APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 10
·1042
·
IF 3
Song Yizhe,Wang Yuqin,Tang Qian,Li Lianbi,Zhang Guoqing,Zhou Hu,Han Chao,Li Zebin,Chen Xuli
Visual pH-responsive films provide a simple approach for distinguishing acidic and alkaline conditions. Herein, polyaniline (PANI) was polymerized in situ on graphene oxide (GO) sheets to form polyaniline-functionalized graphene oxide (PGO), which was subsequently combined with additional GO to construct a sheet-assembled GO/PGO composite film. This design was intended to distinguish the structural-supporting role of GO from the proton-responsive chromatic function of PGO. Among the discrete compositions examined, the PGO-60% and PGO-80% samples exhibited relatively uniform and distinguishable color responses. The films were evaluated at the discrete pH values of 0, 1, 2, 4, 8, 10, 12, and 14. Across the PGO-80% and PGO-60% spectral datasets, the wavelength of maximum transmittance (λ T, max ) ranged from 470 to 500 nm at pH 0–10 and from 428 to 440 nm at pH 12–14. Visual differences within pH 0–4 and between pH 8 and 10 were limited, and λ T, max did not change monotonically across successive pH values. The clearest optical separation was observed between strongly alkaline conditions at pH 12–14 and the lower-pH conditions at pH 0–10. Accordingly, the proposed GO/PGO composite film is presented as a proof-of-concept material for broad visual screening, particularly for identifying strongly alkaline conditions, rather than as a calibrated sensor capable of resolving the full pH 0–14 range.
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ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Feiyun Li,Cheng Cai,Hongming Lou,Yuxia Pang,Xinyi Liu,Xueqing Qiu
Enzymatic conversion of lignocelluloses into fermentable sugar is a key step in the production of cellulosic ethanol. In this work, enzymatic hydrolysis lignin (EHL)-grafted phosphobetaine (EHLPB) was prepared, and the phosphobetaine intermediate, 3-chloro-2-hydroxypropyl(2-(trimethylammonio)ethyl)phosphate, was synthesized from phosphocholine chloride calcium salt and epichlorohydrin. EHLPB showed a pH-sensitive response. When pH ≥ 5.0, it was completely dissolved in the buffer solution, whereas 95.5% of EHLPPB was precipitated when pH ≤ 3.0. Adding 1.2 wt % EHLPB-210 can increase the high-solid enzymatic digestibility of Eu-SPORL (sulfite pretreatment to overcome recalcitrance of eucalyptus) and CCR (corncob residue) from 33.6% and 52.6% to 71.5% and 73.6%, respectively. After the enzymatic hydrolysis of Eu-SPORL, 95% of EHLPB-210 was recovered by adjusting the slurry pH from 5 to 3. The recovered EHLPB-210 still kept the ability to enhance enzymatic hydrolysis of lignocelluloses. Adding 1.2 wt % recovered EHLPB-210 can increase the enzymatic digestibility of Eu-SPORL from 33.6% to 75.1%. Investigation of the adsorption of cellulase on lignin by sodium dodecyl sulfate–polyacylamide gel electrophoresis (SDS-PAGE) showed that EHLPB can significantly reduce the nonproductive absorption of cellulase on lignin and therefore enhance the enzymatic hydrolysis of lignocelluloses. By adding recoverable pH-responsive EHLPB, the enzymatic hydrolysis efficiency of lignocelluloses improved and the value-added utilization of enzymatic hydrolysis lignin was realized.
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RSC Advances
·
2016
·Vol. 6
·期 6
·4850-4857
·
IF 3.289
Xue Jiao Liu,Hai Qiang Li,Bao Yuan Zhang,Ya Jun Wang,Xiu Yan Ren,Shuang Guan,Guang Hui Gao
Stimuli-responsive hydrogels are becoming increasingly important for controlled drug delivery, biosensing, and tissue engineering. However, few pH-sensitive hydrogels with good mechanical property have been extensively reported. In this investigation, we reported the preparation of extremely stretchable and tough pH-sensitive hydrogels by introducing a linear polysaccharide-agar into the poly(acrylamide-co-acrylic acid) (P(AM-co-AA)) network and using diacrylated PEG (PEGDA) as a chemical crosslinker based on a simultaneous interpenetrating polymer networks (IPN) structure. It was found that longer PEGDA chains would lead to the obvious increase in swelling ratio and the stretchability of hydrogels. Moreover, the content of agar, the crosslinker concentration and the pH of the external environment would significantly affect the mechanical characteristics of the hydrogels. The compression strength and dissipated energy could reach 4.56 MPa and 0.56 MJ m−3 under the deformation of 85%, respectively. Also, hydrogels exhibited excellent reversible swelling and recoverable deformation. The improved mechanical properties enable the pH-sensitive hydrogels to be potential candidates in the field of load-bearing soft tissues.
