JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
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2025
·
IF 1.6
Liu Jing-Long,Ye Xiao-Dan,Chen Lu-Si,Jia Ai-Quan,Zhang Qian-Feng
New ten tetrakis(benzoxazine) calix[4]resorcinarenes modified by organic amine through Mannich reaction were obtained in this paper. Compounds 2 ~ 11 were characterized by infrared spectroscopies, nuclear magnetic resonance spectroscopies. The structure of compounds 2 , 10 and 11 was characterized by single crystal X-ray diffraction. Compound 7 possesses a MIC value of 3.13 μg/mL against S. Aureus , demonstrating a favorable inhibitory effect, and a MIC value of 6.25 μg/mL against E. Coli , likewise showing a good inhibitory effect. The UV and 1 H NMR titration experiments were conducted to explore the host–guest chemistry between compound 10 and acetonitrile molecules, indicating that compound 10 exhibited encapsulation behavior towards acetonitrile molecules through hydrogen bonding interactions. Then Hirshfeld surface analysis showed that H⋅⋅⋅H, C − H⋅⋅⋅O, C − H⋅⋅⋅π, O − H⋅⋅⋅O played an important role in the crystal accumulation of compounds 2 , 10 and 11 .
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高影响因子
LANGMUIR
·
2025
·
IF 3.9
Min Xu,Zhayun Gong,Yangyang Wu,Zhiyong Zhu,Kun Wang,Hefeng Xu,Cong Yu,Xiaodong Chu
4-Nitrophenol (4-NP) pollution in the chemical, dye, and other industries poses significant risks to humans and aquatic organisms. In this study, we prepared metal oxide-supported gold nanoparticles (AuNPs/Al2O3, AuNPs/TiO2, and AuNPs/ZnO) and applied them to the catalytic reduction of 4-NP. The Bader charge and differential charge, dos and d band centers, work function, and reaction free energy of AuNP composites were analyzed through DFT calculations. The influence of metal oxide carriers on the catalytic activity of AuNPs was explored, which decreased in the following order: AuNPs/Al2O3 > AuNPs/TiO2 > AuNPs/ZnO. In addition, the catalytic reduction performance of these AuNP composites for 4-NP in the presence of NaBH4 was investigated. The results showed that the AuNPs/Al2O3 catalyst exhibited the best performance (3.62 ± 0.17 min–1), consistent with the theoretical calculations. Meanwhile, the AuNPs/Al2O3 catalyst exhibited good reusability. More relevantly, the catalytic reduction mechanism of metal oxide-supported AuNPs for 4-NP was proposed from both experimental and theoretical calculations.
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PubMed
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Jie Li,Ji- Yu Che,Hong- Yu Wang,Rui-Yao Wang,Si-Yuan Huang,Zhong-Ming Wu,Xin-Ge Zhang
Pattern recognition receptors on immune cells play essential roles in detecting pathogen-associated molecular patterns and initiating downstream immune defense cascades. Toll-like receptor-4, a key member of the PRR family, regulates macrophage-mediated innate immune responses; however, its dysregulation due to excessive activation often exacerbates inflammatory processes. Herein, we report a Toll-like receptor-4-targeted nano-extinguisher designed to combat acute pneumonia caused by multidrug-resistant Pseudomonas aeruginosa infection. This innovative nanoplatform integrates bacterial capture ligands, a photothermal agent, and a Toll-like receptor-4 signaling inhibitor. Upon near-infrared light irradiation, the nano-extinguisher generates localized hyperthermia, leading to bacterial death through disruption of membrane integrity. Moreover, the heat-triggered release of the Toll-like receptor-4 signaling inhibitor enables dual immunomodulation by simultaneously regulating macrophage polarization and scavenging reactive oxygen species. The nano-extinguisher significantly alleviated the pathological progression of infection-induced acute pneumonia in our experiments. By combining photothermal antibacterial activity with spatiotemporal immunomodulation, this nanoengineered system offers a promising translational strategy for the treatment of acute bacterial infections and concurrent mitigation of Toll-like receptor-4-mediated immunopathology. Statement of Significance TLR4, which is crucial for initiating innate immunity via pathogen detection, often exacerbates inflammation when hyperactivated. We developed TLR-4-targeted nano-extinguishers to combat multidrug-resistant