ACS Applied Bio Materials
·
2026
·Vol. 9
·期 15
·7069-7080
·
IF 5.6
Chi Chunyu,Gao Yuantao,Chen Jiazhu,Ge Xuejun,Gao Zexing,Li Yinggang,Yan Shuang
The delayed healing of skin wounds poses significant health risks and increases medical burdens, necessitating the development of multifunctional dressings that can actively monitor and promote the healing process. In this study, a multifunctional CeO 2 /PCL nanofibrous scaffold integrating real-time pH sensing, enhanced stem cell adhesion, and antioxidant functions was developed. A series of composite scaffolds with tunable CeO 2 nanoparticle loadings (7.1–31.6 wt %) were fabricated via a facile one-step electrospinning technique. Notably, the CeO 2 /PCL-13.3 wt % scaffold achieved an optimal balance of tensile strength (1.927 MPa) and elongation at break (70%), fully satisfying clinical wound dressing requirements. Phenol red loading enabled naked-eye pH monitoring (4.0–10.0) via metal−phenolic coordination. Comprehensive evaluations demonstrated that the composite scaffolds exhibited significant antibacterial activity, potent reactive oxygen species scavenging capability, and excellent biocompatibility. The scaffolds maintained over 80% human umbilical cord mesenchymal stem cells viability within 72 h and significantly promoted stem cell migration in wound healing assays. This integrated platform unifies visual diagnostics and therapeutic functions for advanced wound management.
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Case Studies in Construction Materials
·
2026
·
IF 6.9
Jiale Yu,Jiayang Zhu,Cheng Wang,Binmeng Chen
This study evaluated the feasibility of using cadmium-containing wastewater (CCW) as mixing water for cement paste and elucidated the coupled relationship among hydration evolution, pore structure evolution, permeability variation, and Cd 2+ transport under different pH conditions. The results demonstrated that the initial pH of CCW significantly influenced cement hydration and pore connectivity, thereby controlling Cd 2+ transport and leaching behavior. Specifically, H + ions inhibited cement hydration and etched the hydration products, resulting in a porous structure while OH - ions accelerated the hydration and increased the amount of hydration products, refining the pore structure. It is worth noting that as the pH increases, the dominant Cd species gradually shifted from the highly mobile free Cd 2+ (which prevails under strongly acidic conditions, though minor hydroxy complexes like Cd(OH) + may also coexist) towards less soluble hydroxide complexes and ultimately to stable precipitates such as Ca 0.67 Cd 0.33 CO 3 , which further enhanced pore tortuosity and inhibited Cd 2+ migration. Furthermore, the Katz-Thompson model revealed the pH-regulated evolution of permeability-controlling pore structures, showing a strong linear correlation with Cd leaching (R 2 =0.979). Permeability-controlling pores shifted from bimodal distributions (1–10 μm and 0.003–0.01 μm) under acidic conditions to a concentrated micropore range (0.003–0.01 μm) under alkaline conditions. These findings established a predictive permeability-controlled framework that quantitatively links micro structure to leaching behavior, providing theoretical support for the safe utilization of CCW in construction materials.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zheng Yuan,Ziteng Wang,Haidong Shen,Quanlong Zhang,Jiahui Zhou,Jinzhou Cai,Lin Hu,Zetong Chen,Qing He,Kai Zhang,Kai Yang,Pei Pei,Jin Zhou
