TALANTA
·
2026
·
IF 6.7
Hang Tian,Lingli Qu,Shihui Chen,Zhuwang Shao,Kerui Li,Qinghong Zhang,Yaogang Li,Hongzhi Wang,Chengyi Hou
Wearable cortisol monitoring offers a noninvasive approach for assessing dynamic physiological stress, but reliable on-body analysis remains challenging owing to limited sweat availability, unstable electrode contact, and use-induced mechanical deformation. Here, we report a compartmentalized multi-lumen, hydrogel-integrated cortisol-sensing fiber (HCSF) for rapid and reliable detection of cortisol in sweat that combines sweat collection, molecular recognition, and wireless readout in a glove-based wearable platform. The interface-engineered interlayer provides topological anchoring for the MIP matrix and promotes efficient charge transfer, while the porous compartmentalized hydrogel sheath functions as an in situ sweat collector, hydrated ion-conducting medium, electrode spacer, and mechanical buffer, collectively stabilizing the fiber–polymer interface under repeated bending. With Prussian blue embedded in the MIP network as an internal redox probe, the sensor enables label-free quantitative cortisol detection through steric-hindrance-mediated signal modulation, achieving a low limit of detection of 0.87 pM and a broad linear range from 1 pM to 10 μM. After integration into a wearable glove with a miniaturized wireless readout module, the platform tracks dynamic cortisol fluctuations during physical exercise and acute cold-pressor tests. This robust and ergonomically integrated platform provides a promising strategy for noninvasive endocrine monitoring and personalized stress assessment.
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高影响因子
ACS Applied Energy Materials
·
2026
·
IF 5.5
Zhang Lei,Zhang Yunlong,Zhao Mengfan,Wang Jing,Hou Yifan,Liu Jifan,Huang Jitao,Wang Qian,Jin Zhong,Wang Shi
While polymer electrolytes offer a promising path to suppress dendrite growth and side reactions in aqueous zinc-ion batteries, their implementation often compromises ion transport kinetics and interfacial stability. Here, we report an ion-regulating copolymer electrolyte, poly(4-acryloylmorpholine)-co-poly(3-sulfopropyldimethyl-3-methacrylamidopropylammonium inner salt), engineered through a facile one-pot synthesis. This molecularly designed architecture combines multi-dentate zinc-binding sites with dynamic zwitterionic channels, enabling simultaneous anion confinement and rapid zinc-ion transport. The copolymer electrolyte promotes uniform ion flux and dense zinc deposition while maintaining intimate electrode contact, effectively eliminating dendrite formation and interfacial degradation. Symmetric Zn||Zn cells achieve excellent cycling stability over 1400 h with minimal polarization (∼110 mV) at 0.5 mA cm –2 . When integrated with V 2 O 5 cathodes, full cells exhibit outstanding reversibility, rate capability, and cycling durability. This work demonstrates a rational electrolyte design strategy that synchronizes bulk and interfacial ion regulation, providing a viable platform for high-performance, long-lived zinc batteries.
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高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Anzhuo Weng,Dongxu Jia,Xin Chen,Xinyan Zheng,Wei Yang,Yujuan Jia,Tongtong Yin,Yanxia Zhang,Qian Yu
Biofilm-associated infections remain a major challenge, as the inherent recalcitrance of the extracellular polymeric substance matrix renders conventional antibiotics ineffective, further driving antimicrobial resistance. To address this, combination therapies have emerged as a potent strategy to enhance therapeutic outcomes. In this study, a dual-functional, antibiotic-free nanoplatform was designed to eradicate biofilms through combined quorum sensing (QS) inhibition and chemodynamic therapy (CDT). This nanoplatform consists of calcium peroxide (CaO2) nanoparticles coated with a quercetin/copper ion (Qe/Cu2+) complex. Upon exposure to the acidic biofilm microenvironment, the Qe/Cu2+ complex dissociates, releasing Qe and Cu2+ while exposing the CaO2 core. The subsequent reaction of CaO2 with water generates hydrogen peroxide, which is then catalyzed by Cu2+ via a Fenton-like reaction to produce highly bactericidal hydroxyl radicals. Simultaneously, Qe disrupts bacterial QS pathways, attenuating pathogenicity and sensitizing the biofilm-embedded bacteria to oxidative damage. This antibiotic-free nanoplatform demonstrated robust in vitro antibiofilm activity against Pseudomonas aeruginosa and Staphylococcus aureus, while significantly reducing bacterial colonization and accelerating wound healing in an infected mouse model, suggesting that the synergetic integration of QS inhibition and CDT represents a promising strategy for combating biofilm-associated infections.
