JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 23
·9446-9458
·
IF 4.5
Cheng Zhipeng,Yin Jingzhou,Chu Xiaozhong,Yang Tingting,Gao Yuan,Zhong Hui,Zhang Lili
Transition metals (TMs) have an excellent catalytic effect on the thermal decomposition of ammonium perchlorate (AP). However, nanosized TM catalysts tend to agglomerate due to their high surface energy and magnetism. In this work, a new Fe/Al composite catalyst was synthesized by loading Fe nanoparticles onto Al powder through a facile replacement route, and its effect on the thermal decomposition stability of AP and AP-based propellants was investigated. Morphological and structural characterization showed that Fe nanoparticles were successfully decorated on the Al surface without noticeable aggregation or shedding. The diameter of Fe nanoparticles was approximately 10 nm. The constructed Fe/Al composite catalyst presented a strawberry-like structure. Elemental mapping analysis revealed that the dispersion state of the Fe/Al composite catalyst was better than that of commercial Fe nanoparticles with AP. Thermal analysis indicated that the Fe/Al composite catalyst presented excellent catalytic stability in the high-temperature decomposition (HTD) of AP, reducing the HTD temperature by approximately 100 °C. Burning tests showed that the relative standard deviations of the burning rate with the Fe/Al composite catalyst were 2.5 and 2.2% at 5 and 10 MPa, respectively, whereas those with Fe reached 17.1 and 13.9% at 5 and 10 MPa, respectively. The Fe/Al composite catalyst inherited the good dispersion of Al, effectively resolving the problems of Fe nanocatalyst agglomeration. Therefore, the as-obtained Fe/Al composite catalyst can significantly improve the thermal decomposition stability of AP and AP-based propellants and will have wide application prospects in the field of AP-based propellants.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 6
·1-9
·
IF 5.7
Liu Cheng,Guo Ping,Lu Yan-Rui,Zhu Yu-Lan,Ran Xiao-Yan,Wang Bang-Jin,Zhang Jun-Hui,Xie Sheng-Ming,Yuan Li-Ming
The manufacturing of chiral covalent triazine framework core-shell microspheres CC-MP CCTF@SiO 2 composite is reported as stationary phase for HPLC enantioseparation. The CC-MP CCTF@SiO 2 core-shell microspheres were prepared by immobilizing chiral COF CC-MP CCTF constructed using cyanuric chloride and (S)-2-methylpiperazine on the surface of activated SiO 2 through an in-situ growth approach. Various racemates as analytes were separated on the CC-MP CCTF@SiO 2 -packed column. The experimental results indicate that 19 pairs of enantiomers were well separated on the CC-MP CCTF@SiO 2 -packed column, including alcohols, phenols, amines, ketones, and organic acids. Among them, there are 17 pairs of enantiomers that can achieve baseline separation with good peak shapes. Their resolution values on this chiral column are between 0.4 and 5.61. The influences of analyte mass, column temperature, and composition of the mobile phase on the resolution of enantiomers were studied. In addition, the chiral resolution ability of CC-MP CCTF@SiO 2 -packed column was compared with the commercial chiral chromatographic columns (Chiralpak AD-H and Chiralcel OD-H columns) and some CCOF@SiO 2 chiral columns (β-CD-COF@SiO 2 , CTpBD@SiO 2 , and MDI-β-CD-modified COF@SiO 2 ). The CC-MP CCTF@SiO 2 -packed column exhibited some unique advantages and can complement these chiral columns in chiral separations. The research results show that the CC-MP CCTF@SiO 2 chiral column offered high column efficiency (e.g., 17680 plates m −1 for ethyl mandelate), low column backpressure (5–9 bar), high enantioselectivity, and excellent chiral resolution ability for HPLC enantioseparation with good stability and reproducibility. The relative standard deviations (RSD) ( n = 5) of the retention time, and peak areas by repeated separation of ethyl mandelate are 0.23% and 0.67%, respectively. It demonstrates that the CC-MP CCTF@SiO 2 core-shell microsphere composite has great potential in enantiomeric separation by HPLC. Graphical abstract