A pH-responsive nanoplatform was developed to enhance gastric cancer chemo-immunotherapy. • Tumor acidity-triggered charge reversal improved intracellular delivery of oxaliplatin and BAPTA-AM. • Calcium chelation blocked pyroptosis reversibility and amplified immunogenic cell death. • The nanoplatform weakened tumor stemness and reshaped the immune microenvironment. The clinical response rate of combined chemotherapy and immunotherapy in gastric cancer remains unsatisfactory, largely due to insufficient release of tumor antigens and immunogenic cell death signals under treatment-tolerant conditions, as well as immune evasion driven by cancer stem cells (CSCs). To address this, this study constructed a membrane-affinity intelligent nanodelivery system (pHP + -O/B) that responds to the acidic tumor microenvironment, for the co-delivery of oxaliplatin and the calcium ion chelator BAPTA-AM. Under acidic tumor conditions, pHP + -O/B undergoes PEG detachment and exposes a positively charged core, enhancing its interaction with gastric cancer cell membranes and improving intracellular drug delivery. Mechanistically, oxaliplatin induces GSDME-mediated pyroptosis, while BAPTA-AM synergistically amplifies this effect by blocking calcium dependent membrane repair processes, thereby significantly promoting the release of immunogenic molecules such as HSP70 and HMGB1 and remodeling the tumor immune microenvironment. Further investigations reveal that this strategy effectively suppresses Wnt/β-catenin associated stemness signaling, reduces the CSCs population, enhances DC maturation and promotes T-cell activation. Patient-derived xenograft (PDX) models further confirmed the antitumor efficacy of pHP + -O/B and its ability to enhance pyroptosis and suppress tumor stemness. In summary, we present a nano-delivery strategy that synergistically amplifies pyroptosis and suppresses tumor stemness, thereby enhancing chemo-immunotherapy efficacy in gastric cancer.
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MATERIALS & DESIGN
·
2026
·
IF 8.2
Yunxin Ye,Weian Wu,Yaping Chen,Jiyuan Zou,Ting Lin,Bo Wu,Tao Luo,Li Yang,Lvhua Guo
BCA with modified molecular skeleton exhibits potent GSH scavenging capacity. • M@PB nanozyme was designed with Pd NPs and BCA co-loaded on MPDA NPs. • M@PB achieves adaptive ROS regulation via microenvironmental pH changes. • M@PB can effectively promote the healing of MRSA-infected wounds. Nanozymes show great potential in reactive oxygen species (ROS)-based antibacterial therapy. However, bacterial glutathione (GSH)-mediated ROS scavenging and tissue damage caused by residual ROS after sterilization remain challenges. Herein, we report a ROS-adaptively regulated M@PB, which is constructed by co-loading multienzyme Pd nanoparticles and a GSH scavenger α-bromocinnamaldehyde (BCA) onto mesoporous polydopamine (MPDA). The M@PB exhibits pH-switchable enzyme-like activities: under acidic conditions, it exerts peroxidase (POD)-like activity to generate ROS for efficient bacterial elimination; as bacteria are eradicated and the local pH rebounds, it switches to catalase (CAT)-like activity to scavenge residual ROS and produce oxygen, thereby accelerating cell migration. Furthermore, backbone-modified BCA exhibits strong GSH-scavenging activity; its acid-triggered release from M@PB further disrupts bacterial antioxidant systems, driving greater oxidative stress to accelerate the antibacterial-to-healing progression. Experiments demonstrate that M@PB exhibits potent antibacterial and antioxidant properties with favorable biosafety, and can effectively promote the healing of methicillin-resistant Staphylococcus aureus ( MRSA )-infected wounds. This work provides a pH-Switchable nanoplatform that enables flexible regulation of ROS, offering a robust strategy for the care of wounds infected with drug-resistant bacteria. Download: Download high-res image (177KB) Download: Download full-size image
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Qin Geng,Lihua Zhou,Kuan Gao,Xiaomei Yi,Zhihua Wu,Hongbing Chen
