ADVANCED POWDER TECHNOLOGY
·
2024
·
IF 4.2
Jiali Chen,Peng Gao,Jie Liu,Yimin Zhu
Scheelite and calcite was firstly separated by new depressant Poly(sodium 4-styrenesulfonate) (PSS) with NaOL system. The recovery of scheelite was 87.18 % and the recovery of calcite was 5.57 % in single flotation experiments, the recovery and grade of WO 3 was 70.53 % and 61.08 % respectively in artificial mixed ore flotation under the optimal conditions of 10 mg/L NaOL, 10 mg/L PSS and pH of 8. Contact angle measurements, atomic force microscope (AFM) analysis, zeta potential analysis, fourier transforming infrared spectra (FT-IR) analysis and X-ray photoelectron spectroscopy (XPS) analysis were performed to uncover the reaction mechanism. The results showed that PSS could not adsorbed on scheelite by chemical reaction, and PSS had no impact on the further adsorption of NaOL onto the scheelite surface. Therefore, scheelite could still keep a high recovery with PSS. However, PSS could be strongly adsorbed on calcite by chemisorption between the Ca site of calcite and O site of PSS, which increased the hydrophilia of calcite and imped the further adsorption of NaOL. Therefore, it could selectively depress the flotation of calcite.
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ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Zhenjun Zhao,Jingyi Chi,Zhang FangFang,Yinglin Song,Wenda Xv,Yan Li,Hui Shi
4-Octylphenol, a major environmental degradation product of alkylphenols (Aps) used in industry, is an endocrine-disrupting chemical with significant estrogenic activity. It is one of the most toxic Aps, poorly biodegradable in the environment, and can accumulate in organisms through the food chain, thereby affecting the male reproductive system. In this study, the effect of 4-octylphenol on male reproductive health was analyzed. Male pubertal mice were exposed to 4-octylphenol at doses of 0, 1, 10, and 100 mg/kg once daily for 28 days. Our findings indicated that pubertal exposure to 4-octylphenol has significant negative effects on the male reproductive system. Pubertal mice exposed to 4-octylphenol exhibited dose-dependent reproductive toxicity. In the medium- and high-dose groups, a significant reduction in testicular mass, structural damage to the seminiferous tubules, increased oxidative stress and apoptosis within the testicular tissue, and a decline in sperm quality were observed. Additionally, autophagy processes in the testicular tissue, germ cell proliferation, and meiotic processes are inhibited. Serum testosterone and estradiol levels decreased, whereas oxidative stress levels in the testes and spermatozoa increased. In contrast, the low-dose group showed only a reduction in body weight, a decrease in motile sperm count, and mild oxidative stress in the testes without significant pathological changes in Western blot experiments. These results indicate that 4-octylphenol exposure during puberty caused reproductive toxicity in male mice.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Hao Dai,Ziyi Deng,Yanbo Zeng,Jian Zhang,Yiwen Yang,Qinyan Ma,Wenling Hu,Longhua Guo,Lei Li,Shulin Wan,Haiying Liu
A coumarin-based fluorescent molecularly imprinted poly (ionic liquid) (FL-MIPIL) was prepared using a new coumarin-based alkenyl fluorescent ionic liquid (coumarin-FL-IL) as the functional monomer, IL [V 2 C 4 (mim) 2 ][(PF 6 ) 2 ] and ethyleneglycol dimethacrylate as the cross-linkers, and 4-NP as the template molecule. The absolute quantum yields of coumarin-FL-IL and FL-MIPIL were 7.26 % and 30.66 %, respectively. As a result of the electron transfer between coumarin-FL-IL which contains amino groups and 4-NP bearing hydroxyl groups, FL-MIPIL fluorescence was effectively quenched by 4-NP. The prepared FL-MIPIL sensor can rapidly respond to 4-NP within 60 s. The FL-MIPIL sensor had good linear response to 4-NP from 0.001–7.5 μM and low detection limit of 0.5 nM (S/N = 3). The FL-MIPIL sensor exhibited high sensitivity and good selectivity for 4-NP. The outstanding performance of FL-MIPIL could be ascribed to high fluorescence intensity of FL-MIPIL without matrixes and more interactions between FL-MIPIL and 4-NP. The FL-MIPIL sensor has successfully applied to the determination of 4-NP in lake, rain and waste water samples, river sediment, soil and urine samples.
