CARBOHYDRATE POLYMERS
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2020
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IF 7.182
Qun Liu,Haihuan Yu,Fanming Zeng,Xiao Li,Jing Sun,Chun Li,Hai Lin,Zhongmin Su
A novel composite HKUST-1/cellulose/chitosan aerogel (HKUST-1/CCSA) as an efficient adsorbent with hierarchical pores was prepared through a facile in situ growth way combining covalent cross-linking, vacuum freeze-drying, and solvothermal methods. By incorporating with cellulose (CE), covalently cross-linked cellulose (CE)/chitosan (CS) composite aerogel exhibits good stability, maintaining fine morphology and structures in acidic solutions under solvothermal conditions. Meantime, a high content of CS is beneficial to enhancing the growth of HKUST-1. Finally, the mass loading ratio of HKUST-1 is as high as 42.54 % in HKUST-1/CCSA. The BET specific surface area of HKUST-1/CCSA reaches 457.75 m 2 g −1 , which is much larger than that of CCSA (9.74 m 2 g −1 ). HKUST-1/CCSA was applied to remove methylene blue with high adsorption capacity (526.3 mg g −1 ) and good recycling capability. This strategy can provide an effective and facile pathway to prepare ultra-stable polysaccharide-based composite aerogel with high specific surface area and hierarchical pores, branching out more applications in pollutant treatment fields.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2020
·
IF 5.065
Xiaoxing Lu,Shaoxia Xie,Jian Kuang,Hujun Xie
A comprehensive experimental investigation on the microstructures of microemulsion constructed with Gemini surfactant has been carried out. The structural transition of the microemulsion system, 14-4-14/1-propanol/ n -heptane/water, from water-in-oil (W/O) to bi-continuous (B.C.) has been characterized by electrical conductivity and cyclic voltammetry . Being a typically percolative system, spherical nanodroplets are observed in the W/O system, while interlinks of water and oil continuous phases are observed in the middle phase, as confirmed by cryo-TEM. Most importantly, the role of water is clearly revealed. Increasing the water content results in size enhancement as well as improvement of micropolarity and diffusion behavior. Results of DSC measurements suggest that free water dominates only at high total water content. The unfrozen water which is not detected by DSC takes a considerable amount in the W/O system at low total water content, while the interphasal water reaches over 50% of total water in the middle phase system.
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高影响因子
ENERGY
·
2020
·
IF 6.082
Kun Fu,Chenxu Liu,Lemeng Wang,Xiayu Huang,Dong Fu
In this work, novel non-aqueous absorbents composed of 2-ethylhexan-1-amine (EHA) and glyme were proposed for CO 2 capture. The absorption performance of CO 2 in EHA + diglyme, EHA + triglyme and EHA + tetraglyme non-aqueous solutions was investigated and the viscosities ( η ) of the CO 2 -saturated absorbents were measured. Besides the experiments, kinetic models were applied to correlate the CO 2 absorption. The activation energy ( E a ) was obtained from Arrhenius equation , and the absorption mechanism was deduced. The results showed that both Lagergren model and Avrami model can accurately correlate and predict the time-dependent absorption amount, thus an optimized composition under which excellent absorption performance and relatively low η and E a can be simultaneously achieved was determined. Compared to water-based absorbents like MEA, the optimized non-aqueous absorbents take the advantages of better absorption performance and lower activation energy. Moreover, the glyme solvents have about 50% lower specific heat capacities and much higher boiling points (≥435 K) than water, which is expected to greatly reduce the sensible heat and the latent heat of the solvent during regeneration. Therefore, the proposed novel absorbents have promising industrial application potential in the CO 2 capture process.