Developing effective strategies to reduce peanut protein allergenicity while preserving functionality remains a challenge. This study investigated the pH-shifting-mediated coassembly of peanut protein with quercetin and rutin through spectroscopic and thermodynamic analyses for structural characterization, in vitro digestion, and BMDC-based assays for allergenicity assessment, along with functional analyses. The pH-shifting treatment significantly enhanced the polyphenol binding efficiency, concurrently inducing protein unfolding and the formation of soluble aggregates, thereby reducing surface hydrophobicity and altering the secondary structure. Coassembled complexes exhibited markedly lower IgE-binding and slower gastric digestibility than native or direct-mixed complexes. Immunologically, pH-shifted complexes better inhibited BMDC uptake, down-regulated maturation markers (MHC-II, CD40, CD80, and CD86), promoted a tolerogenic phenotype, and redirected T-cell responses from Th2/Th17 toward Th1/Treg. Functionally, the treatment enhanced foaming capacity but variably affected water-holding capacity, and foam stability may depend on polyphenol structure. Therefore, this study offers a novel strategy for designing hypoallergenic and functional peanut protein ingredients.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Haofeng Qiu,Jingfang Zheng,Zheyu Yao,Ximing Cai,Gaoke Pan,Xufeng Mao,Xin Zhao,Lei Shao,Dangsheng Xiong,Rong Wang,Yi Zhang
Cartilage degradation after joint injury often leads to post-traumatic osteoarthritis, a process accompanied by a drop in synovial pH. Traditional dynamically crosslinked hydrogels overlook how their mechanical and tribological properties change in such acidic, inflammatory environments. Here, we report an arthritis-responsive, injectable hydrogel designed to both regenerate articular cartilage and inhibit its further degradation. The hydrogel is formed via Schiff base chemistry between aldehyde groups of oxidized hyaluronic acid (OHA) and amino groups of adipic acid dihydrazide-grafted chondroitin sulfate (Chs-ADH) and carboxyethyl chitosan (CEC). Under neutral pH, the imine bonds remain stable, allowing precise defect filling and minimizing stress-induced debris; under acidic conditions, their reversible nature enhances lubrication and resists wear. The hydrogel formulation was optimized using molecular dynamics simulations to achieve excellent injectability, shear-thinning behavior, and low friction without impeding normal joint motion. In vitro , the hydrogel exhibited outstanding biocompatibility and stimulated cell migration. In vivo , it accelerated cartilage repair, prevented cartilage degradation, and restored the lubrication of newly formed tissue to levels comparable with healthy cartilage. Together, these findings demonstrate that the pH-sensitive hydrogel is a promising candidate for effective cartilage repair and prevention of cartilage degradation.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Jian Wang,Aiqian Ye,Jian He,Huadong Sheng,Hua Huang,Kan Jiang,Qiaozhi Zhang,Linglin Fu
Synergistic pH-shifting and glycation modify β-Lg's structure and functionality. • Acidic pH shifting enhances β-Lg flexibility, improving glycation efficiency. • XOS shows superior glycation efficiency with β-Lg compared to branched GOS. • Acidic-XOS treatment improves emulsifying and foaming properties of β-Lg. • Basic-GOS conjugation achieves the greatest reduction in IgE-binding capacity. As a major milk allergen with limited functionality, β-lactoglobulin (β-Lg) requires effective modification strategies to enhance its applicability. This study investigated the synergistic effects of pH-shifting pretreatment and glycation on the structure, functional properties, and allergenic potential of β-Lg. The protein was first treated under strongly acidic or basic conditions to induce conformational rearrangements, followed by glycation with galacto-oligosaccharides (GOS) or xylo-oligosaccharides (XOS). Pretreatment under acidic conditions