CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Lirui Cong,Zhiyuan Ding,Tian Lan,Minjie Guo,Fangyou Yan,Jin Zhao
The present study reports the development of an electrochemical sensor based on sulfobutylether- β -cyclodextrin modified reduced graphene oxide hybrid (SBCD-rGO) for simultaneous detection of nitrophenol isomers. First, SBCD-rGO hybrid was synthesized and detailed characterized. Afterwards, a sensor was fabricated via the modification of glassy carbon electrode (GCE) with SBCD-rGO, and its electrochemical detection performances were also investigated. Then, the constructed electrochemical sensor was applied to detect nitrophenol isomers by voltammetry analysis. The results suggested that the sensitivities were 389.26, 280.88 and 217.19 μA/mM for p -nitrophenol ( p -NP), m -nitrophenol ( m -NP), and o -nitrophenol ( o -NP), respectively, and their corresponding detection limits were all about 0.05 μM. Significantly, the combination of voltammetry analysis with the constructed sensor and data analysis by multiple linear regression realized the simultaneous detection of nitrophenol isomers.
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INORGANIC CHEMISTRY
·
2024
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IF 4.3
Xueting Zhang,Cecile Genevois,Cheng Li,Xiaoyan Yang,Michael J. Pitcher,Mathieu Allix,Xiaojun Kuang,Alberto J. Fernández-Carrión
La2Mo2O9 is acknowledged as an exceptional oxide ion conductor. It undergoes a reversible phase transition around 580 °C from the nonconductive low-temperature monoclinic α-La2Mo2O9 phase to the highly conductive high-temperature cubic β-La2Mo2O9 phase. In addition, La2Mo2O9 demonstrates complex chemistry under reducing conditions. This study reports, for the first time, the stabilization at ambient temperature of a novel cubic phase through a topotactic reduction of α-La2Mo2O9 employing CaH2. This phase contains approximately ∼3 atom % oxygen vacancies relative to the nominal composition (La2Mo2O8.68(1)). The cubic symmetry is associated with a static distribution of these vacancies, in contrast to the dynamic distribution observed in the high-temperature cubic β-La2Mo2O9 phase reported previously. Additionally, the material exhibits mixed-ion-electronic conduction, which expands its potential use in applications requiring both ionic and electronic transport.
研究领域:
材料科学
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固体化学
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离子学
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功能材料
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电陶瓷
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Mingxiao Feng,Zhenjie Chen,Qian Yu,Chunyan Yan,Dawei Zhang
Pinellia ternata (Thunb.) Breit. has been used in China for more than two thousand years to treat cough and vomiting. P. ternata is rich in polysaccharides; however, current research on the bioactivity of polysaccharides from P. ternata is relatively limited. In particular, there are no reports on their application in the treatment of osteoporosis. In this study, two β -glucan-like polysaccharides were isolated from P. ternata . The primary structures of PTTP50–1-3 and PTTP50–1-4 were comprehensively analyzed using high performance liquid chromatography, gas chromatography–mass spectrometry, and nuclear magnetic resonance. The results indicated that they possess a similar backbone structure. Notably, compared with PTTP50–1-3, PTTP50–1-4 exhibits characteristics of a higher degree of branching, a higher β -glucan content, and a lower molecular weight. In vitro experiments demonstrated that both PTTP50–1-3 and PTTP50–1-4 could increase the alkaline phosphatase activity of MC3T3-E1 cells. In addition, PTTP50–1-4 was able to enhance the mineralization of MC3T3-E1 cells by upregulating the expression of Runx2 , Osx , Bmp2 , Ocn , Opn , and Bsp mRNA. These findings suggest that P. ternata polysaccharides with a β -glucan-like structure may possess strong anti-osteoporotic potential, which provides a theoretical foundation for further research and development of P. ternata polysaccharides in the prevention and treatment of osteoporosis.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Shanglin Li,Shuaiyan Liu,Yiding Yu,Xinyi Huang,Meng Yang,Longjiang Tian,Ting Zhang,Jingbo Liu,Yajuan Li,Zhiyang Du
