INTERNATIONAL IMMUNOPHARMACOLOGY
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2017
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IF 2.956
Xiaobao Gong,You Yang,Ligua Huang,Qingyan Zhang,Rong-Zhen Wan,Peng Zhang,Baoshun Zhang
To evaluate the hepatoprotective effects and potential mechanisms of paeonol (Pae) against acute liver failure (ALF) induced by lipopolysaccharide (LPS)/ d -galactosamine ( d -GalN) in mice, we examined anti-oxidative, anti-inflammatory and anti-apoptotic activities of Pae. We found that Pae pretreatment markedly reduced the activities of alanine transaminase and aspartate transaminase as well as the histopathological changes induced by LPS/ d -GalN. Catalase , glutathione and superoxide dismutase activities increased and reactive oxygen species activity decreased after Pae treatment compared with LPS/ d -GalN treatment. Pretreatment with Pae also significantly inhibited the expression levels of iNOS, nitric oxide (NO), COX-2 and prostaglandin E 2 (PGE 2 ). In addition, Pae administration prevented the phosphorylated expression of IκB kinase, inhibitor kappa B in the nuclear factor-kappa B (NF-κB) signaling pathway , and suppressed the phosphorylated expression of extracellular signal-regulated kinase (ERK), c-jun-N-terminal kinase and p38 in the MAPK signaling pathway. Pretreatment with Pae also inhibited hepatocyte apoptosis by reducing the expression of caspases 3, 8, 9, and Bax, and increasing Bcl-2. In total, protective effects of Pae against LPS/ d -GalN-induced ALF in mice are attributed to its antioxidative effect, inflammatory suppression in NF-κB and MARK signaling pathways, and inhibition of hepatocyte apoptosis inhibition. Therefore, Pae can be a potential therapeutic agent in attenuating LPS/ d -GalN-induced ALF in the future.
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Surfaces and Interfaces
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2025
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IF 6.3
Baiwei Ma,Xuanyu Lin,Tiaotiao Zhu,Xiaofei Zheng,Juanfang Zhu
s Bacterial infections pose a threat to human health worldwide. Developing antibiotic-free strategies or integrating multiple bactericidal methods is urgently needed for efficient sterilization. Covalent organic frameworks (COFs) have attracted considerable attentions for killing bacteria using photodynamic and photothermal therapy methods, which prevent drug resistance. In this study, a donor–acceptor (D–A)-type COF anchored with pyridinium and quaternary ammonium, named BPDS-COF, was developed to achieve ternary synergistic antibacterial effects. The pyridinium cations generated in situ not only sterilize but also attract and accommodate electrons to thus promote the photoelectric generation of ROS. Additionally, the quaternary ammonium salts provide good antibacterial activity. The simultaneous presence of pyridinium and quaternary ammonium can enhance the hydrophilicity and bacterial adsorption and improve adsorption for oxygen to more easily generate ROS, which are beneficial to sterilization. Moreover, BPDS-COF has the potential to be used as an oral antibacterial dental filler and implant coating material. This ternary synergistic antibacterial strategy could inspire the design of other multifunctional antimicrobial COFs.
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FOOD RESEARCH INTERNATIONAL
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2025
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IF 8
Zirou Xiao,Shuang Wu,Hongshan Liang,Bin Li,Jing Li
The reduction of sucrose in dough formulations disrupts mechanical properties, fermentation performance, and structural organization, leading to rigidity and impaired gas retention. This study investigated how composite improvers—oligosaccharides (XOS/KOS), CMCNa, and D-allulose—mitigate these challenges by restoring viscoelastic balance, enhancing fermentation, and stabilizing protein and starch interactions. Correlation analysis was further conducted to explore the complex relationships between these parameters. Results revealed that D-allulose optimized gas retention by contributing to a denser gluten network, achieving the highest retention rate of 90.92 %. Oligosaccharides improved water availability, promoting gluten development and enhancing starch gelatinization, while CMCNa strengthened the gluten network through its binding and film-forming properties, collectively increasing fermentation height by 79.78 % compared to sugar-reduced dough. These structural improvements were further confirmed by SEM images, which revealed a more uniform microstructure with continuous gluten films encapsulating starch granules. These findings elucidate the mechanisms underlying the deterioration of sugar-reduced dough and highlight the potential of composite improvers in mitigating the adverse effects of sucrose reduction, paving the way for the development of high-quality sugar-reduced products.
