MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 5
·1-8
·
IF 5.705
Chen Wanlu,Yao Xun,Zhou Xinchun,Zhao Kang,Deng Anping,Li Jianguo
A flower-like Au/Cu alloy nanocomposite (Au/Cu NFs) was synthesized and used in an electrochemiluminescence (ECL) based method for sensitive determination of the dye Sudan I. The Au-g-C 3 N 4 nanosheets as an ECL emitter were prepared by electrostatic adsorption between gold nanoparticles and g-C 3 N 4 . They form a film on a glassy carbon electrode (GCE) and then can be connected with Sudan I antigen via gold-nitrogen bond and amidation reactions. The Au/Cu NFs combined with Sudan I antibody also via the Au-N bond and was introduced into the modified GCE by specific recognition between the antibody and the antigen. The overlap between emission spectra of the Au-g-C 3 N 4 nanosheets and absorption spectra of Au/Cu NFs enabled the appearance of ECL resonance energy transfer process. That is, when the Sudan I analyte not present, the ECL was weakened due to absorption by the gray Au/Cu NFs on applying voltages from −1.7 V to 0 V. Conversely, the Au/Cu NFs on the GCE are reduced due to the competition for the antibody between the analyte and the antigen. A strong green ECL emission was obtained. The ECL response is linear in the 0.5 pg mL −1 to 100 ng mL −1 Sudan I concentration range, and the detection limit is 0.17 pg mL −1 .
An Au/Cu alloy flower-like nanocomposite (Au/Cu NFs) is firstly synthesized as an acceptor to constitute an electrochemiluminescence-resonance energy transfer (ECL-RET) system for sensitive measurement of Sudan I, while Au nanoparticles (Au NPs) functionalized graphitic carbon nitride (g-C 3 N 4 ) acted as a donor.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Yiru Wang,Yizhou Zhang,Zhe Shen,Yuan Qiu,Chaoyang Wang,Zhifang Wu,Minjuan Shen,Changyu Shao,Ruikang Tang,Matthias Hannig,Baiping Fu,Zihuai Zhou
The phosphorylated noncollagenous proteins (NCPs) play a vital role in manipulating biomineralization, while the mechanism of phosphorylation of NCPs in intrafibrillar mineralization of collagen fibril has not been completely deciphered. Poly(vinylphosphonic acid) (PVPA) and sodium trimetaphosphate (STMP) as templating analogs of NCPs induce hierarchical mineralization in cooperation with indispensable sequestration analogs such as polyacrylic acid (PAA) via polymer-induced liquid-like precursor (PILP) process. Herein, STMP-Ca and PVPA-Ca complexes are proposed to achieve rapid intrafibrillar mineralization through polyelectrolyte-Ca complexes pre-precursor (PCCP) process. This strategy is further verified effectively for remineralization of demineralized dentin matrix both in vitro and in vivo. Although STMP micromolecule fails to stabilize amorphous calcium phosphate (ACP) precursor, STMP-Ca complexes facilely permeate into intrafibrillar interstices and trigger phase transition of ACP to hydroxyapatite within collagen. In contrast, PVPA-stabilized ACP precursors lack liquid-like characteristic and crystallize outside collagen due to rigid conformation of PVPA macromolecule, while PVPA-Ca complexes infiltrate into partial intrafibrillar intervals under electrostatic attraction and osmotic pressure as evidenced by intuitionistic 3D stochastic optical reconstruction microscopy (3D-STORM). The study not only extends the variety and size range of polyelectrolyte for PCCP process but also sheds light on the role of phosphorylation for NCPs in biomineralization.
✓ 已验证
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Chao-Ying Gao,Lin Ding,Yang Li,Ning Xu,Yakun Wu,Wenbo Wang,Jinghai Liu,Yang Yang
In the era of global warming, the conversion of carbon dioxide into high-value products has become a widely scrutinized emerging mitigation strategy. Metalation of bpy-containing MOF-253 led to the synthesis of MOF-253–0.5Ag, which acts as an efficient catalyst for the carbonylative cyclization of CO2 with alkyne molecules (such as propynyl alcohols and propynyl amines) at room temperature and ambient CO2 pressure, yielding the corresponding α-alkyl cyclic carbonates and oxazolidinones, thus endowing the catalytic system with bifunctional characteristics. Additionally, the MOF-253–0.5Ag catalyst demonstrated stability, high activity, and recyclability. The mechanisms were further elucidated through experimental results and NMR analysis, demonstrating that Ag(I) can effectively activate the C≡C bonds and hydroxy/amino groups of the substrates.