Developing oral nanoparticles (NPs) that combine anti-inflammatory effects with gut microbiome modulation enables an effective strategy for integrated ulcerative colitis (UC) therapy. Yet, the complex and dynamically evolving nature of the gastrointestinal milieu presents formidable challenges to the consistency and specificity of NP interventions. To address this challenge, this study designed and developed gastrointestinal microenvironment-adaptive NP via self-assembly, utilizing curcumin (Cur) for anti-inflammatory effects and anthocyanin (Cy) for microbiome regulation to achieve dual functional therapeutic outcomes. Employing the esterification strategy, hydroxypropyl-β-cyclodextrin (HPCD) was modified using citric acid (CA) and sulfonic acid (SA) to synthesize CACD (CA-modified HPCD) and SACD (SA-modified HPCD), respectively, which self-assembled in the presence of quaternary ammonium chitosan (HTCC), Cur, and Cy to yield NPs. NPs demonstrated high Cur encapsulation efficiency (EE) and encapsulation capacity (EC) across pH 2.0–7.0, highlighting their high gastrointestinal adaptability. In vivo experiments showed clear amelioration of colitis symptoms, including downregulation of pro-inflammatory cytokines and attenuation of tissue damage. HTCC-Cy-CACD-Cur NPs enriched Eubacterium siraeum_group and Prevotellaceae , HTCC-Cy-SACD-Cur NPs favored Peptococcus expansion , potentially contributing to improved immune regulation and attenuation of UC. These bifunctional NPs offer innovative UC therapy and precision nutrition interventions.
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ADVANCED FUNCTIONAL MATERIALS
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2026
·
IF 19
Xiuyun Xu,Zhaofan Yang,Hao Sun,Xinyi Dong,Zeying Wang,Yang Li,Ziting Liu,Shixian Lv,Hao Liu,Yongsheng Zhou
Current treatments for osteoporosis and osteoporotic fractures, such as bisphosphonates and teriparatide, are limited by poor bone-targeting and systemic toxicity. To address these issues, we developed a bone-targeted nanodelivery platform (FPBE) by encapsulating β-glycerophosphate (β-GP) in a fluorinated polyethylenimine carrier. The platform was further functionalized with the E7 peptides to enhance the affinity for mesenchymal stem cells (MSCs) and improve bone marrow targeting. Biocompatibility and delivery efficiency were optimized by the degree of screening fluorination. Single-cell RNA sequencing revealed that FPBE upregulates Wnt/β-catenin, driving MSC osteogenic and chondrogenic differentiation to support regenerative processes. In postmenopausal mice, systemic FPBE increased bone mineral density (BMD), matching zoledronic acid levels with fewer side effects. In non-human primates, FPBE increased BMD by 83.07% (males) and 55.92% (females), with serum analyses confirming its efficacy and safety. This nanoplatform—which delivers β-GP to restore phosphate balance—provides a cost-effective therapy for osteoporosis and osteoporotic fracture repair, with strong potential for clinical application.
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FOOD CHEMISTRY
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2026
·
IF 9.8
Chun Li,Chang Liu,Xiu-Bin Liu,Jun-Hu Cheng,Rana Muhammad Aadil,Zhi-Wei Liu
The effects of cold plasma (CP) treatment on the formation of β-lactoglobulin (β-LG) amyloid fibrils (AFs) and its impact on the antigenicity and emulsifying properties of β-LG, were investigated. Results indicated that moderate CP treatment significantly accelerated AFs formation, and remodeled the fibril structure of β-LG, as evidenced by Thioflavin T (ThT) fluorescence and atomic force microscopy. Short, worm-like β-LG fibrils with an average length of 160.10 ± 50.42 nm were formed in CP-3 after 16 h of fibrillation time, whereas long, rigid, straight fibrils with an average length of 1344.00 ± 1075.67 nm were generated in AT (AFs prepared by conventional acidic heat treatment). Further antigenicity analysis revealed an 80.25 ± 1.67% reduction in antigenicity of β-LG was obtained in CP-3 after 16 h of fibrillation time, compared with a 62.95 ± 0.21% reduction in AT, as confirmed by Western blotting and enzyme-linked immunosorbent assay (ELISA). Additionally, CP-induced AFs exhibited improved emulsifying properties comparable to those produced by acidic heating, despite differences in fibril morphology and viscosity.
