ACS Biomaterials Science & Engineering
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2023
·
IF 5.8
Shuang Li,Dongyang Niu,Tuhe Shi,Wentao Yun,Shifeng Yan,Guohua Xu,Jingbo Yin
Injectable hydrogels have drawn much attention in the field of tissue engineering because of advantages such as simple operation, strong plasticity, and good biocompatibility and biodegradability. Herein, we propose the novel design of injectable hydrogels via a Schiff base cross-linking reaction between adipic dihydrazide (ADH)-modified poly(l-glutamic acid) (PLGA-ADH) and benzaldehyde-terminated poly(ethylene glycol) (PEG-CHO). The effects of the mass fraction and the molar ratio of −CHO/–NH2 on the gelation time, mechanical properties, equilibrium swelling, and in vitro degradation of the hydrogels were examined. The PLGA/PEG hydrogels cross-linked by dynamic Schiff base linkages exhibited good self-healing ability. Additionally, the PLGA/PEG hydrogels had good biocompatibility with bone marrow-derived mesenchymal stem cells (BMSCs) and could effectively support BMSC proliferation and deposition of glycosaminoglycans and upregulate the expression of cartilage-specific genes. In a rat cartilage defect model, PLGA/PEG hydrogels significantly promoted new cartilage formation. The results suggest the prospect of the PLGA/PEG hydrogels in cartilage tissue engineering.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Xingyilong Zhang,Houfang Lu,Man Zhang,Hui Han,Rubo Tian,Kejing Wu,Yingying Liu,Yingming Zhu,Bin Liang
Low-temperature production of 5-hydroxymethylfurfural (HMF) from fructose in ternary deep eutectic solvents (TerDESs) of choline chloride (ChCl), ethylene glycol (EG), and maleic acid (MalA) is proposed. A fructose conversion of 99.9% and an HMF yield of 87.3% are achieved in TerDES with ChCl/EG/MalA = 3:1:1 at 70 °C in 30 min. The ChCl can effectively activate the hydroxy groups of fructose by lengthening the C–O bonds. The EG can both improve the formation of ChCl–MalA DES with wide ranges of component ratios and reduce the viscosity of the DES. A reaction mechanism considering the synergistic effect of the components in TerDES is suggested to explain the enhanced dehydration of fructose under mild conditions. The recycling results of the TerDES show stable yields of HMF within five recycle runs. This work offers an efficient solution to a green and sustainable process for a high yield of HMF production.
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POLYMER
·
2019
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IF 3.771
Hassan Younas,Yue Zhou,Xiaogang Li,Xue Li,Qianyun Sun,Zhaoliang Cui,Zhaohui Wang
To overcome the fouling issue of membrane, hydrophilic membrane fabrication is a rich research domain. In this study, hydrophilic membrane was fabricated by incorporating the hydrophilic polymer into dope solution. Polymethyl methacrylate (PMMA) was blended with polyvinylidene fluoride (PVDF) (12%), polyethylene glycol (PEG) (2%), and N,N dimethyl acetamide (DMAc) solution and membranes were prepared by non-solvent induced phase separation process (NIPS). The synthesized membranes were characterized for their surface and cross-sectional morphology, crystallinity , chemical composition , hydrophilicity , pore size, porosity, permeability, pollutant retention, and fouling resistance. The addition of only PEG to PVDF and PMMA to PVDF increased the porosity, pore size and hydrophilicity of the membrane. Whereas, a combination of both PEG (2%) and PMMA (1%) into PVDF further increased the hydrophilicity (contact angle 60°) and porosity (90%) of the membrane. The maximum pure water flux (PWF) (565 LMH) was also recorded with PVDF-PEG-PMMA membrane without compromising the humic acid (HA) retention rate (80%). Moreover, flux recovery ratio of PVDF-PEG-PMMA membrane was more than 80% with hydraulic flushing. The combination of PEG and PMMA proved to be very effective for improving the properties of PVDF membrane resulting in better flux and antifouling potential of the membrane.