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EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2023
·Vol. 249
·期 8
·2017-2027
·
IF 3.3
Han Zai-Gang,Zhang Lingli,Qi Chao,Shi Qing,Min Jun Zhe
The detection and analysis of α-dicarbonyl compounds (α-DCs) in food can guide the daily diet of patients with various chronic diseases. However, these compounds have poor stability, lack color-generating groups, and have low ionization efficiency. Therefore, it is difficult to monitor them. We established a new simple and sensitive method for the simultaneous determination of four α-DCs, including glyoxal (GO), methylglyoxal (MG), 2,3-butanedione (DMGO), and 3-deoxyglucosone (3-DG) in beer by ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) with pre-column derivatization using 3-benzyl-2-oxo-4λ 3 -thiazolidine-4-carbohydrazide (BOTC), a novel MS probe for targeted identification of carbonyl compounds. α-DCs were derivatized with BOTC at 60 °C for 60 min, and the gradient analysis was carried out on a CSH C18 (2.1 mm × 50 mm; 1.7 μm) column for 5 min with a mobile phase A of 0.1% formic acid (FA) in water and mobile phase B of 0.1% FA in acetonitrile. The linearity range of this method was 0.39–500 μM ( R 2 ≥ 0.9995). The limits of detection (LOD) were in the range of 13–50 fmol. The average recoveries of α-DCs were 95.15–101.67%. This method was successfully applied to the detection of α-DCs in beer; the content of 3-DG was the highest, several hundred times higher than that of GO, MG, and DMGO, and the difference was significant. This new BOTC derivatization-based UHPLC-MS/MS method for the simultaneous detection of four α-DCs in beer is highly sensitive and can be used for the detection of α-DCs in alcoholic beverages. Graphical abstract
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CELLULOSE
·
2023
·Vol. 30
·期 9
·5987-6000
·
IF 5.7
Luo Cheng-Long,Huang Ming-Lu,Sun Chang,Zhao Kun-Yan,Hu Zongqian,Wang Ming
Herein, non-woven cotton fabrics (NWCFs) with excellent microwave shielding, Joule heating and self-cleaning performance were achieved by modifying NWCFs with dopamine, then depositing a thin copper (Cu) layer, and finally coating with a thin polydimethylsiloxane (PDMS) layer. Because of the high conductivity of Cu layer and unique heterogeneous structure, the electrical conductivity of 22,548 S/m and electromagnetic interference shielding effectiveness (EMI SE) of ~ 110 dB were obtained in the surface modified NWCFs under 25 mM copper plating solution. Furthermore, the composite fabrics have excellent Joule heating performance, which can reach 43 °C in 15 s at a voltage of 0.5 V even after 1000 bends. In addition, the composite fabrics also have outstanding super-hydrophobic properties, which can protect against a variety of common solutions and achieve self-cleaning. This study provides a simple strategy to prepare excellent Joule heating and electromagnetic interference shielding and self-cleaning cotton fabrics. Graphic Abstract
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Military Medical Research
·
2023
·Vol. 10
·期 1
·1-23
·
IF 21.1
Yu Yong-Lin,Wu Jun-Jie,Lin Chuan-Chuan,Qin Xian,Tay Franklin R.,Miao Li,Tao Bai-Long,Jiao Yang
Background Treatment of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium (Ti) implants. There is a need to explore more effective approaches for the treatment of MRSA biofilm infections.Methods Herein, an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles (PDA), nitric oxide (NO) release donor sodium nitroprusside (SNP) and osteogenic growth peptide (OGP) onto Ti implants, denoted as Ti-PDA@SNP-OGP. The physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy, X-ray photoelectron spectroscope, water contact angle, photothermal property and NO release behavior. The synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe, 