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高影响因子
CARBOHYDRATE POLYMERS
·
2012
·
IF 3.628
Yihao Luan,Jinming Zhang,Maosheng Zhan,Jin Wu,Jun Zhang,Jiasong He
Using 4-dimethylaminopyridine (DMAP) as the catalyst, highly efficient propionylation and butyralation of cellulose were successfully carried out in an ionic liquid 1-allyl-3-methylimidazolium chloride (AmimCl) under mild conditions. Cellulose propionate (CP) and cellulose butyrate (CB) with a degree of substitution (DS) in the range from 0.89 to 2.89 were synthesized within only 30 min at 30 °C. The DS values of the products could be well controlled just by molar ratio of acid anhydride/anhydroglucose unit (AGU). More interestingly, the conversions of acid anhydrides in both propionylation and butyralation were as high as above 90%, even 96%. Therefore, this work provides a facile and highly efficient way for the synthesis of cellulose esters CP and CB.
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高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Lin Jiuyang,Yu Zijian,Chen Tianci,Huang Junming,Chen Lianxin,Li Jiangjing,Li Xuewei,Huang Xiaolei,Luo Jianquan,Ang Elisa Yun Mei,Toh William,Wang Peng Cheng,Ng Teng Yong,Seo Dong Han,Zhao Shuaifei,Zhong Kuo,Xie Ming,Ye Wenyuan,Van der Bruggen Bart,Wan Yinhua
During the synthesis of dyes, desalination of high-salinity dye-containing waste liquor is a critical premise for high-quality, clean dye production. Conventional membrane processes, such as electrodialysis, nanofiltration and ultrafiltration, are inevitably subjected to serious membrane fouling, deteriorating the dye/salt fractionation efficacy. Integrating the technical merits of electrodialysis and pressure-driven membrane separation, we devise an electro-driven filtration process using a tight ultrafiltration membrane as alternative to conventional anion exchange membrane for rapid anion transfer, in view of dye desalination and purification. By employing a sub-4 nanometer tight ultrafiltration membrane as anion conducting membrane, the electro-driven filtration process achieves 98.15% desalination efficiency and 99.66% dye recovery for one-step fractionation of reactive dye and NaCl salt, markedly outperforming the system using commercial anion exchange membranes. Notably, the electro-driven filtration system displays a consistently high and stable fractionation performance for dyes and salts with unprecedentedly low membrane fouling through an eight-cycle continuous operation. Our results demonstrate that the electro-driven filtration process using nanoporous membranes as high-performance anion conducting membranes shows a critical potential in fractionation of organic dyes and inorganic salts, unlocking the proof of concept of nanoporous membranes in electro-driven application.
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高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2025
·Vol. 95
·期 7
·1670-1685
·
IF 0.8
Liu X.,Yue Q.-x.,Wang Y.-h.,Lei M.-d.,Zhang Y.-l.,Zhang Y.-w.,Ji A.-l.,Zhang Y.-c.,Zhang X.-q.,Ding R.,Liu J.
The catalytic performance and mechanism of the prepared iron meso-tetra (4-carboxyphenyl) porphyrin (FeTCPP) on oxygen reduction reaction in alkaline environments were studied. At high concentrations of FeTCPP, the oxygen reduction reaction followed an efficient direct 4-electron transfer mechanism instead of 2+2 electron transfer mechanism. The central iron ion in FeTCPP underwent redox reactions from Fe III to Fe II . O 2 molecules formed a superoxide anion coordination complex with Fe II TCCP, transferring an electron from the central iron ion. Protonation of the complex formed a superoxide hydrogen radical complex, which then acquired another electron, generating a hydroperoxide radical and completing the first 2-electron reduction. The peroxide formed a coordination complex with Fe II TCCP to produce a peroxide complex Fe III TCCP:O 2 – with intramolecular charge transfer. And then it acquired two electrons, completing the second 2-electron reduction and being reduced to OH – . When the concentration of Fe III TCCP was high, the complex Fe III TCCP:O 2 – could protonate without stepwise reactions, directly acquiring three electrons from the electrode surface and being reduced to OH – . The oxygen reduction reaction exhibited a 4-electron mechanism. Both the 2+2 and 4-electron pathways occurred simultaneously, with the 4-electron pathway becoming more prominent as the concentration of FeTCPP increased.
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DALTON TRANSACTIONS
·
2025
·
IF 3.3
Jie Zhang,Qifeng Jia,Meng Li
Pyroelectric catalysis utilizes temperature fluctuations to drive hydrogen production reactions, but its application is limited due to the relatively weak spontaneous polarization intensity of most materials. Electron localization function (ELF) and density functional theory (DFT) calculations demonstrates that the presence of oxygen vacancies induces an asymmetric charge distribution in the BiVO4 lattice and disrupts its local symmetry. This distortion leads to an enhanced local dipole moment, thereby effectively improving the macroscopic spontaneous polarization capability. The COMSOL simulation indicates that the fluctuation of temperature difference and the pyroelectric potential exhibit a nonlinear response relationship. The polarization field induced by the pyroelectric effect effectively promotes the separation of electrons and holes, resulting in a remarkably high hydrogen evolution rate of 5.38 mmol h-1 g-1 for BiVO4-VO. This work not only provides profound atomic-level insight into the defect-mediated polarization enhancement mechanism but also establishes a practical foundation for designing high-performance pyroelectric catalysts that can efficiently harvest low-grade waste heat for sustainable hydrogen production.