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COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 297
·期 9
·1233-1243
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IF 1.906
Zhang Xueqin,Wang Lu,Tao Huiwen,Sun Ying,Yang Hong,Lin Baoping
Two series of multicomponent silicone hydrogels based on poly (ethylene glycol)- polydimethylsiloxane-poly (ethylene glycol) (PEG-PDMS-PEG) triblock oligomers were prepared by copolymerization of silicon-containing monomers methacrylate-terminated PEG-PDMS-PEG (MTSM), tris (trimethylsiloxy)-3-methacryloxpropylsilane (TRIS), and hydrophilic monomers such as N,N-dimethylacrylamide (DMA), N-vinylpyrrolidone (NVP), and hydroxypropyl-methacrylate (HPMA). The influences of PEG chain length on hydrophilicity, oxygen permeability, and mechanical properties of silicone hydrogels were explored. The hydrophilic properties of silicone hydrogels were characterized by water contact angle, equilibrium water content, and swelling-dehydration process. The results showed that the water contact angles of dry samples decreased while the swollen ones increased with the increase of PEG chain length. The equilibrium water content decreased first and then increased as the length of the PEG chain increased. The results of swelling and dehydration process showed that PEG chains improved the water-retaining capacity of silicone hydrogels. Moreover, the protein adsorption of samples with PEG chains decreased. The surface morphologies of silicone hydrogels were characterized by scanning electron microscope (SEM), and a reconstruction model was proposed. In addition, the oxygen permeability and mechanical properties of silicone hydrogels also varied with the length of the PEG chain. These results could provide a theoretical reference for the design and modification of new hydrogels.
The properties of silicone hydrogels obtained by copolymerization of MTSM with hydrophilic monomers vary with the chain length of PEG, when PEG chains are presented as a segment of MTSM.
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Scientific Reports
·
2019
·Vol. 9
·期 1
·1-10
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IF 4.011
Zhang Xingyuan,Guo Zhao,Zhang Xiao,Gong Linji,Dong Xinghua,Fu Yanyan,Wang Qing,Gu Zhanjun
Developing robust and high-efficient synthesis approaches has significant importance for the expanded applications of upconversion nanoparticles (UCNPs). Here, we report a high-throughput synthesis strategy to fabricate water-dispersible core-shell structured UCNPs. Firstly, we successfully obtain more than 10 grams core UCNPs with high quality from one-pot reaction using liquid rare-earth precursors. Afterwards, different core-shell structured UCNPs are fabricated by successive layer-by-layer strategy to get enhanced fluorescence property. Finally, the hydrophobic UCNPs are modified with poly(ethylene glycol) monooleate (PEG-OA) though a novel physical grinding method. On the basis of mass-production, we use the as-prepared PEG-UCNPs to construct an 808-nm stimuli photodynamic therapy agent, and apply them in cancer therapy and bio-imaging.
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高影响因子
LIQUID CRYSTALS
·
2019
·
IF 3.078
Peng Wei,Yanping Wang,Yumin Xia,Yong He,Yimin Wang
Firstly, PEGn-TA monomers with carboxyl functional groups were synthesised by terephthalic acid (TA) and poly(ethylene glycol) (PEG) with molecular weight of 200, 400 and 600. Then, photocrosslinkable thermotropic liquid crystal copolyesters derived from PEGn-TA, 4,4ʹ-biphenol, 4-hydroxy-cinnamic acid and 4-hydroxy-benzoic acid were successfully obtained by Vilsmeier adduct solution polymerisation method. Influence of PEG molecular weight on thermal behaviour, liquid crystal mesophase, hydrophilicity, structure and photoactivity were investigated by various measurements. Experimental results indicated that all copolyesters showed nematic mesophase textures, relative low melting temperatures, and two glass transitions as well as better hydrophilicity were observed for those contained higher PEG molecular weight. Photocrosslinking rate was increased first and then decreased due to effect of flexible PEG moieties. The resulted copolyesters with liquid crystal behaviour, excellent hydrophilicity and photoactivity could be potentially used as biomaterial.