1-N-phenylnaphthylamine assay, adenosine triphosphate intensity, o-nitrophenyl-β-d-galactopyranoside hydrolysis activity, bicinchoninic acid leakage. Fluorescence staining, assays for alkaline phosphatase activity, collagen secretion and extracellular matrix mineralization, quantitative real‑time reverse transcription‑polymerase chain reaction, and enzyme-linked immunosorbent assay (ELISA) were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells (MSCs), RAW264.7 cells and their co-culture system. Giemsa staining, ELISA, micro-CT, hematoxylin and eosin, Masson’s trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms, inhibition of inflammatory response, and promotion of osseointegration of Ti-PDA@SNP-OGP in vivo.Results Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light irradiation, and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species (ROS)-mediated oxidative stress, destroying bacterial membrane integrity and causing leakage of intracellular components (P < 0.01). In vitro experiments revealed that Ti-PDA@SNP-OGP not only facilitated osteogenic differentiation of MSCs, but also promoted the polarization of pro-inflammatory M1 macrophages to the anti-inflammatory M2-phenotype (P < 0.05 or P < 0.01). The favorable osteo-immune microenvironment further facilitated osteogenesis of MSCs and the anti-inflammation of RAW264.7 cells via multiple paracrine signaling pathways (P < 0.01). In vivo evaluation confirmed the aforementioned results and revealed that Ti-PDA@SNP-OGP induced ameliorative osseointegration in an MRSA-infected femoral defect implantation model (P < 0.01).Conclusion sThese findings suggest that Ti-PDA@SNP-OGP is a promising multi-functional material for the high-efficient treatment of MRSA infections in implant replacement surgeries.
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Chinese Journal of Integrative Medicine
·
2023
·
IF 2.9
Qian Xiao-li,Meng Di,Liu Heng,Liu Chao-he,Zhou Ping,Yang Yin-he,Wang Jia-peng,Xiao Huai,Ding Zhong-tao
Objective To explore the proliferation inhibitory effect of quinones from Blaps rynchopetera defense secretion on colorectal tumor cell lines. Methods Human colorectal cancer cell HT-29, human colorectal adenocarcinoma cell Caco-2 and normal human colon epithelial cell CCD841 were chosen for the evaluation of inhibitory activity of the main quinones of B. rynchopetera defense secretion, including methyl p-benzoquinone (MBQ), ethyl p-benzoquinone (EBQ), and methyl hydroquinone (MHQ), through methyl thiazolyl tetrazolium assay. The tumor-related factors, cell cycles, related gene expressions and protein levels were detected by enzyme-linked immunosorbent assy, flow cytometry, RT-polymerase chain reaction and Western blot, respectively. Results MBQ, EBQ, and MHQ could significantly inhibit the proliferation of Caco-2, with half maximal inhibitory concentration (IC 50 ) values of 7.04 ± 0.88, 10.92 ± 0.32, 9.35 ± 0.83, HT-29, with IC 50 values of 14.90 ± 2.71, 20.50 ± 6.37, 13.90 ± 1.30, and CCD841, with IC 50 values of 11.40 ± 0.68, 7.02 ± 0.44 and 7.83 ± 0.05 µg/mL, respectively. Tested quinones can reduce the expression of tumor-related factors tumor necrosis factor α, interleukin (IL)-10, and IL-6 in HT-29 cells, selectively promote apoptosis, and regulate the cell cycle which can reduce the proportion of cells in the G 1 phase and increase the proportion of the S phase. Meanwhile, tested quinones could up-regulate mRNA and protein expression of GSK-3β and APC, while down-regulate that of β-catenin, Frizzled1, c-Myc, and CyclinD1 in the Wnt/β-catenin pathway of HT-29 cells. Conclusion Quinones from B. rynchopetera defense secretion could inhibit the proliferation of colorectal tumor cells and reduce the expression of related factors, which would be functioned by regulating cell cycle, selectively promoting apoptosis, and affecting Wnt/β-catenin pathway-related mRNA and protein expressions.
