TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2020
·
IF 3.347
Yang Zhang,Jiabei Zhou,Qin Ye,Kui Zeng,Jie Pan,Lu Chen,Yingying Wang,Bo Yang,Qiaojun He,Jianqing Gao,Su Zeng,Lushan Yu
Thioredoxin 1 (Trx1) and telomerase play key roles in the development and progression process of most tumors, and they both are promising drug therapy targets. We have, for the first time, discovered that Trx1 and telomerase had a dual-target synergistic effect. Based on that results, we designed a series of 6-dithio-2′-deoxyguanosine analogs (named as YLS00X) and verified whether they can inhibit Trx1 and telomerase simultaneously. TrxR1/Trx1 system activity and telomerase expression were significantly inhibited by 6-dithio-2′-deoxyguanosine analogs, especially YLS004. YLS004 can also cause ROS accumulation, and induce tumor cell apoptosis . The vitro antitumor activity of 6-dithio-2′-deoxyguanosine analogs using MTT assay on 11 different human cancer cells and found that human colon cancer cells(HCT116) and melanoma cells (A375) were the most sensitive cells to 6-dithio-2′-deoxyguanosine analogs treatment and vivo xenografts models also confirmed that. The serum biochemical parameters and multiple organs HE staining results of subacute experiments indicated that YLS004 might be mildly toxic to immune organs, including the thymus, spleen, and hematopoietic system . Besides, YLS004 was rapidly metabolized in the rats' blood. Our study revealed that YLS004, a Trx1 and telomerase inhibitor , has strong anti-tumor effects to colon cancer and melanoma cells and is a promising new candidate drug.
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PubMed
高影响因子
JOURNAL OF RARE EARTHS
·
2026
·
IF 9.6
Zhaojing Kuang,Chenhao Yang,Panpan Li,Yongmin Duan,Wenyan Zheng,Mengdi Ye,Ying Tian
The rapid growth of artificial intelligence is driving demand for secure and rewritable optical information technologies. Bi-based photochromic glasses are promising, yet achieving high optical contrast, stable rewritability, and controllable formation of low-valence Bi species remains challenging. Here, Ce partially replaces Sb to regulate the multivalent redox environment, while Eu 3+ provides luminescent readout. The optimized glass containing 0.2 mol% CeO 2 exhibits a coloration contrast of 24.85% within 30 s, 4.3 times that of the Ce-free glass, and reaches 70.86% after 130 s of 465 nm irradiation. It exhibits a relative transmittance recovery of 99.66% after heating at 300 °C for 5 min and retains 98% of its coloration contrast after 50 writing–bleaching cycles. Photochromism-induced optical attenuation enables a reversible Eu 3+ emission modulation of 84.78% in the optimized glass. Combined X-ray photoelectron spectroscopy (XPS), electron paramagnetic resonance (EPR), and high-resolution transmission electron microscopy (HRTEM) analyses indicate that Ce substitution regulates charge redistribution among Bi/Sb/Ce redox centers and oxygen-related localized states, facilitating reversible Bi 3+ reduction and the photoinduced formation of low-valence Bi-related nanoclusters. The coupled coloration and luminescence responses enable rewritable pattern recording, dual-mode optical verification, and matrix-based information encoding and reconstruction, providing an integrated Bi-based glass medium for multimodal optical storage and encryption.
