CARBOHYDRATE POLYMERS
·
2023
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IF 11.2
Xiaoyu Jie,Bing-Chiuan Shiu,Yuchi Zhang,Huazhong Wu,Yuansong Ye,Run Fang
Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products. However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries. Here, we present a chitosan-urushiol composite nanofiber membrane prepared by electrospinning. Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol. The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance. After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength. In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus ( S. aureus ), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli ( E. coli ) that far exceeded that of neat chitosan membrane and urushiol. Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan. In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
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PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Pan Wu,Yaru Fang,Kezhou Chen,Mi Wu,Wenchang Zhang,Shiyu Wang,Dongwen Liu,Junqing Gao,Huaiguo Li,Jianhua Lv,Yan Zhao
Based on sodium methacrylate alginate (MASA) and carboxymethyl chitosan (CMCS), double network (DN) hydrogels were formed by covalent crosslinking and physical crosslinking in succession. Covalent crosslinking was achieved by using poly(ethylene glycol) diacrylate (PEGDA) as the crosslinker and initiated by ammonium persulfates, while physical crosslinking was realized by the electrostatic interactions between the carboxyl group of MASA and the amino group of CMCS induced by acetic acid atmosphere. With the addition of PEGDA (1.25 wt% of mixture solution), the compressive strength of hydrogel was increased from 9.0 kPa to 73.3 kPa. Compared with the physically cross-linked hydrogels, the light transmittance of the DN hydrogels at 600 nm was significantly increased from 23.7% to 93.8%. The drug release studied by taking berberine hydrochloride hydrate (Ber) as the model drug showed that drug release behaviors of the DN hydrogels were pH sensitive and notably correlated with the content of PEGDA. In addition, DN hydrogels existed excellent water absorption rate (38.3-fold). Therefore, the enhanced mechanical properties, high transparency, excellent water absorption rate, and pH sensitivity of the DN hydrogel suggested the promising applications of the hydrogels as visual transdermal drug delivery systems.
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FOOD HYDROCOLLOIDS
·
2022
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IF 11.504
Yan-Wei Liu,Qing-Hao Li,Guo-Qing Huang,Jun-Xia Xiao
The complexation between Aspergillus oryzae lipase (AOL) and chitosan (CS) was investigated as a function of phase separation pH and the resultant complexes were characterized. The results indicated that AOL and CS could assemble micron-sized complexes in pHs 5.0–6.5 and the strongest interaction occurred in pH 5.5. QCM-D analysis revealed that association in pH 5.5 generated a viscoelastic hydrated adlayer with the largest thickness. ITC analysis indicated that the interaction between AOL and CS was driven by enthalpy and the highest one-site binding stoichiometry was recorded in pH 5.5, which was 1.3 and 7.9 times higher than in pHs 5.0 and 6.0, respectively. Both electrostatic attraction and hydrophobic interaction played dominant role in AOL-CS complexation. Compared with free AOL, the interaction with CS reduced its α-helix content, increased its β-sheet content, and changed its tertiary structure; besides, the AOL-CS complex assembled in pH 5.5 exhibited the highest contact angle up to 85.5° and demonstrated enhanced lipase activity retention after incubation in pHs 3.0–9.0 and temperatures 35–75 °C. Hence, the AOL-CS complexes could be used to construct novel biphasic catalysis media based on O/W Pickering emulsions .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Yongyan Yang,Gangying Feng,Jingfei Wang,Ruiting Zhang,Shuangling Zhong,Jia Wang,Xuejun Cui
In this study, a supramolecular hydrogel was fabricated with orotic acid (OA) modified chitosan (OACS) and 2,6-diaminopurine (DAP). The obtained OACS-DAP supramolecular hydrogels have dual responsiveness to temperature and pH. Phase transition experiments indicate this is a temperature-dependent thermoreversible supramolecular hydrogel. Rheological experiments proved the formation of the supramolecular hydrogel and its thixotropic properties. FTIR spectra confirmed that hydrogen bonds and π-π interactions are the main driving forces for OACS and DAP to form hydrogels through intermolecular self-assembly. XRD pattern confirmed the amorphous morphology of OACS-DAP hydrogels. The hydrogel has excellent electrical conductivity with a conductivity of 9.48 μ S·cm −1 . And can achieve the precise release of gastrointestinal drugs. OACS-DAP hydrogel is expected to have better applications in the field of gastrointestinal drug release.