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NANO
·
2026
·
IF 1.3
Zhida Yang,Wenkai Wang,Binbin Gao,Tianzi Xu,Dongxue Zhou,Rongjie Li,Wei Liu,Honglu Liang,Guangsheng Dong,Hongzhi Yuan,Wenjun Dong,Honglin Chen
The Cu@Ag core-shell particles can be employed as conductive phase in conductor paste. Ag shell is designed to protect Cu core from oxidation. To obtain thin, dense and uniform Ag shell on Cu core, a novel electroless Ag plating process for Ag coating is developed. In the process, acacia gum (AG) acts as surfactant and dispersant, manipulating Ag deposition on Cu slowly and accurately. Benefit from the reduction potential difference between Ag and Cu, a thin reduced Ag shell is plated on Cu core with layer growth mode firstly. Then, inhomogeneous surface energy of Ag shell commands its following growth with an island mode. Finally, these Ag islands grow to contact and bond together, resulting in an uniform and dense Ag shell for Cu@Ag. After optimization, the Cu@Ag particle shows excellent oxidation resistant. A mass increase of only 0.5% is observed in it at 300°C. Meanwhile, the Cu@Ag with regular structure also presents remarkable volume conductivity. Over all, the spectacular performance of prepared Cu@Ag powder indicates its promising application in conductive paste.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Andong Hu,Bing Li,Shang Yang,Ruili Li,Yuefei Huang,Shungui Zhou,Guangqian Wang
The mobilization of abundant but immobilized phosphorus into bioavailable forms is conventionally attributed to microbial metabolite production. Yet the persistence of reductive transformations in hydrodynamically active environments with limited microbial metabolism implies a previously overlooked abiotic pathway. Here, we reveal hydrodynamic-driven phosphorus mobilization via a piezoelectric energy-transduction pathway. Hydrodynamic forces enhanced phosphate release 3-fold in natural intertidal sediments, whereas ultrasonic treatment further elevated the release through processes operating independently of microbial activity. Mechanistic investigation confirmed that piezoelectrically generated electrons directly reduce Fe(III) species, releasing mineral-bound phosphate while simultaneously facilitating secondary mineral formation. This pathway fundamentally challenges the established paradigm of biologically dominated phosphorus cycling and establishes hydrodynamic energy as a primary driver of phosphorus transformation. Given the global distribution of hydrodynamic energy and piezoelectric minerals, this mechanism likely operates worldwide, particularly under climate-intensified hydrodynamic conditions. These processes may elevate aquatic nutrient fluxes and eutrophication risks, highlighting the need to quantify their environmental significance and develop management strategies. In addition, our findings could advance the interpretation of historical phosphorus cycling while enabling sustainable phosphorus recovery through piezoelectric processes.