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高影响因子
ChemCatChem
·
2019
·Vol. 12
·期 5
·1376-1384
·
IF 4.495
Wen-Di Guo,Lei Liu,Shu-Qing Yang,Xiao-Chao Chen,Yong Lu,Giang VO-Thanh,Ye Liu
Graphical Synergetic catalysis : The one-pot tandem bis-alkoxycarbonylation of alkynes was accomplished over the bi-functional catalytic system containing Xantphos-modified Pd-complex and Lewis super-acid of Al(OTf) 3 . Via the synergetic catalysis, the involved Xantphos-modified Pd-complex was responsible for the activation of CO and the alkynes through coordination to Pd-center while Al(OTf) 3 was in charge of the activation of the alcohol to facilitate the formation of [Pd−H] + active species. Tandem bis-alkoxycarbonylation of alkynes allows for the preparation of 2-substituted succinates from alkynes and nucleophile alcohol via two successive alkoxycarbonylation with advantages of 100 % atomic economy and simplified one-pot operation. Herein, the one-pot tandem bis-alkoxycarbonylation of alkynes was accomplished over the bi-functional catalytic system containing Xantphos-modified Pd-complex and Lewis super-acid of Al(OTf) 3 . It was found that, via the synergetic catalysis, the involved Xantphos-modified Pd-complex was responsible for the activation of CO and the alkynes through coordination to Pd-center while Al(OTf) 3 was in charge of the activation of the alcohol to facilitate the formation of [Pd−H] + active species. The in situ high-pressure FT-IR analysis, coupled with 1 H/ 13 C NMR spectral characterizations, confirmed that the introduced Al(OTf) 3 with intensive oxophilicity (via acid-base pair interaction) was able to activate nucleophilic MeOH to be a reliable proton-donor ( i. e . hydride-source) to warrant the formation and stability of [Pd−H] + species upon the oxidation of Pd 0 by H + (Pd 0 +H + →[Pd II −H] + ). Over the developed bi-functional catalytic system, the yields of the target diesters were obtained in the range of 36∼86 % in this sequence with the wide substrate scope.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Nan Wang,Xing Li,Yanling Yang,Tingting Guo,Xiaoxuan Zhuang,Siyang Ji,Tingting Zhang,Yi Shang,Zhiwei Zhou
The antibiotic sulfamethazine (SMT) has emerged as a water pollutant that is recalcitrant to conventional water treatment process. A number of technologies based on hydroxyl radical or sulfate radical induced SMT degradation have been described, but photo-induced degradation is not widely examined. Herein, photocatalysts of Bi-doped TiO 2 nano-composites supported by powdered activated carbon (PAC) were prepared, with variable molar ratios of Bi/Ti (0.06:1(6%), 0.08:1(8%), 0.1:1(10%) and 0.12:1(12%)) by a sol-hydrothermal method. The ratio of 10% (Bi-Ti/PAC (10%)) was most efficient to degrade SMT. Experimental variables during photocatalytic degradation were optimized for solution pH, catalyst dosage, initial SMT concentration, and coexisted anions. Under optimal conditions of 1.0 g/L catalyst, 20 mg/L initial SMT concentration, pH 6.0 and visible light irradiation at 400–780 nm, the degradation rate reached 81.18% in 300 min. Compared to Bi-Ti(10%) nano-composite without PAC, pure TiO 2 or commercially available P 25 , Bi-Ti/PAC(10%) was superior for SMT degradation with a degradation kinetic rate of 0.00531 min −1 . The properties of the prepared photocatalysts were characterized by X-ray powder diffraction, scanning electron microscope, X-ray photo-electron spectroscopy, Brunauer-Emmett-Teller and ultraviolet-visible diffuse reflection spectroscopy. This revealed that Bi-Ti/PAC (10%) had a smaller crystal size, larger specific surface area, larger pore size, stronger visible light absorption ability and lower band gap energy than pure TiO 2 . Ten intermediates of SMT were identified and a possible degradation pathway was proposed.
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高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Gangqiang Zhu,Mirabbos Hojamberdiev,Shaolin Zhang,Syed Taj Ud Din,Woochul Yang
In order to further improve its photocatalytic activity , the BiOI microspheres were activated by a synchronous coupling of Bi metal and graphene under solvothermal conditions. The effects of the synthesis temperature (160–200 °C) on crystallinity, morphology, and photocatalytic activity were studied in particular. As expected, the ternary Bi-BiOI/graphene photocatalyst synthesized at 180 °C exhibited higher photocatalytic activity for NO oxidation removal under visible light irradiation than individual BiOI, and binary Bi-BiOI and BiOI/graphene composites. The photocatalytic efficiency for the NO removal of the ternary Bi-BiOI/graphene photocatalyst synthesized at 180 °C reached 51.8% within 30 min of visible light irradiation. The enhanced photocatalytic activity of the ternary Bi-BiOI/graphene photocatalyst is attributed to (I) the efficient transfer of photo-generated electrons from BiOI and Bi to graphene, leading to the effective separation of the photo-generated electron-hole pairs and (II) the surface plasmon resonance effect of Bi nanoparticles in the composite photocatalyst. Furthermore, the results of the scavenger experiments and DMPO-ESR spin-trapping measurements reveal that O 2 − radical species play the most critical role and holes serve as a secondary active species in the oxidative removal process of NO by 180BOI/GR composite under visible light irradiation.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Dafeng Zhang,Hao Liu,Changhua Su,Hong Li,Yanling Geng
