Catalysts
·
2016
·Vol. 6
·期 9
·134
·
IF 2.964
Songbai Qiu,Ying Xu,Yujing Weng,Longlong Ma,Tiejun Wang
A series of MCM-41 supported Ni catalysts with high metal dispersion was successfully synthesized by simple co-impregnation using proper ethylene glycol (EG). The acquired Ni-based catalysts performed the outstanding hydrogenolysis activity of guaiacol. The effects of the synthesis parameters including drying temperature, calcination temperature, and metal loading on the physical properties of NiO nanoparticles were investigated through the use of X-ray diffraction (XRD). The drying temperature was found to significantly influence the particle sizes of NiO supported on MCM-41, but the calcination temperature and metal loading had less influence. Interestingly, the small particle size (≤3.3 nm) and the high dispersion of NiO particles were also obtained for co-impregnation on the mixed support (MCM-41:HZSM-5 = 1:1), similar to that on the single MCM-41 support, leading to excellent hydrogenation activity at low temperature. The guaiacol conversion could reach 97.9% at 150 °C, and the catalytic activity was comparative with that of noble metal catalysts. The hydrodeoxygenation (HDO) performance was also promoted by the introduction of acidic HZSM-5 zeolite and an 84.1% yield of cyclohexane at 240 °C was achieved. These findings demonstrate potential applications for the future in promoting and improving industrial catalyst performance.
✓ 已验证
DOI
高影响因子
Catalysts
·
2025
·Vol. 15
·期 5
·465
·
IF 4
Zongke He,Pengfei Jiang,Qianqian Cui,Ziyue Wang,Yaozhong Wei,Chao Luo,Jichang Guo,Chang Liu,Wei Zhang
In this work, the method of highly efficient conversion ofl-rhamnose to 5-methylfurfural (MF) catalyzed by various catalysts in a biphasic system was developed. To enhance the MF yield, the effects of the catalyst species, reaction temperature (150–180 °C), extraction solvents and volume ratio of the extraction to the aqueous phase (0–5) on the conversion ofl-rhamnose to MF were systematically investigated. Under optimal conditions, a high MF yield of 94% was achieved in the biphasic “diisopropyl ether (DIPE) + H2O” system due to the fact that the extraction of MF to the DIPE phase significantly inhibits the condensation and degradation of MF in water. Finally, detailed reaction energetics and chemical structures of intermediates of thel-rhamnose dehydration to MF were investigated using the B3LYP level of theory and the SMD solvation model. It is evident that MF, which exhibits excellent chemical stability, harbors the potential to function as a bio-derived platform chemical within the domain of the green industry.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
·
2025
·Vol. 29
·期 6
·e70470
·
IF 4.2
Chuchu Xu,Renjun Zhu,Qingfeng Dai,Yaoqing Li,Gengyuan Hu,Kelong Tao,Yuhong Xu,Guangen Xu,Guolin Zhang
The main reason for the failure of chemotherapy therapies based on 5-Fluorouracil (5-Fu) is the development of resistance to 5-Fu in cancer patients, particularly those with colorectal cancer. Tissue inhibitor of metalloproteinases 2 (TIMP-2) has been shown to be associated with colorectal cancer (CRC), but its correlation with 5-Fu resistance in colorectal cancer has not been thoroughly studied. We screen the expression of different cytokines through Cytokine array. CCK-8 assay was conducted to evaluate the IC 50 of 5-Fu and cell proliferation. ELISA and RT-qPCR were performed to detect TIMP-2 expression levels in cells and patient serum. Western blotting was utilised to analyse the differences in the expression of proteins related to signalling pathways in cells. Through cytokine array screening, we found that the expression of TIMP-2 was significantly increased in CRC drug-resistant cell lines. In addition, the expression of TIMP-2 in the serum of patients with CRC resistance to 5-Fu was significantly increased. Subsequent mechanistic experiments showed that TIMP-2 regulated the resistance of CRC cells to 5-Futhrough the JAK–STAT signalling pathway. Moreover, anti-TIMP-2 antibody or small molecule drug LY2784544 targeting the JAK–STAT signalling pathway can effectively reverse the resistance of CRC cells to 5-Fu. It is exactly TIMP-2 that mediates the resistance of CRC to 5-Fu through the JAK–STAT signalling pathway. Targeting drugs for TIMP-2 or the JAK–STAT signalling pathway are expected to be opportunities to reverse 5-Fu resistance in CRC.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2025
·
IF 4.9
Yang Chen,Cai Peng
