iScience
·
2021
·
IF 5.458
Qing-Nan Wang,Xianghui Liu,Kai Wang,Yan Liu,Sheng-Mei Lu,Can Li
Summary p -Methyl benzaldehyde ( p -MBA) is a class of key chemical intermediates of pharmaceuticals. Conventional industrial processes for p -MBA production involve the consecutive photochlorination, amination, and acid hydrolysis of petroleum-derived p -xylene, while producing vast pollutants and waste water. Herein, we report a direct, green route for selective synthesis of p -MBA from acetaldehyde using a diphenyl prolinol trimethylsilyl ether catalyst. The optimized p -MBA selectivity is up to 90% at an acetaldehyde conversion as high as 99.8%. Intermediate structure and 18 O-isotope data revealed that the conversion of acetaldehyde to p -methylcyclohexadienal intermediates proceeds in an enamine-iminium intermediate mechanism. Then, controlled experiments and D-isotope results indicated that the dehydrogenation of p -methylcyclohexadienal to p -MBA and H 2 is catalyzed by the same amines through an iminium intermediate. This is an example that metal-free amines catalyze the dehydrogenation (releasing H 2 ), rather than using metals or stoichiometric oxidants.
✓ 已验证
DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2018
·
IF 5.807
Tingwei Zhang,Wenzhi Li,Shengxin An,Feng Huang,Xinzhe Li,Jingrong Liu,Gang Pei,Qiying Liu
In this work, p-hydroxybenzenesulfonic acid-formaldehyde resin acid catalyst (MSPFR), was synthesized by a hydrothermal method, and employed for the furfural production from raw corn stover. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), N 2 adsorption-desorption, elemental analysis (EA), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR) were used to characterize the MSPFR. The effects of reaction time, temperature, solvents and corn stover loading were investigated. The MSPFR presented high catalytic activity for the formation of furfural from corn stover. When the MSPFR/corn stover mass loading ratio was 0.5, a higher furfural yield of 43.4% could be achieved at 190 °C in 100 min with 30.7% 5-hydroxymethylfurfural (HMF) yield. Additionally, quite importantly, the recyclability of the MSPFR for xylose dehydration is good, and for the conversion of corn stover was reasonable.
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Zhibiao Zhu,Yafei Hou,Tingyu Fu,Jing Cuan,Weiping Li
Given its wide application ranges, dielectric capacitors have garnered extensive attentions. However, due to the excessive premature agglomeration of free electrons, capacitors with nanocomposites as dielectrics fail to attain high breakdown strength ( E b ), and thereby constrain their ability to achieve superior energy storage performances. To alleviate the effects of free electrons and secondary impact-ionized electrons (SIE) on E b and leakage currents, here, a novel organic-inorganic core–shell Ni(OH) 2 @PDI (N@P) nanofiller with opposite double-PN-junction was well-designed and successfully synthesized by coating p-typed Ni(OH) 2 nanosheets with n-typed perylene diimide (PDI). It could reduce free electron kinetic energy and mitigate SIE amounts regardless of the applied electric field direction. Furthermore, PDI, as an organic compound, can uniformly and densely coat onto surfaces of 2D Ni(OH) 2 , as well as enhance compatibilities between Ni(OH) 2 and matrix, and thereby reducing structure defects at their interfaces. Last but not the least, Ni(OH) 2 nanosheets also contribute to E b improvement via acting as scattering centers. Experimental and simulation results concurrently affirmed positive influences of organic-inorganic N@P nanofillers on discharge energy density ( U d ) and efficiency ( η ) of P(VDF-HFP)-based (PVH-based) nanocomposites. Remarkably, 1.3 vol% N@P/PVH achieves a high U d of 21.7 J/cm 3 and η of 81.2 % under 569.0 MV/m. More importantly, it maintains an excellent energy storage performance throughout 10 4 cyclic tests. This study presents a valid strategy for concurrently improving U d and η of polymer-based nanocomposites.