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Food & Function
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2026
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IF 5.4
Wei Liao,Ronghai Hu,Huan Liu,Jielun Hu
Probiotics have shown considerable health benefits, especially concerning gastrointestinal health, however, environmental stress during production and transit through the gastrointestinal digestive system will adversely impact their viability. This study aimed to explore the protective effects of co-encapsulating highland barley β-glucan (HBBG) with probiotics on cell bioavailability during gastrointestinal digestion. The incorporation of HBBG (0.5% w/w) significantly improved probiotic viability and enhanced microcapsule morphology during spray drying. Both in vivo and in vitro gastrointestinal digestion assays demonstrated superior probiotic survival rates (>8.5 Log CFU/g) within HBBG-containing microcapsule samples. Furthermore, the production of short-chain fatty acids, particularly acetic acid reached 9.22 mM) and the growth of beneficial gut microbiota (e.g., Lactobacillus and Bifidobacterium) were both enhanced significantly. The findings highlighted the prominent prebiotic potential of HBBG and its synergistic role in improving probiotic stability and functionality during gastrointestinal digestion.
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CHEMICAL ENGINEERING JOURNAL
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2012
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IF 3.461
Kungang Chai,Hongbing Ji
Removal of benzoic acid from industrial wastewater is important for the water treatment, and adsorption is an efficient treatment process. Chitosan and β-cyclodextrin (β-CD) are well investigated as feedstock for preparing polysaccharide-based toxic compounds removing adsorbents. In this study, chitosan grafted β-CD (CGC) was synthesized using glutaraldehyde as cross-linker in acidic aqueous solution. The successful grafting of β-CD onto chitosan was confirmed by FTIR and XRD. Compared with β-CD-epichlorohydrin copolymer (CDP) and cross-linked chitosan resin (CCR), CGC showed an excellent ability to adsorb benzoic acid. The CGC adsorption kinetics toward benzoic acid at 298.15 K, and isotherms at varying temperatures were studied systematically. Kinetics of the adsorption process agreed well with the pseudo-second-order kinetic model, and the experimental data of equilibrium isotherms fitted well with Langmuir model ( R 2 > 0.99). Furthermore, thermodynamic parameters revealed the spontaneity and exothermic nature of the adsorption process. The adsorption–desorption of benzoic acid by CGC and other two commercial adsorbents were evaluated and compared in five cycles, demonstrating high regeneration efficiency of CGC. The reversibility of benzoic acid adsorption by CGC was further proved by column recycle test. Finally, the adsorption mechanism was proposed according to the inclusion behavior of β-CD toward benzoic acid as well as the electrostatic interaction between chitosan units and benzoic acid.
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CARBOHYDRATE POLYMERS
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2026
·
IF 13.2
Wenhui Nian,Miao Zhao,Alejandra Moenne,Tang Li,Heng Yin
Agarose, a hydrophilic polysaccharide derived from red algae, is widely used in biochemical and agricultural applications, but its intrinsic gelation below ~40 °C limits enzymatic conversion into high-value neoagarooligosaccharides (NAOS). Here, we report the systematic characterization of a novel thermophilic β-agarase, Sa AgaD, identified from Salegentibacter agarivorans . Sa AgaD is a 398-residue GH16 enzyme that expresses solubly in Escherichia coli and exhibits a high catalytic efficiency ( k cat / K m = 1.76 × 10 4 mM −1 s −1 ) toward agarose. Distinct from many characterized agarases, Sa AgaD displays optimal activity at pH 8.0 and 55 °C, retains ~90% activity at 65 °C, and remains stable under neutral to mildly alkaline conditions, enabling effective hydrolysis above the agarose gelation point. The enzyme preferentially degrades agar and crude Gracilaria agar, with minimal activity on sulfated porphyran. Product profiling by HPAEC-PAD and ESI-MS demonstrates an endolytic mechanism yielding predominantly neoagarotetraose (NA4) and neoagarohexaose (NA6), with a scale-up NAOS yield of ~75%. Molecular dynamics simulations of Sa AgaD and its NA8 complex reveal a stable substrate binding mode and highlight flexible loop regions that coordinate substrate recognition. The combination of high thermal tolerance, catalytic efficiency, and product specificity positions Sa AgaD as a promising biocatalyst for industrial NAOS production from marine biomass.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 10