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2019
·
IF 5.714
Zhihan Tu,Xinyi Mu,Xuemei Chen,Yanqing Geng,Yan Zhang,Qingying Li,Rufei Gao,Taihang Liu,Yingxiong Wang,Junlin He
Dibutyl phthalate (DBP), one of the most widely used plasticizers , is a known environmental endocrine disruptor that impairs male and female fertility. In this study, oral administration of DBP was given to pregnant mice on 14.5 days post coitus (dpc) for 3 days; and additionally, DBP was added into the culture of 14.5 dpc fetal ovaries for 3 days. DBP exposure during gestation disturbed the progression of meiotic prophase I of mouse oocytes , specifically from the zygotene to pachytene stages. Meanwhile, the DBP-exposed pachytene oocytes showed increased homologous recombination sites and unrepaired DNA damage. Furthermore, DBP caused DNA damage by increasing oxidative stress , decreased the expression of multiple critical meiotic regulators, and consequently induced oocyte apoptosis. Moreover, the effect of DBP on meiosis I prophase involved estrogen receptors α and β. Collectively, these results demonstrated a set of meiotic defects in DBP-exposed fetal oocytes. As aberrations in homologous recombination can result in aneuploid gametes and embryos, this study provides new support for the deleterious effects of phthalates.
✓ 已验证
DOI
PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2018
·Vol. 32
·期 8
·e4423
·
IF 3.581
XueWen Liu,Jie Huang,YuXuan Tang,YouMing Shen,JiLin Lu
A new polypyridyl ligand containing a nitro group and two new ruthenium complexes of it were synthesized. The two complexes exhibited non-dppz DNA ‘light switch’ effects after interaction with calf thymus DNA. Introducing both electron-withdrawing group (─ NO 2 ) and electron-donating group (─ CH 3 ) may be the reason that the two complexes display DNA ‘light switch’ behaviors. Furthermore, one of the complexes showed higher photocleavage activity, topoisomerase I inhibition activity and DNA affinity than the other. The present work shows that the more active complex can be employed as a non-dppz DNA ‘light switch’, DNA photocleaver and topoisomerase I inhibitor. In addition, the two complexes have no or weak cytotoxic activities against Eca-109 and A549 cells.
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yuhuan Lin,Jiayi Li,Jiayu Zheng,Jun Shao,Ming Wu,Yulin Liu,Ziqiao Wu,Jiandong Fan,Wenzhe Li
Cesium-based all-inorganic lead-halide perovskites CsPbX3 (X = I, Br, Cl) have emerged as highly promising optoelectronic materials with a wide bandgap, which are commonly utilized in tandem solar cells. However, the I–Br hybrid CsPbI3–xBrx perovskites still face stability issues such as halide segregation-induced phase transition and decomposition under ultraviolet or high-temperature conditions. We synthesize a series of single crystals DMAPbI3–xBrx (x = 0.1, 0.15, 0.2, 0.3, 0.6), featuring an I–Br ordered distribution. By introducing the crystal intermediate into the perovskite precursor, we successfully obtained high-quality CsPbI3–xBrx thin films, exhibiting high stabilities and low trap state density. The formation kinetics of the high-quality perovskite thin films are in situ studied and the possible reaction mechanisms are proposed. Benefiting from this approach, the solar cells have an improved photoelectric conversion efficiency and significantly enhanced thermal stability. This method is proven to be feasible and innovatively offers a new strategy for the continuous development of mixed-halide perovskite solar cells.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Chenyu Zeng,Anting Ding,Xi Chen,Yongfei Ma,Hui Lin,Han Ding,Fuyu Xie,Lu Zang,Song Cui,Ping Li,Junwei Ma,Zulin Zhang
Cu/BC-PAA (Peroxyacetic acid) system was established in this study to remove sulfamethoxazole (SMX) from waters. Cu/BC-PAA achieved high elimination efficiency (91.2 %, k = 0.081 min −1 ) for SMX within 30 min. Cu (II) loaded on corn straw biochar was converted into form Cu (I) site. Characterization, electron paramagnetic resonance (EPR), and electrochemical analysis proved that Cu (I) and C O took part in the reaction, which accelerated electron transfer and produced free radicals and non-radicals (R-O· and singlet oxygen ( 1 O 2 )). Fukui index and Liquid Chromatograph Mass Spectrometer (LC–MS) analysis revealed that sulphonamide bond cleavage and isoxazole ring opening were the main detoxification pathway. Density functional theory (DFT) calculation exhibited the adsorption energy of Cu/BC (E ads = −3.68 eV) enhanced the electron transfer between Cu (I) and PAA. The evaluation of anion effects, diverse water matrices, various sulfonamide antibiotics, and catalyst cycling tests demonstrated the Cu/BC-PAA system's exceptional stability, broad-spectrum applicability, and excellent reusability. This work successfully synthesized a stable environment-friendly catalyst for efficient activating PAA to eliminate antibiotics in waters.
