OPTICAL MATERIALS
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2022
·
IF 3.754
Zhenzhen Huang,Yanxin Wang,Xianhang Yan,Xinhui Mao,Zhiyuan Gao,Matt J. Kipper,Linjun Huang,Jianguo Tang
In this work, a luminescent lanthanide complex, namely, Eu(tta) 3 phen (Eu = europium , tta = 2-thenoyltrifluoroacetone, phen = 1, 10-phenanthroline) is used as a luminescent dopant to prepare fluorescent nanofiber films. The resulting nanofibers (CS/PEO-SiO 2 @Eu(tta) 3 phen) are composed of chitosan and polyethylene oxide containing silica nanoparticles , encapsulating the Eu(tta) 3 phen. The nanofibers are stabilized by treatment with sodium bicarbonate (NaHCO 3 ) aqueous solution as neutralizer and then repeatedly washed with deionized water. A more stable Na-CS/PEO-SiO 2 @Eu(tta) 3 phen fiber film is obtained as a fluorescence sensor for Cu 2+ ions. The Na-CS/PEO-SiO 2 @Eu(tta) 3 phen has high sensitivity, and a wide detection range. The response is linear in the concentration range from 10 to 90 μmol/L, and the detection limit is 0.826 μmol/L. In addition, Na-CS/PEO-SiO 2 @Eu(tta) 3 phen nanofiber film can be used as a recyclable sensor for the detection of Cu 2+ ions in aqueous solution due to its good recyclability, selectivity and rapid optical response.
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FOOD HYDROCOLLOIDS
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2022
·
IF 11.504
Yan-Wei Liu,Qing-Hao Li,Guo-Qing Huang,Jun-Xia Xiao
The complexation between Aspergillus oryzae lipase (AOL) and chitosan (CS) was investigated as a function of phase separation pH and the resultant complexes were characterized. The results indicated that AOL and CS could assemble micron-sized complexes in pHs 5.0–6.5 and the strongest interaction occurred in pH 5.5. QCM-D analysis revealed that association in pH 5.5 generated a viscoelastic hydrated adlayer with the largest thickness. ITC analysis indicated that the interaction between AOL and CS was driven by enthalpy and the highest one-site binding stoichiometry was recorded in pH 5.5, which was 1.3 and 7.9 times higher than in pHs 5.0 and 6.0, respectively. Both electrostatic attraction and hydrophobic interaction played dominant role in AOL-CS complexation. Compared with free AOL, the interaction with CS reduced its α-helix content, increased its β-sheet content, and changed its tertiary structure; besides, the AOL-CS complex assembled in pH 5.5 exhibited the highest contact angle up to 85.5° and demonstrated enhanced lipase activity retention after incubation in pHs 3.0–9.0 and temperatures 35–75 °C. Hence, the AOL-CS complexes could be used to construct novel biphasic catalysis media based on O/W Pickering emulsions .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Zhimeng Chen,Tiantian Wen,Xueyuan Wang,Lin Yang,Zhongjie Wang,Yanru Qin,Yixue Hu,Tianyu Zhang,Dongna Wang,Amin Liu,Liefeng Zhang,Meng Lei,Yongqiang Zhu
Herein, a cyclodextrin derivative (R6RGD-CMβCD) with tumor target and a carboxymethyl chitosan derivative (M2pep-CMCS) with tumor-associated macrophages 2 (TAM2) target were successfully synthesized, respectively. DOX-loaded nanoparticles (R6RGD-CMβ [email protected] NPs, RCNP DOX ) and R848-loaded nanoparticles ( [email protected] NPs, MCNP R848 ) were prepared. Furthermore, the RCNP DOX and MCNP R848 exhibited good DOX and R848 absorption. Meanwhile, the synergetic cell toxicity of RCNP DOX and MCNP R848 was found. Additionally, RCNP DOX + MCNP R848 nanoparticles greatly promoted the expression levels of cleaved Caspase3, which indicated that the nanoparticles could induce cell apoptosis. At the same time, the immunohistochemical images exhibited that RCNP DOX + MCNP R848 group could effectively transform the phenotype of tumor-associated macrophages. Importantly, in vivo experiments revealed that RCNP DOX + MCNP R848 NPs exerted excellent anticancer effects in tumor-bearing mice. To summarize, RCNP DOX + MCNP R848 NPs are effective anticancer treatment combining chemotherapy and immunotherapy, M2pep-CMCS and R6RGD-CMβCD are good delivery materials.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
