MACROMOLECULES
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2025
·
IF 5.2
Ruru Wan,Bo Li,Jun Xu,Huihui Li,Shouke Yan
Thin-film crystallization of polymers is governed by diffusion processes, often resulting in branching morphologies. According to the theory of branching instability, the characteristic length scale of branch patterns is determined by the diffusion constant (D) and growth velocity (v). In this study, poly(vinylidene fluoride) (PVDF) was blended with several aliphatic polyesters and an aliphatic-aromatic copolyester. The resultant crystalline patterns of γ-PVDF crystals in the blend ultrathin films varied systematically with the polyester content (φp). By analyzing the branch width (λ) and v of γ-PVDF crystals, we established the relationship between φp and D in the depletion zone. Our findings reveal that polyesters stabilize the crystal growth front, with D exhibiting an exponential dependence on φp. Moreover, fitting-parameter K at φp = 1.0, serving as a relative indicator of the diffusion ability across pure polyesters, exhibits a clear inverse correlation with the polyester molecular weight. It is further found that at low polyester concentrations (φp ≤ 50%), the depletion zone ahead of the PVDF crystal growth front contains both mass and concentration gradients, enhancing PVDF chain mobility. However, at higher concentrations (φp > 50%), excessive polyester migration to the PVDF crystal growth front leads to a pure concentration gradient in the depletion zone.
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PROGRESS IN ORGANIC COATINGS
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2025
·
IF 7.3
Yanhe Wu,Yushuai Cheng,Zhengke Wang
To address the toxicity, weight, and environmental limitations of lead-based radiation shields, this research develops a lightweight water-based radiation attenuation coating via facile integration of core-shell structured Gd@Si and Bi@Si fillers into a waterborne polyurethane/polyvinyl alcohol matrix. The tetraethyl orthosilicate-modified core-shell design enables uniform dispersion of high atomic number fillers (up to 70 wt%) while enhancing interfacial photon scattering. At 1.5 mm thickness, this coating achieves 99.1 % X-ray attenuation efficiency at 31 keV, which is comparable to 0.25 mm lead, and a γ-ray mass attenuation coefficient of 0.1408 cm 2 /g at 662 keV, exceeding lead by 44 %. Simultaneously, the composite maintains robust mechanical properties (683.9 % elongation at 50 wt% loading) and thermal stability (264.9 °C onset decomposition temperature). With a density 78 % lower than lead, inherent hydrophobicity (97.5° contact angle), and adhesion to diverse substrates, this sprayable coating offers a scalable, eco-friendly solution for radiation protection in medical, nuclear, and aerospace applications.
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RENEWABLE ENERGY
·
2025
·
IF 9.1
Yingfu Tian,Tianliang Lu,Hongjin Qu,Xiaomei Yang,Lipeng Zhou
Efficient conversion of ethyl levulinate (EL) in high concentration to γ-valerolactone (GVL) at moderate temperature via catalytic transfer hydrogenation strategy is highly desirable. In this work, hydrothermally synthesized Sn-β zeolite with high Sn content was employed as a catalyst to realize this aim. Fully crystallized Sn-β zeolite with high Sn content ( n Si / n Sn = 60) was successfully synthesized within 12 days using MgCl 2 as a promoter. The synthesized zeolites were characterized by XRD, SEM, UV-vis spectroscopy, FT-IR spectroscopy and XPS. The L acid density of Mg-Sn-β-60-12d increased to 90 μmol g −1 compared to Mg-Sn-β-100-7d (56 μmol g −1 ). 92% yield of GVL was achieved on Mg-Sn-β-60-12d using high concentration of EL (1.2 mol L –1 ) as reactant at 130 o C for 8 h. The performance of Mg-Sn-β is better than that of Sn-β with same n Si / n Sn . The reaction mechanism over Mg-Sn-β was discussed. In addition, Mg-Sn-β-60-12d showed excellent stability and reusability during five runs.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2018