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POLYMER BULLETIN
·
2023
·
IF 3.2
Xiong Ao,Li Junqian
Fabrication of waterproof decorative paintings has attracted a great deal of interest. In this work, in situ reaction using poly(glycidyl methacrylate) (PGMA) and polyhedral oligomeric silsesquioxane with amino group at end (amino-POSS) was utilized to fabricate coatings at surfaces of papery/cloth decorative paintings via spray, which endowed the decorative paintings with excellent hydrophobicity, transparency, and weather ability. Firstly, ring opening of epoxy groups in PGMA, cross-linking structure in coatings, and strong coating/painting interface adhesion were achieved. Then, surface morphology of coatings was observed, and high surface roughness was confirmed. Next, high transparency and thermal stability of coatings were confirmed. Finally, surface water-contact-angles (WCAs) of coatings with various substrates were tested as a function of POSS content. Weathering resistances of coating surface on cloth substrate were studied. Coatings exhibit excellent properties such as high light transmittance (over 80%), high glass-transition temperature (upper limit ~ 113 ℃), high hydrophobicity (maximum WCA ~ 149°), and strong weathering resistances (the aged WCAs over 140°). Work innovation lies in simultaneously gained high hydrophobicity, good transparency, and strong weather ability. This work might pave a road for fabricating excellent coatings for protecting decorative paintings.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Ouyang Wenqi,Xu Xiayi,Lu Wanping,Zhao Ni,Han Fei,Chen Shih-Chi
There has been a compelling demand of fabricating high-resolution complex three-dimensional (3D) structures in nanotechnology. While two-photon lithography (TPL) largely satisfies the need since its introduction, its low writing speed and high cost make it impractical for many large-scale applications. We report a digital holography-based TPL platform that realizes parallel printing with up to 2000 individually programmable laser foci to fabricate complex 3D structures with 90 nm resolution. This effectively improves the fabrication rate to 2,000,000 voxels/sec. The promising result is enabled by the polymerization kinetics under a low-repetition-rate regenerative laser amplifier, where the smallest features are defined via a single laser pulse at 1 kHz. We have fabricated large-scale metastructures and optical devices of up to centimeter-scale to validate the predicted writing speed, resolution, and cost. The results confirm our method provides an effective solution for scaling up TPL for applications beyond laboratory prototyping.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 41
·期 11
·1695-1705
·
IF 4.3
Xie Yan-Kun,Feng Lu-Kun,Li Dong-Dong,Tang Yin,Zhu Cai-Zhen,Wang Ming-Liang,Xu Jian
Quasi solid-state succinonitrile (SN)-based polymer electrolytes have emerged for lithium-metal batteries due to their excellent ion-conductivity at room temperature, wide electrochemical stability window (ESW, usually >5 V). However, the practical application of these solid SN-based polymer electrolytes is hampered by the flammability and the inherent instability of SN to Li-metal anode. In this work, solid SN-based polymer electrolytes were prepared with succinonitrile, ethoxylated trimethylolpropane triacrylate (ETPTA), triethyl phosphate (TEP) and fluoroethylene carbonate for Li-metal battery via in situ polymerization method. The SN-based polymer electrolytes with 5 wt% triethyl phosphate and FEC showed good nonflammability, superior ion-conductivity as high as 1.01×10 −3 S/cm, and wide ESW of 5.41 V. This SN-based polymer electrolyte also exhibited excellent interfacial compatibility to lithium metal anode. And it also delivered a high specific capacity of 156 mAh/g at 0.2 C at ambient temperature, and presented stable cycling at 1.0 C with a specific capacity retention of 98.4% after 1000 cycles. This work provides an alternative and simple strategy to realize the practical application of the solid-state SN-based polymer electrolyte.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 14
·2677-2692
·
IF 4.3
Meng Xin,Zong Hou,Zheng Zhong,Xing Junpeng,Liu Zhiqiang,Song Fengrui,Liu Shu
α-Glucosidase inhibitors in natural products are one of the promising drugs for the treatment of type 2 diabetes. However, due to the complexity of the matrix, it is challenging to comprehensibly clarify the specific pharmacodynamic substances. In this study, a novel high-throughput inhibitor screening strategy was established based on covalent binding of α-glucosidase on chitosan-functionalized multi-walled carbon nanotubes coupled with high-resolution mass spectrometry. The synthesized MWCNTs@CS@GA@α-Glu was characterized by TEM, SEM, FTIR, Raman, and TG. Performance studies showed that the microreactor exhibited stronger thermostability and pH tolerance than that of the free one while maintaining its inherent catalytic activity. Feasibility study applying a model mixture of known α-glucosidase ligand and non-ligands indicated the selectivity and specificity of the system. By integrating ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-QTOF-MS) with ion mobility mass spectrometry (IMS), 15 ligands were obtained and tentatively identified from Tribulus terrestris L., including 8 steroidal saponins, 4 flavonoids, and 3 alkaloids. These inhibitors were further validated by in vivo experiments and molecular docking simulation.