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BRAIN BEHAVIOR AND IMMUNITY
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2021
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IF 7.217
Yun Wang,Ce Gao,Tianyu Gao,Lu Zhao,Shiguang Zhu,Lin Guo
A growing body of studies indicated that exosomes are one of vital players in pathological process of neuropsychiatric diseases, but their role in major depressive disorder (MDD) remains poorly understood. Here we purified plasma exosomes from depression including lipopolysaccharide (LPS)-challenged depression, chronic restraint stress (CRS)-induced depression, MDD subjects, and from control mice or volunteers. The therapeutic effect of these exogenous exosomes was assessed utilizing behavioral tests and biochemical approaches in the LPS-caused depression or microglial BV2 cells. The expression of exosomal sigma-1 receptor (Sig-1R) was evaluated by western blotting. The role of Sig-1R in the biological function of exosomes was determined using Sig-1R knockout mice and HEK 293 cells. Our results revealed that injection of exosomes from depression models or patients rather than normal controls significantly ameliorated depressive-like behaviors, deficiency of BDNF expression and neuro-inflammation in LPS-challenged mice. In addition, co-culture with exosomes from depression models or patients instead of from controls prevented LPS-induced inflammation responses in microglial BV2 cells. Moreover, Sig-1R was demonstrated for the first time to significantly be enriched in exosomes from depression models or patients compared with that from normal controls. However, Sig-1R null exosomes no longer emerged antidepressant-like action in LPS-challenged mice. Thus, we demonstrated that plasma exosomes from depression exerted antidepressant-like effects in a Sig-1R dependent manner in the LPS-induced depression. This work improves our understanding of the exosomes in depression, suggesting a novel exosomes-based approach for MDD treatment.
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高影响因子
Journal of CO2 Utilization
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2020
·
IF 5.993
Haihong Zhao,Ning Zhao,Qin Wang,Feng Li,Feng Wang,Subing Fan,Ekaterina V. Matus,Zinfer R. Ismagilov,Lei Li,Fukui Xiao
In this work, a series of HK/MCFs-x sorbents consisting of metal organic framework (HKUST-1) and mesocellular foams (MCFs) were prepared using solvothermal method. The samples were characterized by various techniques including XRD, N 2 adsorption/desorption, TG, SEM, FT-IR, and water vapor adsorption, respectively. The CO 2 adsorption isotherms and adsorption kinetic curves at different temperatures were obtained. Results showed that the Langmuir-Freundlich model and pseudo-first-order equation could be used to describe the CO 2 adsorption isotherms and kinetic curves, thus proving the exothermic, multilayer, physical adsorption processes. The isosteric heats of adsorption of the pure HKUST-1 and HK/MCFs-1 were in the range of 19–26 KJ/mol. The mass-transfer coefficient increased along with the temperature. The adsorption activation energies of the pure HKUST-1 and HK/MCFs-1 were 4.150 and 4.203 KJ/mol, respectively. Compared with the pure HKUST-1, HK/MCFs-1 had a substantially equivalent amount of CO 2 adsorption capacity under the same conditions, while the water resistance was improved. The CO 2 mass-transfer rate was higher than the pure HKUST-1. Meanwhile, HK/MCFs-1 also showed better recyclability.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2020
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IF 7.864
Xiaodan Ma,Bin Liang,Mengyuan Qi,Hui Yun,Ke Shi,Zhiling Li,Yuanqiang Guo,Peisheng Yan,Shuang-Jiang Liu,Aijie Wang
The chlorinated nitroaromatic antibiotic chloramphenicol (CAP) is a refractory contaminant that is widely present in various environments. However, few CAP-mineralizing bacteria have been documented, and a complete CAP catabolism pathway has yet to be identified. In this study, the bacterial strain Sphingobium sp. CAP-1 was isolated from an activated sludge sample and was shown to be capable of aerobically subsisting on CAP as the sole carbon, nitrogen, and energy source while simultaneously and efficiently degrading CAP. p-Nitrobenzoic acid (PNBA), p-nitrobenzaldehyde (PNBD), protocatechuate (PCA), and the novel side chain C3-hydroxy-oxygenated product of CAP (O-CAP) were identified during CAP degradation. Strain CAP-1 was able to convert O-CAP to intermediate product PNBA. The putative functional genes associated with PNBA catabolism into the tricarboxylic acid cycle via PCA and floc formation were also identified by genome sequencing and comparative proteome analysis. A complete pathway for CAP catabolism was proposed. The discovery of a novel CAP oxidation/detoxification process and a complete pathway for CAP catabolism enriches the fundamental understanding of the bacterial catabolism of antibiotics, providing new insights into the microbial-mediated fate, transformation, and resistance risk of CAP in the environment. The molecular basis of CAP catabolism and floc formation in strain CAP-1 also offers theoretical guidance for the enhanced bioremediation of CAP-containing environments.