Bi/BiOBr composites with oxygen vacancies were synthesized by a simple combustion method. The as-synthesized catalysts were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, electron paramagnetic resonance spectroscopy, UV–Vis diffuse reflectance spectroscopy, and photoluminescence spectroscopy. Along with the formation of BiOBr, the reduction of partial Bi 3+ cations was achieved, and thus Bi/BiOBr composites were one-pot obtained. Moreover, the formation of oxygen vacancies was confirmed. Compared with pure BiOBr, Bi/BiOBr composites exhibit significantly improved photodegradation performances under visible light irradiation, which can be attributed to the surface plasma resonance effect, electron sink effect of metallic Bi nanoparticles, and the narrowed band gap caused by the formed oxygen vacancies. Moreover, the main active species and photocatalytic mechanism of Bi/BiOBr under visible light irradiation were discussed in detail.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2019
·
IF 7.65
Ningyuan Zhu,Chunquan Li,Lingjun Bu,Cilai Tang,Sichu Wang,Pengfei Duan,Lunguang Yao,Jun Tang,Dionysios D. Dionysiou,Yonghong Wu
An innovative advanced oxidation process was successfully developed to photocatalytic-degradation of estrone through the synergistic effect of biochar and Bi/Bi 2 O 3 in bismuth-containing photocatalytic biochar (BiPB). The highest reaction rate constant ( k obs ) of estrone degradation by BiPB was 0.045 min −1 under the conditions of initial concentration of estrone =10.4 μmol L −1 , [BiPB] =1 g L −1 , pH = 7.0. The k obs was almost tenfold and more than 20 times than that of biochar without bismuth impregnation and pristine Bi/Bi 2 O 3 , respectively. The best photocatalytic performance of BiPB composites for the degradation of estrone was primarily attributed to generation of OH radicals. Impregnation of bismuth helped control the concentration of persistent free radicals (PFRs) and develop a hierarchical porous structure of biochar. The presence of biochar facilitated pre-concentration estrone on BiPB and improved the separation and transfer efficiency of charge carriers. The synergistic effect between biochar and Bi/Bi 2 O 3 contributed to the generation of OH radicals for estrone degradation under neutral pH conditions. The transformation pathway of estrone was also proposed based on the measured transformation products in the presence of BiPB. The high efficiency of BiPB composites indicated that this easily-obtained material was promising for estrone-wastewater treatment applications as a low-cost composite photocatalyst.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Tao Wang,Stephan Handschuh-Wang,Panpan Qin,Yang Yang,Xuechang Zhou,Yongbing Tang
Colloidal stability of nanoparticles with particle sizes smaller than 100 nm is a critical issue for various research areas, including material science, electronics and biomedicine. We propose a facile, fast and cost-efficient method to increase the colloidal stability by simply adding organic molecules as ligands, which adsorb to the nanoparticle surface subsequently. Citric acid , oxalic acid , glutamic acid and propylamine were found to stabilize the nanodiamond (ND) particles with a mean diameter of approx. 30–100 nm. The charge of the particles could be controlled by the pH of the dispersions and by stabilizing with carboxylic acids or amino acids mentioned above. ND particles stabilized with citric acid and oxalic acid at a pH higher than 2.5 were negatively charged, while ND dispersions stabilized with glutamic acid were charged positively below a pH of 3.2. Furthermore, the stability of the dispersion was found to be dependent on the concentration of the stabilizing agent and the pH of the dispersion. Finally, we proposed the stabilizing mechanism of ND particles with propylamine. Glutamic acid and propylamine stabilized ND dispersions can be utilized for high seeding densities on negatively charged surfaces due to the amino-groups, which can be helpful for adsorption processes in electronics and material science. Due to the high biocompatibility, non-cytotoxicity and chemical inertness of ND particles, carboxylic acids and amino acids stabilized ND particles are envisaged to be useful in the biomedical field, i.e. bio-labels, drug delivery vehicles , and effective enterosorbent.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Tianyu Gong,Jinyang Zhang,Yang Liu,Linrui Hou,Jianlin Deng,Changzhou Yuan
It is an enormous challenge to develop low-cost non-noble metal bi-functional catalysts toward overall water splitting. The efficient water decomposition electrocatalysts need both intrinsic activities determined by electronic structure and superb mass transfer ability. For this, in the contribution, an efficient self-supported bi-functional catalyst, i.e. , nanoscale hetero Mo 2 C-CoO encapsulated in N -doped carbon nanofibers (Mo 2 C-CoO@ N -CNFs), is designed and fabricated with facile electrospinning avenue. Density functional theory and electrochemical investigation manifest that the synergistic effect of bimetallic Mo/Co accelerates kinetics of hydrogen evolution reaction (HER) and lowers the energy barrier of oxygen evolution reaction (OER). Thanks to the structural and compositional merits, the optimized integrated Mo 2 C-CoO@ N -CNFs film demonstrates remarkable catalytic activities in both OER and HER, and renders a current density of 10 mA cm −2 at 1.56 V when used for alkaline whole water cracking. The design concept here provides insights for future rational construction of advanced water decomposition catalysts.