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JOURNAL OF MEMBRANE SCIENCE
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2019
·
IF 7.015
Chao Li,Ying Huang,Xuansheng Feng,Zheng Zhang,Panbo Liu
Polymer electrolytes are considered as the most commercially valuable solid electrolytes due to their flexibility and electrochemical stability. In this work, we prepared solid polymer electrolytes (SPEs) based on poly(ethylene oxide) (PEO) and a liner amorphous copolymer 2,4 -toluene diisocyante/polyethylene glycol (TDI/PEG). The optimal electrolyte PEO/TDI/PEG(PTP) with 20% TDI-PEG content presents a maximum conductivity of 0.17 mS cm -1 at 60 °C in addition to a superior wide electrochemical window (reaches 5 V). Simultaneously, this SPEs also show excellent thermal stability up to 300 °C. Meanwhile, 3D-graphene foam was synthesized to modified LiFePO 4 as cathode material with improved electrochemical performance. The assembled solid-state GLFP/PTP20%/Li battery exhibits an initial reversible discharge specific capacity of 141.3 mAh·g -1 and robust galvanostatic cycle performance with negligible capacity loss over 100 cycles. Therefore, the PEO-TDI-PEG films are highly promising polymer electrolytes for high performance all-solid-state lithium batteries.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2019
·
IF 1.479
Zhuang Xu,Wenjing Lou,Gaiqing Zhao,Qin Zhao,Nan Xu,Junying Hao,Xiaobo Wang
A novel biomimetic surface modification method utilizing mussel-inspired chemistry was used to prepare tungsten disulfide (WS2) nanocomposites, which enhanced the dispersion stability and tribological performance of WS2 in polyalkylene glycol (PAG). Herein, WS2-polydopamine-methoxypolyethylene glycol amine (WS2-PDA-MPGA) was first synthesized via mussel-inspired chemistry and used as a lubricant additive in PAG. After modification, the dispersion stability of WS2 nanosheets in PAG was obviously improved. Moreover, the tribological performance of WS2-PDA-MPGA in PAG at high temperature was evaluated by the oscillating reciprocating tribometer. Compared to pure PAG, the lubricant composition containing WS2-PDA-MPGA exhibited excellent performance in friction reduction and anti-wear properties at high temperature. The optimal tribological performance could be obtained when the percentage of additives was 0.9 wt%. The tribological results indicate that WS2-PDA-MPGA, with its good dispersion stability, has better friction reduction and anti-wear properties than does WS2 in PAG base oil. The chemical composition analysis of the wear surface indicated that a stable protective film had been formed by physical adsorption and tribo-chemical reactions. Therefore, the surface modification strategy is an effective way to improve the dispersion stability of WS2 in PAG, which can be expanded application of WS2 in the tribological field.
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JOURNAL OF CHROMATOGRAPHY A
·
2019
·
IF 3.858
Nan Li,Jing Qiu,Huiying Liu,Zhijun Chen,Yongzhong Qian
Oligo(ethylene glycol)-based thermoresponsive polymers with Wulff-type boronate affinity were anchored on magnetic nanoparticles . The resultant magnetic nanoparticles were used as sorbents for extracting luteolin, a cis -diol-containing model analyte. By exploiting the thermoresponsive properties and Wulff-type boronate affinity of the sorbents, target adsorption at room temperature (25 °C) and target release at high temperature (40 °C) were achieved under neutral conditions without pH alteration. The proposed thermoregulated extraction method was favorable for automated boronate affinity extraction, preventing degradation of the target and avoiding acidic elution for breaking Wulff-type boronate sites. Compared to reported sorbents for extracting luteolin, the sorbents possessed higher maximum adsorption capacity (98.7 mg g −1 ) with acceptable sensitivity, simplified operation procedure, and mild extraction condition. Furthermore, the sorbents were applied in thermoregulated extraction of luteolin from honey samples. Satisfactory recoveries in the range of 83.2% ˗ 89.1% with RSD ranging from 2.2% to 4.6% were achieved. The results demonstrated that this work provided a new research direction to design and synthesize efficient thermoresponsive materials for recognition and release of cis -diol compounds under neutral conditions.