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Small
·
2024
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IF 13
Yaqi Li,Sijie Wan,Weichen Liang,Bei Cheng,Wang Wang,Yao Xiang,Jiaguo Yu,Shaowen Cao
Owing to the improved charge separation and maximized redox capability of the system, Step-scheme (S-scheme) heterojunctions have garnered significant research attention for efficient photocatalysis of H 2 evolution. In this work, an innovative linear donor–acceptor (D–A) conjugated polymer fluorene-alt-(benzo-thiophene-dione) (PFBTD) is coupled with the CdS nanosheets, forming the organic–inorganic S-scheme heterojunction. The CdS/PFBTD (CP) composite exhibits an impressed hydrogen production rate of 7.62 mmol g −1 h −1 without any co-catalysts, which is ≈14 times higher than pristine CdS. It is revealed that the outstanding photocatalytic performance is attributed to the formation of rapid electron transfer channels through the interfacial Cd─O bonding as evidenced by the density functional theory (DFT) calculations and in situ X-ray photoelectron spectroscopy (XPS) analysis. The charge transfer mechanism involved in S-scheme heterojunctions is further investigated through the photo-irradiated Kelvin probe force microscopy (KPFM) analysis. This work provides a new point of view on the mechanism of interfacial charge transfer and points out the direction of designing superior organic–inorganic S-scheme heterojunction photocatalysts.
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Journal of Materials Chemistry B
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2024
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IF 6.1
Yu Ma,Jiawei You,Jianquan Hou,Yupeng Shi,Engui Zhao
Photodynamic antimicrobial therapy (aPDT) can effectively kill bacteria without promoting drug resistance. However, the phototoxicity of photosensitizers in aPDT against normal cells hinders their practical applications. In this work, we report the utilization of an aggregation-induced emission (AIE)-active photosensitizer, DTTPB, to develop antibacterial dressing for effective eradication of both Gram-positive and Gram-negative bacteria. The D–π–A structure of DTTPB facilitates efficient ROS generation in the aggregate state, addressing the limitations of a traditional photosensitizer. Notably, DTTPB demonstrates good biocompatibility towards normal cells, which minimizes its phototoxicity to normal tissues. To demonstrate its practical implications, DTTPB is combined with Carbomer 940 to create an injectable hydrogel dressing (DTTPB@gel). DTTPB@gel not only adheres to wounds but also maintains the antimicrobial properties of DTTPB, which together contributes to its enhanced wound-healing performance. Biocompatibility and toxicity assessments confirm the safety of this novel material, highlighting its potential as a practical and effective treatment for bacterial infections in wounds. The results underscore the importance of innovative antimicrobial strategies in fighting against antibiotic resistance, paving the way for safer and more effective therapeutic options.