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高影响因子
MOLECULES
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2020
·Vol. 25
·期 5
·1022
·
IF 3.267
Yue Zhang,Yifang Xie,Leifang Zhang,Hang Zhao
Smoke inhalation causes acute lung injury (ALI), a severe clinical disease with high mortality. Accumulating evidence indicates that microRNA-155 (miR-155) and suppressor of cytokine signaling 1 (SOCS-1), as mediators of inflammatory response, are involved in the pathogenesis of ALI. In this paper, we explored the proinflammatory mechanism of miR-155 in smoke-inhalation-induced ALI. Our data revealed that smoke inhalation induces miR-155 expression, and miR-155 knockout (KO) significantly ameliorates smoke-inhalation-induced lung injury in mice. Neutrophil infiltration and myeloperoxidase (MPO), macrophage inflammatory protein 2 (MIP-2) and keratinocyte chemoattractant (KC) expressions were decreased in miR-155–/–mice after smoke inhalation as well. Real-time RT-PCR and immunoblotting results showed that SOCS-1 level was remarkably increased in miR-155–/–mice after smoke exposure. Furthermore, the experiments performed in isolated miR-155 KO pulmonary neutrophils demonstrated that the lack of SOCS-1 enhanced inflammatory cytokines (MIP-2 and KC) secretion in response to smoke stimulation. In conclusion, smoke induces increased expression of miR-155, and miR-155 is involved in inflammatory response to smoke-inhalation-induced lung injury by inhibiting the expression of SOCS-1.Keywords:acute lung injury;neutrophils;microRNA-155;suppressor of cytokine signaling-1
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CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Xue Zhang,Guoshuai Li,Feng Mao,Dongdong Han,Chengbin Jing,Ye Chen,Pingxiong Yang,Junhao Chu,Fangyu Yue
Doping- and temperature-induced phase transitions and optical/electric-properties for (1- x )KNbO 3 - x (Ba 0.5 Bi 0.5 )(Nb 0.5 Zn 0.5 )O 3 ceramics are studied. With the increase of x -value, a series of structural phase transitions from orthorhombic to tetragonal and to cubic is observed, and the phase transition temperatures are also improved for forming a stable phase. The deteriorated ferroelectric property , which also suggests the doping-induced phase transition due to the enhancement of the crystal symmetry , can be tentatively interpreted from the optical evolution with doping. This doping can introduce or enhance the bandedge- or in-gap states but without influence upon the optical bandgap of KNbO 3 . These results help in understanding the control of the structure, optical and electrical properties in KNbO 3 -based ferroelectric oxides.
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NEUROPHARMACOLOGY
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2020
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IF 4.431
Kaiyang Ma,Xiao Ding,Qiqi Song,Zhitao Han,Hang Yao,Jianhua Ding,Gang Hu
In recent years, with the discovery and research of lactate-specific receptor HCAR1(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in astrocytes, but also as a signaling molecule which has gradually received attention. Studies have found that lactate can be used as an intercellular signaling molecule involved in synaptic plasticity , and so that peripheral administration of lactate can produce antidepressant effects. Here, we focus on HCAR1 on the most widely distributed astrocytes in the brain, found and verified that lactate could cause Arc/arg3.1 protein overexpression in astrocytes through HCAR1. However, the expression of Arc/arg3.1 does not depend on the Gi protein pathway of HCAR1, and we found that lactate enhanced the expression of Arc/arg3.1 protein through the HCAR1-β-arrestin2 pathway. In summary, lactate acts on HCAR1 of astrocytes. It enhances the expression of MAPK-dependent Arc through β-arrestin2, thereby reducing the influx of calcium ions when astrocytes are exposed to glutamate damage, achieving the role of protecting astrocytes and indirectly enhancing the absorption of glutamate by astrocytes. These results also demonstrate that HCAR1 in the brain is a potential therapeutic target in an experimental in vitro model of glutamate damage, which is strongly associated with many neurodegenerative diseases .