Pseudomonas aeruginosa -induced pneumonia. This system integrates bacterial capturing, photothermal therapy, and TLR-4 inhibition. Photo-driven localized hyperthermia disrupts bacterial membranes while thermally releasing the inhibitor, thereby achieving simultaneous macrophage polarization modulation and reactive oxygen species scavenging, effectively mitigating infection-induced pneumonia. By integrating precision photothermal sterilization with spatiotemporal immunoregulation, our nanoengineered strategy addresses both bacterial eradication and TLR-4-mediated immunopathology, offering translational potential for the treatment of acute infections.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuyu Peng,Yina Jiang,Chunyan Wang,Kelei Pang,Xiwang Li,Xiaofeng Zhou,Zhengjie Wang
Surface-enhanced Raman scattering (SERS) technique has significant advantages in the detection of gaseous small molecules, but it still faces challenges such as low adsorption capacity of gaseous small molecules on the surface of the SERS substrate, and low detection sensitivity due to the small Raman scattering cross section. In this paper, a nucleophilic addition strategy based on Ag@Au@4-nitrophenylhydrazine (4-NPH) @zeolite imidazolium ester backbone material-8 (ZIF-8) is proposed for achieving highly sensitive SERS detection of gaseous acetone. The SERS sensing platform was constructed by synthesizing Ag@Au nanoparticles with a core-shell structure modified with 4-NPH as a Raman reporter molecule, which was then encapsulated in a ZIF-8 porous framework. The nucleophilic addition reaction mechanism between acetone and 4-NPH was systematically investigated using density-functional theory (DFT), which revealed the changes in Raman spectra of 4-NPH due to the reaction and provided a theoretical basis for the specific detection of acetone. In addition, the charge transfer effect of more adsorption sites between the reaction product and the nanogold surface further enhanced the SERS signal. The constructed SERS substrate was demonstrated to have a low relative standard deviation (RSD) as low as 4.8 % for the detection of gaseous acetone, which ensured high sensitivity and reliability, and could detect at a concentration of 100 ppb. The method's excellent immunity to interference in complex exhaled gases gives it the potential to be applied to the non-invasive diagnosis of diabetes, demonstrating significant clinical applications.
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高影响因子
ChemCatChem
·
2025
·
IF 3.9
Hengyu Zhao,Jing Zhao,Xue Li,Bate Nasen,Yang Wu,Xinlong Wang,Jinxiong Wu,Yaya Wang
The catalytic reduction of 4-nitrophenol (4-NP), a persistent environmental pollutant faces dual challenges reliance on noble metals and inefficient utilization of hydrogen radicals (H*). Meanwhile, nickel-containing sludge generated by the electroplating industry, classified as hazardous waste has long posed significant disposal conundrums. Herein, we developed a noble metal-free pyroxene-type CaNi(Si 2 O 6 ) catalyst, synthesized from electroplating sludge, that simultaneously addresses these challenges through dynamically reconstructed Ni–O–Ca interface with oxygen vacancies and interfacial electron transfer channels. Ni@Ca-195/20 establishes a self-sustaining catalytic system, achieving a remarkable conversion of 96.8% with 0.1 mM NaBH 4 and 0.05 mg catalyst, while maintaining stability over 31 cycles in low concentration regimes. Integrated characterization combined with catalytic performance evaluation reveals an interfacial electron transfer mechanism: the engineered interface enables in situ reduction of Ni 2+ generates metallic electron-deficient Ni δ+ species, enhancing 4-NP − and BH 4 − adsorption through dual-site coordination. Oxygen vacancies accelerate BH 4 − hydrolysis, while electron transfer channels sustain H* flux via Ca 2+ modulated charge equilibration. This work establishes a waste-to-functionality paradigm for designing defect-engineered catalysts while advancing sustainable remediation of nitroaromatic pollutants. Graphical The Ni-plating sludge was converted into a Ni@Ca-195/20 catalyst with abundant oxygen vacancies and Ni–O–Ca heterointerfaces via the solvothermal method, which was used to efficiently catalyze the hydrogenation reduction of 4-nitrophenol.
