VACUUM
·
2026
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IF 4.3
Kuanysh Nurbolat,Wanting Liu,Zhengwei Wu
Flexible battery-type supercapacitors are often limited by sluggish interfacial charge transfer and poor adhesion of active materials on carbon cloth, leading to rapid performance decay under high-rate cycling. Here, we combine O2/N2 plasma activation, hydrothermal growth of Bi2O3, and Cu magnetron sputtering to construct a hierarchical Cu–Bi2O3/plasma-activated carbon electrode on carbon cloth without a conventional carbon overlayer. The mixed O2/N2 RF plasma introduces nanopores and O/N-containing functional groups onto carbon fibers, improving wettability and creating anchored surface sites for homogeneous Bi2O3 nanosphere growth. An ultrathin sputtered Cu overlayer is deposited onto the Bi2O3/plasma-activated carbon electrode, acting as a conductive shell that bridges Bi2O3 nanospheres and the carbon substrate, reinforcing contact, reducing interfacial resistance, and improving active-material utilization. SEM, TEM, XRD, and XPS confirm this plasma-engineered architecture and a conformal Cu coating. Electrochemical tests in 6 M KOH reveal accelerated redox kinetics, reduced charge-transfer resistance, and good rate performance. The electrode delivers an areal capacitance of 4086.3 mF cm−2 at 1 mA cm−2 and retains 84.2% after 5000 cycles. Overall, these findings suggest a practical, potentially general strategy for designing high-performance carbon/transition-metal-oxide composite electrodes for supercapacitors.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Jia-Sheng Li,Li-Fang Cai,Hao-Nan Chen,Hua-Dong Dong,Xuan-Yu Yang,Li-Juan Yue,Fei-Long Gong,Ke-Feng Xie,Yong-Hui Zhang
A Cu 2+ -regulated one-step hydrothermal route simultaneously tailors the dimension and facet exposure of WO 3 nanostructures. • In-situ atomically coherent WO 3 /CuWO 4 p-n heterointerfaces stabilize Cu + as highly active oxygen-activation centers. • Cu + /Cu 2+ redox-coupled oxygen activation and H 2 S dissociation enable high response, fast kinetics, and robust selectivity. Precise control over crystal morphology and interfacial electronic structure is pivotal for advancing gas sensing performance, yet simultaneously optimizing these parameters remains a formidable challenge. Herein, we report a one-step hydrothermal strategy that orchestrates the dimensional evolution of WO 3 -based nanomaterials from high-aspect-ratio nanorods to ultrathin nanosheets by simply tuning Cu 2+ concentration. This morphological transformation is driven by a synergistic mechanism involving competitive citrate coordination and facet-selective adsorption of Cu 2+ ions. Crucially, this in-situ growth protocol constructs atomically coherent WO 3 /CuWO 4 p-n heterojunctions that uniquely stabilize a high density of metastable Cu + species. These Cu + centers act as potent electron donors, dramatically enriching surface-active superoxide radicals (O 2 − ) and lowering the activation energy for gas reactions. The optimized Cu-WO 3 -1 sensor exhibits exceptional performance toward hydrogen sulfide (H 2 S), the sensor exhibits a relatively high response (R a /R g = 218.2 at 50 ppm, 150 °C), ultrafast response/recovery kinetics (13 s/101 s), and remarkable selectivity against interfering gases. Mechanistic studies reveal that the superior performance stems from a dual-function Cu + /Cu 2+ redox cycle: Cu + facilitates efficient H S bond dissociation and oxygen activation, while the reversible formation of conductive CuS and subsequent surface regeneration ensure rapid signal recovery. This work establishes a universal paradigm for synchronizing facet engineering with valence-state modulation to design next-generation high-performance chemiresistive sensors. Employing a one-step Cu 2+ -modulated hydrothermal strategy, we simultaneously achieved dimensional control of WO 3 -based nanostructures and constructed atomically coherent WO 3 /CuWO 4 p–n heterojunctions. This approach successfully stabilized a high density of metastable Cu + species, significantly enriched surface-active superoxide radicals (O 2 − ), and lowered the activation energy for gas reactions. The Cu-WO 3 -1 composite enabled ultrasensitive H 2 S detection, exhibiting a high response of 218.2 toward 50 ppm H₂S at 150 °C, along with rapid response (13 s) and recovery (101 s) kinetics. The outstanding performance originates from a bifunctional Cu + /Cu 2+ redox cycle: Cu + facilitates efficient H S bond cleavage and oxygen activation, while the reversible formation of conductive CuS and the subsequent surface regeneration ensure rapid signal recovery. Download: Download high-res image (259KB) Download: Download full-size image
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高影响因子
Frontiers in Oncology
·
2025
·
IF 3.3
Xiao Liu,Honglin Qu,Jingmin Li,Xuhong Sun,Zhenlin Wang,Dong Wang,Xianyong Bai,Xiaoyan Li