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Current Molecular Pharmacology
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2024
·Vol. 17
·期 1
·e18761429267000
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IF 2.4
Fengyan Tang,Bo Zhao,Li Zhang,Faisal Raza,Hajra Zafar,Shao Zhong,Lin Li,Wenhua Zhu,Lingna Fang,Bing Lu,Liwen Shen,Ping Guo,Nengxing Yu,Quanmin Li
Objective: The potential mechanism underlying the protective effect of Astragaloside IV (AS-IV) co-treatment with 1, 25-dihydroxy-vitamin D (Vit-D) on neuropathy in diabetic high-fat rats was investigated. Methods: The rat diabetic hyperlipidemia (DH) model was established via streptozotocin and a high-fat diet (HFD). After co-treatment (of AS-IV and Vit-D at respective doses of 50 mg/kg via oral gavage and 30000 IU/kg via intramuscular injection), blood glucose levels, markers of inflammation and oxidative stress, as well as apoptosis and histopathology were evaluated with appropriate techniques. Results: Co-treatment could effectively reduce blood glucose levels substantially (p< 0.01), improve weight loss, and decrease oral glucose tolerance. Reduced respective sensory and motor nerve conduction velocities in rats were substantially improved (p<0.01) after co-treatment. Also, we observed obvious improvement in DH-induced injured nerve fiber myelin structure and other organ pathologies in co-treated rats. Besides, we observed up-regulated expressions of peroxisomal-proliferator activated receptor-alpha (PPAR-α) and Vit-D receptors (VDR) (p< 0.01) through the western blotting technique. Using the same technique, we also discovered reduced levels of interleukin (IL)1 beta, IL-6, and tumor necrosis factor-alpha, coupled with increased IL-10 and superoxide dismutase levels (p< 0.01). Importantly, co-treatment could effectively exert anti-oxidative and anti-inflammatory effects. Also, co-treatment resulted in the up-regulation of PPAR-α and VDR expressions, inhibition of the renin–angiotensin–aldosterone system, and promotion of β-cell sensitivity to insulin. Conclusion: The combined application of AS-IV and Vit-D exhibited health effects such as anti-oxidation, regulation of inflammatory factors, and promotion of cell repair, which may be considered as the mechanisms underlying treatment of diabetic peripheral neuropathy and improvement in biochemical indicators.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2025
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IF 14.3
Xianyu Chu,Yanan Wang,Li Jing,Wei Jiang,Yuanyuan Wu,Ming Lu,Bo Liu,Chunbo Liu,Yantao Sun,Guangbo Che
Constructing heterostructures to regulate the electronic structure is an effective strategy for enhancing the oxygen evolution reaction (OER) electrocatalytic activity. Herein, we prepared heterostructured Co 4 S 3 /CoP 3 (CoPS/NFF) electrocatalysts through a one-step phosphorization and sulfuration process. The synthesized electrode drives an overpotential of 190, 272, and 331 mV at 20, 50, and 100 mA cm −2 for OER in 1 M KOH alkaline media, respectively. These values outperformed those of monophase Co 4 S 3 and CoP 3 as well as the majority of transition metal-based catalysts previously reported. Furthermore, the Density Functional Theory (DFT) calculation results show that charge redistribution occurs at CoPS/NFF heterogeneous interfaces, which facilitates charge transfer and improves catalytic activity. The CoPS/NFF with heterostructure optimizes the adsorption strength of oxygen-containing intermediates (*O, *OH, and *OOH) by appropriately adjusting the d-band center energy level, thereby reducing the energy barrier of OER. This work provides a new perspective on rational design strategies for efficient transition metal-based electrocatalysts by inducing d-band center regulation through the construction of heterostructures.
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FOOD CHEMISTRY
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2024
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IF 8.5
Cong Liu,Ying Zou,Manli Zhang,Chaoxian Chi,Di Zhang,Fangling Wu,Chuan-Fan Ding
This work presents a straightforward approach to the separation d / l -carnitine ( d / l -Carn) using ion mobility–mass spectrometry (IM-MS) and theoretical calculations. Natamycin (Nat) was used as separation reagent to interact with the Carn, metal ions (G) were employed as ligand, the resultant ternary complexes [ d / l -Carn + Nat + G] + were observed experimentally. IM-MS results revealed that d / l -Carn could be baseline separated via complex formation using Li + , Na + , K + , Rb + , and Cs + , with a maximum peak separation resolution (R p-p ) of 2.91; Theoretical calculations were performed to determine the optimal conformations of [ d / l -Carn + Nat + Li/K] + , and the predicted collisional cross section values were consistent with the experimental values. Conformational analysis was used to elucidate the enantiomeric separation of d / l -Carn at the molecular level via the formation of ternary complexes. Furthermore, quantitative analyses for the determination of the enantiomers were established with effective linearity and acceptable sensitivity. Finally, the proposed method was successfully applied in the determination of d / l -Carn in food samples.