·Vol. 43
·期 16
·7973-7981
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IF 4.229
Shaowei Yang,Hui Xie,Hongwei Zhu,Lijuan Zhang,Yunshan Zhou,Huixian Zhang,Zipeng Zhao
In this work, metal-organic framework compound CPL-1 of a formula {[Cu 2 (pzdc) 2 (pyz)]⋅2H 2 O} n (pzdc = pyrazine-2,3-dicarboxylate, pyz = pyrazine) possessing kinetic quantum sieving effect on H 2 /D 2 separation was selected to prepare two new chromatography stationary phase materials CPL-1@γ-Al 2 O 3 and MnCl 2 @CPL-1@γ-Al 2 O 3 by loading CPL-1 on γ-Al 2 O 3 particles with size 80–100 mesh through repeating in situ crystallization process , and afterwards by loading MnCl 2 on CPL-1@γ-Al 2 O 3 via impregnation approach. The two optimized materials were thoroughly characterized by IR, XRD , SEM, EDS and TG/DTA method. The experimental results showed that, under liquid nitrogen temperature by using just 1-m chromatographic column and cheap He gas as carrier gas, the MnCl 2 @CPL-1@γ-Al 2 O 3 can solve the problem of long separation time and trailing phenomenon existing in the CPL-1@γ-Al 2 O 3 column, can realize highly effective hydrogen isotope H 2 /D 2 separation with good separation resolution (R = 1.62) and approximate Gauss distribution of chromatographic peak, can be used for both qualitative and quantitative analysis of hydrogen isotope H 2 /D 2 with short separation time of 6.5 min.
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JOURNAL OF SEPARATION SCIENCE
·
2013
·Vol. 36
·期 20
·3330-3337
·
IF 2.591
Wanjun Li,Xiao Zhou,Juanjuan Ye,Qiong Jia
Monolithic materials were synthesized in capillaries by in situ polymerization with N -isopropylacrylamide, glycidyl methacrylate, and ethylene dimethacrylate as the monomers, and methanol and PEG as the porogens. With γ -alumina nanoparticles attached to the surface of the porous monolithic column via epoxide groups, a novel polymer monolith microextraction (PMME) material was prepared with a good mechanical stability and a high extraction capacity. SEM and X-ray photoelectron spectroscopy were employed to characterize the modified monolithic column, demonstrating that γ -alumina nanoparticles were effectively functionalized onto the monolithic column. In addition, a new method was developed for the analysis of Sudan I–IV dyes using PMME coupled with HPLC. In order to obtain the optimum extraction efficiency, the PMME conditions including desorption solvent type, sample pH, sample volume, sample flow rate, and eluent flow rate were investigated. Under the optimum conditions, we obtained acceptable linearities, low LODs, and good intra- and interday RDSs. When applied to the determination of Sudan I–IV dyes in red wine samples, satisfactory recoveries were obtained in the range of 84.0–115.9%.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 4.7
Zhenshuai Zhang,Li Jiang,Lu Chen,Xinyan Cai,Yuteng Wang,Wenqian Xue,Kaijian Lei,Tianxiao Wang