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Xingshi Li,Ruihan Zhang,Linlin Chen,Zhihui Cheng,Yaoguo Huang,Yali Zhang
A novel composite material, MIBuXATT@GO, was synthesized by functionalizing graphene oxide (GO) with a bi-ligand triazole-thione ligand, 3-methyl isobutylxanthate-4-amino-1,2,4-triazole-5-thione (MIBuXATT), for the efficient adsorption of Cu(II) ions. This modified material served as an adsorbent to enhance the selective adsorption of Cu(II) from wastewater by synergistically combining physical and chemical adsorption mechanisms. MIBuXATT@GO was characterized by XRD, SEM/EDS, and FTIR. Under the optimal conditions (pH=4, adsorbent dosage 250 mg/L, contact time 60 minutes), the maximum adsorption capacity of Cu(II) by the material is 97.24 mg/g, which is 1.3 times higher than that of GO. Meanwhile, the adsorption process of MIBuXATT@GO to Cu(II) is characterized as spontaneous endothermic chemisorption. Furthermore, the experimental results regarding metal ion adsorption selectivity indicate that MIBuXATT@GO exhibits superior selectivity for Cu(II) compared to Mn(II), Zn(II), Co(II), and Ni(II), which is an improvement over GO. The results indicate that MIBuXATT@GO is a promising adsorbent for the removal of Cu(II) ions from aqueous solutions, offering high capacity, rapid kinetics, and excellent selectivity. The adsorption mechanism was elucidated through FTIR, UV, XPS, and DFT calculations, revealing the critical role of the thiocarbonyl and triazole-thione functional groups in Cu(II) coordination. This work provides a new strategy for designing efficient adsorbents for heavy metal ion removal.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jiaoping Si,Hongjing Liu,Wendong Zhang,Dengyu Jiao,Wangxing Ai,Yuerui Ma,Lihuan Feng,Xing’an Dong,Wenjie He,Peng Chen
The catalytic conversion of nitrogen oxides (NO x ) to non-toxic products has emerged as a critical strategy for air pollution control under stringent emission regulations. Photocatalytic NO x removal performance highly depends on the transmission of photogenerated electrons and the amount of reactive oxygen species (ROS) generated. Herein, the Bi/BiOCl/SrTiO 3 heterostructure photocatalyst was prepared by a simple in situ synthesis method to address the limitations of conventional NOx removal systems. Due to the synergistic effect of bismuth (Bi) surface plasmon resonance (SPR) and the built-in electric field in BiOCl/SrTiO 3 S-scheme heterojunction, Bi/BiOCl/SrTiO 3 showed strong light absorption ability and high charge separation efficiency, with the highest NO removal efficiency reaching 70 %. The enhanced electronic interaction between Bi and BiOCl/SrTiO 3 induced Bi-O covalent bonds with the BiOCl layer to facilitate fast charge separation, promoting the rapid transfer of interfacial photogenerated carriers, this process induces the activation of O 2 and H 2 O to form reactive oxygen species (ROS) to promote the oxidative removal of NO. This study provides new insights into the development of effective photocatalysts with fast charge separation by synergistic metal active sites and built-in electric field of heterojunction for air pollutant purification.
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PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Liu Yang,Zihao Fan,Fujun Cui,Taolong Wu,Tingxu Fang,Yujie Guo,Li Tian,Bo Pang,Gaohong He,Xuemei Wu
Vanadium redox flow battery (VRFB) is promising large-scale energy storage technology for renewable energies, while the sluggish kinetics of vanadium redox reaction restricts the efficiency at high current density. Herein, the strategy of boosting V 2+ /V 3+ redox reaction by atomic Bi active sites decorated graphite felt electrode derived from bismuth-based metal−organic framework (Bi-MOF) is proposed. Bi-MOF, dispersing abundant Bi metal sites on porous carrier, helps the Bi atoms to form atomic active sites easily by coordinating with N through the nitrogen source mediated carbonization process. Porous nanobundles of atomic Bi catalyst uniformly bind to the graphite felt, exhibiting over 2 folds increase in specific surface area, higher V 2+ /V 3+ redox peak currents and reversibility, and one order of magnitude lower of charge-transfer resistance. The atomic Bi active sites decorated graphite felt negative electrode achieves high VRFB performance even with the vanadium ions heavily permeable Nafion membrane, showing 13.1 % higher energy efficiency at 200 mA cm –2 (80.2 % vs. 70.9%), 68.1% increase in electrolyte utilization comparing to the pristine graphite felt, and keeping stable during 1500 charge/discharge cycles. The performance is superior to the reported metal−organic frameworks (MOFs)-derived catalyst decorated electrodes.
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高影响因子
危险品化学品经营许可证（带存储）