RSC Advances
·
2016
·Vol. 6
·期 77
·73699-73708
·
IF 3.289
Ning Cui,Junmin Qian,Jinlei Wang,Chuanlei Ji,Weijun Xu,Hongjie Wang
In this study, novel foamy scaffolds of poly(γ-benzyl-L-glutamate) (PBLG) and poly(γ-benzyl-L-glutamate-co-L-phenylalanine) (P(BLG-PA)) were fabricated via a combination of a sintered NaCl templating method and ring-opening polymerization of α-amino acid N-carboxyanhydrides. The obtained polypeptide-based scaffolds displayed a foamy structure and had a desirable glass transmission temperature (23.2–44.6 °C), contact angle (78.5–88.5°), compression modulus (56.3–110.2 kPa) and degradation time (>8 weeks). MC3T3-E1 cells were used to test the in vitro biocompatibility, and we found that PBLG scaffolds could significantly promote cell viability and proliferation compared to P(BLG-PA) scaffolds. In addition, micro-scale bioglass particles (BG) were incorporated into PBLG to form a porous scaffold, namely PBLG/BG composite scaffolds, which further enhanced the cell viability and adhesion, as confirmed by live-dead staining and SEM observation. The results of the ALP activity assay suggested that PBLG/BG composite scaffolds could promote the osteogenic differentiation of MC3T3-E1 cells. The results of histology analysis showed that the PBLG/BG composite scaffolds rather than PBLG scaffolds significantly promoted connective tissue and vascular ingrowth. The results obtained using digital radiography technology showed that PBLG/BG composite scaffolds significantly improved osteogenesis in vivo. In summary, our results indicated that PBLG/BG composite scaffolds could be a promising bioactive substance for bone regeneration.
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高影响因子
MACROMOLECULES
·
2025
·
IF 5.2
Ruru Wan,Bo Li,Jun Xu,Huihui Li,Shouke Yan
Thin-film crystallization of polymers is governed by diffusion processes, often resulting in branching morphologies. According to the theory of branching instability, the characteristic length scale of branch patterns is determined by the diffusion constant (D) and growth velocity (v). In this study, poly(vinylidene fluoride) (PVDF) was blended with several aliphatic polyesters and an aliphatic-aromatic copolyester. The resultant crystalline patterns of γ-PVDF crystals in the blend ultrathin films varied systematically with the polyester content (φp). By analyzing the branch width (λ) and v of γ-PVDF crystals, we established the relationship between φp and D in the depletion zone. Our findings reveal that polyesters stabilize the crystal growth front, with D exhibiting an exponential dependence on φp. Moreover, fitting-parameter K at φp = 1.0, serving as a relative indicator of the diffusion ability across pure polyesters, exhibits a clear inverse correlation with the polyester molecular weight. It is further found that at low polyester concentrations (φp ≤ 50%), the depletion zone ahead of the PVDF crystal growth front contains both mass and concentration gradients, enhancing PVDF chain mobility. However, at higher concentrations (φp > 50%), excessive polyester migration to the PVDF crystal growth front leads to a pure concentration gradient in the depletion zone.
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高影响因子
NEUROPHARMACOLOGY
·
2019
·
IF 4.367
Chunting Zhang,Weiwei Liang,Hongyong Wang,Yueqing Yang,Tianhang Wang,Shuyu Wang,Xudong Wang,Ying Wang,Honglin Feng
Oxidative stress plays a critical role in mutant copper/zinc superoxide dismutase 1 ( SOD1 )-linked amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by selective loss of motor neurons . Thus, an anti-oxidative stress remedy might be a promising means for the treatment of ALS. The aim of the present study is to investigate the neuroprotective effects of γ-oryzanol (Orz) and elucidate its relevant molecular mechanisms in mutant hSOD1 -linked Drosophila and cell models of ALS. Orz treatment provided neuroprotection in flies with expression of hSOD1-G85R in motor neurons, as demonstrated by the prolonged survival, improvement of motor deficits, reduced oxidative damage and regulated redox homeostasis when compared with those in controls. Moreover, Orz significantly decreased neuronal apoptosis and upregulated the nuclear factor erythroid 2-related factor 2 (Nrf2)/glutamate-cysteine ligase catalytic subunit (GCLC) antioxidant pathway via activating Akt in hSOD1-G93A -expressing NSC-34 cells. In addition, our results showed that both in vivo and in vitro , Akt served as an upstream regulator of signal transducers and activators of transcription (Stat) 3 stimulated by Orz, which further increased the level of another anti-oxidative stress factor heat-shock protein 70 (HSP70). Altogether, these findings provide evidence that Orz has potential neuroprotective effects that may be beneficial in the treatment of ALS disease with SOD1 mutations.