✓ 已验证
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2023
·
IF 4.1
Feng Wei,Yuchen Guo,Shichao Wang,Yaojie Gao,Jun Qiao,Songlin Ran,Mengcheng Han
Supercapacitors (SCs) have been widely used owing to their merits of long cycle life, excellent physiochemical stability and zero-carbon emission. However, the low energy density of SCs restricts their further applications. Herein, the N, P doped carbon nanosheets (NPCNs) were prepared by using silicon-removed carbon as carbon resource derived from rice husk . The as-prepared NPCN not only possesses a large surface area of 1701.6 m 2 g −1 and a high ratio of mesopore volume to total pore volume (62.11 %) for adsorption and transfer of electrolyte ions , but also has a suitable nitrogen and phosphorus content for electron conduction and contribution of additional active sites to generate pseudo-capacitance through redox. Therefore, the excellent electrochemical properties have been obtained for NPCN-based SCs in the alkaline electrolyte , e.g. satisfactory capacitance of 396.1 F g −1 at 0.1 A g −1 , outstanding rate properties of 319.2 F g −1 at 40 A g −1 , long cyclability with capacitance decay of 0.95 % after 30,000 cycles. Additionally, the energy density of the NPCN-based SCs with neutral electrolyte and ionic liquid electrolyte increased 2.67-fold and 11-fold to 33.25 and 137.24 Wh kg −1 , respectively. This study opens up a feasible route by crafting heteroatoms and using high voltage window electrolyte to obtain the high energy density for SCs.
✓ 已验证
DOI
高影响因子
Brazilian Journal of Pharmaceutical Sciences
·
2022
·
IF 1.214
Zhang Rong,Huang Limin,Pan Di,Zhang Wen
Drug resistance is a crucial obstacle to achieve satisfactory chemotherapeutic effects. Numerous studies have shown that the PI3K/Akt signaling pathway plays a significant role in various processes of cellular events and tumor progression, while few studies have focused on the PI3K/Akt signaling pathway in drug resistance of endothelial cells. The present study aims to explore the relationship of PI3K/Akt signaling and cellular resistance to anticancer drugs in human microvessel endothelial cells (HMEC-1). We established stable sunitinib-resiatant human microvessel endothelial cells (HMEC-su) after long-term exposure to sunitinib (a small-molecule tyrosine kinase receptor inhibitor) for 12 months. HMEC-su showed significant alternations of cell morphology and exhibited a 2.32-fold higher IC50 of sunitinib than parental HMEC-1 cells. Expression of P-glycoprotein (P-gp) and breast cancer-resistance protein (ABCG2) which mediates drug efflux, increased significantly in HMEC-su lines compared with HMEC-1 cells by western blots assay. Our study further demonstrates that LY294002 (blocking the PI3K/Akt pathway) enhances the sensibility of HMEC-su to suntinib and inhibits the gene transcription and protein expression of P-gp, ABCG2 in HMEC-su cells. In conclusion, these results indicate that LY294002 could reverse P-gp and ABCG2 mediated-drug resistance to sunitinib in HMEC-su cells by inhibiting PI3K/Akt signaling.
✓ 已验证
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 7
·3949-3957
·
IF 3.108
Enjie Yu,Qilong Zhang,Nuoxin Xu,Hui Yang
In this study, self-assembly flower-like TiO2 (F-TiO2) particles with an average diameter of 400 nm are synthesized via a facile one-pot solvothermal method. P(VDF-HFP)-based composites with F-TiO2 particles of different volume ratio as fillers are prepared. Microstructure and thermal analyses confirm that F-TiO2 does not change the crystallization process of the polymer matrix, but disrupts the crystallization degree of P(VDF-HFP). Dielectric properties measured at various frequencies and temperatures indicate that the addition of the F-TiO2 fillers enhances the dielectric constant of the composites, while the dielectric loss and electric conductivity do not significantly increase. The dielectric permittivity of the polymer nanocomposites is enhanced by 200% over that of the P(VDF-HFP) matrix at a filler content of 20 vol% while maintaining a rather low dielectric loss (0.043 at 1 kHz). Especially, the F-TiO2/P(VDF-HFP) composites exhibit low electric conductivity (≤10−11 S cm−1) at low frequencies. All the improved performances suggest an easy method to fabricate nanocomposites having potential electrical applications.
✓ 已验证
DOI
高影响因子
SOLAR ENERGY
·
2016
·
IF 3.685
Haifeng Yang,Jincheng Zhang,Chunfu Zhang,Jingjing Chang,Zhenhua Lin,Dazheng Chen,Xu Sun,He Xi,Genquan Han,Yue Hao
In this work, we demonstrated a high performance planar heterojunction perovskite solar cell with the polyethylenimine ethoxylated (PEIE) interlayer. By adopting a less polar solvent for PEIE, enhanced device performance and uniformity are achieved. The power conversion efficiency (PCE) of the best device increases by 22% compared to the reference device and reaches 14.82% with J SC of 19.45 mA/cm 2 , V OC of 1.00 V, and FF of 76.31% under AM 1.5G 100 mW/cm 2 light illumination. The UPS measurement shows that the PEIE layer can effectively decrease the energy offset between PCBM and metal electrode. The recombination mechanism was explored by measuring V OC and J SC at various light intensities from 100 to 0.1 mW/cm 2 . It shows that the PEIE layer can suppress the trap-assisted recombination for the devices. The enhancement of the probability of the carriers collection also shows that the recombination is reduced by the PEIE interlayer. Moreover, it is found PEIE layer can improve the stability of the device.
