RSC Advances
·
2024
·Vol. 14
·期 53
·39779
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IF 3.9
Hongshuang Qin,Huaying Niu,Yanxiang Guo,Xiaoting Wang,Tao Liu,Chuanqi Zhao
Photodynamic therapy (PDT) has emerged as an effective way to deal with drug-resistant bacterial infections. Especially, blue light (BL) mediated PDT (BL-PDT) presents unique advantages in the treatments of skin infection due to the strong light absorption of superficial skin, weak penetration of BL and little damage to deep tissues. However, the photosensitizers used for BL-PDT are very limited, and the ongoing development of novel BL photosensitizers is indispensable. Porphyrins are good sources for developing efficient photosensitizers. Herein, for developing more effective BL photosensitizers, five porphyrin derivatives that can be excited by BL [5,10,15,20-tetraphenylporphyrin (TPP), 5,10,15,20-tetrakis(4-bromophenyl)porphyrin (TBPP), 5,10,15,20-tetrakis(4-chlorophenyl)porphyrin (TCPP), 5,10,15,20-tetrakis(4-fluorophenyl)porphyrin (TFPP), 5,10,15,20-tetrakis(4-iodophenyl)porphyrin (TIPP)] are subjected to the investigation of PDT against MRSA (methicillin resistant Staphylococcus aureus ). The results reveal that TBPP-mediated BL-PDT shows outstanding bactericidal effects. Mechanism studies show that TBPP + BL can induce reactive oxygen species (ROS) up-regulated in MRSA, rupture cell membrane, inhibit ATP (adenosine triphosphate) production and virulence factor expression. Furthermore, TBPP + BL effectively eliminates MRSA form biofilms, inhibits biofilm formation and disintegrates mature biofilms. More importantly, TBPP-PDT significantly accelerate mouse skin wound healing in a biofilm infection model. Our work offers new insights into the development of novel BL photosensitizers. Photodynamic therapy mediated by 5,10,15,20-tetrakis(4-bromophenyl)porphyrin (TBPP) effectively eliminates drug-resistant Staphylococcus aureus , inhibits biofilm formation and accelerates wound healing in a mouse model.
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ACS Applied Nano Materials
·
2024
·
IF 5.3
Caiwen Pan,Xiaoyan Dong,Qinghong Shi,Linling Yu,Yan Sun
Methyl parathion (MP) is a typical organophosphate pesticide widely used in agriculture, causing serious pollution. MP hydrolysis generates a toxic 4-nitrophenol (4-NP) with environmental risks, but a subsequent reduction of 4-NP produces a nontoxic 4-aminophenol (4-AP), which serves as a resource for further use in chemical synthesis. Thus, the detoxification and resourcilization of MP are of great significance for environmental remediation and sustainable development. However, most reports on MP cascade conversion require two different catalysts, each of which is single-catalytic. Herein, we report the first self-cascade nanocatalyst with bicatalytic activities of hydrolysis and reduction based on cupric metal–organic framework (Cu-AZB) nanosheets for the conversion of MP to 4-AP. It was found that Cu-AZB could completely convert MP to 4-AP in the presence of NaBH4 within 10 min. Moreover, hydrolysis was 19-fold accelerated by the NaBH4-mediated reduction in the self-cascade catalysis, so a catalyst with a high cascade conversion efficiency against MP with an activity factor of 513.2 min–1 g–1, a reaction rate constant of 0.25 min–1, and a half-life of 2.82 min was achieved, which was more efficient than literature-reported cascade catalysts. The results demonstrated the application potential of the bicatalytic Cu-AZB in the complete detoxification and conversion of the toxic pollutant into a nontoxic resource through one-pot cascade catalysis.