Background Cuproptosis, a novel cell death pathway mediated by ferredoxin 1 (FDX1) and protein lipoylation, has emerged as a valuable target in cancer therapy. Although the findings of previous research have indicated a potential correlation between p53 and cuproptosis, the precise role and underlying mechanisms of p53 in cuproptosis, particularly within the context of hepatocellular carcinoma (HCC), remain unclear. Methods To evaluate cuproptosis, three HCC cell lines (HepG2, PLC/PRF/5, and Hep3B2.1-7) with distinct p53 statuses were treated with elesclomol-Cu. p53 overexpression/knockdown, siRNA-mediated ferredoxin reductase (FDXR)/FDX1 knockdown, and the p53 activators CP-31398 and nutlin-3 were employed to elucidate the associated molecular mechanisms. Cell viability, protein expression [FDX1, dihydrolipoyl transacetylase (DLAT), FDXR], and DLAT oligomerization were assessed via Cell Counting Kit-8 (CCK-8), western blotting, and immunofluorescence analyses. A PLC/PRF/5 xenograft mouse model was used to assess combined the therapeutic efficacy of elesclomol-Cu and CP-31398. Results Elesclomol-Cu triggered cuproptosis in HCC cells, as evidenced by a dose-dependent suppression of proliferation, FDX1 upregulation, DLAT oligomerization, and rescue by the copper chelator tetrathiomolybdate (TTM). p53 activation enhanced FDXR expression, promoting FDX1 upregulation and subsequent DLAT oligomerization, thereby sensitizing HCC cells to elesclomol-Cu, whereas FDXR knockdown reversed these effects, demonstrating its role in p53-mediated potentiation of cuproptosis sensitivity. In mutant p53-R249S cells, CP-31398 functioned synergistically with elesclomol-Cu to suppress proliferation. In vivo , elesclomol-Cu and CP-31398 combination therapy significantly reduced tumor growth and Ki67 expression whilst upregulating FDXR levels. Conclusions These findings revealed that p53 enhances elesclomol-Cu-induced cuproptosis in HCC via FDXR-mediated FDX1 upregulation. This study provides mechanistic insights into p53’s role in cuproptosis and may serve as a basis for targeting copper metabolism in therapeutic strategies for HCC.
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
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IF 9
Xinyuan Zheng,Xiao Huang,Haohan Wan,Guangming Yan,Xiujing Xing,Haohao Ren,Gang Zhang
In this study, a novel cuprous ion (Cu + ) complexed polyarylate (PAR) membrane was developed. Polymers with vary ratios of cinchoninic unit were prepared by copolymerizing of dibenzoic chloride and bicinchoninic acid (BCA) that can coordinate with Cu + . The resultant functional PARs with differing ratios of BCA unit were casting to form ultrafiltration membranes using non-solvent induced phase transition (NIPs) method, then the membrane was treated with Cu + solution to form a metal cross-linking structure, then the membrane pore size was further shrunk. The coordination between Cu + and the PARs containing BCA units were characterized by X-ray photoelectron spectroscopy (XPS) and energy dispersive spectroscopy (EDS), it was also calculated and analyzed by simulations and visualizations. Compared with the un-treated membrane, it can be found that the rejection rate of the membranes treated with Cu + was largely improved (the rejection rates of Methyl Blue (MB), Congo Red (CR) and Evans Blue (EB) were enhanced from 75 % to 93 %, 91 % to 99.99 % and 83 % to 99.99 %, respectively), while exerting a minimal effect on the water permeance. The present work provides a new strategy for the development and application of metal ion complexation in the modification of ultrafiltration (UF) membranes.
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高影响因子
Biomolecules
·
2025
·Vol. 15
·期 6
·895
·
IF 4.8
Yuhuan Wu,Ziyao Chang,Wenhao Wang,Chuanbin Wu,Xin Pan,Zhengwei Huang
Cuproptosis, a newly discovered copper-dependent programmed cell death pathway, represents a promising approach for anticancer therapy. However, the efficacy of cuproptosis critically depends on intracellular copper accumulation. Traditional copper ionophores have limited therapeutic efficacy due to their reliance on serum copper levels. Therefore, the development of novel copper ionophores to enhance intracellular copper levels is urgently needed. In this study, we targeted a melanoma model and pioneered the application of Bis(2-hydroxyethyl)dithiocarbamic acid copper(II) [Cu(HEDTC)2] as a highly efficient copper ionophore for inducing cuproptosis in B16 melanoma cells. Compared to conventional copper ionophores, Cu(HEDTC)2exhibits superior intracellular copper delivery efficiency, thereby enhancing the induction of cuproptosis. We further constructed a Cu(HEDTC)2@Soluplus-nanomicelle (CS NM) system designed to disrupt copper ion homeostasis in tumor cells and amplify cuproptosis. In this system, Cu(HEDTC)2, as a novel copper ionophore, significantly enhanced the copper level in B16 melanoma cells. Upon cellular internalization, CS NM underwent degradation and released copper ions, which subsequently triggered cuproptosis by causing abnormal aggregation of mitochondrial lipoylated proteins. This study provides a new experimental foundation and potential therapeutic strategy for cuproptosis-based cancer treatment.
