JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2020
·
IF 3.807
Xujie Su,Yujie Han,Zhiguang Liu,Lifang Fan,Yujing Guo
Simple, rapid, sensitive, and specific detection of cancer cells plays a pivotal role in the diagnosis and prognosis of cancer. This paper describes an alternative method for detection of nucleolin, which is a major nucleolar protein, overexpressed in several types of cancer, and is a cancer-specific target. Gold nanoparticles/molybdenum disulfide/reduced graphene oxide (AuNPs/MoS 2 /rGO) was easily synthesized with hydrothermal method and characterized by transmission electron microscopy (TEM), x-ray diffraction (XRD) and x-ray photoelectron spectroscopy (XPS). Combining the properties of large surface area and good electrical conductivity of AuNPs/MoS 2 /rGO with the high affinity and specificity of aptamer, a smart hierarchically self-assembled electrochemical aptasensor was established for the specific and sensitive nucleolin (as a model analyte) detection. Under the optimized conditions, AuNPs/MoS 2 /rGO based aptasensor exhibits a great performance for the detection of nucleolin with a linear response from 0.5 nM to 1.0 μM and a low detection limit of 0.16 nM. In addition, this electrochemical aptasensor has good reproducibility towards nucleolin. Besides, the practicability of the TNA (thiolated nucleolin aptamer)/AuNPs/MoS 2 /rGO was demonstrated by analysis of nucleolin in the blood sample. This work paves a promising way for the facile synthesis and design MoS 2 /rGO nanocomposite-based electrochemical aptasensor for testing tumor markers in clinical diagnostics.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Benteng Sun,Zhangqian Liang,Yeye Qian,Xuesong Xu,Ye Han,Jian Tian
Here, we reported that sulfur vacancy-rich O-doped 1T-MoS2 nanosheets (denoted as SV-1T-MoS2) can surpass the activity of Pt as cocatalysts to assist in the photocatalytic nitrogen fixation of CdS nanorods. SV-1T-MoS2 cocatalysts exhibit sulfur vacancies, O-doping, more metallic 1T phase, and high electronic conductivity, thus leading to the exposure of more active edge sites, high Brunauer–Emmett–Teller surface area, enhanced visible light absorption, and improved electron separation and transfer, which are beneficial for photocatalytic nitrogen fixation. Consequently, the optimized 30 wt % SV-1T-MoS2-/CdS composites exhibit an outstanding nitrogen fixation rate of 8220.83 μmol L–1 h–1 g–1 and long-term stability under simulated solar light irradiation, significantly higher than pure CdS nanorods, CdS–Pt (0.1 wt %), and 30 wt % 1T-MoS2/CdS composites. The catalytic mechanism of photocatalytic nitrogen fixation on SV-1T-MoS2 is discussed by density functional theory calculations.
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COMPOSITES COMMUNICATIONS
·
2021
·
IF 6.617
Chao Liu,Xi Li,Yang Lin,Xin Xue,Qiming Yuan,Wenbo Zhang,Yan Bao,Jianzhong Ma
In order to promote the formation of high-quality graphene-based self-lubricating transfer film. The reduced graphene oxide (RGO) deposited with molybdenum disulfide quantum dots (MoS 2 QDs) were successfully prepared. The as-prepared MoS 2 QDs/RGO hybrid was used for the first time to improve the tribological properties of polymer composites . Compared with the neat bismaleimide (BMI) and RGO filled composites, the MoS 2 QDs/RGO/BMI showed the best tribological properties, and the frictional coefficient and volume wear rate could be decreased to 0.15 and 8.9 × 10 −6 mm 3 /(N·m), respectively. This is mainly due to the MoS 2 QDs loaded on the graphene surface are beneficial to prevent the graphene nanosheet stacking, and the introduction of MoS 2 QDs can make the self-lubricating transfer film formed more uniform, smooth and robust during the friction process.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2021
·
IF 19.503
Jia-Cheng E. Yang,Min-Ping Zhu,Xiaoguang Duan,Shaobin Wang,Baoling Yuan,Ming-Lai Fu
Two-dimensional layered MoS 2 recently demonstrates great potentials in water purification via adsorption and catalysis. The structure-catalysis relationship of MoS 2 has not been well addressed. Herein, we investigated the mechanistic difference of 1 T-2H MoS 2 homojunctions in catalytic activation of peroxymonosulfate (PMS) and peroxydisulfate (PDS) for degrading butyl paraben (BPB). PMS/1 T-2H MoS 2 attains higher performance in BPB removal compared to PDS/1 T-2H MoS 2 . 1 T phase in MoS 2 primarily contributed to PMS activation to produce SO 4 − , OH and 1 O 2 , while the defects in MoS 2 coordinated the PDS activation to generate OH, 1 O 2 and O 2 − . Nevertheless, OH-induced BPB removal was the top priority for PMS/1 T-2H MoS 2 and PDS/1 T-2H MoS 2 . The different activation pathways and reactive species resulted in the varying BPB removal, by-product distributions and toxicity. This work provides new insights into the different functions of MoS 2 in persulfates activation and the guidance in rational design of oxidant-oriented MoS 2 composites for sewage purification.