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PubMed
高影响因子
NANOTECHNOLOGY
·
2023
·Vol. 34
·期 24
·245401
·
IF 3.5
Wenjing Fu,Cundi Wei,Shaonan Xu,Enhui Wang,Jinyi Zhang,You Xu,Jiyuan Zou,Jilun Wei,Jing Zuo
A particular bird's nest-like pseudo-boehmite (PB) composed of cohesive nanostrips was prepared by a novel and facile approach based on the reaction of Al–Ga–In–Sn alloy and water, together with ammonium carbonate. The PB possesses a large specific surface area (465.2 m2 g−1), pore volume (1.0 cm3 g−1), and pore diameter (8.7 nm). Subsequently, it was utilized as a precursor to form the TiO2/γ-Al2O3 nanocomposite for tetracycline hydrochloride removal. The removal efficiency can reach above 90% at TiO2:PB = 1:1.5 under the Sunlight irradiation simulated by a LED lamp. Our results indicate that the nest-like PB is a promising carrier precursor for efficient nanocomposite catalysts.
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高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Yi Wang,Jialiang Chen,Lan Wang,Hanqin Weng,Zhihao Wu,Limin Jiao,Yusa Muroya,Shinichi Yamashita,Sheng Cheng,Fuhai Li,Hongbing Chen,Wei Huang,Mingzhang Lin
The large-scale synthesis and the stabilization of noble metal nanocatalysts with ultrasmall sizes are crucial to their practical application. Herein, Pd, Au, and Pt nanoparticles (NPs) are in situ embedded on boron nitride nanosheets (BNNSs) via the reduction of precursor salts induced by 60 Co γ-irradiation, which is a mature technique widely used in industry. The reduction mechanism was elucidated by pulse radiolysis experiments. In comparison with other BN substrates like hexagonal BN ( h -BN), BNNSs had not only large surface area of 263 m 2 g −1 , but also abundant hydroxyl groups produced during the sonicated exfoliation, resulting in ultrasmall sizes, large loading amounts, and uniform distribution of the anchored NPs. The particle sizes of the loaded Pd, Au, and Pt NPs were measured to be 2.9, 3.1, and 3.0 nm, respectively. As a consequence, in the model reaction of 2-nitroaniline reduction, the Pd-, Au- and Pt-BNNSs composite nanocatalysts showed much higher catalytic activities than those composites loading the corresponding NPs on other BN substrates. Particularly, most of the 2-nitroaniline could be reduced within merely 40 s when using Pd-BNNSs as catalysts, performing a rate constant of 1.1 × 10 −1 s −1 . The number of hydroxyl groups on BNNSs support as well as the catalytic performance of the corresponding NPs-loaded BNNSs composites could be improved by extending the sonicated exfoliation time, because more NPs were loaded and the hydroxyl groups were also proved to play an important role in enhancing the catalytic activity. Moreover, Pd-BNNSs catalysts still displayed prominent activity even after five cycles owing to the high stability of BNNSs and their strong affinity for PdNPs. This work not only demonstrates BNNSs as ideal supports to load noble metal NPs for catalysis, but also reveals the feasibility to synthesize and in situ embed ultrasmall noble metal NPs on BNNSs via γ-irradiation.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Hao Lu,Xinlei Yao,Jing Li,Shuiliang Yao,Zuliang Wu,Huanhuan Zhang,Hanghao Lin,Tomohiro Nozaki
Plasma-catalytic oxidation of particulate matter (PM) has potential applications for diesel exhaust cleaning. There is a grand requirement to explore the mechanism of carbonaceous PM oxidation for the development of plasma catalysts. Herein, Au/γ-Al 2 O 3 was used to catalyze the gasification of the graphitic carbon. A modified diffuse reflectance infrared Fourier transform spectrometer equipped with a mass spectrometer was originally utilized to in situ characterize the surface intermediates of graphite on Au/γ-Al 2 O 3 and the gaseous products during the discharges processes in the O 2 -He balanced gases. It was found that O atoms and O 3 play important roles in the formation of surface oxygen complexes (SOCs) and facilitate the gasification of SOCs to CO 2 in the presence of Au/γ-Al 2 O 3 . The findings are helpful to understand the plasma-catalytic oxidation mechanism of PM and further develop efficient plasma catalysts.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2018
·Vol. 43
·期 16
·7973-7981
·
IF 4.229
Shaowei Yang,Hui Xie,Hongwei Zhu,Lijuan Zhang,Yunshan Zhou,Huixian Zhang,Zipeng Zhao