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Small
·
2024
·Vol. 20
·期 10
·2302943
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IF 13
Yanfen Wan,Yingfei Hu,Hongyu Tu,Wenbo Zhuang,Xuemin Geng,Tian Zhang,Jinghao Zhang,Ming Wen,Peng Yang
Herein, an integrated solar-thermal-power protocol is presented at a micro-nanoscopic level to maximize the energy utilization efficiency involving utilization period and utilization patterns, and the nexus of freshwater production and nanogeneration is realized. This sophisticated vaporization device is constructed with the merits of thermally confined evaporation space in favor of recycling latent heat of condensation and optimizing light absorption based on the local sunlight angle of incidence. Inspired by a bird's nest, Sb 2 WO 6 /D-Fructose composites are prepared as photothermal absorbers to achieve a superior water evaporation rate of 2.78 kg m −2 h −1 in the Multi-stage evaporator. In addition, a synergistic tandem photo thermal-electric device with a combination of solar-driven water evaporation and further waterflow-driven hydrovoltaic generation, which can output a stable voltage of up to 360.8 mV with effective utilization of steam energy and a limited water source, is exploited. Such integrated configurations pave a pathway for clean water production and renewable power generation simultaneously toward energy issues.
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JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Sihao Zhang,Danmei Tian,Zixuan Xia,Fengge Yang,Yanhui Chen,Zhihong Yao,Yi He,Xinglong Miao,Guirong Zhou,Xinsheng Yao,Jinshan Tang
Ethnopharmacological relevance Chang-Kang-Fang (CKF), originated from traditional Chinese medicine (TCM) formulas, has been utilized to treat diarrhea predominant irritable bowel syndrome (IBS-D) based on clinical experience. However, the underlying mechanism of CKF for treating IBS-D remains unclear and need further clarification. Aim of the study The objective of this present investigation was to validate the efficacy of CKF on IBS-D model rats and to uncover its potential mechanism for the treatment of IBS-D. Materials and Methods We first established the IBS-D rat model through neonatal maternal separation (NMS) in combination with restraint stress (RS) and the administration of senna decoction via gavage. To confirm the therapeutic effect of CKF on treating IBS-D, abdominal withdrawal reflex (AWR) scores, the quantity of fecal pellets, and the fecal water content (FWC) were measured to evaluate the influence of CKF on visceral hypersensitivity and the severity of diarrhea symptom after the intragastric administration of CKF for 14 days. Subsequently, enzyme linked immunosorbent assay (ELISA) was applied to assess the effect of CKF on neuropeptides substance P (SP) and 5-hydroxytryptamine (5-HT), as well as inflammatory cytokines in serum and in intestinal tissues. Further, colonic pathological changes, the amount of colonic mast cells, and the expression level of occludin in rat colon tissues, were investigated by hematoxylin-eosin (HE) staining, toluidine blue staining, and immunohistochemistry, respectively. To explore the underlying mechanisms, alterations in colonic RNA transcriptomics for the normal, model, and CKF treatment groups were assessed using RNA sequencing (RNA-Seq). Subsequently, quantitative real-time polymerase chain reaction (qRT-PCR), western blot (WB), and immunofluorescence (IF) assays were applied to validate the effect of CKF on predicted pathways in vivo and in vitro . In addition, to elucidate the potential active compounds in CKF, 11 representative components found in CKF were selected, and their anti-inflammation potentials were evaluated using LPS-treated RAW264.7 cell models. Results CKF treatment significantly reduced the number of fecal pellets, attenuated visceral hypersensitivity, and decreased 5-HT and SP concentrations in serum and colon tissues, along with a reduction in colonic mast cell counts, correlating with improved symptoms in IBS-D rats. Meanwhile, CKF treatment reduced the colonic inflammatory cell infiltration, lowered the levels of IL-6, TNF- α , and IL-1 β in serum and colon