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高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Xiaolan SONG,Jie WANG,Yi WANG,Chongwei AN,Fengsheng LI
Utilizing micro-channel technology and meticulously regulating the differential flow rates of the oil and water phases, we successfully synthesized remarkably spherical nB/F 2602 /HNS (hexanitrostilben)microspheres, measuring approximately 200 μm in diameter. The morphological and compositional characteristics of these microspheres were thoroughly analyzed using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), infrared spectroscopy (IR), X-ray photoelectron spectroscopy (XPS), and laser microscopy. Meanwhile, we conducted an in-depth investigation into the catalytic effects of the microspheres on the thermal decomposition of ADN(Ammonium dinitramide)/DAP-4((C 6 H 14 N 2 )[NH4(ClO 4 ) 3 ]), employing thermogravimetric-differential scanning calorimetry (TG-DSC) and burst point assessments. The combustion performance of ADN/DAP-4, both prior to and following the incorporation of nB/F 2602 (fluoroelastomer)/HNS microspheres, was evaluated through high-speed imaging, high-sensitivity infrared thermography, and combustion calorimetry measurements. Furthermore, this study contemplated the combustion mechanism of nB/F 2602 /HNS microspheres. The findings indicated that, after adding nB/F 2602 /HNS microspheres, the thermal decomposition activation energy of ADN/DAP-4 was significantly reduced. These results revealed that the introduction of nB/F 2602 /HNS microspheres markedly enhanced the combustion intensity of ADN/DAP-4, with the pressurization rate accelerating dramatically from 0.55 MPa/s to 3.47 MPa/s. As the burning rate escalated, the maximum combustion temperature increased from 1697°C to 1788°C, and the combustion heat surged from −4478 kJ/kg to −17593 kJ/kg. Moreover, the comparative experimental outcomes, when juxtaposed with samples based on micro-boron (μB), reveal that nano-boron (nB) exhibits a superior burning rate and combustion efficiency. Consequently, the collective findings of these experiments emphatically indicate that nB/F 2602 /HNS markedly enhances the thermolytic and combustion processes of ADN/DAP-4.
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高影响因子
Nano Energy
·
2022
·
IF 19.069
Ting Xiang,Ting Li,Miaosheng Wang,Wei Zhang,Mahshid Ahmadi,Xiaoyan Wu,Tianfei Xu,Meiqin Xiao,Long Xu,Ping Chen
It is always difficult to control the growth of crystals during the formation of multiple quantum wells (MQWs) in the quasi-2D perovskite light emitting diodes (PeLEDs). In this study, we introduce the 1, 4, 7, 10-tetraoxacyclododecane ether into the quasi-2D perovskite of PEA 2 Cs n-1 Pb n Br 3n+1 to reduce the coordination rate between the phenethylamine bromide and the perovskite framework. As a result, Crown-ether assisted in-situ grown (CAIG) perovskite crystals (PCs) is grown with thick PbBr 4 layers (n > 55) during the spin-coating. For the CAIG PCs, the generation of small n phases (n = 1, 2 and 3) are significantly suppressed, resulting in almost flat energy structure with the phases of n ≥ 4. The generation rate of the excited states of the n ≥ 4 remains ultra-fast within ~0.77 ps even without the MQWs structures; however the decay of excited states becomes much slower. The CAIG PCs film has lower trap density , therefore promoting the carrier mobility , carrier diffusion length and the photoluminescence quantum yield . The PeLEDs based on the CAIG PCs film achieves the maximum luminescence of ~27562 cd m −2 and the maximum external quantum efficiency (EQE) of ~16.1%. The half-lifetime of the luminescence and the EQE measured in the atmosphere (a relative humidity of ~52% at 27 ℃) are exceeding ~17 and 43 h, respectively. Hence, it can be recognized as the most ambient stable device based on the PEA 2 Cs n-1 Pb n Br 3n+1 perovskite.