In this work, metal-organic framework compound CPL-1 of a formula {[Cu 2 (pzdc) 2 (pyz)]⋅2H 2 O} n (pzdc = pyrazine-2,3-dicarboxylate, pyz = pyrazine) possessing kinetic quantum sieving effect on H 2 /D 2 separation was selected to prepare two new chromatography stationary phase materials CPL-1@γ-Al 2 O 3 and MnCl 2 @CPL-1@γ-Al 2 O 3 by loading CPL-1 on γ-Al 2 O 3 particles with size 80–100 mesh through repeating in situ crystallization process , and afterwards by loading MnCl 2 on CPL-1@γ-Al 2 O 3 via impregnation approach. The two optimized materials were thoroughly characterized by IR, XRD , SEM, EDS and TG/DTA method. The experimental results showed that, under liquid nitrogen temperature by using just 1-m chromatographic column and cheap He gas as carrier gas, the MnCl 2 @CPL-1@γ-Al 2 O 3 can solve the problem of long separation time and trailing phenomenon existing in the CPL-1@γ-Al 2 O 3 column, can realize highly effective hydrogen isotope H 2 /D 2 separation with good separation resolution (R = 1.62) and approximate Gauss distribution of chromatographic peak, can be used for both qualitative and quantitative analysis of hydrogen isotope H 2 /D 2 with short separation time of 6.5 min.
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高影响因子
RENEWABLE ENERGY
·
2025
·
IF 9.1
Yingfu Tian,Tianliang Lu,Hongjin Qu,Xiaomei Yang,Lipeng Zhou
Efficient conversion of ethyl levulinate (EL) in high concentration to γ-valerolactone (GVL) at moderate temperature via catalytic transfer hydrogenation strategy is highly desirable. In this work, hydrothermally synthesized Sn-β zeolite with high Sn content was employed as a catalyst to realize this aim. Fully crystallized Sn-β zeolite with high Sn content ( n Si / n Sn = 60) was successfully synthesized within 12 days using MgCl 2 as a promoter. The synthesized zeolites were characterized by XRD, SEM, UV-vis spectroscopy, FT-IR spectroscopy and XPS. The L acid density of Mg-Sn-β-60-12d increased to 90 μmol g −1 compared to Mg-Sn-β-100-7d (56 μmol g −1 ). 92% yield of GVL was achieved on Mg-Sn-β-60-12d using high concentration of EL (1.2 mol L –1 ) as reactant at 130 o C for 8 h. The performance of Mg-Sn-β is better than that of Sn-β with same n Si / n Sn . The reaction mechanism over Mg-Sn-β was discussed. In addition, Mg-Sn-β-60-12d showed excellent stability and reusability during five runs.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Ke Song,Liyan Xue,Minzhong Huang,Kaixian Wang,Zhiyi Wang,Haiying Xin,Fan Yang,Fengzhi Tan,Heng Chen
The development of multifunctional protective materials with electromagnetic wave absorption and (n, γ) radiation shielding properties is urgently required to guarantee secure functioning of space nuclear power sources. In this work, the multicomponent perovskite ferrites (Ca 0.2 Nd 0.2 Gd 0.2 Yb 0.2 Bi 0.2 )FeO 3 (RE-1), (Ca 0.2 Nd 0.2 Gd 0.2 Ho 0.2 Bi 0.2 )FeO 3 (RE-2), and (Ca 0.2 Nd 0.2 Gd 0.2 Ho 0.2 Bi 0.2 ) (Fe 0.9 Ti 0.1 )O 3 (RE-3) were prepared by the sol-gel method. Through multicomponent regulation, the dipole polarization and interfacial electronic transitions can be affected by the lattice distortion effect, which enhances the electromagnetic wave absorption characteristics. With an effective absorption bandwidth of 2.92 GHz and a minimum reflection loss of −46.94 dB, RE-3 exhibits the most efficient electromagnetic wave absorption of the three manufactured samples. Regarding the shielding of neutrons, the shielding efficiency of the RE-3 (45 wt%)-polypropylene (RE-3/PP 3 ) reached 99.78 %, which is mainly due to the large neutron absorption cross section of the rare-earth element Gd. With respect to the γ-ray protection capabilities, the lead equivalent values for the RE-3/PP 3 composites are 0.5083 mmPb at a 65 keV energy when narrow-band filtered X-rays are used and 1.1977 mmPb at a 1250 keV energy when a 60 Co gamma source is used. These findings indicate that multicomponent regulation can enhance the Compton effect by altering the valence electron coverage space and that rare-earth elements significantly improve the γ-ray shielding effectiveness of a material in the weak absorption region of lead. In this work, the integration of electromagnetic wave absorption and (n, γ) radiation shielding properties was achieved by multicomponent regulation, which provides a novel tactic for the developing multifunctional protective materials used in the field of deep space exploration.
