Scientific Reports
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2026
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IF 4.9
Zu Kaiyang,Xue Jionghao,Wang Yicong,Li Zhonghan,Gao Jianping,Chen Yu,Luo Xi,Ju Lili,Wang Hao
The study aimed to characterize the regional histological architecture, collagen type I/III composition, and biomechanical properties of human dura mater to provide insights for the biomimetic design of dural repair substitutes. Dura from nine formalin-fixed cadavers were harvested from four anatomical regions: the cranial calvaria, skull base, cervical enlargement, and lumbosacral enlargement. Histological architecture and collagen type I/III composition were assessed using H&E and picrosirius red staining; elastic fibers were visualized with aldehyde fuchsin staining. Collagen type I/III contents were quantified by LC–MS/MS. Mechanical properties, including thickness, ultimate tensile strength, elastic modulus, elongation at break, and toughness, were determined by uniaxial tensile testing. Prototype patches were fabricated using a collagen type I/III blend and mechanically compared against those made from type I collagen alone using uniaxial tensile testing. Cranial dura exhibited four to five interwoven collagen lamellae, whereas spinal dura comprised three predominantly longitudinal layers. Low levels of collagen III were detected in both cranial and spinal dura. Cranial samples were dominated by collagen I with lower collagen III/I ratio, whereas spinal dura showed a relatively higher collagen III/I ratio, mainly attributable to lower collagen I content rather than an increase in absolute collagen III content. Elastic fibers were sparse in cranial dura, least abundant at the skull base, and most abundant in the lumbosacral region. Tensile tests showed that spinal dura had higher elastic modulus than the calvaria. The lumbosacral region exhibited greater tensile strength, elongation at break, and toughness than the calvaria, and higher tensile strength than the skull base. Correlation analyses suggested regional collagen subtype ratio and elastic fiber abundance were associated with elastic modulus. In the preliminary proof-of-concept tensile comparison, patches incorporating 20% type III collagen exhibited increased elongation at break and higher ultimate tensile strength than type I collagen-only control patches. Human dura mater displays pronounced site-dependent structure-composition-mechanics relationships. Regional variations in architecture, collagen type I/III ratio and elastin abundance help explain the distinct mechanical characteristics in cranial and spinal dura. The findings provide a basis for the design of biomimetic dural graft to improve repair outcomes.
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高影响因子
INORGANIC CHEMISTRY
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2026
·
IF 4.6
Siqi Wang,Jiawang Liu,Meiting Chen,Xueqi An,Shuang Guo,Zihui Liang,Ping Wang,Yinghui Wang,Xiaotian Yang
Semiconductor quantum dots (QDs) are attractive building blocks for photocatalytic hydrogen evolution because their optical and electronic properties can be tailored through nanoscale structural design. However, in many QD-based hybrid systems, limited interfacial coupling between the QDs and cocatalyst hinders charge transfer and obscures the relationship between the interfacial structure and function. Herein, we report a Ni-modified giant reverse type-I CdS/CdSe core/shell QD system prepared by photodeposition, in which the Ni loading can be quantitatively tuned from 1 to 7 atoms per QD. Structural and spectroscopic characterizations indicate that the deposited Ni species are intimately associated with the CdS/CdSe QDs, while the giant core/shell architecture is retained. This interfacial modification leads to systematic changes in charge-carrier behavior, as evidenced by photoluminescence, photocurrent, electrochemical impedance, transient photovoltage, and transient absorption measurements. Among the series, CdS/CdSe-Ni4 exhibits the most efficient visible-light-driven hydrogen evolution, with a rate of 4492 μmol g–1 h–1 and a turnover frequency of 2.6 s–1 per Ni site. The results show that the regulation of the QD/Ni interface plays an important role in promoting electron extraction and interfacial charge transfer. This study provides a useful model for understanding how surface metal-site modification influences the photophysical and photocatalytic properties of colloidal semiconductor core/shell nanostructures.