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高影响因子
Advanced Science
·
2022
·Vol. 9
·期 20
·2201241
·
IF 17.521
Yubo Cui,Mengyang Wang,Peizhe Dong,Shuangshuang Zhang,Junjie Fu,Libo Fan,Chaoliang Zhao,Sixin Wu,Zhi Zheng
A main concern of the promising DMF-based Cu 2 ZnSn(S x ,Se 1- x ) 4 (CZTSSe) solar cells lies in the absence of a large-grain spanning structure, which is a key factor for high open-circuit voltage ( V oc ) and power conversion efficiency (PCE). A new strategy to achieve CZTSSe large-grain spanning monolayer is proposed, by taking advantage of the synergistic optimization with a Cu 2+ plus Sn 2+ redox system and pre-annealing temperatures. A series of structural, morphological, electrical, and photoelectric characterizations are employed to study the effects of the pre-annealing temperatures on absorber qualities, and an optimized temperature of 430 ℃ is determined. The growth mechanism of the large-grain spanning monolayer and the effect of redox reaction rate are carefully investigated. Three types of absorber growth mechanisms and a concept of critical temperature are proposed. The devices based on this large-grain spanning monolayer suppress the recombination of carriers at crystal boundaries and interfaces. The champion device exhibits a high V oc (>500 mV) and PCE of 11.76%, which are both the maximum values among DMF-based solar cells at the current stage.
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Zetao Wang,Ke Ma,Xianfang Jiang,Jiali Xie,Peian Cai,Fuxin Li,Ruiming Liang,Jinmin Zhao,Li Zheng
Membranes used in guided bone regeneration (GBR) are required to exhibit high mechanical strength, biocompatibility, biodegradation, osteogenic and osteoinductive potential. In our study, poly(3-hydroxybutyrate- co -4-hydroxybutyrate)(P(3HB-co-4HB))/octacalcium phosphate (OCP) (P(3HB-co-4HB)/OCP) nanofibrous membranes were fabricated by electrospinning with two different P(3HB-co-4HB) to OCP ratios (P(3HB-co-4HB):OCP = 95:5 wt% and 90:10 wt%, termed P(3HB-co-4HB)/OCP(5)and P(3HB-co-4HB)/OCP (10), respectively) for GBR. The developed P(3HB-co-4HB)/OCP nanofibrous membranes were analysed for their osteogenic and osteoinductive properties using mesenchymal stem cells (MSCs) in vitro and in a calvarial bone defect rat model. The composite P(3HB-co-4HB)/OCP nanofibrous membranes showed decreased fibre size and enhanced tensile strength compared with those of P(3HB-co-4HB) nanofibrous membranes. In the in vitro studies, the P(3HB-co-4HB)/OCP membranes facilitated cell growth and osteoblastic differentiation of MSCs and were superior to P(3HB-co-4HB) membranes. After covered on the calvarial bone defects, P(3HB-co-4HB)/OCP membranes facilitated greater neobone formation than P(3HB-co-4HB) membranes did, as the result of histological evaluation and micro-CT analysis with higher bone volume/total volume (BV/TV) ratio and bone mineral density (BMD). P(3HB-co-4HB)/OCP(10) membranes with higher OCP content showed greater stiffness and osteoinductivity than P(3HB-co-4HB)/OCP (5)membranes, demonstrating the role of OCP in the composite membranes. These results indicated that electrospun P(3HB-co-4HB)/OCP nanofibrous membranes hold promise for the clinical application of GBR.