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高影响因子
ACS Omega
·
2026
·
IF 5.2
Jingjing Kuang,Yu An,Jianguo Zhu,Kehua Jiang,Fa Sun,Kun Chen
Interleukin-7 (IL7) plays a pivotal role in T cell biology; however, its therapeutic potential is constrained by its short half-life. Conventional chemical biotinylation frequently results in random modifications that compromise its bioactivity. This study endeavors to establish a prokaryotic system for the site-specific biotinylation of IL7 utilizing AviTag and underscores its advantages over random biotinylation in retaining functionality. A recombinant plasmid (pET-Dual-His-IL7-avi-birA) was constructed to coexpress AviTag-fused IL7 and BirA ligase, which was subsequently transformed into Escherichia coli BL21(DE3). Optimal expression conditions were determined as follows: cultivation at 37 °C with shaking at 200 rpm for 12 h following induction with 0.5 mM IPTG in the presence of 80 μM biotin. The expressed protein, predominantly localized in inclusion bodies, was purified using Ni-NTA resin supplemented with 250 mM imidazole. Biotinylation efficiency was confirmed through Western blot analysis and native polyacrylamide gel electrophoresis (PAGE). Functional characterization encompassed T cell proliferation and apoptosis assays employing CCK-8 methodology and flow cytometry, respectively, alongside comparative analyses against chemically randomized biotinylated IL7. Site-specifically biotinylated IL7 (biotin-IL7) was successfully generated and purified. It specifically bound streptavidin and retained T cell proliferative activity comparable to native IL7. Compared with randomly biotinylated IL7, site-specific exhibited stronger induction of T cell proliferation, less interference with antibody binding, and more effective downregulation of T cell apoptosis. The AviTag/BirA-based biotinylation system provides an efficient, economical, and scalable method for producing functional biotin-IL7 with enhanced stability and targeting potential. The key advantages of site-specific over random biotinylation were confirmed: preservation of IL7’s bioactivity, reduction of functional interference, and enhancement of therapeutic efficacy. This approach offers a paradigm for optimizing small therapeutic proteins, particularly in cancer immunotherapy, while highlighting the need to improve soluble expression and biotinylation efficiency.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Wenyue Du,Rongcai Jia,Liang Guo,Yanlu Yang
Accurate and rapid ammonia detection is critical for environmental monitoring and clinical diagnosis of chronic kidney disease. Herein, a highly sensitive room-temperature ionic liquid (RTIL) in electrochemical ammonia sensor based on a Pt-Ru electrode was developed for detecting ammonia concentrations ranging from 0 to 100 ppm. To achieve prolonged operational life and stability, 1-(2-hydroxyethyl)-3-methylimidazolium tetrafluoroborate ([HOETMIM][BF 4 ]) was utilized as the electrolyte. Nickel cobaltite (NiCo 2 O 4 ) and γ-MnO 2 were synthesized separately via hydrothermal methods. The effects of modified ionic liquids on the sensor’s performance were investigated by incorporating different mass fractions of NiCo 2 O 4 and γ-MnO 2 . Comprehensive analyses, including X-ray diffraction (XRD), scanning electron microscopy (SEM), Mapping, energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS), confirmed the successful and rational synthesis of the samples. The ammonia sensing performance of the ILs/NiCo 2 O 4 /γ-MnO 2 sensor was studied at room temperature (25°C) using constant potential polarization (it) and electrochemical impedance spectroscopy (EIS) techniques. The testing data demonstrated that the optimized ILs/NiCo 2 O 4 /γ-MnO 2 sensor(5 wt% composite, 1:1 mass ratio) exhibited good sensitivity of 0.10 ± 0.02 μA/ppm, a limit of detection(LOD) of 1 ± 0.2 ppm, and a limit of quantification(LOQ) of 3 ± 0.5 ppm. The response and recovery times show clear difference among different sysrems: pure IL system exhibited 510 s/530 s, 5 wt% composite modified system achieved 12.22 s/3.6 s, and the fastest recorded values in batch tests were 17 s/14.5 s. Compared to traditional ionic liquid sensors, the ILs/NiCo 2 O 4 /γ-MnO 2 sensor demonstrated a significant improvement in ammonia sensing performance, with a selectivity ratio > 10 against common interfering gases.