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Nature Communications
·
2026
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IF 18.1
Zhang Zhenlin,Yan Lang,Li Weiwei,Hu Jinyan,Wang Yang,Dou Hongjing,Pan Dengyu,Shen Longxiang,Shi Sheng,Geng Bijiang
In the development of clinically translatable triplet photosensitizers for hypoxia regulated photodynamic therapy (PDT), there is an unmet need for engineering sensitizers as near-infrared (NIR)-responsive, type I/type Ⅱ dual photosensitizers and mild photothermal agents. Herein, we develop a binary precursor-engineering strategy for precise regulation of the D-π-A configuration of carbon dots (CDs) as ultralong-lived triplet, type I/Ⅱ dual photosensitizers by utilizing phenolic hydroxyl as an electron-rich donor and pyridine N as an electron-withdrawing acceptor. The photodynamic performance of CDs is enhanced by intramolecular charge transfer and mild photothermal conversion. We further design M1-like macrophage-derived cell membrane‑camouflaged CDs to realize preferential tumor accumulation while guaranteeing rapid systemic clearance. D-π-A sensitized CD-mediated PDT induces anti-tumor activity against primary and distant tumors. Our work highlights the crucial roles of D-π-A sensitization of CDs in boosting PDT by triplet state tuning, surface charge transfer, and mild photothermal relief of hypoxia.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2026
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IF 4.7
Gao Yuxuan,Kong Qiyu,Wang Jun,Sun Fengwei,Liu Xinyu,Wang Deliang,Li Jiangao,Yang Zhen
Developing organic type I photosensitizers (PSs) that generate less oxygen-dependent reactive oxygen species (ROS) has long been recognized to be an appealing yet significantly challenging task in the field of photodynamic therapy (PDT), owing to the high oxygen dependency of conventional PDT, which impairs its overall therapeutic efficacy, particularly in hypoxic solid tumors. Herein, a molecular fluorination strategy to finely regulate PSs with bright near-infrared (NIR) fluorescence and superior type I ROS generation ability was exploited. Benefited from the improved donor-acceptor interaction, promoted intersystem crossing process, and increased spin-orbit coupling (SOC) constant, the optimal TIBT-5F simultaneously exhibits broad absorption with a larger molar extinction coefficient in the visible-light region, bright NIR fluorescence emission and stronger type I ROS generation efficiency, making TIBT-5F a promising candidate for precise NIR fluorescence-guided PDT. The as-prepared TIBT-5F nanoparticles (NPs) can quickly accumulate in the tumor site, effectively produce both type II and type I ROS and prominently suppress the tumor growth under a safe white light irradiation (40 mW/cm 2 ) with minimized systemic toxicity. This study thus offers a new insight into constructing advanced type I PSs for precise fluorescence imaging-guided tumor theranostics.
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SOLID STATE SCIENCES
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2026
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IF 3.6
Yingxia Ma,Shuo Zhou,Tianze Li,Miaoshi Li,Wenhui Han
A superparamagnetic Fe 3 O 4 @Zn-AST nanocomposite was constructed. • The Fe 3 O 4 @Zn-AST had abundant N, S-containing functional groups. • The Fe 3 O 4 @Zn-AST exhibits a saturation magnetization of 61.29 emu/g. • The maximum adsorption capacity of Fe 3 O 4 @Zn-AST for Ag(I) was 1410.68 mg/g. Silver as a precious metal, is extensively utilized in jewelry, electronics and some other fields due to its excellent conductivity and ductility. With the growing demand for silver, excessive exploitation of silver ore resources has generated large volumes of Ag(I)-containing wastewater. The direct release of untreated Ag(I)-containing wastewater contaminates ecosystems and poses risks to human health. Metal-Organic Frameworks (MOFs) exhibit a notably specific surface area, ample unsaturated metal sites, ease of functionalization, and tunable pore size and structure, which make them highly promising materials for effective adsorption of pollutants from wastewater. However, pure MOFs are typically in powder form, which are not easy to separate and recover after adsorption. In this work, using the zinc nitrate hexahydrate as the metal precursor along with 2-amino-5-sulfanyl-1,3,4-thiadiazole (AST) as the multi-dentate organic ligand, a superparamagnetic Fe 3 O 4 @Zn-AST nanocomposite was prepared via in-situ solvothermal method. The Fe 3 O 4 @Zn-AST exhibits a saturation magnetization of 61.29 emu/g, meeting the requirements for magnetic separation. The maximum Ag(I) adsorption capacity of Fe 3 O 4 @Zn-AST is 1410.68 mg/g, and adsorption process is mainly chemical adsorption, featured by endothermic, disordered, and spontaneous. Adsorption-desorption experiments prove that the removal efficiency can remain above 91% even after five cycles. From FT-IR and XPS, the Fe 3 O 4 @Zn-AST adsorbing Ag(I) was mainly through the synergistic effect of -SH, N-containing functional groups and electrostatic interactions. Given the magnetic separation advantage and superior Ag(I) adsorption, Fe 3 O 4 @Zn-AST could serve as a promising adsorbent. Download: Download high-res image (241KB) Download: Download full-size image
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ELECTROCHEMISTRY COMMUNICATIONS
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2025
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IF 4.2
Fang Liu,Yingying Gao,Ying Guo,Jianchun Li,Wei Huo,Weiwei Dai
Cardiac troponin I (cTnI) detection plays a critical role in the early diagnosis of acute myocardial infarction (AMI). In this study, a sandwich-type electrochemical immunosensor was developed for ultrasensitive quantification of cardiac troponin I (cTnI). The sensor platform utilized silver nanoclusters (AgNCs) incorporated with β -cyclodextrin functionalized 3D porous graphene ( β -CD@3DG-AgNCs) to enhance electrical conductivity and primary antibody (Ab 1 ) immobilization. For signal amplification, ferrocenecarboxylic acid combined with β -CD@3DG ( β -CD@3DG-Fc-COOH) was employed as the signal probe, which demonstrated excellent secondary antibody (Ab 2 ) capture capability. The synthesized nanomaterials were characterized using SEM, TEM, FTIR spectroscopy, X-ray Photoelectron Spectroscopy (XPS) and Thermo-Gravimetric Analysis (TGA). The electrochemical performance of the surface-modified electrodes was systematically investigated through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Under optimized conditions, differential pulse voltammetry (DPV) revealed that the developed sensor exhibited an extensive linear response range (100 fg mL −1 –100 ng mL −1 ) for cTnI quantification, with an exceptionally low detection limit of 45.5 fg mL −1 . The recovery rate ranging from 97.39% to 102.83% was achieved in human serum analysis, suggesting the potential applicability of this immunosensor for clinical diagnosis.
