JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Hua Yu,Zhexuan Gao,Huanping Wang,Shilong Zhao,Degang Deng,Shiqing Xu
Developing phosphor-converted light-emitting diodes (pc-LEDs) for portable near-infrared (NIR) spectroscopy applications has generated significant demand for NIR-II phosphors. However, developing a NIR-II phosphor with both broadband emission and good thermal stability remains a significant challenge. Herein, we report a novel Ni 2+ -doped Mg 4 Nb 2 O 9 (MNO) phosphor that exhibits a full-width at half maximum (FWHM) of 213 nm, covering a wavelength range of 1100–1700 nm, with a peak at 1319 nm when excited by 405 nm ultraviolet (UV) light. The optimized phosphor exhibited an internal quantum efficiency (IQE) of 38.31 %. By combining first-principles calculations with experimental analysis, we established that Ni 2+ ions occupy the three octahedral cation sites in the MNO host. Notably, the MNO: 0.004Ni 2+ phosphor maintains 102 % of its initial emission intensity at 423 K compared to room temperature (RT), exhibiting a zero-thermal-quenching property, which can be attributed to the thermal energy transfer from oxygen vacancy defects to activator ions, large thermal energy barrier, as well as the high rigidity of the MNO host. An NIR-II pc-LED device was constructed by encapsulating the optimized phosphor within a UV LED chip. The application of nondestructive NIR spectroscopy in detection, night vision, and bioimaging further demonstrates the potential of this device.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Mengyao Zhang,Xin Hu,Yudai Huang
Compared to the first near-infrared (NIR-I) window (650–1000 nm), the second near-infrared (NIR-II) window (1000–1700 nm) is more valuable for photothermal treatment (PTT) due to its deeper tissue penetration and lower phototoxicity. However, the therapeutic efficacy of PTT remains suboptimal owing to the inherently low photothermal conversion efficiency (PCE) of existing materials. Therefore, the development of nanomaterials with high PCE is a promising strategy for improving anti-tumor therapy. In this study, hollow semimetal PtTe 2 nanorods were synthesized. Their unique electronic properties and hollow structure contribute to achieving high PCE under NIR-II irradiation, while simultaneously promoting reactive oxygen species (ROS) generation. Additionally, PtTe 2 catalyzed the endogenous conversion of hydrogen peroxide (H 2 O 2 ) into oxygen (O 2 ) and hydroxyl radicals (•OH), further enhancing anti-tumor effects via chemodynamic therapy (CDT). In vivo experiments confirmed the excellent biocompatibility of PtTe 2 , and laser treatment following PtTe 2 administration significantly inhibited tumor growth, demonstrating its favorable therapeutic efficacy. This study establishes a new nanoplatform for the treatment of malignant tumors through photothermal/photodynamic/chemodynamic therapy, providing valuable insights for future research on multifunctional cancer therapies.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qing Li,Ning Liu,Dayu Wang,Lie Ma,Mingzhou Wu,Enna Ha,Junqing Hu,Zhe Zhang,Shuqing He
Silver sulfide (Ag 2 S) quantum dots (QDs), which emit light in the near-infrared II window (NIR-II, 1000–1700 nm), exhibit unique and remarkable potential in bioluminescence. However, their widespread application in experimental research is currently limited by a relatively low quantum efficiency. Cation exchange reactions have emerged as a remarkably versatile approach for synthesizing nanomaterials with adjustable structures and customizable compositions. In this study, we developed a NIR-II fluorescent probe based on Sn-doped silver sulfide (Sn-Ag 2 S) QDs via a straightforward cation exchange method. The stoichiometric ratios of precursors play a crucial role in tailoring the optical properties of the resultant materials during structural modifications involving cation exchange processes. By optimizing the ratio of Ag and Sn, we obtained ca. 16-fold quantum yields enhancement of Sn-Ag 2 S QDs in the NIR-II range, specifically around strong emission peak at ca. 1200 nm. Following hydrophilic modification, the Sn-Ag 2 S-GSH/MPA QDs exhibited high NIR-II fluorescence signal signal-to-noise ratio (S/N) with a ca. 1.7-fold increase compared to Ag 2 S-GSH/MPA QDs in the femur of mice, showing significant potential for bone imaging. To further investigate the QDs biodistribution mechanisms within osseous microenvironments, we devised a comprehensive multimodal analytical approach incorporating: (1) optical spectral analysis, (2) ultrastructural validation through transmission electron microscopy (TEM), and (3) spatial resolution mapping via laser scanning confocal microscopy (LSCM). These integrated methodologies consistently demonstrated preferential QDs accumulation within trabecular bone marrow compartments, revealing distinct biodistribution patterns in mineralized tissues.