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Zhu-Rui Zhong,Hong-Liu Jiang,Na Shi,Hu-Wei Lv,Zhi-Jie Liu,Fu-An He
A new tetrafluoroterephthalonitrile crosslinked quercetin/chitosan (T-QT/CS) adsorbent was successfully synthesized for the adsorption of both cationic and anionic dyes in water. The structure of the resulting T-QT/CS was characterized by FTIR, 13 CNMR, TGA, BET, SEM, and XPS, and the surface-charge property of the T-QT/CS at different pH values was determined by the zeta potential measurement. It was found that the adsorption behavior of the T-QT/CS for the cationic methylene blue (MB) dye and the anionic orange G (OG) dye conformed to the pseudo-second-order kinetic model and the linear Langmuir isotherm model. Furthermore, basing on the linear Langmuir isotherm model, the T-QT/CS possessed good dye-adsorption ability, and the maximum adsorption capacities of the T-QT/CS for the MB (at pH=9) and OG (at pH=2) at 303 K were 917.4 mg/g and 349.9 mg/g, respectively. The thermodynamic experimental results showed that the MB and OG adsorption processes of the T-QT/CS were endothermic and spontaneous. In addition, the T-QT/CS exhibited good reused ability for the adsorptions of MB and OG even after five adsorption-desorption experiments.
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OPTICAL MATERIALS
·
2022
·
IF 3.754
Zhenzhen Huang,Yanxin Wang,Xianhang Yan,Xinhui Mao,Zhiyuan Gao,Matt J. Kipper,Linjun Huang,Jianguo Tang
In this work, a luminescent lanthanide complex, namely, Eu(tta) 3 phen (Eu = europium , tta = 2-thenoyltrifluoroacetone, phen = 1, 10-phenanthroline) is used as a luminescent dopant to prepare fluorescent nanofiber films. The resulting nanofibers (CS/PEO-SiO 2 @Eu(tta) 3 phen) are composed of chitosan and polyethylene oxide containing silica nanoparticles , encapsulating the Eu(tta) 3 phen. The nanofibers are stabilized by treatment with sodium bicarbonate (NaHCO 3 ) aqueous solution as neutralizer and then repeatedly washed with deionized water. A more stable Na-CS/PEO-SiO 2 @Eu(tta) 3 phen fiber film is obtained as a fluorescence sensor for Cu 2+ ions. The Na-CS/PEO-SiO 2 @Eu(tta) 3 phen has high sensitivity, and a wide detection range. The response is linear in the concentration range from 10 to 90 μmol/L, and the detection limit is 0.826 μmol/L. In addition, Na-CS/PEO-SiO 2 @Eu(tta) 3 phen nanofiber film can be used as a recyclable sensor for the detection of Cu 2+ ions in aqueous solution due to its good recyclability, selectivity and rapid optical response.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
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IF 8.025
Zhimeng Chen,Tiantian Wen,Xueyuan Wang,Lin Yang,Zhongjie Wang,Yanru Qin,Yixue Hu,Tianyu Zhang,Dongna Wang,Amin Liu,Liefeng Zhang,Meng Lei,Yongqiang Zhu
Herein, a cyclodextrin derivative (R6RGD-CMβCD) with tumor target and a carboxymethyl chitosan derivative (M2pep-CMCS) with tumor-associated macrophages 2 (TAM2) target were successfully synthesized, respectively. DOX-loaded nanoparticles (R6RGD-CMβ [email protected] NPs, RCNP DOX ) and R848-loaded nanoparticles ( [email protected] NPs, MCNP R848 ) were prepared. Furthermore, the RCNP DOX and MCNP R848 exhibited good DOX and R848 absorption. Meanwhile, the synergetic cell toxicity of RCNP DOX and MCNP R848 was found. Additionally, RCNP DOX + MCNP R848 nanoparticles greatly promoted the expression levels of cleaved Caspase3, which indicated that the nanoparticles could induce cell apoptosis. At the same time, the immunohistochemical images exhibited that RCNP DOX + MCNP R848 group could effectively transform the phenotype of tumor-associated macrophages. Importantly, in vivo experiments revealed that RCNP DOX + MCNP R848 NPs exerted excellent anticancer effects in tumor-bearing mice. To summarize, RCNP DOX + MCNP R848 NPs are effective anticancer treatment combining chemotherapy and immunotherapy, M2pep-CMCS and R6RGD-CMβCD are good delivery materials.