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IF 3.8
Zhu-Rui Zhong,Hong-Liu Jiang,Na Shi,Hu-Wei Lv,Zhi-Jie Liu,Fu-An He
A new tetrafluoroterephthalonitrile crosslinked quercetin/chitosan (T-QT/CS) adsorbent was successfully synthesized for the adsorption of both cationic and anionic dyes in water. The structure of the resulting T-QT/CS was characterized by FTIR, 13 CNMR, TGA, BET, SEM, and XPS, and the surface-charge property of the T-QT/CS at different pH values was determined by the zeta potential measurement. It was found that the adsorption behavior of the T-QT/CS for the cationic methylene blue (MB) dye and the anionic orange G (OG) dye conformed to the pseudo-second-order kinetic model and the linear Langmuir isotherm model. Furthermore, basing on the linear Langmuir isotherm model, the T-QT/CS possessed good dye-adsorption ability, and the maximum adsorption capacities of the T-QT/CS for the MB (at pH=9) and OG (at pH=2) at 303 K were 917.4 mg/g and 349.9 mg/g, respectively. The thermodynamic experimental results showed that the MB and OG adsorption processes of the T-QT/CS were endothermic and spontaneous. In addition, the T-QT/CS exhibited good reused ability for the adsorptions of MB and OG even after five adsorption-desorption experiments.
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Polymers
·
2022
·Vol. 14
·期 24
·5509
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IF 4.967
Haoying Wang,Xiaoxia Song,Junfeng Xiong,U Kei Cheang
Magnetically actuated microrobots showed increasing potential in various fields, especially in the biomedical area, such as invasive surgery, targeted cargo delivery, and treatment. However, it remains a challenge to incorporate biocompatible natural polymers that are favorable for practical biomedical applications. In this work, bilayer magnetic microrobots with an achiral planar design were fabricated using a biocompatible natural polymer and Fe3O4nanoparticles through the photolithography by applying the layer-by-layer method. The microrobots consisted of a magnetic bottom layer and a photo-crosslinked chitosan top layer. The SEM results showed that the microrobot processed the L-shaped planar structure with the average width, length, and thickness of 99.18 ± 5.11 μm, 189.56 ± 11.37 μm, and 23.56 ± 4.08 μm, respectively. Moreover, microrobots actuated using a three-dimensional (3D) Helmholtz coil system was characterized and reached up to an average maximum velocity of 325.30 μm/s and a step-out frequency of 14 Hz. Furthermore, the microrobots exhibited excellent cell biocompatibility towards L929 cells in the CCK-8 assay. Therefore, the development of bi-layered chitosan-based microrobots offers a general solution for using magnetic microrobots in biomedical applications by providing an easy-to-fabricate, highly mobile microrobotic platform with the incorporation of biocompatible natural polymers for enhanced biocompatibility.Keywords:chitosan;microrobot;photolithography;natural polymer;magnetic actuation
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FOOD HYDROCOLLOIDS
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2022
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IF 11.504
Danmin Yang,Qun Liu,Yahui Gao,Shoumei Wan,Fanrong Meng,Wuyin Weng,Yucang Zhang