Metal-organic frameworks (MOFs), consisting of both organic linkers and metallic ions, are expected to be excellent drug delivery agents for the treatment of cancer. However, the stability of MOF in the gastrointestinal tract remains to be resolved. In this study, we synthesized a MOF, namely Zr-NDC. Next, a thiolated chitosan (TCS) surface-modified Zr-NDC was developed, providing a strong impetus for oral 5-FU delivery. The most favorable interaction sites between 5-FU and Zr-NDC were explored by computer simulation. Then, the physicochemical properties of TCS-MOF, such as particle size, size distribution, and morphology, were evaluated. Through a series of experiments, including in vitro drug release experiments, MTT analysis, and in situ single small intestinal perfusion (SPIP), the results showed that under the protection of TCS-MOF, the release rate (2.3%) of 5-FU in an acidic environment was far lower than in artificial intestinal juice (60%). The coating of TCS on the surface of Zr-NDC has the effect of controlling drug release. TCS coating can enhance the acid resistance limit of MOF and further increase the adhesion and permeability of 5-FU to the intestinal mucosa. It is expected that TCS-MOF@5-FU can serve as a potential drug delivery system for oral 5-FU.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Medical Sciences
·
2020
·
IF 2.523
Hao Hu,Liang Xu,Shao-Ju Luo,Ting Xiang,Yan Chen,Zhi-rui Cao,Yu-jian Zhang,Zhuomao Mo,Yongdan Wang,Dong-fang Meng,Ling Yu,Li-zhu Lin,Shi-Jun Zhang
Retinal dehydrogenase 5 (RDH5) is an important enzyme in the visual cycle. Several studies have reported that the RDH family may play crucial roles in tumor prognosis. However, the role of RDH5 in tumor prognosis is still unclear. We examined the mRNA level of RDH5 by using q-PCR in hepatocellular carcinoma (HCC) and adjacent non-cancerous tissues. The proliferation rate of HCC cells was detected by MTS assay, and the invasive ability was examined by transwell and scratch wound assays. The YAP protein localization and expression were visualized by immunofluorescence in two different cell lines. CpG islands in the promoter region were predicted by using the methprimer database. Clinical characteristics of a patient cohort data came from The Cancer Genome Atlas database. RDH5 was significantly downregulated in hepatocellular carcinoma tissues, and low RDH5 expression was associated with metastasis and poor patient prognosis. Functional assays revealed that the RDH5 promoter is methylated in HCC cell lines. Moreover, overexpressing RDH5 can suppress metastasis by reversing the epithelial-mesenchymal transition (EMT) process, and RDH5 also inhibits cell proliferation in HCC cell lines. Furthermore, suppressing RDH5 can activate the Hippo/YAP signaling pathway and promote the nuclear translocation of YAP. Clinical data demonstrated that RDH5 is an independent prognostic factor in HCC. In our study, we provided the first evidence that RDH5 plays a crucial role in suppressing proliferation and metastasis, and the RDH5 promoter is methylated in hepatocellular carcinoma. And as an important regulator, RDH5 can suppress the Hippo/YAP signaling pathway. Taken together, it revealed that RDH5 might be a potential therapeutic target in HCC patients.
✓ 已验证
DOI
PubMed
高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Wang Xu,Yuhuang Huang,Zhuohan Lin,Qiaohui Ruan,PeiQing Yuan,Yan Li
Efficient zeolitic recycling of polyolefin waste into C2–C4 light olefins offers an attractive route toward resource recovery; however, conventional zeolite catalysts suffer from severe mass transport limitations that lead to undesired secondary reactions and coke formation. Here, we report a “structure modulation and intelligent optimization” strategy to develop hierarchical ZSM-5 (H-ZSM-5), integrating tailored mesoporosity and crystal size control via Bayesian optimization (BO). Catalytic performance was evaluated in a two-stage system combining thermal pyrolysis and subsequent catalytic cracking. BO efficiently navigates this multivariate design space, identifying an optimal architecture (∼100 nm crystals, 4.0 nm mesopores) that achieved 92.6 wt % total gas yield and 85.1 wt % light olefin selectivity at 500 °C with a low catalyst-to-feed ratio (0.2). The nanoscale H-ZSM-5 also exhibited durability over 40 consecutive cycles and broad compatibility with postconsumer plastic mixtures. Mechanistic studies revealed that the synergy between nanoscale morphology and hierarchical porosity enhances mass transport and acid site accessibility, demonstrating that complex catalyst architectures can be precisely optimized via artificial intelligence strategies, such as BO.