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ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 42
·2103214
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IF 18.808
Xianbo Yu,Guangyu Zhao,Chao Liu,Canlong Wu,Huihuang Huang,Junjie He,Naiqing Zhang
Owing to the low-cost, dendrite-free formation, and high volumetric capacity, rechargeable Li + /Mg 2+ hybrid-ion batteries (LMIBs) have attracted great attention and are regarded as promising energy storage devices. However, due to the strong Coulombic interaction of Mg 2+ with host materials, the traditional “Daniell Type” LMIBs with only Li + intercalation usually cannot ensure a satisfactory energy density. Herein, graphene monolayers are arranged intercalating into MoS 2 interlamination to construct van der Waals heterostructures (MoS 2 /G VH). This operation transforms the construction of ion channels from pristine interlamination of two MoS 2 monolayers to the interlamination of MoS 2 monolayer with graphene monolayer, thereby greatly reducing ion diffusion energy barriers. Compared with pristine MoS 2 , the MoS 2 /G VH can obviously reduce the migration energy barriers of Li + (from 0.67 to 0.09 eV) and Mg 2+ (from 1.01 to 0.21 eV). Moreover, it is also demonstrated that MoS 2 /G VHs realize Li + /Mg 2+ co-intercalation even at a rate current of 1000 mA g −1 . As expected, the MoS 2 /G VH exhibits superior electrochemical performance with a reversible capacity of 145.8 mAh g −1 at 1000 mA g −1 after 2200 cycles, suggesting the feasibility of potential applications for high-performance energy storage devices.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 8
·1-9
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IF 5.833
Wang Lina,Zhang Li,Yu Ying,Lin Bixia,Wang Yumin,Guo Manli,Cao Yujuan
A sensitive electrochemical strategy was established for kanamycin determination. A specific aptamer was modified on the electrode as the probe, followed by a cyclic hybridization chain reaction (HCR) with methylene blue, causing an increasing signal response. In the presence of kanamycin, it can initiatively convolve the aptamer and prevent further DNA assembling, resulting in a signal distinction sensitive to the target amount. However, the signal reproducibility is low. To improve the precision, the HCR procedure was investigated. The results demonstrated that the optimal amount of assembled DNA is 12-fold to that of aptamer. This amount was then controlled in further assays. Admittedly, controlled DNA assembling commonly indicates a limited signal amplification. To further enhance the sensitivity, a nanocomposite based on MoS 2 and AuNPs was modified on the electrode. The results of the assay proved that the signal distinction sensitive to target amount increased by 50%. A linearity range is obtained from 0.01 nM to 1.0 μM of kanamycin, and the LOD is 8.4 pM. Subsequently, this strategy was employed to detect kanamycin in chicken liver and milk sample; the recovery results suggest that it possess a satisfactory application prospect in analysis of agricultural products. Graphical abstract
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APPLIED CLAY SCIENCE
·
2021
·
IF 5.467
Sheng Wang,Yan Wang,Yin Liu,Tianshu Zhang,Ling Bing Kong
It is an effective strategy to use clay minerals (palygorskite) to prevent the aggregation of molybdenum disulfide (MoS 2 ) nanosheets prepared with hydrothermal process. The palygorskite/molybdenum disulfide (Pal/MoS 2 ) nanocomposites presented notable microwave absorption performances, which can be optimized by adjusting the content of Pal. The sample with optimized composition has a minimum reflection loss (RL) of -59.91 dB at 9.92 GHz at a thin thickness of 2.28 mm, owing to the enhanced interface polarization and improved impedance matching . It is believed that the 2D hierarchically structured Pal/MoS 2 nanocomposites can serve as a potential microwave absorber for practical applications.