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2019
·Vol. 102
·期 10
·5899-5909
·
IF 3.094
Puxian Xiong,Mingying Peng,Jiangkun Cao,Xueliang Li
Mechanoluminescence (ML) is a phenomenon upon external mechanical stimuli and it has found diverse applications such as stress sensing, structure health diagnosis, 3-D signature, energy harvesting etc because of its unique properties of in situ and real-time response to the stimuli. However, ML of most of the state-of-art phosphors primarily appears within the spectral range from ultraviolet to visible, which does not lie in the biological transparent windows, and, therefore, limits its applications in biological field. Here, we report a strong near infrared (NIR) ML from orthorhombic Cmcm perovskite Sr 3 Sn 2 O 7 : Nd 3+ , which is peaked at ~ 900 nm and located exactly within the first optical transparent window of tissues. The ML apparates after gradual discharge of the traps deeper than 0.73 eV triggered by the external mechanical stimuli and subsequently excitation of Nd 3+ to the state of 4 F 3/2 . The rechargable ML presents well repeatable linearity to loaded force at least up to 5000 N, and it can penetrate tissues easily that are thick up to 30 mm such as pigskin and the ceramic disk of hydroxy apatite which is the main constituent of bone. These results demonstrate the potential application for in situ biomechanical sensor. Meanwhile, by recording and processing these ML signals during signing on a pellet sample, for the first time, we provide a novel signature system based on NIR ML. This could raise the security level of existed signature anti-countering to a higher level.
研究领域:
材料科学
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生物医学工程
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光学
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安全系统
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Fengtian Zhang,Weihong Luo,Zhongjie Min,Darong Lu,Weiliang Chen,Lijuan Wen
Targeted mitochondrial-based therapeutic strategies for tumors have emerged as a significant research focus in the field of cancer treatment in recent years. Mitochondria, often referred to as the “energy factory” of cells, play a crucial role in the metabolic reprogramming of tumor cells, as well as in oxidative stress and immune evasion. In this study, we utilized a mitochondria-targeted photosensitizer, IR780, to engineer Celastrol (Cela)-loaded lipid nanoparticles, designed as Cela@Lip-IRH, for the synergistic therapy of chemotherapy and photodynamic therapy (PDT) against glioma. Cela@Lip-IRH could respond to the weakly alkaline environment of tumor cell mitochondria for rapid Cela release. Leveraging the mitochondrial targeting capacity and PDT property of IR780, Cela@Lip-IRH nanoparticles showed enhanced cellular uptake and mitochondria targeting distribution in vitro, as well as obvious tumor accumulation in vivo. Cela@Lip-IRH nanoparticles exhibited prominent intracellular reactive oxygen species (ROS) generation upon NIR laser irradiation, which was accompanied by pronounced photocytotoxicity and cell apoptosis, finally producing remarkable tumor growth suppression efficacy in vivo. We further verified that the potential antitumor molecular mechanism was triggered by the release of Cytochrome C, leading to an activated mitochondrial apoptosis pathway, alongside an immune response characterized by enhanced recruitment of CD4+ T cells and CD8+ T cells in tumor tissues. Currently, this mitochondria-targeted nanoplatform presents an ideal method to enhance the synergistic performance of chemotherapy and PDT in glioma, and it is anticipated that such a strategy will provide a promising alternative to optimize the tumor-targeted therapies.