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JOURNAL OF ORGANIC CHEMISTRY
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2026
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IF 3.3
Yanrui Wang,Weiqi Zhu,Jiangbin Yang,Zihui Lu,Yu Ding,Jianchun Wang,Honghua Rao
Transition metal (TM)-catalyzed direct C–H amination on free and fused pyridines is challenging, while it is much easier for their N-oxide derivatives. Unfortunately, most TM-catalysis is commonly used for nondeoxyamination and often limited to specific N-oxide and amine substrates. We herein disclose a combination of a copper(I) catalyst and dppf for deoxygenated oxidative C–N coupling of azine N-oxides to realize facile aminations on their parent azines, wherein dppf plays a crucial role in the deoxygenation step in the catalytic cycle. Moreover, this protocol tolerates a wider variety of N-oxides and free alicyclic amines to promise broader application potential.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Yumeng Liang,Weiquan Zhan,Yuan Yuan,Noe Zamora-Romero,Feifei Jia,Bingqiao Yang,Zamoniddin Nasrddinov,José Luis Arauz-Lara,Shaoxian Song
The necessity for application of molybdenum disulfide (MoS 2 ) in photocatalytic reduction field required speedy improvement with high reduction and adsorption performance. Here, manganese (Mn) and oxygen (O) dual-doping strategy were taken for demonstrating that enhancing photocatalytic reduction could achieve simultaneous modulation of the reduction and adsorption parameters by optimizing the electronic configuration and hydrophilicity ability in MoS 2 . Benefiting from the Mn and O dual-doping collective effect, the developed Mn,O-MoS 2 exhibited outstanding photocatalytic reduction and recovery performances of gold(I) from thiosulfate leaching solutions with reduction capacity of 1386.98 mg/g and the corresponding recovery of 92.50%. Besides, Mn and O atoms dual doping in MoS 2 accelerated the recovery rate, which was 3 folds higher compared with that of MoS 2 . Experimental and first-principle approaches suggested that the reduction and adsorption ability of MoS 2 were strengthened through tuning the electronic structure and surface property with Mn and O dopants : (1) Mn atoms notably enhanced the conductivity and optimized the electronic structure for facilitating the reduction performance; (2) The incorporated O atoms greatly promoted the adsorption of [Au(S 2 O 3 ) 2 ] 3- by improving the affinity of water molecules and Mn,O-MoS 2 . The work provides a promising strategy to manipulate two-dimensional materials for various applications about catalysts and adsorbent.
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Catalysis Science & Technology
·
2022
·Vol. 12
·期 21
·6416-6426
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IF 6.177
Binxiong Guang,Wei Zhang,Yiwei Zhang,Yahui Xiao,Yong Liu
A novel, efficient and economical process of cyclohexanol (CHOL) production based on cyclohexene esterification–hydrogenation has become a research hotspot in recent years. Wherein, hydrogenation of cyclohexyl acetate (CHA) derived from the esterification of cyclohexene with acetic acid is a crucial step. Combining the advantages of metal complexes and heterogeneous catalysts, the robust Cu(I) coordinated amino-functionalized poly(ionic liquid)s (PILs-Cu(I)) were, in this research, synthesized for use in the mild and highly selective hydrogenation of CHA to CHOL. The results of FT-IR, UV-vis, BET, XPS and SEM-EDS confirmed that the Cu(I) was dominant in the PILs-Cu(I), and was homogeneously and stably coordinated on the amino-functionalized poly(ionic liquid)s. Benefiting from that, the PILs-Cu(I) was endowed with an unprecedented performance in the mild and highly selective hydrogenation of CHA to CHOL. Specifically, 95.6% CHA conversion with 96.6% selectivity of CHOL, and 97.0% selectivity of ethanol was obtained under extremely mild conditions of 80 °C and 2 MPa H2. Furthermore, no significant activity loss was observed over the PILs-Cu(I) after recycling for at least five times, delivering excellent stability and reusability.