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高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2021
·
IF 5.537
Pengyu Zhao,Weidan Li,Chaoying Zhen,Ke Wang,Zhen Qin,Haiyan Gao
γ-Aminobutyric acid (GABA) has several physiological functions and broad application prospects. In this study, as a tool used for transcriptomics , RNA-seq sequencing was employed to determine the mechanism by which GABA slows browning and induces resistance against the growth of bacterial in fresh-cut apples. GABA altered the expression level of genes related to the synthesis of browning enzymes and phenolic substances in fresh-cut apples, which slowed the browning process during storage. Additionally, GABA promoted the gene expression of enzymes or proteins related to disease resistance, which resultantly induced disease resistance in fresh-cut apples. Notably, GABA maintained the integrity and stability of the cell wall composition and structure in apple tissues to reduce browning and induce disease resistance. Our findings revealed the mechanism by which GABA acts as a protective agent against browning and bacterial growth in for fresh-cut apples.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Liheng Chen,Yunfeng Shi,Bo Gao,Yilun Zhao,Yueming Jiang,Zhengang Zha,Wei Xue,Liang Gong
Lignin nanoparticles (LNPs), as a special aggregate of renewable and biodegradable lignin available in abundant amounts, are a perfect building-block material because of their advantages, including good dispersibility in water, great biocompatibility, and eco-friendly characteristics. To exploit a promising method of producing LNPs, we developed a simple and sustainable synthesis approach using a recycled γ-valerolactone (GVL)/water binary solvent (GWBS). Up to 200 g/L lignin from several sources could be completely dissolved in GWBS. LNPs were easily obtained through nanoprecipitation (dropping or dialysis) of the lignin solution. The yield and size of LNPs can be controlled during nanoprecipitation. The highest yield of LNP reached 90% via dropping nanoprecipitation, and its relevant initial concentration was up to 24 g/L. This highly efficient dropping method might provide a method for scaled-up production of LNPs. The resultant LNPs, having a diameter of ca. 250 nm and a ζ-potential of −40 mV, also showed good dispersibility and stability in water. LNPs can stabilize essential oils and promote their growth inhibition activity against microbes. These results indicated that we also initiated a new method of achieving enhanced antimicrobials with whole biomass-based chemicals.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Qiangqiang Xue,Binhang Yan,Meng Chen,Yujun Wang,Guangsheng Luo
Hydrogen-rich syngas production via diesel steam reforming (DSR) is of great interest because of the high H2/CO ratio and available external heat sources. In this study, catalysts (particle size (dp) = 3–5 mm) containing 10 wt % Ni were prepared through wet impregnation, and their performance was evaluated in a semipilot fixed-bed reactor (Φ = 42 mm). The catalyst was doped with La, which resulted in excellent catalytic performance under different operating conditions. The apparent activation energies of the catalysts for the model diesel (n-dodecane) steam reforming increased in the order Ni/Ce0.75La0.25O2−δ-γ-Al2O3 (17 kJ/mol) < Ni/CeO2-γ-Al2O3 (18 kJ/mol) < Ni/γ-Al2O3 (27 kJ/mol). The model DSR over Ni/Ce0.75La0.25O2−δ-γ-Al2O3 showed product stability and produced a high H2 content (32 vol %). Fresh and spent catalysts were characterized by X-ray diffraction, N2 adsorption–desorption isotherms, H2-temperature programmed reduction, inductively coupled plasma–mass spectrometry, X-ray photoelectron spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, and thermogravimetric analysis. The origin of the oxygen vacancies in the La-doped catalyst was elucidated using density functional theory calculations. The improvements in the activity and stability of the Ni/Ce0.75La0.25O2−δ-γ-Al2O3 catalyst are attributed to (1) the enhancement in the oxygen release/storage capacity, (2) the stabilizing interaction between Ni and the surface La2O3 phase, and (3) the small size (11 nm) and uniform distribution of Ni particles. Out of the tested catalysts, the spent Ni/Ce0.75La0.25O2−δ-γ-Al2O3 catalyst showed the lowest coke deposition (5.8 mg/g-cat.) and the least severe Ni agglomeration after 10 h of testing because of its superior ionic mobility and oxygen storage capacity.
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高影响因子
危险品化学品经营许可证（带存储）