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PubMed
高影响因子
ChemMedChem
·
2017
·Vol. 12
·期 4
·327-336
·
IF 3.225
Zixin Xie,Zaikui Zhang,Shufang Yu,Donghua Cheng,Huan Zhang,Chao Han,Handeng Lv,Faqing Ye
Graphical Taking the heat off : The 24 curcumin analogues in this study were found to have no toxicity toward mouse bone marrow cells, and some of them showed potent anti-inflammatory activity by inhibiting LPS-stimulated TNFα, IL-6, IL-1β, PGE2, and NO production in rat macrophages. Pharmacokinetic studies indicated that compound c6 has better bioavailability than curcumin in vivo. Both c6 and c10 may be valuable leads for the development of new anti-inflammatory agents. A total of 24 N-substituted 3,5-bis(2-(trifluoromethyl)benzylidene)piperidin-4-one derivatives were synthesized via aldol condensation, and their anti-inflammatory activities were evaluated. These compounds were found to have no significant cytotoxicity against mouse bone marrow cells in vitro. However, some compounds, such as c6 ( N -(3-methylbenzoyl)-3,5-bis-(2-(trifluoromethyl)benzylidene)piperidin-4-one) and c10 ( N -(2-chlorobenzoyl)-3,5-bis-(2-(trifluoromethyl)benzylidene)piperidin-4-one), displayed potent anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), IL-1β, prostaglandin E2 (PGE2), and nitric oxide (NO) production in RAW 264.7 cells. Treatment with c6 or c10 at 2.5 or 10 mg kg −1 significantly decreased the paw edema induced by carrageenan in rats, and the anti-inflammatory effects of these compounds were found to be better than those of celecoxib or indomethacin as well as their parent compound C66 (2,6-bis-(2-(trifluoromethyl)benzylidene)cyclohexanone). Pharmacokinetic analysis indicated that c6 has better bioavailability than curcumin. Therefore, these compounds may be valuable leads for the development of new anti-inflammatory drugs.
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PubMed
高影响因子
Bioresources and Bioprocessing
·
2019
·Vol. 6
·期 1
·1-12
·
IF 0
Zhang Can,Song Wei,Liu Jia,Chen Xiulai,Liu Liming
( R )- or ( S )-2-Hydroxy-4-(methylthio)butanoic acid (HMTBA) is used as a poultry nutritional supplement and to treat renal failure disease. Herein, we report an artificially designed biocatalytic cascade process, which uses l -methionine to synthesize ( R )- or ( S )-HMTBA. This biocatalysis cascade comprises a basic module and two different extender modules and operates in a modular assembly manner. The basic module responsible for the transformation of l -methionine to α-keto-γ-methylthiobutyric acid (KMTB) is comprised of the l -amino acid deaminase. Two different extender modules responsible for the transformation of KMTB to ( R )- or ( S )-HMTBA are comprised of the R/S-specific lactate dehydrogenase in combination with the formate dehydrogenase, respectively. Engineered Escherichia coli catalysts, one containing the basic module, the other containing the one of two different extender modules, produced 97.6 g L −1 ( R )-HMTBA and 96.4 g L −1 ( S )-HMTBA with a yield of 96.9% and 95.8% at the large scale (1 L) using a two-stage strategy in one pot, respectively. Therefore, this biocatalytic process lays the foundation for the industrial-scale conversion of low-cost l -amino acids to corresponding high-value enantiopure chiral 2-hydroxy acids.
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APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Guomin Geng,Mengyang Cai,Rui Fang,Qian Luan,Zhiqiang Zhang,Jianjun Song,Jian Zhang
Developing highly efficient and stable catalysts toward advanced oxidation technology is the key to achieve industrial peroxymonosulfate (PMS) activation for pollution degradation. Perovskite-type oxide catalysts show high activity and stability for PMS activation, yet the small specific surface area of perovskite catalysts limits the increase of catalytic performance. Metal-organic frameworks (MOFs) have been widely used as the templates/precursors to prepare high specific surface area nanomaterials. In this study, two kinds of high surface area perovskites LaCoO 3 and LaMnO 3 were firstly fabricated with MOFs as templates. Benefiting from the extraordinary skeleton structure of MOFs, well-defined architecture and porous perovskite catalysts show superior catalytic performance towards PMS activation for the degradation of 2, 4-dichlorophenol (2, 4-DCP), with a 99.8% degradation of 2, 4-DCP in 25 min for LaCoO 3 catalyst. Moreover, the LaCoO 3 catalysts exhibit long-term stability with a slight loss of catalytic activity during 3 times recycled experiments. This study not only developed high activity catalysts for PMS activation, but also expanded the MOFs applications for environment and energy.
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高影响因子
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