Colorectal cancer (CRC) remains one of the most prevalent malignancies globally, with limited therapeutic options for advanced-stage patients due to acquired drug resistance and systemic toxicity. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target for CRC, while cystathionine γ-lyase (CSE)—a key enzyme in hydrogen sulfide (H 2 S) biosynthesis—plays a critical role in maintaining redox homeostasis and suppressing ferroptosis in cancer cells. Here, we synthesized a novel small-molecule compound, DPhA-EtOBz-TSC, and systematically evaluated its anti-CRC efficacy and underlying molecular mechanism. The chemical structure of DPhA-EtOBz-TSC was confirmed by 1 H nuclear magnetic resonance ( 1 H NMR), 13 C NMR, and high-resolution mass spectrometry (HRMS). In vitro studies using human CRC cell lines (HCT8 and SW480) demonstrated that DPhA-EtOBz-TSC specifically targeted and inhibited CSE: molecular docking and cellular thermal shift assay (CETSA) confirmed direct binding between DPhA-EtOBz-TSC and CSE (binding affinity ΔG = −29.07 ± 3. 85 kcal/mol), while Western blot analysis revealed a concentration-dependent reduction in CSE protein levels in SW480 and HCT8 cells treated with DPhA-EtOBz-TSC. Mechanistically, DPhA-EtOBz-TSC-induced CSE downregulation disrupted the CSE-H 2 S-GPX4 axis, leading to reduced glutathione (GSH) levels, decreased glutathione peroxidase 4 (GPX4) activity, and accumulation of lipid reactive oxygen species (ROS) and malondialdehyde (MDA)—hallmarks of ferroptosis. Additionally, Electron microscopy and JC-1 staining revealed that DPhA-EtOBz-TSC induced significant alterations in mitochondrial morphology and a marked reduction in mitochondrial membrane potential (ΔΨm). Functionally, DPhA-EtOBz-TSC exhibited potent in vitro anti-CRC activity with IC 50 values of 25.15 μM (HCT8) and 26.11 μM (SW480) respectively, and suppressed migration and invasion. In vivo, DPhA-EtOBz-TSC (10 mg/kg/day, i.p.) significantly suppressed the growth of CT26 cell-derived xenograft tumors in BALB/c mice without causing obvious histopathological abnormalities in major organs (heart, liver, spleen, lung, kidney). Immunohistochemical staining of tumor tissues confirmed increased lipid peroxidation and decreased CSE/GPX4 expression in DPhA-EtOBz-TSC-treated mice, consistent with in vitro findings. In conclusion, DPhA-EtOBz-TSC is a novel CSE-targeting compound that induces ferroptosis in CRC cells and inhibits tumor growth in vivo. Our findings identify DPhA-EtOBz-TSC as a potential lead compound for CRC therapy and highlight the CSE-H 2 S-GPX4 axis as a viable therapeutic target for ferroptosis-based anticancer strategies.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 24
·52335
·
IF 3.057
Hao Zhang,Ying Jun Li,Jun Zeng,Hui Ping Liu,Yuan Lin Zhou
In order to solve the problem of poor thermal conductivity of polymer-based radiation shielding composite materials, h-BN@PDA@PbWO 4 hybrid powders were prepared by combining h-BN with high thermal conductivity and PbWO 4 with γ shielding. With the assistance of polydopamine, PbWO 4 particles were synthesized in situ on the h-BN surface. The effects of h-BN@PDA@PbWO 4 on thermal conductivity, γ-ray shielding, and mechanical properties of chloroprene rubber were studied. The results showed that the hybrid particles had better dispersibility than the pure mixing of h-BN and PbWO 4 in chloroprene rubber and significantly improved the thermal conductivity gamma-ray shielding performance and mechanical properties of CR composites. When the filler content of the hybrid powder reaches 40 wt%, the thermal conductivity of the composite is about 3.16 times that of the pure CR. The γ shielding rates at 86.5 KeV and 105.3 KeV photon energies increase by 14.14% and 17.61% compared with the pure CR. Compared with pure CR, the tensile strength of the composites increased by 4.79 MPa, and the elongation at break decreased slightly. These were because h-BN@PDA@PbWO 4 shows had an excellent synergistic effect in CR substrate. The new kind of CR/h-BN@PDA@PbWO 4 composite can be used for thermal management and gamma shielding.