研究领域:
纳米医学
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癌症治疗
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光动力治疗
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药物递送
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线粒体生物学
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PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Wenkang Liu,Tao Wu,Wenxuan Ye,Mingyang He,Jianfu Zhao,Wei Xue,Siming Yu
Currently, Pseudomonas aeruginosa ( P. aeruginosa ) infections pose a significant threat to public health, owing to the high morbidity, mortality and antibiotic resistance. Alkyl radical (AR)-based photodynamic therapy exhibits great potential in antibacterial applications due to its oxygen-independent advantage. Nevertheless, targeted delivery systems capable of precisely controlling AR release at bacterial infectious foci are still lacking. In the present work, a mesoporous gold nanorod (mGNR)-based multifunctional nanogenerator with P. aeruginosa -targeting and near infrared (NIR) laser-controlled AR release properties was fabricated for enhanced bacterial wound treatment. Herein, mGNR with mild-photothermal therapeutic (MPTT) effect was firstly synthesized and used as a carrier for effective loading of an AR initiator 2, 2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH). Then, cysteamine and polymer of HOOC-PEG 5000 -Mal were added in sequence to functionalize the nanosystem, obtaining nanogenerator of mGNR@AIPH@PEG-Mal. Due to the specific maleimide (Mal) and Type IV Pilus (T4P) reaction, mGNR@AIPH@PEG-Mal displayed high binding efficiency on P. aeruginosa . Upon NIR laser irradiation, mGNR@AIPH@PEG-Mal triggered AIPH cleavage to generate substantial amount of AR, which enabled high-efficient inhibition on P. aeruginosa and biofilms via the synergistic MPTT/AR antibacterial effect. Moreover, mGNR@AIPH@PEG-Mal exhibited excellent antibacterial and wound healing effect on P. aeruginosa infectious rats’ wounds. In-depth mechanism study revealed that the synergistic MPTT/AR therapeutic effect of mGNR@AIPH@PEG-Mal induced P. aeruginosa death by breaking bacterial membrane, triggering ROS boost, GSH depletion and DNA damage, as well as promoted wound healing by repolarizing M2-type macrophages and upregulating CD 31 and α-SMA expressions.
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高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Zengyue Li,Nan Kang,Yixun Jin,Weiyan Yao,Jin Cheng,Zimei Liu,Xiaoqing Qian,Qian Zhang
Accurate diagnosis and effective treatment of pancreatic cancer are essential to improving survival rates, yet current strategies are highly limited by toxicity of therapeutic drugs and efficacy challenges. Herein, we proposed a biodegradable nanosystem (denoted as MnCO3–BSA@DOX/IR820) based on manganese carbonate (MnCO3) loaded with doxorubicin (DOX) and photothermal agent IR820. This platform integrates chemotherapy with photothermal/photodynamic therapy (PTT/PDT) under 808 nm laser irradiation, achieving synergistic antitumor efficacy against pancreatic cancer. Specifically, the MnCO3-based nanosystem can enhance tumor accumulation, while the hydrogen peroxide (H2O2)-enriched acidic tumor microenvironment (TME) triggers oxidative stress pathways to generate reactive oxygen species (ROS). Upon 808 nm laser irradiation, IR820 is activated to exert a combined therapeutic effect. It mediates PDT to generate ROS, while the localized hyperthermia induced by PTT causes direct cellular apoptosis and facilitates DOX release, thereby enhancing therapeutic efficacy. Additionally, the nanosystems integrate magnetic resonance imaging (MRI) and near-infrared fluorescence (NIR) imaging capabilities, enabling real-time treatment monitoring and precise diagnosis. In vivo studies demonstrated that MnCO3–BSA@DOX/IR820 nanosystems effectively inhibit tumor growth without causing notable damage to normal tissues. Therefore, this pH-responsive and MRI/NIR imaging-guided nanoplatform represents a targeted theranostic system for pancreatic cancer, enabling chemo-PTT/PDT synergy.