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RSC Advances
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2021
·Vol. 11
·期 52
·33149-33159
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IF 3.361
Yu-qiong Gao,Yan-yan Rao,Han Ning,Da-qiang Yin,Nai-yun Gao
In this study, molybdenum disulfide (MoS2) was chosen as a co-catalyst to enhance the removal efficiency of phenacetin (PNT) in water by a ferrous ion-activated peroxymonosulfate (Fe2+/PMS) process. Operating parameters, such as the initial solution pH and chemical dose on PNT degradation efficiency were investigated and optimized. Under an initial pH of 3, an Fe2+ dose of 25 μM, a PMS dose of 125 μM and a MoS2 dose of 0.1 g L−1, the degradation efficiency of PNT reached 94.3%, within 15 min. The presence of common water constituents including Cl−, HCO3−, SO42− and natural organic matter (NOM) will inhibit degradation of PNT in the MoS2/Fe2+/PMS system. Radical quenching tests combined with electron paramagnetic resonance (EPR) results indicated that in addition to free radical species (˙OH, SO4˙− and O2˙−), nonradical reactive species (1O2) were also crucial for PNT degradation. The variations in the composition and crystalline structure of the MoS2 before and after the reaction were characterized by XPS and XRD. Further, the degradation pathways of PNT were proposed according to the combined results of LC/TOF/MS and DFT calculations, and primarily included hydroxylation of the aromatic ring, cleavage of the C–N bond of the acetyl-amino group, and cleavage of the C–O bond of the ethoxy group. Finally, toxicity assessment of PNT and its products was predicted using the ECOSAR program.
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Small
·
2021
·Vol. 17
·期 51
·2104747
·
IF 13.281
Ke Ma,Chuanan Liao,Lanli Huang,Ruiming Liang,Jinmin Zhao,Li Zheng,Wei Su
Electrospun nanofiber membranes have been widely used for guided bone regeneration (GBR). For assistance in bone healing, photothermal therapy which renders moderate heat stimulation to defect regions by near-infrared (NIR) light irradiation has attracted much attention in recent years. Combined with photothermal therapy, novel electrospun poly(ε-caprolactone)/molybdenum disulfide (PCL/MoS 2 ) nanofiber membranes are innovatively synthesized as GBR for bone therapy, wherein the exfoliated MoS 2 nanosheets served as osteogenic enhancers and NIR photothermal agents. With the doping of MoS 2 , the mechanical properties of nanofiber membranes got improved with the degradation unaffected. The composite PCL/MoS 2 membranes show enhanced cell growth and osteogenic performance compared with PCL alone. Under NIR-triggered mild photothermal therapy, osteogenesis and bone healing are accelerated by using PCL/MoS 2 nanofiber membranes for growth of bone mesenchymal stem cells in vitro and repair of rat tibia bone defect in vivo. The novel nanofiber membranes may be developed as intelligent GBR in the therapy of bone defects.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 33
·期 1
·163-172
·
IF 3.665
Xiaming Feng,Wei Cai,Xin Wang,Yuan Hu
Here we report a facile strategy to fabricate phosphoric acid doped polyaniline/molybdenum disulfide (PANI/MoS 2 ) hybrids as high-performance nanofillers in epoxy (EP) resin for the first time. In situ growth of PANI on the surface of two-dimensional MoS 2 template resulted in the uniform dispersion and strong interfacial adhesion of PANI/MoS 2 hybrids within EP matrix, which can be confirmed by the obvious increase (13.5°C) in glass transition temperature ( T g ) of EP composites. The MoS 2 nanosheets also acted as a critical component to generate synergistic effect with PANI on reducing the fire hazards of EP resin. It resulted in a remarkable removal of flammable decomposed products and a considerable reduction of toxic CO yield. The dramatical decreases in real-time smoke density and total smoke production, and high-graphitized char layer in condensed phase were obtained for EP composite with 5 wt% PANI/MoS 2 hybrids. The multiple synergistic effects (synergistic dispersion and synergistic char formation) are believed to be the primary source for these obvious enhancements of properties of EP composites. This facile strategy may achieve the potential application of functionalized MoS 2 in polymeric nanocomposites.