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DYES AND PIGMENTS
·
2024
·
IF 4.1
Xiaochen Zhu,Haiyan Qi,Tao Jing,Jun Li,Ming Zhao,Jiayu Zhang,Chao Luo,Maoxia Ran
4-Hydroxybenzoic acid is one of the important metabolism biochemical markers of the urine in gastric cancer patients. In this work, a fluorescence sensor based on N,S-doped carbon dots conjugated molecular imprinting polymers (N,S-CDs@SiO 2 @MIPs) was prepared to detect4-hydroxybenzoic acid. The novel fluorescence sensor in response to 4-hydroxybenzoic acid ranged from 0 to 100 μmol/L, with a detection limit of 1.27 μmol/L. Furthermore, 4-hydroxybenzoic acid demonstrated strong fluorescence quenching capability on our fluorescence sensor, with the fluorescence quenching mechanism involving a combined effects of dynamic quenching and electron transfer. Lastly, the N,S-CDs@SiO 2 @MIPs were applied to analyze 4-hydroxybenzoic acid inhuman urine samples with high accuracy. The findings showed that N,S-CDs@SiO 2 @MIPs sensor might have high potential for effectively, selectively, accurately diagnosing gastric cancer patients.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Xiao-Chen Huang,Hao Chen,Shou-Lian Wei,Jin-Kui Ma
Sulfonamide antibiotics with superior performance are widely used in aquaculture. However, the residues of sulfonamide antibiotics in aquatic products may pose a threat to human health. In this work, a novel type of magnetic molecularly imprinted polymer (mMIP) was synthesized and coupled with ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) for the selective separation and determination of 4 sulfonamide antibiotics residues in tilapia. The structure and adsorption properties of the polymers were characterized and evaluated. The key mMIP variables were investigated to determine the optimal magnetic solid phase extraction conditions. Results showed that the mMIPs had saturated adsorption capacities of 137.4, 78.7, 65.2, and 58.4 mg/g for trimethoprim, sulfadiazine, sulfamethazine, and sulfamethoxazole, respectively. Under optimized conditions, the linear range of the method for the detection of the 4 sulfonamides was 0.1–100 ng mL −1 ( R > 0.991), the detection limit was 0.015 μg kg −1 (S/N = 3), the recovery rate was 78.6–101%, and the relative standard deviation (RSD%) was 4.2–7.8%. This new rapid and ultra-sensitive pretreatment method was successfully applied to the monitoring of trace sulfonamide antibiotics residues in fish samples.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2024
·
IF 3
Zhang Cong,Guo Yan,Xiao Libai,Gao Hongxu,Zhao Fengqi,Huang Jie,Lü Xingqiang,Ma Haixia
Three 4-(1 H -tetrazole-5-yl-amino)-1,2,4,5-tetrazine-1-one (TATzO) metal salts, K 2 (TATzO)(H 2 O) ( 1 ) and Mg(TATzO)(H 2 O) 6 ·2H 2 O ( 2 ) and Sr(TATzO)(H 2 O) 4 ( 3 ), were synthesized and characterized using Fourier transform infrared (FTIR), elemental analysis, single-crystal X-ray diffraction, and powder X-ray diffraction patterns. The crystal structure and hydrogen bonding interactions have been analyzed. It turns out that 1 and 3 crystallize into a three-dimensional topological network and have strong π – π stacking and hydrogen bonding interactions. Furthermore, the geometric optimization of 1 – 3 was performed using B3LYP-D3/def2svp in Gaussian 16 software package and then analyzed by reduced density gradient. The thermal behavior was conducted using differential scanning calorimetry and thermogravimetric (TG). The decomposition temperature of the three complexes exceeds 250 °C, much higher than that of TATzO (230 °C). The thermal decomposition products of 1 were further studied using thermogravimetric-Fourier transform infrared-mass spectrometry (TG/FTIR/MS). The impact sensitivity test indicated that making complexes can help decrease the sensitivity of the original energetic ligand. Graphical abstract
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2011
·
IF 1.77
Xue-Ping Ding,Dong-Bao Tang,Tao Li,Su-Fan Wang,Yun-You Zhou
The characteristics of host–guest complexation between tetrabutyl ether derivatives of p -sulfonatocalix[4]arene (SC4Bu) and methiocarb [3,5-dimethyl-4-(methylthio) phenyl methylcarbamate] were investigated by fluorescence spectrometry. Upon addition of methiocarb, the fluorescence intensity of SC4Bu was quenched regularly and a slight red shift was observed for the maximum emission peak. These results indicated that the SC4Bu-methiocarb complex was formed a 1:1 mole ratio. An association constant of 1.67 × 10 4 L mol −1 was calculated by applying a deduced equation. The interaction mechanism of the inclusion complex was discussed. Based on the results, a novel spectrofluorimetric method was described for the determination of methiocarb with a detection limit at 0.05 μg mL −1 . This method is very simple and shows high sensitivity and selectivity. Moreover, the proposed method was successfully applied to the determination of methiocarb in water samples.