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ACS Catalysis
·
2026
·
IF 13.6
Ruan Yuhao,Liu Peng,Liu Jianqiao,Yang Yiwei,Shen Zhangfeng,He Jiehua,Huang Chen,Zhang Siqian,Ge Zhigang,Pan Yun-Xiang,Wang Yangang
Catalytic CO 2 methanation converts CO 2 with hydrogen into methane, enabling carbon recycling and chemical energy storage. However, the precise roles and synergy of critical active sites, oxygen vacancies and metal–support interfaces remain elusive in CO 2 methanation, impeding the development of highly active and selective low-temperature catalysts. Based on density functional theory calculations, herein, Ni-doped CeO 2 supports were designed to load Ni nanoparticles for constructing Ni/Ni x CeO 2-γ catalysts. With 2 mol % Ni doping, the Ni/Ni 0.02 CeO 2-γ catalyst exhibited 75.5% CO 2 conversion and 100% CH 4 selectivity at 250 ° C, and maintained its activity over 200 h at 300 ° C. Compared to Ni/CeO 2 , Ni/Ni 0.02 CeO 2-γ features smaller CeO 2 nanoparticles, higher oxygen vacancy concentration, and stronger metal–support interaction. The abundant oxygen vacancies create frustrated Lewis pairs with adjacent basic sites (e.g., hydroxyls and lattice oxygen) for effective CO 2 adsorption and activation, while the strong metal–support interaction facilitated the adsorption and dissociation of H 2 on the metallic Ni sites. Consequently, the above synergy boosted key steps including hydrogen spillover and intermediate hydrogenation, resulting in a marked improvement in the CO 2 methanation rate at low temperatures. The in situ diffuse-reflectance infrared Fourier transform spectroscopy revealed that the formate pathway served as the principal reaction mechanism for CO 2 methanation over Ni/Ni 0.02 CeO 2-γ . This study elucidates the role of oxygen vacancy-mediated synergy in low-temperature CO 2 methanation and offers a strategy for designing CO 2 hydrogenation catalysts.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Mingsha Jie,Amei Zhu,Zhendong Liu,Junguang Li,Zeyu Xu,Xiaoyue Yue,Yanhong Bai
γ-CD-MOF@Eu-MOF flower-like probe synthesized for sensitive sulfonamides detection. • Paper-based sensor enables portable, visual on-site testing via smartphone imaging. • Machine learning algorithm boosts detection speed and reliability for quantitation. • The detection limit of the γ-CD-MOF@Eu-MOF for SAs is as low as 25.5 nmol/L. The protection of human health and the guarantee of food safety necessitate rapid and precise identification of sulfonamides (SAs) residues in food. Herein, we propose a fluorescence sensor based on γ-CD-MOF@Eu-MOF, which is used for quantitative and visual detection of SAs. The γ-CD-MOF@Eu-MOF exhibits high selectivity toward SAs, with detection limits for sulfamerazine (SMR), sulfamethazine (SM 2 ), and sulfamethoxydiazine (SMD) as low as 25.5 nmol/L, 36.7 nmol/L, and 39.8 nmol/L, respectively. The fluorescent probes were immobilized on paper substrates to construct a paper-based sensor, which was combined with a smartphone-assisted machine learning algorithm to enable high-throughput, intelligent, and rapid detection of SAs. After optimizing the constructed prediction model, the coefficient of determination can reach 0.99, indicating the accuracy and applicability of the model. Overall, this sensor exhibits excellent stability, sensitivity, and specificity, providing a practical approach for the intelligent, rapid, and high-throughput on-site visual detection of SAs. Download: Download high-res image (163KB) Download: Download full-size image
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Zhengyi Sun,Weijia Li,Xin Wang,Hongyu Wu,Xiaofei Wang,Yifei Shen,Dong Zhou
A novel ATT/γ-Fe₂O₃ nanoparticle was synthesized via the alkaline co-precipitation method. • Submicro/nanofibrous membranes incorporating ATT/γ-Fe₂O₃ particles can respond to external magnetic field stimuli. • Moderate-strength static magnetic field enhanced bone regeneration and vascular repair. • In vivo studies suggested that the BMP2-Smad-RUNX-2 signaling pathway was involved in the improvement and healing of cranial bone defects in rats. Currently, the development of multifunctional scaffolds that synergistically promote osteogenesis and angiogenesis remains a significant challenge in bone tissue engineering. It is increasingly recognized that scaffolds composed of a single material or possessing a single function are often inadequate, as they fail to mimic the complex biochemical and physical microenvironments. In this study, we successfully fabricated a submicro/nanofibrous membrane using electrospinning technology, which creates a biomimetic extracellular environment through a polycaprolactone (PCL) / gelatin (GEL) matrix. The incorporation of attapulgite (ATT) supplies essential osteogenic ions, while γ-iron oxide (γ-Fe₂O₃) facilitates mesenchymal cell differentiation and imparts magnetic responsiveness. Co-culturing the membranes with human umbilical vein endothelial cells (HUVECs) and bone marrow mesenchymal stem cells (BMSCs) revealed that the membranes possessed strong biocompatibility and promoted osteogenic differentiation and angiogenesis. Both in vivo and in vitro studies suggested the involvement of the BMP2-Smad‑RUNX‑2 signaling axis in the effects of the PG/ATT/γ‑Fe₂O₃ scaffold, which also upregulated osteogenesis‑related gene expression under a magnetic field. This work offers new insights and provides a scientific foundation for advancing the use of functionalized nanomaterials in the field of bone tissue engineering.