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Journal of the Taiwan Institute of Chemical Engineers
·
2016
·
IF 2.848
Jiagen Li,Jin Zeng,Xu Jia,Lei Liu,Tingting Zhou,Peng Liu
Multi-responsive polymeric microspheres have attracted more and more interest as drug delivery system (DDS) for anti-tumor drugs because they could achieve “on-demand” drug release, triggered by the tumor micro-environment. Here the pH, temperature and reduction multi-stimuli responsive polymeric microspheres were fabricated via distillation–precipitation polymerization technique, with or without the middle hollow layer between their pH and reduction responsive poly(methacrylic acid) (PMAA) cores and temperature sensitive poly( N -isopropylacrylamide) (PNIPAM) shells. The effect of the hollow layer on their drug loading and drug release performance was investigated in detail. It was found that the PMAA/PNIPAM yolk/shell microspheres with hollow layer possessed a higher drug loading capacity, while the PMAA/PNIPAM core/shell microspheres without hollow layer exhibited a better controlled release behavior. This understanding must be helpful on designing intelligent anti-tumor DDS.
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Science Advances
·
2025
·Vol. 11
·期 44
·
IF 12.5
Ganghua Yang,Jianqiu Yang,Zhaoping Diao,Jiajun Long,Zhiwen Shu,Chengkang Liu,Wenbing Wan
Precise macrophage modulation is essential for diabetic wound treatment, yet mitochondrial dysfunction often sustains proinflammatory states. We developed cascade-targeting nanoparticles [epigallocatechin-3-gallate and metformin nanoparticles modified with mannose (EM/Man NPs)] to regulate macrophage mitochondria, integrated into a detachable core-shell microneedle patch (EM/Man MNs) made of quaternary ammonium chitosan and reactive oxygen species (ROS)–degradable polymer. The patch offered high penetration and antibacterial activity, while its ROS-sensitive core released EM/Man NPs to scavenge ROS, restore adenosine 5′-triphosphate production, and reestablish redox balance. The NPs further activated the adenosine 5′-monophosphate–activated protein kinase/Sirtuin 1/peroxisome proliferator–activated receptor gamma coactivator 1α axis to promote mitochondrial biogenesis and oxidative phosphorylation, repolarizing macrophages to an anti-inflammatory phenotype. In diabetic mice, EM/Man MNs accelerated healing via bacterial clearance, immune reprogramming, angiogenesis, and collagen deposition while inhibiting scar formation through interleukin-17 and phosphatidylinositol 3-kinase–Akt suppression. This cascade-targeting strategy for modulating macrophage mitochondria to regulate immunity and redox homeostasis provides a previously unidentified approach for designing tissue engineering materials.
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PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 21
·3632
·
IF 5.1
Hongyang Pan,Xiaofang Chu,Shiwen Li,Zhaojun Wang,Jie Chen
This study aimed to elucidate the effect of pH on the stability of soluble soybean polysaccharide (SSPS)-stabilized dairy beverages. A single-factor experimental design was employed using model systems containing 1.0% (w/v) protein and 0.4% (w/v) SSPS, with pH values adjusted from 3 to 7. System stability was comprehensively evaluated through centrifugation sedimentation rate, particle size distribution, ζ-potential, viscosity, and LUMisizer analysis. As pH increased from 3 to 7, the stability first decreased and then increased, showing the lowest stability at pH 5 and the highest stability at pH 6–7. At pH 5, large SSPS–protein aggregates formed due to the proximity to the isoelectric point (pI) of milk proteins, resulting in increased viscosity (6.83 mPa·s) and reduced ζ-potential (−5.8 mV). Conversely, at pH 6–7, strong electrostatic repulsion and steric stabilization led to small, uniformly dispersed particles and minimal transmittance change (<5%) in LUMisizer analysis. These findings clarify the stabilizing mechanism of SSPS and provide practical guidance for pH regulation in the formulation of dairy beverages.