·587
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IF 3.5
Xie Yufu,Shan Dexin,Zhang Xinyue,Li Jun,Ning Jingyuan,Yi Guangli,Chen Huimin,Xiang Tingfen
Chlorpyrifos (CPF), a persistent organophosphorus insecticide, threatens soil health and food safety. Most studies focus on CPF adsorption in aqueous systems, while soil applications face challenges such as low adsorption efficiency, poor stability, and difficult recovery of adsorbents. To address these limitations, we synthesized low-cost β-cyclodextrin-magnetic sodium alginate composite-modified biochar (β-CD@MSA-BC) and compared its performance with crude BC (OBC) and β-CD-modified BC (β-CD-BC) for CPF adsorption in soil. The composite demonstrated enhanced thermal stability and a high BET surface area (77.45 m 2 /g) with a tailored pore structure. β-CD@MSA-BC achieved a CPF adsorption rate of 95.10% and a maximum adsorption capacity of 31.71 mg/g, significantly outperforming OBC (59.71%, 20.84 mg/g) and β-CD-BC (80.64%, 28.82 mg/g). Key mechanisms included hydrophobic inclusion, hydrogen bonding, π-π interactions, and Fe 3 ⁺ coordination. The material also demonstrated excellent pH adaptability, efficient magnetic recovery (> 90%), and maintained > 80% adsorption after three regeneration cycles. This work provides an efficient, recoverable, and soil-compatible adsorbent for sustainable remediation of CPF-contaminated soils.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Qingfei He,Lingjun Cheng,Yuanyuan Yang,Zhiyan Zou,Canping Su,Xuan Shi,Jiaming Chen,Weirong Huang,Zhenyu Lin,Guolin Hong
Gold nanoclusters (AuNCs) are emerging electrochemiluminescence (ECL) emitters with unique luminescence and high stability. However, conventional AuNC-based ECL systems, which rely on single-signal regulation, often exhibit weak signal responses and limited stability. To address the challenge of detecting extremely low concentrations of the Alzheimer’s disease (AD) blood biomarker Aβ40, this study presents a novel ECL-based biosensing platform that leverages dual-signal regulation of AuNCs via glutathione (GSH) and H2O2 serving as ECL quenchers. Based on the peroxidase-like activity of the Aβ40–hemin complex, this system restores the ECL signal by catalyzing the consumption reaction between GSH and H2O2. Using this mechanism, a dual-regulation ECL platform was developed, demonstrating a linear detection range of 0.001–100 ng/mL for Aβ40 with a detection limit of 0.18 pg/mL (S/N = 3). This approach not only offers high sensitivity and specificity but also reduces the complexity of surface modification steps. Overall, this study advances ECL technology through dual regulation and provides a sensitive, practical, efficient, and reliable analytical method for early AD screening.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2026
·
IF 3.1
Pan Jianzhen,Liu Xinting,Yang Minghui
By in situ reduction of Pt nanoparticles (Pt NPs) onto the surface of multi-walled carbon nanotubes (MWCNTs), Pt NPs@MWCNTs nanocomposite was successfully synthesized. Experimental results indicate the nanocomposite exhibits good NADH oxidase activity, which can generate •O 2− through O 2 and efficiently catalyze the oxidation of nicotinamide adenine dinucleotide (NADH) to generate biologically active NAD + . Based on this characteristic, we developed an NAD + /NADH dependent dehydrogenase electrochemical cascade biosensor for the detection of β-hydroxybutyric acid (HB) via β-hydroxybutyrate dehydrogenase that does not require additional redox mediators. This biosensor exhibited good performance for HB with high sensitivity and good specificity, and a wide linear range of 10 µM to 10 mM. To verify its practical application, the biosensor was applied to the detection of HB in human serum samples, which indicate the biosensor has potential for clinical diagnosis of diabetes ketoacidosis.
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