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Biomedical Materials
·
2024
·Vol. 19
·期 5
·055026
·
IF 3.9
Yu Yan,Aijia You,Xianxian Chen,Wenyi Huang,Xiaoting Lu,Cuijin Gu,Sen Ye,Jun Zhong,Haiting Huang,Yao Zhao,Yu Li,Chun Li
(+)4-cholesten-3-one has been proved to have potential wound healing effect in the process of wound regeneration. This study aimed to evaluate the effect of (+)4-cholesten-3-one/sodium alginate/gelatin on skin injury and reveal its potential molecular mechanism. First, we prepared sodium alginate/gelatin hydrogel (SA/Gel hydrogel) with different ratios and tested their characteristics. Based on these results, different concentrations of (+)4-cholesten-3-one were added into SA/Gel hydrogel. A full-thickness skin injury model was successfully established to evaluate wound healing activity in vivo. HE staining and Masson staining were used to evaluate the thickness of granulation tissue and collagen deposition level. Immunohistochemical staining and immunofluorescence staining were applied to detect the level of revascularization and proliferation in each group of wounds. Western blot, quantitative-PCR and immunofluorescence staining were used to detect the expression of proteins related to Wnt/β-catenin signaling pathway in each group of wounds. In vitro results showed that the hydrogel not only created a 3D structure for cell adhesion and growth, but also exhibited good swelling ability, excellent degradability and favorable bio-compatibility. Most importantly, in vivo experiments further indicated that (+)4-cholesten-3-one/SA/Gel hydrogel effectively enhanced wound healing. The effectiveness is due to its superior abilities in accelerating healing process, granulation tissue regeneration, collagen deposition, promoting angiogenesis, tissue proliferation, as well as fibroblast activation and differentiation. The underlying mechanism was related to the Wnt/β-catenin signaling pathway. This study highlighted that (+)4-cholesten-3-one/SA/Gel hydrogel holds promise as a wound healing dressing in future clinical applications.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Yuting Guan,Siyu Wang,Guanghua Lei,Zikang Hu,Hengye Chen,Huiwen Gu,Xiaoli Yin,Yuanbin She,Wanjun Long,Haiyan Fu
Enshi Yulu green tea (ESYL) is the most representative traditional steamed green tea in Enshi, Hubei. Different ESYL grades exhibit distinct flavors, tastes, and prices. In this study, a visual sensor based on 4-MPBA Au@AgNPs was developed for the rapid and accurate identification of ESYL grades. The recognition mechanism involved the binding of 4-MPBA Au@AgNPs with polyphenolic compounds in ESYL to form borate esters and the conversion of Ag + to Ag 0 , with the generated Ag 0 depositing on the surface of 4-MPBA Au@AgNPs. The results showed that the sensor can amplify the color differences of different grades of ESYL. The visual results were also validated by the partial least squares discriminant analysis model, demonstrating an enhancement in recognition accuracy from 68.2 % to 95.5 % compared to the original extraction solution. The colorimetric sensor developed in this study is expected to provide a new approach for traceability research of other foods.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Congling Yang,Qianying Guo,Xinchun Wang,Hongmei Chen,Huan Tan,Bo Feng,Jie Weng
Multi-responsive drug-delivery systems have been widely explored to enable specific delivery to target sites. Here, interleukin-4 (IL-4), an anti-inflammatory cytokine, is first encapsulated in situ inside a zeolitic imidazolate framework (ZIF-8) to form IL-4@ZIF-8, which is subsequently coated with a diselenide block copolymer to obtain IL-4@ZIF-8@Se-Se-polymer. This delivery system enables redox-responsive release of IL-4 by the diselenide copolymer and a pH-triggered release by ZIF-8. Moreover, IL-4 release is precisely controlled stepwise by the stimuli response, with the dissociation of the diselenide copolymer, and breakdown of the ZIF-8 structure. The targeted release property of the IL-4@ZIF-8@Se-Se-polymer endows the materials with efficient macrophage immune regulation, as systematically demonstrated in vitro. This study provides an effective example of the delivery and on-demand release of IL-4, and may find promising applications in tissue engineering for the management of inflammation.