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NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 41
·19593-19604
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IF 3.591
Yaoyu Tan,Huan Jiang,Baihui Wang,Xia Zhang
Surface-enhanced Raman scattering (SERS) is an ultrasensitive fingerprint spectroscopy technique. The combined application of SERS and nanozymes has shown excellent prospects in the field of biomedical diagnosis. In the present study, polyaniline@MoS2@Fe3O4@Au (PANI@MoS2@Fe3O4@Au) nanozymes were successfully prepared using hydrothermal reactions. PANI@MoS2@Fe3O4@Au nanozymes have not only dramatically enhanced the peroxidase-like activity but also significantly enhanced the SERS performance. We also studied the effect of different concentrations of HAuCl4·4H2O on the SERS activity of nanozymes and found that PANI@MoS2@Fe3O4@Au nanozymes prepared using 2 mg mL−1 HAuCl4·4H2O solution exhibited the best SERS performance. We used SERS to study the enzyme kinetics of the nanozymes, and the results showed that the nanozymes have a strong affinity for H2O2 and TMB. Finally, we combined PANI@MoS2@Fe3O4@Au nanozymes and glucose oxidase (GOx) to establish a SERS glucose biosensor, which has the advantages of ultrasensitivity, high-precision, and a wide linear response range. The linear response range of glucose is 10−11–10−3 M, and the detection limit is 10−12 M. More importantly, we have successfully determined the glucose content in human serum samples with satisfactory accuracy. This work provides an essential new strategy for designing composite nanozymes for biocatalysis and provides a new idea for constructing high-sensitivity SERS biosensors.
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Nanoscale
·
2019
·Vol. 11
·期 42
·19912-19922
·
IF 6.97
Dongsheng Zhang,Ping Cui,Zhichao Dai,Baochan Yang,Xiuxiu Yao,Qingyun Liu,Zunfu Hu,Xiuwen Zheng
The metastasis and recurrence of tumors are the main reasons for cancer death. In this work, a promising therapy for tumor treatment that can eliminate primary tumors and prevent tumor relapses is introduced by combining chemotherapy, photothermal therapy (PTT) and immunotherapy. Multifunctional FePt/MoS2-FA nanocomposites (FPMF NCs) were obtained via anchoring FePt nanoparticles and folic acid (FA) on MoS2 nanosheets. As an efficient ferroptosis agent, FePt nanoparticles could catalyze the Fenton reaction to produce the reactive oxygen species (ROS). Through the highly effective photothermal conversion of MoS2 nanosheets, the primary tumor cells could be ablated by photothermal therapy (PTT). Moreover, the metastatic tumors were eliminated effectively with the help of oligodeoxynucleotides containing cytosine–guanine (CpG ODNs) combined with systemic checkpoint blockade therapy using an anti-CTLA4 antibody. Even more intriguingly, a strong immunological memory effect was obtained by this synergistic therapy. Taking all these results into consideration, we anticipate that the photo-chemo-immunotherapy strategies show great promise toward the development of a multifunctional platform for anticancer therapeutic applications.
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