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高影响因子
ADVANCED POWDER TECHNOLOGY
·
2026
·Vol. 37
·期 11
·105471
·
IF 4.5
Fuhua Luo,Dan Liu,Pan Yu,Luyi Xu,Mingyan An,Songlin Chen,Shuming Wen
During the separation process of pyrite and chalcopyrite, baicalin has an inhibitory effect on pyrite. • The adsorption amount of baicalin on pyrite is greater than that on chalcopyrite. • It elucidates the adsorption mechanism of baicalin on the surface of pyrite. • Baicalin adsorbed on pyrite and blocked subsequent collector adsorption on the mineral surface. In this study, baicalin (BA), a flavonoid compound, was used as a depressant for the selective separation of chalcopyrite and pyrite. The performance and mechanism of the depressant were comprehensively investigated. BA exhibited selective inhibition of pyrite during flotation separation. Under conditions of pH = 6, a BA dosage of 20 mg/L, a potassium butyl xanthate (KBX) dosage of 15 mg/L, and a MIBC dosage of 20 mg/L, the copper recovery rate in the concentrate reached 74.51%, with a grade of 33.707%. Contact angle and ToF-SIMS measurements showed that BA exhibited selective adsorption on the pyrite surface, thereby enhancing surface hydrophilicity. In contrast, the adsorption of BA on the chalcopyrite surface was found to be negligible. XPS and FTIR analyses further confirmed that the carboxyl or hydroxyl groups in baicalin exhibit strong adsorption at Fe sites on the surface of pyrite, whereas adsorption on the surface of chalcopyrite is weaker. Therefore, BA has the potential to serve as a depressant for the selective separation of chalcopyrite and pyrite. As a flavonoid, BA contains carboxyl (–COO) and hydroxyl (–OH) groups, which readily interact with active metal sites on the mineral surface. XPS results further confirm that the carboxyl (–COO) or hydroxyl (–OH) groups of BA interact with Fe ion sites on the surface of pyrite, while FTIR results further confirm that BA exhibits strong adsorption through the interaction of its hydroxyl (–OH) groups with Fe ion sites on the surface of pyrite. BA adsorbed on the pyrite surface occupies space and exerts electrostatic repulsion, thereby hindering the adsorption of KBX on the pyrite surface, thus achieving the selective flotation separation of pyrite and chalcopyrite. Based on the experimental results and mechanistic analysis, the adsorption of BA and KBX on pyrite and chalcopyrite was qualitatively simulated; Fig. 16 shows a schematic diagram of the qualitative adsorption of BA and KBX on pyrite and chalcopyrite. Download: Download high-res image (206KB) Download: Download full-size image
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-16
·
IF 12.6
Jin Yi,Yang Nengjie,Chen Siyu,Wei Yanan,Wei Xiangyu,Zhu Yujuan,Sun Chi
The inflammatory cascade is a key driver of chronic inflammation in rheumatoid arthritis (RA) and facilitates the migration of circulating immune cells into the inflamed joints. Recent studies have unveiled the complexity of this cascade, which involves intricate interactions between immune cells, neutrophil extracellular traps (NETs), reactive oxygen species (ROS), and inflammatory cytokines. Given the central role of the inflammatory cascade in RA pathogenesis, targeting it represents a highly promising therapeutic strategy. However, research specifically focused on modulating the inflammatory cascade remains limited. In this study, we introduce a novel bioinspired catalytic nanogel designed to target the inflammatory cascade for the immunotherapy of RA. Nanogel coated with cationic polymer enables the targeted penetration into cartilage as well as the capture of NETs via charge-trapping effects. The captured NETs are further degraded by DNase I-conjugating nanogel. To fundamentally reduce ROS that can induce NETs generation, nanogels exhibit intrinsic catalase, superoxide dismutase, and hydroxyl radical activities, effectively inhibiting oxidative stress responses. Of note, the enhanced therapeutic effects are observed in mouse RA model including targeted and long-term accumulation of cascade nanogel in the inflamed joints, efficient NETs scavenging, alleviated intra-articular inflammation, and reduced bone destruction. Also, transcriptome analysis indicates that nanogel treatment markedly downregulates NETs formation signaling pathway, upregulates anti-inflammatory pathways and finally reduces neutrophil infiltration-caused autoimmune damage. These results make the bioinspired catalytic nanogel system an ideal inflammatory cascades-targeting therapy for the systemic autoimmune disease.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Shan Li,Longlong Zhang,Bin Xu,Weihua Qin,Mengdan Wang,Bingli Pan,Hongyu Liu,Honggang Wang
Nanoparticles are of great significance to enhance tribological performances and can be employed as effective lubricant additives. 1T-MoS 2 has been widely applied in many fields. However, it is rarely studied in lubrication application. In this study, a novel core-shell lubricant additive was prepared by combining CuNi-MOF and 1T-MoS 2 via a facile hydrothermal method. The as-prepared CuNi-MOF@1T-MoS 2 exhibited a flower-like structure. Both experimental and theoretical calculation results showed the interlamellar interactions between the layered 1T-MoS 2 and CuNi-MOF sheets. Tribological properties of PEG200 containing CuNi-MOF@1T-MoS 2 were systematically investigated by a four-ball test machine. In comparison with PEG200, the friction coefficient and wear scar diameter were remarkably reduced by 56.8 % and 34.0 %, respectively. Therefore, the combination of 1T-MoS 2 and CuNi-MOF presents a promising candidate for enhancing the tribological properties of PEG200.