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Yang Bai,Yanbiao Zhao,Weidong Li,Linghui Meng,Yongping Bai,Guorong Chen
Solid sulfide electrolyte has been researched for several years, and a high ionic conductivity has been acquired. However, it is difficult to apply in industrial manufacturing partly because the raw materials, such as SiS2, GeS2, P2S5, et al., have strict preparing conditions and are sensitive to water and oxygen in the air. Herein, we report a new method to produce solid sulfide electrolytes Li9.54Si1.74P1.44S11.7X0.3 (LSiPSX) (X = F, Cl, Br, I), that is, using elementary substances Si, P, and S as the starting raw materials, which not only is a promising way to ease the harsh storage conditions of the SiS2 and P2S5 as starting raw materials but also provides a feasible choice for the preparation of solid sulfide electrolyte. The conductivity of solid sulfide electrolyte is further adjusted by controlling the particle size of raw material silicon and the different halogen doping. As a result, the Li9.54Si1.74P1.44S11.7I0.3 releases the highest ionic conductivity of 1.35 mS/cm at room temperature and a wide electrochemical window up to 9 V versus Li/Li+ which is prepared from the 3 nm particle size Si and I doping. The all-solid-state lithium–sulfur battery (ASSLSB) is constructed with LSiPSI and with a good performance. Our study demonstrates the possibility of preparing the LGPS crystal type solid sulfide electrolytes by using elementary substances.
✓ 已验证
DOI
高影响因子
KINETICS AND CATALYSIS
·
2013
·Vol. 54
·期 6
·716-723
·
IF 0.543
Zeng Minfeng,Sun Xudong,Qi Chenze,Zhang Xian-Man
A novel and environmentally friendly heterogeneous catalyst has been prepared through the wet impregnation of copper(I) species onto the highly porous chitosan microspheres (CuI/PCMS). This novel CuI/PCMS heterogeneous catalyst with no additional ligands is much better than CuI homogeneous catalysts when applied in Heck reactions. Moreover, the reaction conditions are much milder than those for the similar copper catalysts mediated cross-coupling reactions reported in the literature. PCMS has been demonstrated not only the excellent solid support, but also have many unique functional groups to chelate the copper (I) species to enhance its catalytic activity.