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PubMed
高影响因子
MEASUREMENT
·
2026
·
IF 6.1
Yang Liu,Changyuan Xu,Yuqin Zhu,Jianxin He,Quanhua Xie,Yuanyuan He,Lei Wu,Dong Lai,Fei Fu,Qiongyao He,Bowen Jing,Guoqing Zhang,Nianbing Zhong
Moss-induced biocorrosion of stone heritage is a slow yet persistent deterioration process that alters the physicochemical conditions within porous stones, leading to structural damage and loss of cultural value. To conduct in-situ decoding of the pathogenic mechanism of mosses on sandstone, we developed a fiber Bragg grating (FBG)–based multi-parameter sensing system. The sensing system integrates three types of FBGs—temperature-sensing (T-FBG), strain-sensing (S-FBG), and polyacrylic acid–polyvinyl alcohol (PAA-PVA) coated pH-sensing FBG (H-FBG). The sensitivities and resolutions of T-FBG, S-FBG and H-FBG are 9.69 pm/℃ (0.01 ℃), 1.23 pm/με (0.1 με) and 38.63 pm/pH (0.02 pH units), respectively. A decoupling model based on a 3 × 3 sensitivity matrix was established to eliminate cross-sensitivity effects. During 60 days of Funaria hygrometrica colonization, the system captured dynamic variations including a maximal pH decrease of 0.5, a temperature fluctuation of 3.2 ℃, and an internal microstrain increase of 11.3 με. Microscopic and porosity analyses further confirmed the dual biochemical–mechanical degradation caused by metabolite secretion and rhizoid penetration. This work provides quantitative insights into moss-induced biocorrosion mechanisms and indicates the feasibility of optical fiber sensing as an early-warning strategy for preventive conservation of stone relics.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yunhao Song,Yihui Lin,Shuangshaung Li,Xueping Huang,Na Wen,Jinlin Long,Ying Wang,Pengzhao Wang,Tengfei Lin,Xunbin Yu,Shiyun Lu
Wound infections caused by bacterial invasion significantly impair tissue regeneration and prolong healing. While injectable hydrogels show promise for wound management, their clinical application is limited by pH sensitivity in infected wound microenvironments. In this study, we successfully developed a novel pH-independent antibacterial hydrogel (FHAg) via hydroxyethyl cellulose (HEC)-guided self-assembly of Fmoc-Glu-OMe and in situ synthesized silver nanoparticles (AgNPs). The HEC matrix provides a stable structural scaffold for the hydrogel, promotes π-π stacking self-assembly, and confers exceptional stability within a broad pH range (3.0–7.4), effectively overcoming the pH-sensitivity limitation of conventional hydrogels in acidic wound microenvironments. The hydrogel exhibited exceptional biocompatibility, potent antibacterial and antibiofilm activity in vitro. In vivo MRSA -infected rat wound model revealed two key advantages: 99.9% bacterial eradication efficacy and accelerated wound healing within 12 days. This pH-resilient hydrogel platform addresses critical challenges in infected wound care, showing strong potential for clinical translation.
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PubMed
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PHYSICA B-CONDENSED MATTER
·
2026
·
IF 3.2
Chuanfang Wu,Zitao Yan,Yong Pu,Dachuan Zhu
A series of bimetallic-organic frameworks (MOFs), Dy x Gd 1-x -L 1 L 2 (x=0.005, 0.01, 0.015, 1), have been synthesized via solvent-thermal method using Gd 3+ as the matrix ion, Dy 3+ as the emission center, 1,10-phenanthroline(L 1 ) and 2-aminoterephthalic acid(L 2 ) as organic ligands, DMF and methanol as solvents. The XRD and FT-IR patterns indicated the concentration of Dy 3+ did not change the crystal structure and bonding, and the SEM morphologies demonstrated the MOFs as irregular flake-like particles. The PL spectra revealed two characteristic peaks of Dy 3+ (481 nm and 575 nm) arisen from transition of 4 F 9/2 → 6 H 15/2 and 4 F 9/2 → 6 H 13/2 appeared, with the highest intensity at x=0.01. Notably, the emission intensity of Dy 0.01 Gd 0.99 -L 1 L 2 increased linearly with the increase of pH within a range of 3.4-8.8, and the acidity coefficient (pKa) was calculated as 3.69, implying a good sensing for pH value, combined with a good cyclic stability and anti-interference, which was deduced from protonation/deprotonation with the variation of pH value.