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JOURNAL OF POROUS MATERIALS
·
2023
·Vol. 30
·期 5
·1675-1685
·
IF 2.6
Liu Xiaolin,Zeng Zexin,Ning Xutao,Zeng Bin,He Tao,Li Kewen,Zhang Lei
A facile method for the preparation of oxygen and nitrogen self-doped biochar is developed in this work through the application of one-step chemical activation by using pre-oxidized camellia combing graphene oxide. The extracted results revealed that the obtained biochar had a micropores structure while the nitrogen, oxygen heteroatoms were successfully homogeneously introduced into the carbon frameworks. The specific surface area of the GC-700-4 was about 1343 cm 2 g −1 with oxygen and nitrogen contents of nearly 15.6 at.% and 2.4 at.%, respectively. When used as an electrode for supercapacitors, the GC-700-4 compound shows the highest area-specific capacitance of 2,206 mF cm −2 at 1 mA cm −2 , and capacitance retention of about 97.4% after 5000 cycles. Moreover, the proposed symmetric supercapacitor device was fabricated based on GC-700-4, which exhibits a high gravimetric capacitance value of 236.5 F g −1 and capacity retention of 94.2% after the enforcement of 10,000 cycles at 20 A g −1 , as well as an excellent rate capability. These results confirm that graphene wrapped in biochar can change its morphology, and improve its conductivity and electrochemical performance, while graphene wrapped on the surface of biochar is only beneficial to improve the cycle stability of capacitors.
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AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 2
·1-16
·
IF 3.3
Wu Wenting,Ding Quan,Zhou Zhiwei,Kuang Wenliang,Jiang Lipeng,Liu Peng,Ai Weiping,Zhu Weifeng
In order to better promote the application of the polymeric mixed micelles (PMMs) in oral delivery, in addition to focusing on the improvement of micellar structural stability, it is necessary to obtain the absorption characteristics of the intact micellar particles. In this work, the transport behavior across Caco-2 cells of FS/PMMs composed of Pluronic F127 and Solutol HS15 was tracked by encapsulating an environment-responsive probe into the particles. The specific property of the probe is the water-initiated aggregation-caused quenching (ACQ) ability, by which integral particles can be identified accurately. The influence of polymeric ratios (FS) on the transcellular behavior of FS/PMMs was explored and the single pass intestinal perfusion experiment was used to further illustrate it. Moreover, pharmacokinetics parameters were detected to analyze the relationship among FS ratios, transport behavior, and pharmacokinetic parameters. FS ratios were found to hardly affect the endocytosis pathways and intracellular itinerary of FS/PMMs, but do affect the proportion of each path. FS/PMMs with high HS15 content, namely System-I, were found to primarily undergo receptor-mediated endocytosis pathway and be less susceptible to lysosomal degradation, which would lead to more absorption and higher Cmax and AUC than drug suspension. In contrast, despite System-II with high F127 content cannot contribute to drug plasma concentration, it can prolong the in vivo retention time. These findings provided evidence for the role of polymeric ratios in modulating the transcellular absorption and pharmacokinetic parameters of the drug-loaded PMMs, and would be a step forward in helping PMMs’ design to enhance oral drug delivery. Graphical Abstract
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危险品化学品经营许可证（带存储）