tissues, and increased the occludin protein expression in colon tissues to improve inflammatory response and colonic barrier function. RNA-Seq, in conjugation with our previous network pharmacology analysis, indicated that CKF might mitigate the symptoms of IBS-D rats by inhibiting the Toll like receptor 4/Nuclear factor kappa-B/NLR family pyrin domain-containing protein 3 (TLR4/NF- κ B/NLRP3) pathway, which was confirmed by WB, IF, and qRT-PCR experiments in vivo and in vitro . Furthermore, coptisine, berberine, hyperoside, epicatechin, and gallic acid present in CKF emerged as potential active components for treating IBS-D, as they demonstrated in vitro anti-inflammatory effects. Conclusion Our findings demonstrate that CKF effectively improves the symptoms of IBS-D rats, potentially through the inhibition of the TLR4/NF- κ B/NLRP3 pathway. Moreover, this study unveils the potential bioactive components in CKF that could be applied in the treatment of IBS-D.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Ya-wei Lu,Li-ya Xie,Meng-han Qi,Shen Ren,Yue-qi Wang,Jun-nan Hu,Zi Wang,Shan Tang,Jing-tian Zhang,Wei Li
Objectives: The aim of this study was to investigate the ameliorative effect of platycodin D (PD) on cognitive dysfunction in type 2 diabetes mellitus (T2DM) and its potential molecular mechanisms of action in vivo and in vitro. Materials and methods: An animal model of cognitive impairment in T2DM was established using a single intraperitoneal injection of streptozotocin (100 mg/kg) after 8 weeks of feeding a high-fat diet to C57BL/6 mice. In vitro, immunofluorescence staining and Western blot were employed to analyze the effects of PD on glucose-induced neurotoxicity in mouse hippocampal neuronal cells (HT22). Results: PD (2.5 mg/kg) treatment for 4 weeks significantly suppressed the rise in fasting blood glucose in T2DM mice, improved insulin secretion deficiency, and reversed abnormalities in serum triglyceride, cholesterol, low-density lipoprotein, and high-density lipoprotein levels. Meanwhile, PD ameliorated choline dysfunction in T2DM mice and inhibited the production of oxidative stress and apoptosis-related proteins of the caspase family. Notably, PD dose-dependently prevents the loss of mitochondrial membrane potential, promotes phosphorylation of phosphatidylinositol 3 kinase and protein kinase B (Akt) in vitro, activates glycogen synthase kinase 3β (GSK3β) expression at the Ser9 site, and inhibits Tau protein hyperphosphorylation. Conclusions: These findings clearly indicated that PD could alleviate the neurological damage caused by T2DM, and the phosphorylation of Akt at Ser473 may be the key to its effect.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Yuci Xin,Yong Wu,Xingan Dong,Yuhan Li,Zhenxiang Cheng,Jianli Wang,Xiaolong Guo,Peng Yu
Amorphous electrocatalysts display several unique advantages in electricity-driven water splitting compared to their crystalline analogs, but understanding their structure–activity relationships remains a major challenge. Herein, we show that the d- and p-electronic states of amorphous Ni-Fe-B can be subtly manipulated by varying the Ni and Fe contents. The optimal Ni-Fe-B alloy exhibits a high performance in the oxygen evolution reaction (OER), as supported by its impressive stability (no clear degradation after 100 h) and considerably lower overpotential compared to those of its crystalline analogs. Based on theoretical calculations, different Ni and Fe contents can cause significant shifts in the d-band levels of Ni and Fe and the p-band level of B, thus altering the OER activity. Additionally, the energy difference between the d- and p-band centers (ΔE ad-p ) may be an effective index for use in reflecting the structure–activity relationship of an amorphous Ni-Fe-B alloy in the OER. An amorphous Ni-Fe-B alloy with a smaller ΔE ad-p displays a higher intrinsic activity. This study supplies a unique direction for use in constructing the structure–activity relationships of amorphous electrocatalysts by revealing the role of ΔE ad-p , which promotes fundamental research and the practical application of amorphous electrocatalysts.
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