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高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2020
·
IF 3.263
Bi-Yun Lin,Wen-Lin Liu,Hui Huang,Ya-Guang Hu,Sha Gong,Yu-Hua Meng,Jun Yan,Yuan-Zhi Lu,Hua-Lin Chen
The important physiological function of microtubules makes them an indispensable and clinically effective target of anti-tumor agents. Herein, we sought to design, synthesize, and evaluate a novel 4-anilinoquinazoline derivative and identify its anti-tumor activity in vitro and in vivo. The novel compound, N -(4-methoxyphenyl)- N -methyl-2-(methyl- d 3 )quinazolin-4-amine ( AQ-4 ), was identified as a representative scaffold and potent microtubule-targeting agent. As a promising antimitotic agent , AQ-4 displayed remarkable anti-tumor activity with an average IC 50 value of 19 nM across a panel of 14 human cancer cell lines. AQ-4 also exhibited nearly identical potent activities against drug-resistant cells, with no evidence of toxicity towards normal cells. A further target verification study revealed that AQ-4 targets the tubulin-microtubule system by significantly inhibiting tubulin polymerization and disrupting the intracellular microtubule spindle dynamics. According to the results of mechanism study, AQ-4 induced cell cycle arrest in the G 2 /M phase, promoting evident apoptosis and a collapses of mitochondrial membrane potential . The superior anti-tumor effect of AQ-4 in vivo suggests that it should be further investigated to validate its use for cancer therapy.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Yue Wu,Jin-Hui Shi,Guang-Hao Zhu,Yuan Xiong,Jia-Hao Gong,Hui-Zhen Wei,Zhao-Bin Guo,Zi-Ru Dai,Xiao-Bo Sun,Guang-Bo Ge
Human cytochrome P450 1B1 (hCYP1B1), an extrahepatic cytochrome P450 enzyme over-expressed in various tumors, has been validated as a promising target for preventing and treating cancers. Herein, two series of chalcone derivatives were synthesized to discover potent hCYP1B1 inhibitors without AhR agonist effect. Structure-activity relationship (SAR) studies demonstrated that 4′-trifluoromethyl on the B-ring strongly enhanced the anti-hCYP1B1 effects, identifying A9 as a promising lead compound. Further SAR analysis on A9 derivatives (modified A-ring of 4′-trifluoromethylchalcone) showed that introducing 2-methoxyl improved the anti-hCYP1B1 effect and selectivity , while introducing a methoxyl at the C-4 site was beneficial for avoiding AhR activation. Ultimately, five 4′-trifluoromethyl chalcones were identified as potent hCYP1B1 inhibitors (IC 50 < 10 nM), while B18 exhibits the most potent anti-hCYP1B1 effect (IC 50 = 3.6 nM), suitable metabolic stability and good cell-permeability. B18 also acted as an AhR antagonist and could down-regulate hCYP1B1 in living systems. Mechanistic studies showed that B18 potently inhibited hCYP1B1 in a competitive inhibition manner ( K i = 3.92 nM), while docking simulations revealed that B18 could tightly bind to the catalytic cavity of hCYP1B1 mainly via hydrophobic and hydrogen-bonding interactions. Furthermore, B18 could potently inhibit hCYP1B1 in living cells and showed remarkable anti-migration ability on MFC-7 cells. Taken together, this study deciphered the SARs of chalcones as hCYP1B1 inhibitors and provided several potent hCYP1B1 inhibitors as promising candidates for the development of more efficacious anti-migration agents.