enhanced the protein structural flexibility, exposing more glycation sites, especially for the linearly structured XOS. Acidic pH-shifting with XOS glycation significantly improved the emulsifying and foaming properties of β-Lg, while reducing its IgE-binding capacity. In comparison, basic pH-shifting plus glycation resulted in the greatest reduction in protein allergenicity through a synergistic masking effect, albeit with compromised functionality due to aggregation. Overall, the combined modulation of structure and conjugation provides an effective strategy to tailor the functionality and allergenicity of milk proteins. Download: Download high-res image (120KB) Download: Download full-size image
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SENSORS
·
2026
·Vol. 26
·期 13
·4205
·
IF 4
Xiao Wu,An Wang,Xiao Cai,Fan-Li Zhang,Bing Pei
Urine pH is an important biomarker related to metabolic status and urinary system health, but reliable SERS quantification in real urine remains limited by matrix interference, heterogeneous hotspot distribution, and the narrow response range of single pH-responsive molecules. Here, we report a core–gap–shell Au@1,4-BDT@Au@4-MBA/MPY nanoprobe for ratiometric SERS detection of urine pH. 1,4-BDT was confined within the gap between the gold core and shell as an internal standard, while 4-MBA and 4-MPY were co-assembled on the outer gold shell to provide complementary protonation/deprotonation responses. The internal standard-corrected ratio I1004/I1400/I731reduced signal fluctuation and enabled segmented linear fitting over pH = 1.0–7.0 and pH = 7.0–10.0, with coefficients of determination of 0.98806 and 0.99989, respectively. The sensing platform also maintained stable ratiometric responses under different interference conditions. In real urine samples from five volunteers, SERS-predicted pH values agreed well with commercial pH meter measurements, with relative accuracies of 98.71–101.9% and RSD values below 2.1%. This confined internal standard and dual-molecule ratiometric strategy provides a feasible approach for urine pH sensing in complex biofluid matrices.
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ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Boning Su,Xiangjie Zhao,Ziyao Li,Bin Gao,Denglun Cheng,Junyin Li,Zekun Wang,Jiahui Liu,Chenghao Liu,Tianlin Shen,Yuanyuan Yao,Shugang Zhang,Yuechao Yang
Biobased controlled-release fertilizers (CRFs) contribute to sustainable agricultural development. However, their nutrient release often lacks sufficient responsiveness to environmental fluctuations, limiting overall fertilizer use efficiency. This study aimed to develop smart and green CRFs capable of modulating nutrient release in response to soil pH variations. A low-cost dehydrated castor oil (DCO)-based or castor oil (CO)-based alkyd resin (DCOCA/COCA) was used as the foundation for polyurethane (PU) reactions to prepare a DCOCA/COCA-coated CRF (DCOCAPF/COCAPF). Next, a one-step polymerization reaction was performed between HDI and differing amounts of 3-dimethylamino-1,2-propanediol (DMAPD), which contains a tertiary amine group with pH-responsive properties. The resulting products (DMAPDIs) were then subjected to a further polyurethane reaction with COCA to produce pH-responsive CRFs (DMAPDIPFs). The DMAPDIPFs exhibited excellent pH responsiveness with approximately 29% increase in the nitrogen release rate and 7-day reduction in the nitrogen release longevity under acidic conditions compared to that under neutral conditions, requiring only 1% of DMAPDI by total mass of the coating materials. This work provides valuable insights for developing smart CRFs that can autonomously adjust their nutrient release characteristics in response to environmental stimuli to increase the fertilizer utilization rate and thereby promote sustainable agricultural development.