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Xinggong Hu,Jiong Li,Guoyong Du,Chunping Deng,Sike Chen
With the development of oil enterprise and petrochemical industry, more and more oily wastewater is generated, which highlights the urgency of oil/water separation. In order to solve the troubles of cumbersome membrane training and effortless clogging when the use of the membrane separation method, this find out about proposes a new and simple technique to prepare modified oil/water separation membranes based on commonly used PVDF membranes with the assist of covalent cross-linking of pyrogallic gallic acid (PG) and glutathione (GSH), and chelating and liganding of copper nanoparticles (Cu NPs). PG can be rapidly oxidized by Michael addition/Schiff response to generate a mussel-like adhesion layer, and the hydrophilic coating formed by way of covalent cross-linking with glutathione (GSH) incorporates a giant variety of catechol functional groups, which can be chelated and ligated with Cu NPs to structure a steady superhydrophilic phenolic community coating. The Cu@MF-PG/GSH membranes were capable to separate more than a few kinds of stable oil-in-water emulsions with surfactants, and the separation fluxes were giant (all fluxes have been >779 L/m2.h). Meanwhile, the separation efficiencies were all greater than 99% with excellent biking stability (flux recovery >97%). In addition, the self-cleaning property of Cu@MF-PG/GSH membranes was tested. The outcomes showed that the Cu@MF-PG/GSH membrane could be restored to a easy kingdom after simple water rinsing even when it was once contaminated by soybean oil with high viscosity. It suggests terrific self-cleaning performance
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Yanqin Zhu,Le Wang,Jinwen Zhao,Jiazhong Zhang,Qinhong Yin
Methamphetamine (METH) is a potent psychostimulant with a high potential for addiction, ranking among the most prevalent and frequently abused illicit substances worldwide. Thus, the development of rapid and precise methodologies for METH detection is essential for law enforcement and public health monitoring. This study reported the first construction of a molecularly imprinted fluorescence sensor utilizing EDTA-Cu quantum dots (EDTA-Cu QDs-MIP) for the fluorescence quantification of methamphetamine. The sensor displayed a linear response within a concentration range spanning from 53 to 371 nM, achieving a limit of detection (LOD) equal to 20.6 nM through fluorescence spectroscopy. Validation with real-world samples confirmed the sensor's high accuracy, with recovery rates in the range from 97.2 to 104.4 %. This study not only broadens the scope of QDs in chemical detection but also introduces a strong and portable platform for forensic investigations and on-site screening of illicit drugs.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Jiajie Xu,Yuhang Huang,Jiayu Xu,Siyu Hu,Xiangyang Tan,Liangchong Yu,Taolei Sun,Guanbin Gao
Glucose oxidase (GOx) is unstable under temperature/pH variations, limiting its biosensing applications. Existing nanozyme-based glucose sensors suffer from narrow detection ranges (0.2–12.0 mM) and poor stability. Herin a Janus-structured GOx-Fe/Cu nanozyme was synthesized via one-pot self-assembly with Fe₁₋ₓS and GOx partially-covered on Cu₃(PO₄)₂ nanoflowers. This nanozyme achieved an ultra-broad glucose detection range (0.5–20 mM, LOD = 34.18 μM), 40 times wider than existing nanozyme, with enhanced stability (>80% activity after 7 h at pH 3 and 5 h at 60 °C) and high specificity. When integrated into a chitosan/agarose hydrogel, it enabled visual glucose quantification through smartphone-based portable detection. In milk samples, it showed reliable glucose and H₂O₂ detection with recovery rates of 95–121% and relative standard deviations (RSD) of 0.31%–8.26%, demonstrating practical applicability. This Janus-structured GOx-Fe/Cu nanozyme improves GOx stability and sensing performance, and the hydrogel platform enables portable detection of glucose and hydrogen peroxide in food chemistry.