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Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Yujiao Zhang,Yujie Lu,Ming Cao,Peng Chen,Bin Yang,Jibin Miao,Ru Xia,Jiasheng Qian
In this study, a Y-shaped amphiphilic block copolymer consisting of hydrophilic poly(ethylene glycol) (mPEG) and two poly(ε-caprolactone) (PCL) as the hydrophobic arms with a ketal linker was synthesized (mPEG-Ketal-(PCL) 2 ). The structure of the copolymer with different compositions was characterized by 1 H NMR, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). The amphiphilic property endows the copolymer with the ability to be self-assembled into micelles for encapsulating anticancer drug doxorubicin (DOX), and the effect of copolymer with different PCL length on drug loading properties were tested. The morphology, size, pH responsiveness, drug release profile and in vitro anticancer activity of the DOX loaded micelles were also studied. In vitro drug release studies showed that over 50% of the DOX was released at pH 5.0 in 24 h because of hydrolysis of ketal linker in the copolymers. The confocal laser microscopy and flow cytometry experiments showed that the DOX-loaded micelles could be effectively internalized by Hela cells, the ketal bond in the backbone was broken in acid endo/lysosomal compartments and triggered the fast release of DOX. The in vitro antitumor efficacy of the DOX loaded mPEG-Ketal-(PCL) 2 micelles was better than that of non-pH sensitive ones. In vivo studies showed that the mPEG-Ketal-(PCL) 2 micelles enhanced the DOX blood circulation time and had good tumor-targeting efficiency.
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高影响因子
Materials
·
2018
·Vol. 11
·期 10
·2011
·
IF 2.467
Xiaolong Su,Shikui Jia,Guowei Lv,Demei Yu
Polyethylene glycol (PEG)/hybrid carbon foam (CF) phase change materials (PCMs) were prepared by integrating PEG into CF via dynamic-vacuum impregnation. The hybrid CF was first synthesized by mixtures of graphene oxide (GO) and carbon nanotubes (CNTs) with different volume ratios. The morphologies, chemical structures, thermal conductivities, shape-stabilization levels, and photo-thermal energy conversion levels of these composite PCMs were characterized systematically. The prepared composite PCMs exhibited good shape-stabilization levels and showed their original shapes without any PEG leakage. It was found that the polyethylene glycol/carbon foam with multi-walled carbon nanotubes (PEG/MCF) composite PCMs had a better shape-stable performance below the temperature of 250 °C, and the thermal conductivity of the PEG/MCF composite PCMs reached as high as 1.535 W/(mK), which was obviously higher than that of polyethylene glycol/carbon foam with single-walled carbon nanotubes (PEG/SCF, 1.159 W/(mK)). The results of the photo-thermal simulation tests showed that the composite PCMs had the ability to absorb light energy and then convert it to thermal energy, and the maximum thermal energy storage efficiency of the PEG/MCF composite PCMs and the PEG/SCF composite PCMs was 92.1% and 90.6%, respectively. It was considered that a valuable technique to produce high-performance composite PCMs was developed.Keywords:polyethylene glycol;hybrid carbon foam;phase change;thermal energy storage
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2018
·Vol. 30
·期 1
·40-50
·
IF 2.137
Feng Su,Xiangke Sun,Rongye Li,Yuandou Wang,Laishun Xi,Yangsheng Chen,Suming Li
A series of poly(ɛ-caprolactone/glycolide)-poly(ethylene glycol) (P(CL/GA)-PEG) diblock copolymers were prepared by ring opening polymerization of a mixture of ɛ-caprolactone and glycolide using mPEG as macro-initiator and stannous octoate as catalyst. Self-assembled micelles were prepared from the copolymers using nanoprecipitation method. The micelles were spherical in shape. The micelle size was larger for copolymers with longer PEG blocks. In contrast, the critical micelle concentration of copolymers increased with decreasing the overall hydrophobic block length. Drug loading and drug release studies were performed under in vitro conditions, using paclitaxel as a hydrophobic model drug. Higher drug loading was obtained for micelles with longer poly(ε-caprolactone) blocks. Faster drug release was obtained for micelles of mPEG2000 initiated copolymers than those of mPEG5000 initiated ones. Higher GA content in the copolymers led to faster drug release. Moreover, drug release rate was enhanced in the presence of lipase from Pseudomonas sp., indicating that drug release is facilitated by copolymer degradation. The biocompatibility of copolymers was evaluated from hemolysis, dynamic clotting time, and plasma recalcification time tests, as well as MTT assay and agar diffusion test. Data showed that copolymer micelles present outstanding hemocompatibility and cytocompatibility, thus suggesting that P(CL/GA)-PEG micelles are promising for prolonged release of hydrophobic drugs.
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