✓ 已验证
产品关联
DOI
高影响因子
FITOTERAPIA
·
2025
·
IF 2.6
Shiyu Li,Kai Xu,Shanpeng Ma,Xueying Qin,Li Jiang,Xiaohong Hou,Zibo Dong,Xun Gao,Lingling Huo
Currently, coronary heart disease (CHD) is prevalent worldwide, with its harmful impact second only to that of malignant tumors. A growing number of studies have confirmed that Choerospondias axillaris can significantly improve the therapeutic effect of CHD treatment and reduce the incidence of adverse reactions. However, its bioactive components and pharmacological mechanisms remain unclear. Based on a targeted fishing strategy, this study synthesized magnetic nanomaterials immobilized with 5-lipoxygenase (5-LOX) for screening and identifying 5-LOX inhibitors from the crude extract of Choerospondias axillaris . A total of 21 active components were identified and analyzed using ultra-high performance liquid chromatography-Q-Exactive Orbitrap tandem mass spectrometry (UHPLC-Q-Exactive Orbitrap-MS/MS). By comparing the screened active components with reported 5-LOX inhibitors, 9 novel 5-LOX inhibitors were discovered. Further molecular docking was performed on these 9 inhibitors, and the pharmacological activity of the selected ligands was verified using a 5-LOX inhibitor screening kit (fluorescence method).The compounds are ranked by activity from strongest to weakest: Lobetyolin (23.92 μM), Anhydroicaritin (29.55 μM), Narirutin(33.66 μM), Fisetin (47.28 μM) and Naringin(59.02 μM). This novel enzyme-immobilized targeted fishing technology is expected to efficiently and accurately screen bioactive components targeting different receptors from complex substrates.
✓ 已验证
DOI
PubMed
高影响因子
American Journal of Cancer Research
·
2022
·
IF 5.942
Yuxin Zhuang,Guang Yang,Shaoyu Wu,Jianjun Chen,Jiayin Guo,Dongling Quan,Tingting Zhang,Zichao Yang,Shaobin Tan,Yuheng Ji,Zhipeng Chen,Lin Lv
The composition of microtubules involving several steps, including the polymerization and depolymerization of α-tubulin and β-tubulin heterodimers. Microtubule-targeting agents can increase or inhibit microtubule polymerization, thereby disrupting the dynamic process and stalling cells in G2/M phase. Microtubule-targeting agents are generally cytotoxic, which neurological toxicity being one of the significant adverse events associated. We recently reported a novel 5-arylalkynyl-2-benzoyl thiophene (PST-3) that exhibited broad-spectrum cellular cytotoxicity and in vivo potency with high safety. PST-3 was a substrate of p-gp, which could not cross the blood-brain barrier and lead to less neurotoxicity. The antitumor activities in vitro demonstrated that PST-3 combined with the colchicine-binding site on microtubule, induces morphological changes, disrupts microtubule networks, inhibits polymerization of tubulin, arrests breast cancer cells in the G2/M phase of the cell cycle and induces apoptosis. Evaluation of the antitumor effect in vivo demonstrated that PST-3 elicited MDA-MB-468 tumor %T/C of 11.75%, whereas elicited MCF7 tumor %T/C of 44.38% in breast cancer xenograft models. Besides, in vivo experiments of a higher dose (60 mg/kg) of PST-3 treatment for 21 days did not produce any significant neurotoxicity. These results provide evidence that PST-3 might possess the potential to be developed into a new microtubule inhibitor without neurological toxicity.