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JOURNAL OF COORDINATION CHEMISTRY
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2022
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IF 1.869
Chengjie Gao,Zhenzhou Sun,Ning Zhu,Hongliang Han,Zhongfeng Li,Chaoyue Gu,Yuping Yang,Xiulan Xin,Qiming Qiu,Wei Yang,Guo Wang,Qionghua Jin
Two new complexes, [Cu(dmp)(2-bdppmapy)](CF3SO3)·CH2Cl2 (1) and [Cu(imidazo[4,5-f])(2-bdppmapy)](SCN) (2) (2-bdppmapy = N,N-bis[(diphenylphosphino)methyl]-2-pyridinamine, dmp = 2,9-dimethyl-(1,10)phenanthroline and imidazo[4,5-f] = 1H-imidazo[4,5f][1,10]phenanthroline), have been synthesized in mixed solvents of CH3OH and CH2Cl2 (1:1, V/V). On the basis of studying the structure and photophysical properties of the Cu(I) complexes, the effects of different N ligands and counter anions on the luminescence properties of the Cu(I) complexes were characterized by single-crystal X-ray diffraction, fluorescence spectra and terahertz time-domain spectroscopy (THz-TDS). The research shows that 1 exhibits excellent photoluminescence quantum yields. It is ascribed to the unique stacked structure. In addition, the relationship between the multiple weak forces, structure, and photophysical properties of the complexes was investigated.
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RSC Advances
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2022
·Vol. 12
·期 55
·36012-36017
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IF 4.036
Ya Di,Jiyao Zheng,Yunwang Zhao,Zikai Yang,Changshun Xie,Jiahan Yu,Yue Zheng,Liming Gao
In this work, a novel strategy of colorimetric and photothermal dual-mode sensing determination of ascorbic acid (AA) based on a Ag+/3,3′,5,5′-tetramethylbenzidine (TMB) system was developed. In this sensing system, Ag+ could oxidize TMB with a distinct color change from colorless to blue color, strong absorbance at 652 nm and a photothermal effect under 808 nm laser irradiation due to the formation of oxidized TMB (oxTMB). When AA was present, oxTMB was reduced accompanied by a change from blue to colorless, and a decrease in absorption peak intensity and the photothermal effect. AA concentration showed a negative linear correlation with the value of both the absorbance intensity at 652 nm and temperature in the range of 0.2–10 μM (A = −0.03C + 0.343 (R2, 0.9887; LOD, 50 nM); ΔT = −0.57C + 8.453 (R2, 0.997; LOD, 7.8 nM)). Based on this, a sensing approach for detection of AA was proposed with dual-mode and without the complicated synthesis of nanomaterials. The photothermal effect and colorimetric signal provided a dual-mode detection strategy for AA, overcoming the limitations of any single mode. This colorimetric and photothermal dual-mode detection has great potential in the detection of AA in clinical pharmaceuticals and the construction of portable and highly sensitive sensors.
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CERAMICS INTERNATIONAL
·
2022
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IF 5.532
Zhangwen Long,Shuai Yang,Jiacheng Pi,Dacheng Zhou,Qi Wang,Yong Yang,Hao Wu,Jianbei Qiu
All-inorganic metal halides perovskites , such as CsPbX 3 quantum dots (QDs), are high-performance photoelectric materials ; they have attracted considerable attention for applications such as LEDs and laser and solar cells. Herein, we report an anion hot injection (HI) method to prepare CsPbX 3 (X = Cl, Br, I, Cl/Br, and Br/I) QDs using trimethylhalosilane (TMXS) as a halogen ion donor. By adjusting the ratio of different TMXSs (trimethylchlorosilane, trimethylbromosilane, and trimethyliodosilane), the synthesized samples can achieve tunable emission in the range of 416–710 nm, narrow emission line widths of 13–33 nm, and luminescence lifetimes of 32–223 ns. These QDs also have better stability in external environment compared with those obtained using traditional HI method.
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危险品化学品经营许可证（带存储）