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2025
·
IF 1.6
Liu Jing-Long,Ye Xiao-Dan,Chen Lu-Si,Jia Ai-Quan,Zhang Qian-Feng
New ten tetrakis(benzoxazine) calix[4]resorcinarenes modified by organic amine through Mannich reaction were obtained in this paper. Compounds 2 ~ 11 were characterized by infrared spectroscopies, nuclear magnetic resonance spectroscopies. The structure of compounds 2 , 10 and 11 was characterized by single crystal X-ray diffraction. Compound 7 possesses a MIC value of 3.13 μg/mL against S. Aureus , demonstrating a favorable inhibitory effect, and a MIC value of 6.25 μg/mL against E. Coli , likewise showing a good inhibitory effect. The UV and 1 H NMR titration experiments were conducted to explore the host–guest chemistry between compound 10 and acetonitrile molecules, indicating that compound 10 exhibited encapsulation behavior towards acetonitrile molecules through hydrogen bonding interactions. Then Hirshfeld surface analysis showed that H⋅⋅⋅H, C − H⋅⋅⋅O, C − H⋅⋅⋅π, O − H⋅⋅⋅O played an important role in the crystal accumulation of compounds 2 , 10 and 11 .
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Hongxi Zhang,Zhongke Li,Shuyu Tang,Xiande Yang,Meng li,Jing Yang,Liang Wei
This study examines the use of tetrabutylammonium tetrafluoroborate (TBABF 4 ) as a catalyst for the depolymerization of lignin and its model compound without the addition of oxidants. The impact of electrolytes, reaction times, and solvents on the cleavage of the α-O-4 bond in lignin is investigated. The experimental setup includes specific conditions such as the use of carbon cloth (CC) as the counter electrode and a platinum plate as the working electrode. The TBABF 4 catalyst effectively cleaved the α-O-4 bond in the lignin model molecule with notable selectivity and minimal formation of by-products, resulting in a substantial conversion rate of benzyl phenyl ether (95.7 %) and a high yield of benzaldehyde dimethyl aceta (92.4 %) under specific conditions. This investigation showcases a mild electrochemical catalytic depolymerization approach for lignin model molecules at ambient temperature, thereby presenting novel avenues for further exploration in the field.
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LANGMUIR
·
2025
·
IF 3.9
Min Xu,Zhayun Gong,Yangyang Wu,Zhiyong Zhu,Kun Wang,Hefeng Xu,Cong Yu,Xiaodong Chu
4-Nitrophenol (4-NP) pollution in the chemical, dye, and other industries poses significant risks to humans and aquatic organisms. In this study, we prepared metal oxide-supported gold nanoparticles (AuNPs/Al2O3, AuNPs/TiO2, and AuNPs/ZnO) and applied them to the catalytic reduction of 4-NP. The Bader charge and differential charge, dos and d band centers, work function, and reaction free energy of AuNP composites were analyzed through DFT calculations. The influence of metal oxide carriers on the catalytic activity of AuNPs was explored, which decreased in the following order: AuNPs/Al2O3 > AuNPs/TiO2 > AuNPs/ZnO. In addition, the catalytic reduction performance of these AuNP composites for 4-NP in the presence of NaBH4 was investigated. The results showed that the AuNPs/Al2O3 catalyst exhibited the best performance (3.62 ± 0.17 min–1), consistent with the theoretical calculations. Meanwhile, the AuNPs/Al2O3 catalyst exhibited good reusability. More relevantly, the catalytic reduction mechanism of metal oxide-supported AuNPs for 4-NP was proposed from both experimental and theoretical calculations.
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