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REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.1
Xiyuan Guo,Yuanfeng Pan,Yuanjian Xie,Pingxiong Cai
Pesticides are essential for agricultural production; however, their improper application can result in ecological damage and potential threats to human health. Therefore, the development of pesticide-controlled-release systems is crucial for the sustainable progress of agriculture and society. This work presents a novel strategy for fabricating a polyelectrolyte hydrogel bead-based pesticide-controlled-release system. The process involves blending a sodium alginate/carboxymethyl chitosan (SA/CMCS) solution with cystine dihydrochloride (CYS), followed by introducing the mixture into a citric acid (CA) solution. The abundant protonated amino groups (-NH 3+ ) and carboxylate anions (-COO-) within the system facilitate the formation of CMCS/SA-CYS/CA composite hydrogel beads (CHGB), subsequently loaded with thiamethoxam (TMX) to create TMX-loaded CHGB (TCHGB) for investigations into drug loading and responsive release. The CHGB exhibits remarkable swelling properties (up to 4200%), along with pH and redox sensitivity. And the release of TMX from TCHGB displays favorable responsiveness to pH and redox stimuli. Under alkaline conditions (pH 9.0) and reductive surroundings (containing glutathione), the cumulative release ratio of TMX surpasses 95%. Furthermore, it has been demonstrated that the release kinetics of TMX comply with Fickian diffusion described by the Korsmeyer-Peppas model. The discoveries of this study hold considerable research and practical value in the domain of controlled-release agricultural chemicals.
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Agriculture-Basel
·
2026
·Vol. 16
·期 12
·1272
·
IF 4.5
Xiang Li,Ziyi Wu,Zijian Jiang,Junwei Zhang,Shuai Liu,Jianguo Feng
Developing zinc oxide-based nano-bactericides as alternatives to conventional chemical bactericides for controlling rice bacterial diseases has become a major research focus. In this study, ZnO nanoparticles were initially surface-modified and subsequently covalently conjugated with chitooligosaccharide (COS)viaimine bonds to get a pH-responsive zinc oxide–chitooligosaccharide (ZnO–COS) delivery system. A series of physicochemical characterizations, including FTIR, UV-vis, XRD, and TGA, confirmed the successful synthesis of ZnO–COS NPs. Building on this foundation, the pH-responsive release behavior, foliar deposition performance, antibacterial activity, and biosafety of the nanoparticles were systematically investigated. The prepared ZnO–COS NPs exhibited pronounced acid-triggered Zn2+release, together with enhanced wettability, spreadability, and retention on rice leaf surfaces, owing to COS incorporation. In both in vitro and in vivo assays againstXanthomonas oryzaepv.oryzae(Xoo), ZnO–COS NPs demonstrated effective antibacterial activity associated with bacterial cell damage and the activation of antioxidant defense responses in plants. Consequently, ZnO–COS NPs achieved a preventive efficacy of 56.0% against rice bacterial blight, surpassing those of ZnO (33.3%) and COS (14.3%). Furthermore, safety assessment confirmed the good biocompatibility of ZnO–COS NPs towards rice seed germination and seedling growth. In summary, the synthesised ZnO–COS NPs integrated pH-responsive release, improved foliar deposition, and enhanced antioxidant capacity of rice, offering a promising strategy for mitigating bacterial diseases in rice.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Liu Zhe,Zhang Mengqi,Zhou Ziyang,Liu Xinyu,Lanson Bruno,Zhao Wantong,Feng Xionghan,Tan Wenfeng,Lu Guining,Wang Xiaoming
The environmental persistence of
glyphosate and its transformation
into aminomethylphosphonic acid (AMPA) necessitate a mechanistic understanding
of its abiotic degradation in natural environments. Manganese (Mn)
oxides are ubiquitous redox-active minerals capable of oxidizing glyphosate;
however, how Mn oxide mineralogy and pH regulate degradation kinetics,
pathway selectivity, and interfacial redox processes remains unclear.
Here, we investigated glyphosate oxidation by three representative
Mn oxides, layered birnessite, disordered-layered vernadite, and tunnel-structured
cryptomelane, across pH 3–7. Vernadite exhibited the highest
and most sustained oxidative reactivity, cryptomelane showed rapid
but strongly pH-dependent oxidation, and birnessite displayed slower
yet persistent reactivity. Mineral structure controlled product selectivity:
under near-neutral conditions, layered Mn oxides favored glycine formation
through C–N bond cleavage adjacent to the phosphonate group,
whereas tunnel-structured cryptomelane promoted AMPA accumulation
through cleavage near the carboxyl group. Acidic conditions (pH 3
and 5) enhanced AMPA accumulation across all Mn oxides, suggesting
increased persistence risks. Spectroscopic and kinetic analyses demonstrated
that glyphosate oxidation involved surface complexation with Mn(IV),
interfacial electron transfer, and propagation through transient,
labile Mn(III) intermediates. These findings reveal that Mn oxide
mineralogy and pH jointly govern bond-selective glyphosate oxidation
and AMPA accumulation, advancing mechanistic predictions of glyphosate
fate in soil and aquatic environments.
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