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Physica Status Solidi-Rapid Research Letters
·
2026
·Vol. 20
·期 3
·e202500440
·
IF 2
Nan Zheng,Yuhan Bian,Mengxiao Chen,Xiandi Wang,Meng Wang
Wearable sweat analytics require sensors that are simultaneously chemically selective, mechanically conformal, and highly breathable. Here, we report a flexible electrochemical platform that integrates a polyaniline-modified gold electrode for pH detection with a laser-reduced graphene oxide electrode for uric acid sensing on a thermoplastic polyurethane nanofiber membrane. The porous substrate (59.5 mm/s air permeability; 2716.6 g/m 2 ·24 h water vapor transmission rate) sustains skin comfort while minimizing sweat-induced drift. The device delivers a near-Nernstian pH response (59.98 mV/pH, pH 4–8) and a linear uric acid signal (50–500 µM) with strong anti-interference capability; on-body tests show <6% deviation from a commercial pH meter and stable dual-analyte readouts during 8 h of activity. The device architecture offers an extensible platform for noninvasive, real-time biochemical monitoring in personal health, athletics, and disease prevention.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Han Jia,Zhe Wang,Yihan Huang,Fujun Lu,Debin Hou,Ziwei Wei,Songling Yuan,Qiang Wang,Pan Huang,Long Xu
Recently, the silicon quantum dots (SiQDs) were widely utilized in enhanced oil recovery (EOR) due to their ultrasmall size, high specific surface area and excellent dispersion stability. Herein, the amphiphilic pH responsive silicon quantum dots (AR-SiQDs) were synthesized via the mild method to stabilize smart Pickering emulsion. Both the carboxyl and cinnamyl aldehyde were successfully grafted on the AR-SiQDs surface as hydrophilic and hydrophobic responsive groups, respectively. The structure of AR-SiQDs was characterized by Fourier transform infrared spectrometer and X-ray photoelectron spectroscopy, and the response mechanism was demonstrated via the zeta potential and interfacial tension (IFT) analyses. The results revealed that the diffusion and adsorption behaviors of AR-SiQDs relied on the protonation/deprotonation of carboxyl and reversible dynamic covalent bonding of imines. Specifically, the AR-SiQDs reduced the oil/water IFT from 51.00 mN/m to 7.58 mN/m at pH of 10.09, whereas the IFT only decreased to 24.12 mN/m at pH of 4.26. The AR-SiQDs effectively emulsified oil at alkaline condition, while the demulsification was rapidly achieved in 30 min upon the addition of hydrochloric acid. The emulsion exhibited excellent recyclability to maintain small average droplets size (from 1.42 μm to 2.12 μm) after five emulsification/ demulsification cycles. The core flooding experiments indicated that the AR-SiQDs stabilized emulsion evidently enhanced oil recovery by 14.65% at pH of 10.09, highlighting the remarkable synergistic effect with alkali. The work provided the novel strategy for designing smart SiQDs and recyclable emulsions for EOR.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Nian Xiang,Chuanyang Chen,Yuming Lin,Wang Li,Zuzeng Qin,Yiheng Ruan,Tongming Su,Xuan Luo,Xinling Xie
Stimuli-responsive fertilizers show great potential for precision nutrient delivery but are often limited by single responsiveness and unsynchronized release with plant growth demands. This study developed a novel polysaccharide-based thermo-pH dual stimuli-responsive gating microcapsule (CSMC-g-PNM) via atom transfer radical polymerization (ATRP). N-isopropylacrylamide (NIPAM) and methacrylic acid (MAA) were sequentially grafted into the chitosan microcapsules (CSMC), with thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM) acting as a macromolecular initiator for the subsequent grafting of MAA by reactivating dormant chain ends. Independent chain lengths of PNIPAM and PMAA were achieved by controlling grafting time, endowing the microcapsules with reversible and dual-responsive gating properties. The PNIPAM and PMAA chains acted as dual-responsive gating mechanisms, extending below the low critical solution temperature (LCST) (25 °C) or above pKa (pH 8), closing the gates to slow release. Conversely, when the temperature exceeds 40 °C or is below the pKa (pH 3), the chains contract, opening the gates to accelerate release. CSMC-g-PNM demonstrated sustained urea release (cumulative release 80.79% over 168 h), following First-order kinetics and Korsmeyer-Peppas diffusion-erosion mechanisms. Biodegradation studies affirmed the system’s environmental compatibility, showing a controlled weight loss of up to 19.74% after 35 days in soil. Furthermore, pot experiments demonstrated significant agricultural efficacy, with maize seedlings treated with CSMC-g-PNM-6 in acidic soil achieving a plant height of 44.1 cm, significantly outperforming the 33.1 cm observed with unmodified microcapsules. This work provides a robust and sustainable strategy for designing intelligent nutrient delivery systems, advancing the development of solutions for precision agriculture.
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危险品化学品经营许可证（带存储）