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高影响因子
Polymers
·
2022
·Vol. 14
·期 24
·5509
·
IF 4.967
Haoying Wang,Xiaoxia Song,Junfeng Xiong,U Kei Cheang
Magnetically actuated microrobots showed increasing potential in various fields, especially in the biomedical area, such as invasive surgery, targeted cargo delivery, and treatment. However, it remains a challenge to incorporate biocompatible natural polymers that are favorable for practical biomedical applications. In this work, bilayer magnetic microrobots with an achiral planar design were fabricated using a biocompatible natural polymer and Fe3O4nanoparticles through the photolithography by applying the layer-by-layer method. The microrobots consisted of a magnetic bottom layer and a photo-crosslinked chitosan top layer. The SEM results showed that the microrobot processed the L-shaped planar structure with the average width, length, and thickness of 99.18 ± 5.11 μm, 189.56 ± 11.37 μm, and 23.56 ± 4.08 μm, respectively. Moreover, microrobots actuated using a three-dimensional (3D) Helmholtz coil system was characterized and reached up to an average maximum velocity of 325.30 μm/s and a step-out frequency of 14 Hz. Furthermore, the microrobots exhibited excellent cell biocompatibility towards L929 cells in the CCK-8 assay. Therefore, the development of bi-layered chitosan-based microrobots offers a general solution for using magnetic microrobots in biomedical applications by providing an easy-to-fabricate, highly mobile microrobotic platform with the incorporation of biocompatible natural polymers for enhanced biocompatibility.Keywords:chitosan;microrobot;photolithography;natural polymer;magnetic actuation
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MATERIALS & DESIGN
·
2023
·
IF 8.4
Jiawei Lu,Xiaokun Fan,Jiawei Hu,Jie Li,Jingjing Rong,Weijia Wang,Ying Chen,Wenyong Liu,Jin Chen,Yi Chen
The main limit of hydrogel used as an independent wound dressing is its poor water retention, brittleness, and weak skin adhesion. Focusing on it, the macromolecular cross-linked chitosan and polyacrylamide double network hydrogel (C-A) is chosen as a functional layer, another robust poly(vinyl alcohol)-polyacrylamide/glycerin (P-A) protective layer is designed to cover its surface, an interfacial reaction happens to link two layers tightly for achieving the function synergy. In this double-layer hydrogel (DH) dressing, the surface P-A layer with strong water locking ability could keep the wound surface moist for a long time, high strength and toughness make the dressing maintain integrity under large deformation and stress to strengthen wound protection, and the C-A layer with modest adhesion ensures the dressing fit the skin, the synergistic swelling ability could guarantee the fast absorption for the wound exudate. Moreover, in vitro and in vivo tests, the DH dressing exhibits excellent antibacterial and cytocompatibility, it could significantly accelerate skin tissue regeneration and wound closure than the commercial hydrocolloid dressings. In general, this DH dressing is easy to prepare and shows superior comprehensive performance, revealing the great potential for use as an independently applied wound dressing.