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PubMed
高影响因子
Journal of Water Process Engineering
·
2026
·
IF 6.6
Yintao Li,Jianwen Wei,Linlin Geng,Dongling Zhao,Xiaobin Zhou
The treatment of copper laden wastewater, particularly from the electroplating industry with the Cu(II) ion concentration ranging from 100 to 300 mg/L, presents a significant challenge for achieving stringent discharge standards. This study reports the synthesis of a pore-expanded core-shell adsorbent with remarkable Cu(II) adsorption performance, accompanied by the electronic-scale investigation of its structure and behavior. This kind of adsorbent both enhances mass transfer and provides abundant chelating sites. It showed superior adsorption performance (122.55 mg/g at 318 K) which originates fundamentally from the electronic heterogeneity of its interfacial coordination environments. By integrating density functional theory (DFT) calculations with X-ray photoelectron spectroscopy (XPS), we systematically decouple the roles of distinct adsorption sites and quantify their electronic interactions with Cu(II). DFT reveals a broad distribution of adsorption energies (−1.650 to −5.989 eV) across three primary coordination modes. Our findings demonstrate that the high adsorption capacity stems from the coexistence of multiple site types: stable multidentate sites enable high metal loading, while electronically active sites with strong charge transfer ability facilitate rapid kinetics. Beyond the specific application, the synergistic strategy of pore-expanded structure and the atomic-scale mechanistic understanding established provide a paradigm for the rational design of advanced adsorbents.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2026
·
IF 2.6
Dayong Zhou,Fuhua Zhang,Ming-Li Chen
Since multicomponent plasmonic nanoparticles (NPs) assisted semiconductors exhibit enhanced photocatalytic performances, their applications in anti-mold of wood and bamboo products have aroused great interest. Herein, Cu NPs were grown on the surface of graphitic carbon nitride (CN) via the microwave treatment of Cu2+/CN solutions. CN/Cu composites were loaded on beech wood (BW), pine wood (PW), oak wood (OW), and bamboo via the vacuum impregnation. Morphology, crystalline phase, porosity, element distribution and ratio, and elemental chemical state of CN/Cu and CN/Cu-loaded woods and bamboo were systematically investigated. Low leaching rates (6.79%-7.88%) of CN/Cu from matrix demonstrated an excellent stability of loading. Woods and bamboo uniformly loaded with CN/Cu presented the inhibition efficiency of Aspergillus niger after cultivating under visible light for 28 days, i.e., grade 1 for loaded woods and grade 2 for loaded bamboo. By combining the evaluation of band gap, electron paramagnetic resonance and photocurrent of CN/Cu composites, the integration of Cu with CN decreased the photo-generated electron−hole recombination rate and presented wider range of visible light response. Moreover, the synergistic antifungal mechanism of CN/Cu composites under visible light was proposed. This work created a pathway to develop the photocatalytic anti-mold for the preservation of wood and bamboo.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Yongqiang Yao,Yongsheng Li,Zhengang Ke
P-xylene (PX) is an essential high-value chemical with a wide range of applications. The use of waste plastics to produce high-valuable chemicals is considered to be one of the most effective and sustainable waste plastic recycling routes. Herein, a simple and efficient CuAlOX catalyst was developed for the upcycling of waste PET plastic to PX. The yield of PX was up to 98%, and the catalyst can be reused for five runs without obvious deactivation. Mechanism investigation indicated that Cu+ and Cu0 are the possible active sites, and the best ratio of Cu+ to Cu0 is 2.9. The optimal Cu+ and Cu0 sites are favorable for the absorption of ester, carboxylic acid, and alcohol groups and the desorption of PX, which is key for the selective hydrodeoxygenation of PET to PX.
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高影响因子
MOLECULES
·
2026
·Vol. 31
·期 11
·1966
·
IF 5.1
Meizi Tian,Hong Zhao,Yanyan Liu,Ge Liu,Xiaogang Guo
Promising network materials with controllable porosity and tunable structures have demonstrated numerous advantages in oil–water separation applications. However, existing preparation methods generally have problems such as complex processes and adverse environmental impacts. Therefore, inspired by lotus leaves and rose petals, we have successfully designed an efficient oil–water separator based on copper meshes using in situ chemical etching, environmentally friendly fatty acid modification, and mild microwave curing treatment. Characterization results from FESEM, EDX, and XRD demonstrate that the product has high purity and a relatively uniform structure. In addition, this efficient oil–water separator has low surface energy, high hydrophobicity, and excellent oil–water separation efficiency (>98%). Moreover, after aging tests, the product has excellent structural stability and repeatable recyclability. Therefore, this research provides a convenient, cost-effective, and environmentally friendly approach for designing feasible superhydrophobic metal mesh-based devices, highlighting their wide application potential in treating industrial oily wastewater.
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高影响因子
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