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2020
·Vol. 412
·期 17
·4155-4163
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IF 3.637
Li Jinge,Zhao Liying,Wen Dongxiao,Li Xiaofei,Yang Huaixia,Wang Dazhong,Kong Jinming
In this work, a new method of CYFRA21-1 DNA (tDNA) detection based on electrochemically mediated atom transfer radical polymerization (e-ATRP) and surface-initiated reversible addition-fragmentation chain transfer polymerization (SI-RAFT) cascade polymerization and AgNP deposition is proposed. Firstly, the peptide nucleic acid (PNA) probe is captured on a gold electrode by Au-S bonds for specific recognition of tDNA. After hybridization, PNA/DNA strands provide high-density phosphate groups for the subsequent ATRP initiator by the identified carboxylate-Zr 4+ -phosphate chemistry. Then, a large number of monomers are successfully grafted from the DNA through the e-ATRP reaction. After that, the chain transfer agent of SI-RAFT and methacrylic acid (MAA) are connected by recognized carboxylate-Zr 4+ -carboxylate chemistry. Subsequently, through SI-RAFT, the resulting polymer introduces numerous aldehyde groups, which could deposit many AgNPs on tDNA through silver mirror reaction, causing significant amplification of the electrochemical signal. Under optimal conditions, this designed method exhibits a low detection limit of 0.487 aM. Moreover, the method enables us to detect DNA at the level of PCR-like and shows high selectivity and strong anti-interference ability in the presence of serum. It suggests that this new sensing signal amplification technology exhibits excellent potential of application in the early diagnosis of non-small cell lung cancer (NSCLC).
Electrochemical detection principle for CYFRA21-1 DNA based on e-ATRP and SI-RAFT signal amplification technology.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2020
·
IF 7.864
Tongxu Liu,Xiaobo Luo,Yundang Wu,John R. Reinfelder,Xiu Yuan,Xiaomin Li,Dandan Chen,Fangbai Li
How metal-reducing bacteria transfer electrons during dissimilatory energy generation under electron acceptor-limited conditions is poorly understood. Here, we incubated the iron and manganese-reducing bacterium Shewanella oneidensis MR-1 without electron acceptors. Removal of soluble extracellular organic compounds (EOCs) dramatically retarded transfer of electrons to an experimental electron acceptor, Cr(VI), by MR-1. However, the return of either high MW (>3000 Da) or low MW (<3000 Da) soluble EOCs produced by MR-1 to washed cells restored Cr(VI) reduction though Cr(VI) reduction was fastest when both size fractions were added together. Spectral and electrochemical characterization of EOCs indicated the presence of flavins and c-type cytochromes (c-Cyts). A model of the kinetics of individual elementary reactions between cells, flavins, released c-Cyts, and Cr(VI), including the direct reduction of flavins, released c-Cyts, and Cr(VI) by cells and the indirect reduction of Cr(VI) by reduced forms of flavins and released c-Cyts, was developed. Model results suggest that released c-Cyts could act as electron mediators to accelerate electron transfer from cells to Cr(VI), and the relative contribution of this pathway was higher than that mediated by flavins. Hence, extracellular c-Cyts produced by MR-1 likely play a role in extracellular electron transfer under electron acceptor-limited conditions. These findings provide new insights into extracellular electron shuttling and the metabolic strategy of metal-reducing bacteria under electron acceptor-limited conditions.
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CHEMOSPHERE
·
2019
·
IF 5.108
Yulin Yang,Ying Liu,Xian Fang,Wei Miao,Xiaoyan Chen,Jing Sun,Bing-Jie Ni,Shun Mao
Transition metal and nanocarbon-based composites with high activity and stability draw great attention in electro-Fenton system for organic pollutants removal . In this study, HKUST-1-derived Cu@C nanoparticles embedded within three-dimensional reduced graphene oxide (rGO) network (denoted as 3DG/Cu@C) is synthesized through a simple strategy. The prepared catalyst shows ordered 3D porous carbon structure and Cu@C NPs are uniformly dispersed in the matrix. The 3DG/Cu@C is used as heterogeneous electro-Fenton (hetero-EF) catalyst and shows outstanding performance in various persistent organic pollutants removal. High concentration Rhodamine B (RhB) (40 mg L −1 ) can achieve a complete decolorization within 150 min with 25 mg L −1 3DG/Cu@C catalyst, which is one of the lowest catalyst dosages in hetero-EF for RhB removal. More importantly, the 3DG/Cu@C achieves high RhB mineralization efficiency of 81.5% and exhibits high catalytic performance in a wide pH window from 3 to 9. The 3DG/Cu@C also remains high efficiency after five successive reaction cycles. The working mechanism study shows that RhB is mainly oxidized by • OH and O 2 •- radicals through hetero-EF and anodic oxidation processes. The high stability and outstanding performance of 3DG/Cu@C provide new insights in organic pollutants removal by hetero-EF process with transition metal and nanocarbon-based catalysts.
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危险品化学品经营许可证（带存储）