✓ 已验证
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2025
·Vol. 36
·期 17
·175701
·
IF 2.8
Wenjuan Zhang,Kangning Xiong,Dashuai Yan
The wear and corrosion resistance of water-based polytetrafluoroethylene (PTFE) coating need to be further improved to cope with various harsh environmental conditions. In this paper, a mulberry-like ZSM-5 molecular sieve was prepared and then was modified to enhance the uniformity, wear resistance and hardness of PTFE coating. In addition, a ZSM-5/MoS2/PTFE coating was developed by adding MoS2 in the chemical composition of coatings, which significantly increased the critical cracking thickness of PTFE to 27 μm. The wear amount of ZSM-5/MoS2/PTFE coating is only 5.7 mg, and after 680 h of salt spray, there is no obvious corrosion on the surface. The friction coefficients under applied loads of 5 N, 10 N, and 20 N are 0.007, 0.057, and 0.055, respectively. The experiment results show that the coating possesses excellent lubrication, wear resistance, and corrosion resistance, and its performance and cost are far superior to commercial products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2021
·Vol. 40
·期 2
·247-255
·
IF 6
Qian Wang,Huanshun Yin,Yunlei Zhou,Lulu Cao,Zhengkun Yu,Yamin Xu,Shiyun Ai
Comprehensive Summary As a key epigenetic modification, 5-formylcytosine (5fC) controls many important cell functions, such as gene expression and cell differentiation. However, 5fC exists in mammalian tissues and cells with low content, and its structure is highly similar to 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-carboxycytosine (5caC), which requires the detection method for detecting 5fC with high sensitivity and specificity. In this experiment, WS 2 /Bi/Bi 2 O 2 CO 3 was used as the photoactive material, 5fC antibody was used as the target molecule recognition reagent, and rolling amplification (RCA) was employed as the signal amplification strategy to construct a novel photoelectrochemical biosensor for detecting 5-formylcytosine deoxynucleotide (5fdCTP). Firstly, WS 2 /Bi/Bi 2 O 2 CO 3 nanocomposite was prepared and characterized, and then modified on the ITO electrode. Then, polyacrylic acid (PAA) was immobilized by electrostatic adsorption, which was employed as the antibody capture reagent based on the covalent reaction of –COOH on PAA with –NH 2 on Ab. Subsequently, 5fdCTP was recognized through immunoreaction, triggering the subsequent rolling circle amplification reaction with the aid of the crosslinker of Zr 4+ . Finally, positive methylene blue (MB) was adsorbed by negative ssDNA, resulting in an increased photoelectric conversion efficiency of WS 2 /Bi/Bi 2 O 2 CO 3 and improved detection sensitivity. The linear range of the PEC biosensor for detecting 5fdCTP was 0.05—100 nmol/L, and the minimum detection concentration was 12.4 pmol/L (S/N = 3). The applicability of this method has been evaluated by studying the influence of Cd 2+ and antibiotic concentration on the 5fC content in the genomic DNA of maize seedlings.
✓ 已验证
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Lifang Cao,Pu Wang,Yuhan Tang,Hong Liu,Jiasheng Wang
Amorphous ZSM-5 was facilely synthesized by simply tuning the aqua ammonia amount and used as support of Mo-V-O for aerobic oxidation desulfurization. It was found that both geometric and electronic effects help to enhance the catalytic performance. Geometrically, the amorphous ZSM-5 could better disperse the metals due to its higher specific area. Electronically, the amorphous ZSM-5 could enable V to enrich electrons availing for oxygen activation to superoxide radical thanks to its low work function. The superoxide radical combines with Mo to form peroxide and then oxidize the sulfur-containing substrates. 100% desulfurization can be realized at 80°C for model oil with sulfur content of 500 ppm over the amorphous ZSM-5 supported Mo-V-O catalyst. This study provides inspiration for designing efficient catalysts for aerobic oxidation desulfurization.
✓ 已验证
产品关联
DOI
高影响因子
BIOMASS & BIOENERGY
·
2025
·
IF 5.8
Junxiang Wang,Xu Wang,Xiaoyan Liu,Yanfei Feng,Yukun Wan,Hui Yang
Electrocatalytic 5-hydroxymethylfurfural oxidation reaction (HMFOR) to produce 2,5-furanedicarboxylic acid (FDCA) offers a promising strategy to produce high value chemicals. Herein, CuO(S-ER-1.5) with excellent catalytic performance was prepared by anodic oxidation, sulfidation and electrochemical reconstruction on the substrate of copper foam. The experimental results of catalytic performance showed that CuO(S-ER-1.5) can catalyze HMFOR with a high current density (200 mA cm −2 ) at a low potential (1.48 V vs RHE) and exhibit outstanding stability. The open-circuit potential time test displayed that more HMF molecules were adsorbed in the Helmholtz layer of CuO(S-ER-1.5), which proved that the CuO(S-ER-1.5) could improve the kinetic adsorption of HMF. The electrochemical impedance spectroscopy further showed that CuO(S-ER-1.5) had faster reaction kinetics than Cu(OH) 2 precursor. The product analysis showed that CuO(S-ER-1.5) electrocatalytic HMFOR followed the DFF path, and the catalytic mechanism was explored by the three-step rate deconvolution procedure. It was found that CuO(S-ER-1.5) electrocatalytic HMFOR was dominated by direct oxidation reaction. This work provides a valuable guidance for the synthesis of value-added chemicals FDCA by electrocatalytic HMFOR.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）