研究领域:
催化化学
·
有机合成
·
材料化学
·
环境友好化学
·
功能高分子材料
✓ 已验证
DOI
高影响因子
ANTIVIRAL RESEARCH
·
2026
·
IF 4
Yarong Song,Yitong Zeng,Han Zheng,Shu Shi,Zhongqing Li,Mingchen Liu,Sijin Shao,Ziheng Luo,Yurong Li,Jie Li,Kuanhui Xiang,Jie Wang
Chronic hepatitis B virus (HBV) infection is a major global health problem. Currently, existing antiviral drugs are difficult to achieve a functional cure for chronic hepatitis B (CHB). Therefore, it is necessary to develop new antiviral targets, especially those that can directly target HBV covalently closed circular DNA (cccDNA) in hepatocytes. Here, we identified a conserved SOX6 binding site in the enhancer I (ENI) region of the HBV genome, and found that SOX6 promotes the replication of multiple genotypes HBV through its HMG domain. Mechanistically, SOX6 binds to the conserved binding site located in the HBV ENI region through its HMG domain, thereby promoting HBV replication by enhancing the transcriptional activity of ENI. Moreover, cisplatin and doxorubicin not only promote HBV replication but also promote SOX6 expression. Knocking down the expression of endogenous SOX6 or mutating the SOX6 binding site in the HBV ENI region significantly weakens the direct promoting effect of cisplatin and doxorubicin on HBV replication. In summary, SOX6 promotes HBV replication by enhancing the transcriptional activity of HBV ENI through its HMG domain, suggesting that it can serve as a potential target for regulating HBV cccDNA transcription. In addition, SOX6 participates in the direct promotion of HBV replication by cisplatin and doxorubicin, providing new insights into the molecular mechanisms of tumor chemotherapy related HBV reactivation (HBVr) and potential targets for the prevention of HBVr during tumor chemotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Russian Journal of Physical Chemistry A
·
2026
·Vol. 99
·期 13
·3279-3287
·
IF 0.8
Hao Lv,Zheng Dan,Liu Xiyue,Li Luyun,Tan Jingjing,Xing Bo
This paper focuses on the preparation, structural characterization, and property investigation of the copper(I) complex [Cu(dppe)(phon)]I based on 1,2-bis(diphenylphosphino)ethane. The target complex was synthesized via a solution method, using 1,2-bis(diphenylphosphino)ethane, cuprous iodide, and 1,10-phenanthroline-5,6-dione as raw materials and acetonitrile as the solvent. It was then characterized by infrared spectroscopy (IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV–Vis), and fluorescence spectroscopy. Methylene blue was used to simulate dyeing wastewater, and the single-factor method was employed to study the effects of the initial concentration of methylene blue, illumination time, complex dosage, and temperature on the- efficiency. The results indicated that the optimal photocatalytic degradation performance was achieved at a relatively low initial concentration of methylene blue, an appropriate complex dosage (25 mg), and a temperature of 40°C. Additionally, the copper(I) complex was utilized as a phosphorescent probe for the detection of tetracycline hydrochloride, doxycycline hydrochloride, and chlortetracycline hydrochloride. It was found that the addition of tetracycline antibiotics led to a decrease in the fluorescence intensity of the complex, and the higher the concentration of the antibiotics, the stronger the quenching effect. The detection limit of the phosphorescent probe for tetracycline hydrochloride antibiotics was 3.0 × 10 –9 mol/L. This study provides a theoretical basis and practical reference for the application of copper(I) complexes in photocatalytic degradation and tetracycline detection.
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Qiushu Du,Peipei Wang,Zhen Song,Xiliang Luo,Shaoping Lv
Electrochemical biosensors often suffer from biofouling in complex biological samples, which compromises detection accuracy and limits their practical applicability. To address this problem, we developed a synergistic antifouling biosensor by integrating the bovine serum albumin hydrogel (BSAG) with a designed multifunctional peptide for the detection of cardiac troponin I (cTnI) in complex biofluids. A stable and versatile antifouling layer was constructed via a facile one-step crosslinking method based on bovine serum albumin (BSA), and the amino-enriched surface of BSA enabled the secondary grafting of a multifunctional peptide that combines with anchoring, antifouling, and recognition properties. This approach not only enhanced the antifouling performance and durability of the coating, but also avoided potential interference associated with the introduction of exogenous recognition molecules. The cooperative antifouling performance of this hierarchical interface was systematically validated through electrochemical measurements and fluorescence imaging, demonstrating excellent resistance to biofouling in various biological fluids. The fabricated biosensor possessed long-term stability, high sensitivity and a broad linear response was obtained within the range of 0.1 pg mL −1 - 100 ng mL −1 , accompanied by a low detection limit of 0.042 pg mL −1 . Overall, this study presents a robust and generalizable interface engineering strategy that significantly enhances biosensor antifouling performance and analytical reliability, highlighting its strong potential for clinical monitoring in complex biological environments.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）