✓ 已验证
DOI
高影响因子
WATER RESEARCH
·
2020
·
IF 9.13
Panxin Wang,Xu He,Wei Zhang,Jun Ma,Jin Jiang,Zhuangsong Huang,Haijun Cheng,Suyan Pang,Yang Zhou,Xuedong Zhai
As a common animal feed additive, p-arsanilic acid (p-AsA) is thought to be excreted with little uptake and unchanged chemical structure, threatening the environment by potentially releasing more toxic inorganic arsenic. We herein investigated the removal of arsenic by in situ formed ferric (oxyhydr)oxides with the promotion of p-AsA degradation in Fe(II)/peroxydisulfate (PDS) system. Results showed that under acid conditions, p-AsA degraded very quickly and over 99% of p-AsA (5 μM) was degraded within 10 min at the optimal dosage of Fe(II) (100 μM) and PDS (150 μM) at pH 3, while less than 66.4% of arsenic was removed at pH 3–5. Higher pH (3–7) would inhibit the degradation of p-AsA but promote the arsenic removal. At pH 6–7, over 98.5% of total arsenic was removed, while the degradation efficiency of p-AsA was lower than 52.4%. HPLC-ICP-MS results indicated that the arsenic group was cleaved from p-AsA in the form of As(III) and then rapidly oxidized to As(V). FTIR and XPS analysis indicated that both As(V) products and residual p-AsA were bonded to ferric (oxyhydr)oxides via hydroxyl groups. Common cations (e.g., Na + , Ca 2+ , Mg 2+ ) and anions such as Cl − , SO 4 2− , CO 3 2− had no significant influence on arsenic removal, while SiO 3 2− , PO 4 3− and HA inhibited the removal of total arsenic, mainly by affecting the zeta potential of iron particles. In summary, the Fe(II)/PDS process, as an efficient method for partial oxidation and simultaneous adsorption of p-AsA under near-neutral conditions, is expected to control the potential environmental risks of p-AsA.
✓ 已验证
DOI
高影响因子
Advanced Materials Interfaces
·
2019
·Vol. 6
·期 9
·1802088
·
IF 4.713
Nianxiang Shi,Baojuan Xi,Zhenyu Feng,Jincheng Liu,Denghu Wei,Jing Liu,Jinkui Feng,Shenglin Xiong
Lithium–sulfur batteries are deemed to be one of the most promising energy storage alternatives due to the high theoretical capacity and cost-effectiveness. The significant challenge in exploring novel sulfur host materials is to simultaneously inhibit the shuttle effect and heighten the reaction kinetics. Herein, a novel hybrid host consisting of W 2 C atomic nanoclusters (NCs) grown on a N/P-codoped graphene framework (W 2 C@N/P-rGO) is designed and fabricated for the first use in lithium–sulfur batteries. By means of first-principle calculations and the kinetics analysis including lithium ion diffusion coefficient and charge transfer resistance, the introduction of W 2 C atomic NCs benefits the enhancement of electrochemical kinetics on a polar hybrid conductor. Furthermore, the intense ability of chemically sequestrating the soluble polysulfides by W 2 C atomic NCs ensures the high utilization of sulfur, making the high capacity retention. With a high sulfur loading of 3.1 mg cm −2 , the W 2 C@N/P-rGO/sulfur composite cathode indicates a significantly enhanced electrochemical performance. This work may open up a new avenue to design novel host candidates for advanced lithium–sulfur batteries.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·741
·
IF 12.6
Liu Xiao,Huang Zixuan,Hu Chenlu,Zhao Yanan,Pan Huili,Wu Yinxin,Fang Xia,Chen Jifan,Liu Yajing,Wang Guowei,Huang Pintong
Pseudomonas aeruginosa -induced biofilm-associated surgical site infections (BSSIs) pose a dual therapeutic challenge: the dense extracellular polymeric substances (EPS) barriers hinder drug enrichment and penetration, whereas the immunosuppressive microenvironment within the biofilm impedes infection clearance, leading to persistent bacterial colonization and recurrence. This study developed an ultrasound-activated P-selectin-targeted liposome (SPCMPL) integrating natural sulfatide ligands (targeting P-selectin overexpressed in inflamed BSSI vasculature), sonosensitizer chlorin e6 (Ce6), meropenem prodrug, and perfluoropentane (PFP) to achieve efficient antibiotic delivery and BSSI treatment via breaking through the biofilm barriers and activating immunomodulation. SPCMPL employed ligand/receptor-mediated transcytosis for enrichment in BSSI lesions, where the PFP phase transition triggered by ultrasound disrupted the biofilm EPS structure. This process can both trigger the in-situ generation of reactive oxygen species (ROS) by Ce6 and loosen the EPS matrix. This degradation then facilitated meropenem release, allowing it to penetrate the biofilm more effectively and achieve antimicrobial concentrations throughout. Furthermore, the mass-produced ROS polarized macrophages to a pro-inflammatory M1 phenotype, thereby enhancing phagocytosis, remodeling the microenvironment, and inhibiting biofilm persistence. Ultrasound-triggered spatial control localized antibiotic release and immunomodulation to the infection site, optimizing local delivery while minimizing systemic toxicity and reducing the risk of systemic cytokine storms. The results demonstrated that the SPCMPL with ultrasound manipulation integrated biofilm disruption, targeted drug release, and immunomodulation to completely eradicate both planktonic and biofilm-embedded bacteria and effectively treat BSSI. Graphical
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2025
·
IF 2
Gao Hongfeng,Lin Xiongchao,Tao Xianfeng,Zhang Xuchun,Wang Caihong,Bai Hongcun,Wang Yonggang
A novel method for enhancing oxidative stabilization through the addition of p-tert-butylphenol (TOH) to the as-prepared pitching process was developed. TOH can be used as a radical initiator to quickly and uniformly stabilize the pitch. The properties of spinnable pitches, the effects of oxidation stabilization, and the polymerization mechanism were thoroughly elucidated. The findings revealed that the introduction of TOH led to an increase in the fraction of aliphatic structures as well as the oxygen content within the pitches. This increase facilitated the formation of oxygen-containing groups and promoted crosslinking reactions among the pitch molecules. Notably, the hydrogen in the OH group of TOH displays high reactivity, readily engaging in cross-linking reactions with the benzyl radicals in halogenated polycyclic aromatic hydrocarbons (PAHs-X) during heat treatment. Consequently, an ether bond is formed between the benzyl radical in PAHs-X and the hydroxyl radical in TOH. High temperatures could expedite the formation of aryl ester functional groups in an inert gas atmosphere and hasten the crosslinking of PAHs molecules, resulting in the formation of a macromolecular structure with a certain degree of polymerization. This modification method is expected to provide a new approach for expediting oxidative stabilization.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Fangzheng Hua,Kang Tan,Jingyu Lv,Fei Wang,Mengting Sun
The industrial implementation of hydrate-based natural gas storage and transportation faces significant challenges due to sluggish hydrate formation kinetics. This study systematically explored the use of sodium p-styrenesulfonate (SS) as a promoter for methane hydrate formation, with comprehensive investigations into its promotion efficiency, underlying mechanisms, foamability, and recyclability. Results indicated that SS at an appropriate concentration (5-12 mmol L -1 ) presented a remarkable performance on promoting methane hydrate formation kinetics, and with increasing concentration, the promotion efficiency was initially enhanced and then slightly declined, and the shortest induction time of 0 min was achieved at 7 mmol L -1 , while the rapidest hydrate growth rate at t 90 (HGR t90 ) of 0.575 ± 0.022 mmol mL -1 min -1 , the largest methane uptake of 149.8 ± 0.8 mmol mol -1 and the highest storage capacity of 148.5 ± 0.8 v/v were achieved at 10 mmol L -1 . Morphological observation on hydrate formation process revealed that SS might induce the development of porous hydrate structures. These structures generated substantial capillary forces on the underlying water, promoting upward hydrate growth and significantly enhancing mass transfer. Hydrate formation from droplet implied that SS at a higher concentration might provide stronger capillary forces on water, thereby more significantly boosting mass transfer. Morphological observation on hydrate dissociation process revealed that SS did not generate foam, and moreover, SS maintained remarkable promoting effects throughout at least five repeated hydrate formation-dissociation cycles, which convincingly proved that SS permitted exceptional non-foamability and admirable recyclability.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）