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高影响因子
TALANTA
·
2019
·
IF 4.916
Yu-Lin Huang,Jian Wang,Ying-Hua Jiang,Peng-Yuan Yang,Guo-Wei Wang,Feng Liu
Protein phosphorylation is a reversible and important post-translational modification. Identification of phosphopeptides without enrichment is difficult for the low-abundance of phosphopeptides in real complex biological samples. Therefore, the effective and selective concentration of phosphopeptides prior to proteomic identification by mass spectrometer is necessary. In this study, we synthesized a novel titanium-based immobilized metal ion affinity chromatography material for highly selective enrichment of phosphopeptides. To improve material hydrophilia to the maximum extent, titanium ions were immobilized on the 4-armed Poly(ethylene oxide)(4μ-PEO-Ti 4+ ), a totally soluble polymer with large molecular weight (20000 g/mol). The 4μ-PEO-Ti 4+ was used to enrich phosphopeptides from tryptic digests of standard proteins and real complex biological samples, followed by MALDI-TOF MS analysis. In enrichment of phosphopeptides from 4 pmol β-casein, the 4μ-PEO-Ti 4+ performed the best property with starting material of 99–132 μg, loading buffer of 50% ACN/5% TFA (v/v), elution buffer of 10% NH 3 ·H 2 O (v/v) and elution time of 30 min. The 4μ-PEO-Ti 4+ has a superior detection sensitivity as low as 2 fmol for phosphopeptides. The high selectivity of 4μ-PEO-Ti 4+ allows a deep enrichment of phosphopeptides of β-casein from a mixture with BSA of 1000-fold abundant. The 4μ-PEO-Ti 4+ shows great stability and endurability and can be recycled up to at least 5 times. In addition, 4μ-PEO-Ti 4+ could detect 10 and 15 phosphopeptides from non-fat milk and nonenzymatic human saliva, respectively. In total, 4μ-PEO-Ti 4+ is a novel excellent material which shows great sensitive and selective enrichment of low-abundance phosphopeptides in real complex biological samples.
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JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 3.9
Xianxin Guo,Jinrong Li,Zimeng Li,Ting He,Tianyu Liu,Xiaomin Zhao
The plastic pollution crisis highlights the urgent demand for bio-based biodegradable polymers. Polyamide 4 (PA4) is a promising candidate, yet its application is severely limited by an extremely narrow thermal processing window (≈2°C). This work broadens this window through Lewis acid (LA) complexation modification and investigates the influence of CaCl 2 on the crystallization kinetics of PA4. Results show that specific LA, particularly CaCl 2 , acts as multifunctional modifiers. CaCl 2 interacts with the amide groups of PA4 and modifies the intermolecular hydrogen-bonding network. This unique interaction significantly increases ductility (elongation at break rises from 99% to 211%) while maintaining tensile strength and approximately maintaining the thermal degradation temperature, and most critically, broadens the thermal processing window from 2°C to 24°C primarily by lowering the melting temperature. Advanced nonisothermal crystallization kinetics analysis reveals a novel concentration-dependent dual mechanism of CaCl 2 : chain-complexation dominates at low loadings, while heterogeneous nucleation prevails at 7 wt.%, substantially reducing the crystallization activation energy (Δ E = −23.36 KJ mol −1 ). This clarifies the precise pathway for regulating PA4 crystallization via additives. In summary, this study elucidates the precise pathway for regulating PA4 crystallization via additives, providing a reference for the thermal processing applications of materials with limited thermal processing windows. Graphical We demonstrate that Lewis acid complexation, especially with CaCl 2 , broadens the processing window of bio-based polyamide 4 from 2°C to 24°C primarily by lowering the melting temperature while approximately maintaining the thermal degradation temperature. This modification also maintains tensile strength while revealing a concentration-dependent mechanism in crystallization kinetics, offering new insights for preparing high-performance biodegradable polymers.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Bo Luo,Wei Zhou,Xingai Zhang,Pei Zhao,Xiaoxiao Zhang,Longge Zhang,Hongyan Ding,Lailiang Qu
To promote the discovery and development of novel SDHIs fungicides, a series of novel pyrazole-4-carboxamides 4a-t and aromatic carboxamides 8a-i with a hydrazine scaffold were designed, synthesized, and evaluated for their antifungal activities. The results showed that compound 4i exhibited outstanding antifungal activity against R. solani with EC 50 value of 0.24 μg/mL, which was about three times more potent than that of Boscalid (EC 50 = 0.74 μg/mL). Moreover, compound 4i also displayed promising antifungal activities against Sclerotinia sclerotiorum, B. cinerea, Alternaria alternate , and F. graminearum (IC 50 = 1.21–4.50 μg/mL), indicating a broad spectrum of antifungal activities. Additionally, in vivo antifungal activities results showed that 4i could significantly inhibit the growth of R. solani in rice leaves with good protective efficacy (55.21%) and excellent curative efficacy (73.06%) at 100 μg/mL. The results of the SDH enzymatic inhibition assay showed that compound 4i generated significant SDH inhibition with IC 50 value of 6.47 μM, which was superior to Boscalid (IC 50 = 7.92 μM). Furthermore, SEM analysis showed that compound 4i could remarkably disrupt the typical structure and morphology of R. solani hyphae. The molecular docking study revealed that compound 4i could form H-bonds interactions and π-π interactions with TRP173 and TRY58 at the activity site of SDH, which was similar to that of Boscalid. The DFT calculation provided crucial information regarding electron transfer, which was essential in understanding the mechanism of molecules and target enzymes. These results indicated that compound 4i showed potential as a SDHIs fungicide and warranted further investigation.
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危险品化学品经营许可证（带存储）