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EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Benshun Huang,Ting Shen,Zhuoyi He,Xi Yang,Zhen Wang,Limin Ji,Yujun Chen,Jiayi Luo,Jun Ling,Yougen Chen
The current study explores the organocatalytic ring-opening polymerization (ROP) of γ - n -butoxyl- ε -caprolactone (BCL) and its one-pot block copolymerization with a strained bridged ester N -Boc-substituted proline lactone (N Boc PL), using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The TBD-catalyzed ROP of BCL in toluene demonstrates the first-order polymerization kinetics and exhibits living polymer characteristics within moderate monomer conversion. It effectively suppresses inter- and intramolecular transesterification side reactions to the minimum, which are commonly observed in base-promoted ROP of lactone monomers. It provides acceptable control over the molecular weight of poly( γ - n -butoxyl- ε -caprolactone) (PBCL) by simply tuning the initial monomer-to-initiator molar ratio and controlling the monomer conversion. For instance, the polymerization using bifunctional 1,4-butanediol as the initiator can produce narrowly distributed PBCL with M n,SEC up to 34.5 kg mol −1 and M w / M n of less than 1.20. The TBD-catalyzed copolymerization of BCL with N Boc PL is successful to synthesize block copolymers. Notably, the one-pot copolymerization of the two monomers demonstrates a strictly sequential monomer consumption with N Boc PL polymerizing first followed by BCL. This unique copolymerization behavior enables the synthesis of block copolymers via a one-pot procedure, and tri-, penta-, and heptablock copolymers are accordingly synthesized by introducing monomers simultaneously or in multiple steps. The polymer structures are characterized using NMR, FT-IR spectroscopy, MALDI-TOF MS, and SEC. The thermal characteristics and self-assembly behavior of the polymers in aqueous solutions are further evaluated using TGA, DSC, and DLS. Additionally, the cytotoxicity of the Boc-deprotected triblock copolymers towards mouse fibroblasts (3T3 cells) and their hemolytic effects on rat red blood cells are further investigated, with the detailed results presented in subsequent sections.
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ACS Materials Au
·
2026
·
IF 9.1
Yuhan Li,Zhuoyang Du,Yongheng Shi,Zeqing Liu,Lingmei Dai,Dehua Liu,Wei Du
Enzyme immobilization on solid supports enhances stability and reusability, yet nanoscale carriers such as metal–organic frameworks (MOFs) still face challenges in efficient recovery. While pyrolysis can magnetize Fe-MOFs, conventional methods often compromise either enzyme activity or structural integrity. This study presents a rational two-step oxidation–reduction (O–R) pyrolysis strategy to convert Meso-MIL-88A into a magnetically recyclable, mesoporous biocatalyst support (O-R500). Unlike one-step carbonization, which generates enzyme-incompatible Fe3O4, or carbonization-oxidation routes that collapse the framework, our approach first transforms the MOF into a robust α-Fe2O3 template while preserving its morphology. Citric acid then acts as a mild, slow-releasing reductant, selectively producing a γ-Fe2O3-rich phase without damaging the mesostructure. The resulting O-R500 exhibits well-defined mesopores (∼13 nm), sufficient magnetization (16 emu/g) for rapid separation, and a biocompatible surface that maintains the native conformation of immobilized Candida antarctica lipase B (CalB). In the synthesis of phosphatidyl EPA/DHA, CalB@O-R500 achieved 84.5% incorporation and retained 90.3% activity over five cycles, outperforming nonmagnetic counterparts. This work not only provides a high-performance magnetic biocatalyst but also establishes a generalizable design principle for converting Fe-MOFs into structured, biocompatible, and functionally integrated carriers.
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