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COMBUSTION SCIENCE AND TECHNOLOGY
·
2023
·
IF 1.9
Chunhui Lyu,Junqing Meng,Yanan Hou,Lijuan Wang,Jie Wang,Yingpei Lyu
Flame‐retardant silicone rubber foams (SRF) were prepared by dehydrogenation at room temperature with chitosan (CS) and cyclodextrin (CD) as flame retardants. The flame retardancy, smoke suppression, mechanical properties, and thermal stability of SRF with CS and CD were tested using the UL-94 test, limiting oxygen index (LOI), cone calorimeter test (CCT), compression test, field emission scanning electron microscope (FESEM), and thermogravimetry analysis (TGA). The results indicated that the fire behavior was good when the content of CS and CD was 1 wt%, and the CD had a flame-retardant efficiency better than CS. The combination of 0.6 wt% CS and 0.4 wt% CD had the best synergistic flame-retardant efficiency, smoke suppression, and excellent thermal stability. The 0.6%CS/0.4%CD/SRF achieved an LOI value of 30% and a UL-94 V-0 rating and did not drip. Compared with pure SRF, the peak heat release rate (pHRR), the total heat release (THR), the peak smoke production rate (pSPR), and the total smoke production (TSP) decreased by 60.00%, 55.52%, 53.82%, and 55.00%, and the char residue increased by 17.40%. However, the addition of CS and CD slightly worsened the mechanical properties of SRF, and the compressive strength of 0.6%CS/0.4%CD/SRF was reduced by 3.62%.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yongjian Xu,Hao Chen,Lan Zhang,Yang Xu
In this study, the formation of clove essential oil loaded chitosan nanocapsules (CEO/CS-NCs) was achieved by the ionotropic gelation technology. The spherical shape and core-shell structure of CEO/CS-NCs were characterized by SEM, TEM , and FT-IR. CEO/CS-NCs have a reasonable encapsulation efficiency rate of 39 % and an average size of 253.63 nm. The simulated release of CEO/CS-NCs in a citric acid buffer solution shows that the nano-encapsulation technology could control the sustained release of clove essential oil (CEO). The shelf life of untreated blueberries at room temperature is only about 3 days, while CEO/CS-NCs combined with low-temperature storage can extend the shelf life to about 12 days. The quality characteristic of blueberries, including fruit firmness and moisture content, were effectively maintained, and the rotting rate of blueberries was significantly reduced with CEO/CS-NCs. As a natural preservative, CEO/CS-NCs have a good antioxidant activity close to the commercial antioxidant butylated hydroxytoluene (BHT) and a high antibacterial activity against pathogenic bacteria (PB) isolated from naturally occurring blueberries. Therefore, this study not only gives a theoretical basis for the development of CEO as a commercial preservative but also provides a practical solution to solve the protection challenge of preserving blueberries.
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EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Yali Zhao,Jiayue Chen,BingXi Wang,Li Wei
An ideal and highly desired wound dressing for the repair of infectious wounds should provide a moist environment, close adhesion to the wound site, and self-healing and antibacterial properties. Thus, in the present study, we manufactured multifunctional, mussel-inspired hydrogels CACS-Fe 3+ -CYCS and CACS-Fe 3+ using catechol-grafted-chitosan (CACS) and cysteine-modified-chitosan (CYCS) as raw materials and ferric chloride as a cross-linking agent. The CACS-Fe 3+ -CYCS hydrogel exhibited excellent adhesion because of metal coordination between the ferric ion (Fe 3+ ) and catechol groups and a strong covalent bond between the catechol groups and the amino and sulfhydryl groups. Its self-healing quality was attributed to the dynamic and reversible properties of metal coordination. The loading of the total flavones of Resina Draconis (RDF) provided the hydrogel with good antibacterial properties. The antibacterial rates of the CACS-Fe 3+ -CYCS and RDF-CACS-Fe 3+ -CYCS hydrogels for Escherichia coli and Staphylococcus aureus were 90.62% and 96.45% and 99.98% and 100.00%, respectively. The RDF-CACS-Fe 3+ -CYCS hydrogel at pH 5.0, 6.8, and 8.0 in phosphate-buffered saline exhibited slow, sustained cumulative release rates of 53.94%, 71.97%, and 85.13% at 60 h, respectively. Complete wound healing was observed by day 12 in the CACS-Fe 3+ -CYCS hydrogel group (healing ratio = 96.59%). In the RDF-CACS-Fe 3+ -CYCS hydrogel group, complete healing was achieved by day 9 (healing rate = 94.46%; highest value at all treatment times). Thus, both hydrogels can be used as an ideal dressing for treating infectious wounds. The combination of traditional Chinese medicine and novel wound dressings can work synergistically, providing a novel strategy for designing biomimetic hydrogels for potential applications in wound healing.
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