Sliver nanoparticles (AgNPs) were loaded on chitosan (CS) and incorporated into polyvinyl alcohol (PVA) to develop novel active food packaging films. AgNPs were fabricated by liquid phase chemical reduction method using CS and sodium citrate friendly reductant of AgNO 3 . The silver we prepared was found to be nanoscale by transmission electron microscopy (TEM) and AgNPs were homogeneously dispersed in the matrix by scanning electron microscopy (SEM). The composite film exhibited excellence mechanical properties with tensile strength of 49.97 MPa and elongation at break of 275.90%. When the concentration of AgNPs was 0.019% (w/w), the diameter of filter paper was 5.00 mm and the inhibition zone against Escherichia coli reached 16.07 mm at 37 °C for 8 h. The water vapor permeability and water solubility of the Ag@CS/PVA films decreased with the incorporation of AgNPs, and this was beneficial for food preservation. Especially, Ag@CS/PVA films could reduce the weight loss of strawberries and avoid microbial infection at 25 ± 1 °C and 50 ± 5% RH. Benefiting for good mechanical properties, antibacterial property, flexibility and high transparency, Ag@CS/PVA films showed its great potential in fruit storage and transportation application.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Tengfang Zhang,Ziqi Wu,Huafeng Zhu,Zhikun Wang,Shuangqing Sun,Songqing Hu
Hypothesis Natural polymer chitosan (CS) has been widely used as emulsifier due to its good stability, salt-resistant, and stimuli-responsive demulsification . However, chitosan is a hydrocarbon structure molecule containing -NH 3+ and -OH with low surface activity, which is mainly suitable for some specific oil-water systems such as corn oil and sunflower oil . Appropriate hydrophilic-hydrophobic modification of chitosan by PNIPAM not only increases its surface activity but also introduces a temperature response on chitosan. Experiments Pickering emulsions (O/W) formed by CS-PNIPAM were prepared. The stability and response performance of the emulsions were investigated by observing the macroscopic states, microscopic images, droplet size distributions, emulsion emulsification indices, water partition rates, etc. Molecular dynamics and dissipative particle dynamics simulations were used to reveal the distribution pattern of the emulsifiers at the water-oil interface and clarify the stabilization and pH/temperature response mechanism of the emulsions. Findings CS-PNIPAM performs excellent emulsification in various oil phases. The addition of salt ions enhances the stability performance of the emulsion. At low pH, CS will be protonated to break the emulsion, while increasing the pH will deprotonate CS and reform the emulsion. Also, the increase of temperature to 80 °C leads to emulsion breakage due to the agglomeration of PNIPAM.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yanzhen Sun,Xiaodong Jing,Yang Liu,Bing Yu,Hao Hu,Hailin Cong,Youqing Shen
Nucleic acid-based agents have advantages in therapeutic efficacy and biological safety. However, due to its facile degradability, it lacks an effective route of administration in wound treatment. Designing smart hydrogels for the spatiotemporally controllable delivery of nucleic acids is of great significance for clinical applications. Here, a near-infrared (NIR)-responsive nanocomposite hydrogel was prepared using methyl methacrylate (GMA)-modified chitosan as the macromolecular cross-linker, N-isopropylacrylamide (NIPAAm) as the backbone, and molybdenum disulfide nanosheets (MoS 2 NSs) as the nanocomponents. The polydeoxyribonucleotide (PDRN), a nucleic acid-based agent that promotes tissue regeneration , was loaded and delivered. The photothermal conversion capability of MoS 2 NSs enables customized care of PDRNs and antibacterial enhancement. In a full-thickness skin defect model, high-quality wound healing effects were demonstrated under the action of nanocomposite hydrogels. The proposed nanocomposite hydrogel provides a new reference for local delivery of nucleic acid-based agents.