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ACS Catalysis
·
2026
·
IF 13.6
Yong Tang,Yongqi Zeng,Chunyu Wang,Chuang Du,Fengxi Li,Lei Wang
The stereoselective cross-dehydrogenative coupling (CDC) reaction represents a highly promising approach for the direct synthesis of high-value non-natural amino acids. The photoenzyme cascade strategy synergistically integrates the reactivity of photocatalysts with the selectivity of enzymes, demonstrating attractive potential for eco-friendly asymmetric synthesis. In this study, we report a photoartificial CDCase cascade method for the asymmetric CDC reaction between N-aryl glycine esters and cycloketones. The optimal artificial CDCase was constructed by anchoring the biotinylated Cu-phenanthroline cofactor (5-NH2Phen-biotin*Cu(OAc)2) within the double mutant (S112H–K121M) of streptavidin obtained through genetic engineering optimization. In a mild aqueous medium, the resulting artificial CDCase cooperates with photocatalysis, efficiently catalyzing the asymmetric CDC reaction at a low enzyme loading (0.5 mol %), yielding a series of α-cycloketone-substituted N-aryl glycine esters with good yields and stereoselectivities. Comprehensive molecular docking and molecular dynamics (MD) simulations provided insights into the critical complex intermediates involved in the proposed reaction mechanism and clarified the interactions between the artificial CDCase and its substrates. Furthermore, through analysis of interatomic distances between pivotal reactive carbon centers and probable nucleophilic attack directions, we have deciphered the structural foundation underlying the formation of the predominant conformation, concurrently rationalizing the enhanced reactivity and stereoselectivity observed for the S112H–K121 M mutant.
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CELL
·
2026
·
IF 42.5
Xiao-Yan Ge,Jie Cheng,Li-Jun Zhang,Lu-Lu Guo,Rui Xiang,Yan Lu,Shang-Lei Ning,Kai-Yu Wang,Kong-Kai Zhu,Ming-Xin Gao,Yue Li,Yu-Song Zhang,Nai-Kang Rong,Xiang Han,Ming-Hui Zhang,Le Fang,Yun-Fei Xu,Su-Wen Zhao,Qian Li,Fan Yang,Yong Hao,Ren-Jie Chai,Xiao Yu,Ji-Chun Yang,Jin-Peng Sun
Oxylipins are important metabolic messengers for normal life activities, and olfactory receptors (ORs) are known for their low affinity for odor and are not considered oxylipin receptors. By developing the “anonymous receptor identification by reverse-G-protein pull-down” (ARIG) method, we identify orphan OR Or5v1/Olfr110 as an oxylipin 12(S)-hydroxyeicosapentaenoic acid (12(S)-HEPE) receptor. The serum from obese patients with increased BMI showed lower Or5v1/Olfr110-Gs activation compared with normal people. Systemic Or5v1/Olfr110 deficiency or liver-specific Or5v1/Olfr110 deficiency impaired glucose homeostasis, even after stimulation with 12(S)-HEPE. Engagement of 12(S)-HEPE with Olfr110 activated Gs-PKA-pATF2-Cpt1α signaling to reduce obesity through promotion of fatty acid oxidation in liver. Structural aided development of synthetic agonist HOR1-C59 improved glucose homeostasis, which is dependent on Or5v1/Olfr110 expression. Overall, we revealed that a high-affinity oxylipin-sensing OR plays key roles in metabolism. The beneficial effects of HOR1-C59 underscore the therapeutic value of small synthetic compounds that target ORs for disease treatment.
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