential for osteoporosis treatment, their performance has been largely restricted by their poor water dispersibility and lack of bone-targeting ability. In this study, curcumin (Cur) was phosphorylated by a facile one-step nucleophilic substitution reaction to create phosphorylated Cur (p-Cur), in which the phenolic hydroxyl groups of Cur were converted to phosphate moieties through reaction with POCl 3 , enabling spontaneous self-assembly of p-Cur into carrier-free nanoparticles (p-Cur NPs) with excellent colloidal stability and bone-targeting ability in aqueous solution. In vitro results revealed p-Cur NPs effectively inhibited osteoclastogenesis in a dose-dependent manner, likely by scavenging reactive oxygen species. Using an ovariectomized murine model, p-Cur NPs demonstrated superior therapeutic outcomes compared to unmodified Cur, particularly in mitigating trabecular bone loss and maintaining skeletal microarchitecture. This phosphorylation-mediated nanonization approach combines simple synthesis with high biosafety, offering a promising paradigm for repurposing hydrophobic natural products into targeted therapeutics for metabolic bone diseases.
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Advanced Healthcare Materials
·
2024
·
IF 10
Jie Gao,Zhenzhen Weng,Ze Zhang,Yuanyuan Liu,Zikang Liu,Xinyue Pu,Simin Yu,Yanhua Zhong,Danmeng Bai,Hongbo Xin,Xiaolei Wang
Androgenetic alopecia (AGA) is a prevalent systemic disease caused by diverse factors, for which effective treatments are currently limited. Herein, the oleogel (OG) containing copper-curcumin (CuR) nanoparticles is developed, designated as CuRG, which is also combined with traditional naturopathic scraping (Gua Sha, SCR) as a multifunctional therapy for AGA. With the assistance of lipophilic OG and SCR, CuR can efficaciously penetrate the epidermal and dermal regions where most hair follicles (HFs) reside, thereby releasing curcumin (CR) and copper ions (Cu 2+ ) subcutaneously to facilitate hair regeneration. Concomitantly, the mechanical stimulation induced by SCR promotes the formation of new blood vessels, which is conducive to reshaping the microenvironment of HFs. This study validates that the combination of CuRG and SCR is capable of systematically interfering with different pathological processes, ranging from improvement of perifollicular microenvironment (oxidative stress and insufficient vascularization), regulation of inflammatory responses to degradation of androgen receptor (AR), thus potentiating hair growth. Compared with minoxidil, a widely used clinical drug for AGA therapy, the designed synergistic system displays augmented hair regeneration in the AGA mouse model. This article is protected by copyright. All rights reserved
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Junpeng Liu,Wei Liu,Yefan Zhang,Junwen Ouyang,Boxiao Zhao,Changyu Wu,Boda Li,Jiaxuan Jiang,Kai Hu
Pterygium is a common ocular surface lesion, and postoperative recurrence remains a major challenge due to insufficient therapeutic strategies targeting fibroblast proliferation and inflammation. Fibrinogen hydrogel (Fibrin glue, FG), a bioadhesive hydrogel, is widely used in pterygium surgery to secure conjunctival autografts. However, its low adhesion often leads to graft detachment, hindering effective repair. To overcome this limitation, we developed an injectable high-adhesion fibrin-silk glue (FG-GP-SF-Cur) by genipin-cross-linking silk fibroin (SF) into FG, enabling sustained release of the anti-inflammatory/antiproliferative drug curcumin (Cur). The material exhibited enhanced shear/tensile adhesion and prolonged Cur release (>10 days) in vitro, supported by FTIR and SEM analyses of its cross-linked structure. In primary pterygium fibroblasts, FG-GP-SF-Cur suppressed migration and proliferation by downregulating α-SMA, FN1, and COL3A1 while reducing VEGF/MMP2 via GSK3β/β-catenin pathway inhibition. Flow cytometry revealed its ability to promote anti-inflammatory M2 macrophage polarization, elevating IL-4/IL-10 and suppressing IL-1β/TNFα. In a corneal alkali burn model, FG-GP-SF-Cur effectively inhibited neovascularization and sustained M2 polarization, correlating with reduced inflammation and fibrosis. This study demonstrates FG-GP-SF-Cur as a dual-functional, high-adhesion biomaterial combining mechanical stability with controlled anti-inflammatory and antiproliferative drug delivery, offering a promising strategy to minimize pterygium recurrence and enhance surgical outcomes.
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