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FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Yuanfei Ge,Jinyong Wu,Min Pang,Dan Hu,Zhongkui Li,Xiangqin Wang,Lijie Sun,Xiangsong Chen,Jianming Yao
In this study, carboxymethyl chitosan (CMCS) and N - acetylneuraminic acid (NeuAc) were used to develop C-NeuAc hydrogels to encapsulate Pediococcus pentosaceus QK-1. The mechanical properties, thermal stability, in vitro degradation, and pH sensitivity of the hydrogel were evaluated. The C-NeuAc concentration required for optimal hydrogel performance was 3% (w/v). Hydrogel swelling behaviour was effectively assessed by Fickian diffusion and Schott’s second-order kinetic models. The hydrogel demonstrated excellent biocompatibility and low in vitro cytotoxicity. An in vitro assay revealed that the viability of Pediococcus pentosaceus QK-1 in C-NeuAc had decreased by only 1.41 log (CFU/ mL) after exposure to simulated acidic gastric fluid. Moreover, the survival rate of the encapsulated and free Pediococcus pentosaceus QK-1 cells were 80.1% and virtually zero, respectively, after passage through the gastrointestinal tract. It was empirically determined that low temperature and freeze-drying were the ideal condition and method to ensure storage longevity of the hydrogel-encapsulated probiotic. Hence, C-NeuAc hydrogel is highly desirable as a food-grade probiotic delivery vehicle.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Guangyao Wang,Junwei Ye,Miao Wang,Ye Qi,Siqi Zhang,Lei Shi,Yueguang Fang,Yiming Tian,Guiling Ning
Chronic wounds resulting from bacterial infection are a global healthcare challenge as they usually impair the healing process and induce various complications. In this work, a chitosan (CS) membrane loaded with copper boron–imidazolate framework (Cu–BIF) was successfully prepared by self-assembly method for bacterial-infected wound-healing dressing. The as-prepared Cu–BIF/CS membrane possessed desirable biocompatibility. The antibacterial activity of Cu–BIF/CS membrane was evaluated by the spread plate and disc diffusion method, which was also verified by the fluorescence-based viability and morphological changes of bacteria. Moreover, Cu–BIF/CS membrane could increase wound closure rate and accelerate skin regeneration via combination therapy with chitosan, Cu 2+ and hydroxyl radicals during infected wound healing process. These results exhibit that Cu–BIF/CS membrane has great potential as wound dressings in the field of clinical treatment of bacterial-infected wounds.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2022
·Vol. 57
·期 5
·2872-2878
·
IF 3.612
Lingyu Zhao,Imran Mahmood Khan,Bin Wang,Lin Yue,Yin Zhang,Zhouping Wang,Wenshui Xia
Summary Inventions into chitosan oligosaccharide (COS) derivatives over recent decades have hugely broadened their application in food safety. Herein, monomethyl fumaric acid (MFA) was grafted on the OH position of COS to synthesise new COS-O-MFA derivatives and evaluated their in vitro antibacterial properties. The degrees of substitution (DS) of the derivatives yielded almost 15% with the range of 0.093 to 0.260. The in vitro antibacterial properties of the new COS-O-MFA1-3 derivatives against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) were significantly enhanced concerning COS. Based on the finding, the introduction of MFA and increasing DS have a great impact on the enhancement of antibacterial properties of the COS-O-MFA1-3 derivatives. This work proves that COS-O-MFA1-3 derivatives can be potential novel antibacterial agents and also open up a new avenue to improve their antibacterial attributes.
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ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Sheng Peng,Yuyan Huang,Sai Ouyang,Junlong Huang,Yueru Shi,Yuan-Jun Tong,Xueli Zhao,Nan Li,Jiating Zheng,Juan Zheng,Xinying Gong,Jianqiao Xu,Fang Zhu,Gangfeng Ouyang
The design and synthesis of novel high-performance solid phase microextraction (SPME) coatings towards organic pollutants with diverse chemical properties is still a challenge in sample preparation. Herein, a stable chitosan cross-linked graphene oxide (GOCS) aerogel was reported as a novel coating for solid phase microextraction. The interpenetrated meso- and macropores ensured the large surface area and high accessibility of the functional groups across the aerogel, resulting in high extraction performance towards target hydrophobic pollutants. The extraction capacities of the GOCS-coated SPME fiber towards analytes (e.g. polycyclic aromatic hydrocarbons , organophosphorus pesticides , organochlorine pesticides , pyrethroids , and polychlorinated biphenyls) were about 0.5–13 times as high as those obtained by the commercial fibers (30 μm polydimethylsiloxane (PDMS), 65 μm polydimethylsiloxane/divinylbenzene (PDMS/DVB)), which was attributed to the hydrophobic, π-π, halogen bond and hydrogen bond interactions between the coating and the analytes. Under the optimized extraction conditions, superior analytical performances for PAHs were achieved with a wide linearity (0.5–1000 ng L −1 ), high enhancement factors (311–3740), and the low limits of detection (0.03–1.28 ng L −1 ). Finally, the GOCS-coated SPME fiber was successfully applied to the determination of PAHs in real water samples with good recoveries (91.6%–110%).
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