研究领域:
纳米医学
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癌症诊疗一体化
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生物医学成像
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光热治疗
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光动力治疗
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药物递送
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活性氧
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肿瘤微环境
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分子成像
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yixin Wang,Ye Zhang,Mengshu Xu,Zhuoran Yang,Wei Guo,Chunyu Yang
Breast cancer is one of the most prevalent malignant tumors worldwide and a leading cause of cancer-related mortality, underscoring the urgent need for innovative therapeutic strategies. In this study, we developed an injectable hydrogel-based system, in which polyvinylpyrrolidone (PVP)-modified NiS 2-x @PVP nanospheres were incorporated with metformin hydrochloride (MH) and dispersed in a hyaluronic acid (HA) hydrogel matrix to form the NiS 2-x @PVP@HA tumor treatment platform. This system exhibits excellent photothermal performance under near-infrared (NIR) light irradiation and can be employed for tumor photothermal therapy (PTT). The Ni 2+ released from the degradation of NiS 2-x @PVP nanospheres can catalyze the decomposition of endogenous hydrogen peroxide in tumor cells, thereby generating toxic hydroxyl radicals for chemodynamic therapy (CDT). By altering the HA concentration, the internal pore structure, mechanical properties, drug release behavior, and swelling capacity of the hydrogel can be modulated. The loaded antitumor drug MH further enhances the therapeutic efficacy. Under NIR and ultrasound stimulation, this platform enables controlled drug release. In vitro and in vivo experiments have demonstrated that the NiS 2-x @PVP@HA hydrogel achieves the synergistic treatment of PTT/CDT/chemotherapy for tumor tissues. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that activation of the MAPK signaling pathway was a key mechanism underlying tumor cell death. This work presents a rational design strategy that addresses the related challenges in breast cancer and promotes precise cancer therapy.
研究领域:
肿瘤学
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纳米医学
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生物材料
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药物递送
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癌症治疗
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产品关联
DOI
PubMed
高影响因子
Catalysis Science & Technology
·
2019
·Vol. 9
·期 9
·2103-2110
·
IF 5.726
Shuhui Liang,Yukun Chang,Yue Wang,Dafeng Zhang,Xipeng Pu
A simple combustion method was reported to prepare a novel BiOBr:Yb3+,Er3+/AgBr (BYE/AgBr) heterojunction photocatalyst. Phase composition, morphology and optical properties of samples were characterized. The diffuse reflectance and photoluminescence spectra showed that the as-synthesized BYE/AgBr can be activated under both visible (vis) and near-infrared (NIR) light. Notably, BYE/AgBr composites exhibited enhanced photocatalytic activity for RhB degradation under vis/NIR irradiation. The degradation rate constants of BYE/AgBr-1 : 1.5 for RhB were 0.0220 min−1 and 0.01368 h−1 under visible and NIR irradiation, which are about 2.6 and 4.9 times higher than that of pure BYE, respectively. The upconversion effect of Er3+ can convert the NIR light (∼980 nm) to visible light which was then absorbed by BYE/AgBr to generate e− and h+. Moreover, the formation of the heterojunction also plays a role in the enhanced vis/NIR photocatalytic abilities; and a corresponding plausible photocatalytic mechanism was proposed.
研究领域:
材料科学
·
光催化
·
环境科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Xiaoyue Wei,Chunyang Liu,Zhiyong Wang,Yongxiang Luo
Localized therapy using hydrogels-based drug delivery system (DDS) is a promising strategy for the treatment of diseases such as cancer in superficial tissues. In this study, we presented a facile method to prepare core-shell hydrogel fibers/scaffolds with controlled drug delivery and designed structures for the treatment of the residual breast cancer and prevention of local recurrence after surgery. Mixtures of polydopamine (PDA) and concentrated alginate inks (15.3 wt%) as the shell layer, and drug-loaded temperature-sensitive hydrogels as the core part were co-injected and coaxial 3D printed into core-shell hydrogel fibers and scaffolds. Under near infrared (NIR) irradiation, PDA with excellent photothermal effect could raise the temperature of core-shell fibers, which induced the gel-sol transition of the core gels, and subsequently resulted in the drug release from the loosened hydrogel network. The photothermal effect and the released drugs could eliminate cancer effectively. Thus, our prepared core/shell fibers and scaffolds with NIR-triggered on-demand drug release would be promising candidates to fill the cavity of breast tissues after surgical resection of cancer achieving a therapeutic effect for the residual and recurred cancer.
研究领域:
生物医学工程
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药物递送系统
·
癌症治疗
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 42
·8871-8881
·
IF 6.331
Huiping Dang,Quan Cheng,Youliang Tian,Changchang Teng,Kai Xie,Lifeng Yan
To achieve accurate fluorescence imaging-guided cancer therapy, intelligent systems with specific responsiveness to the tumor microenvironment need to be designed. Here, we have achieved both enhanced NIR fluorescence and photodynamic therapy by introducing a dimethylamino functional group in BODIPY dyes, which can be used as a pH sensor under acidic conditions by coordinating with the proton. At pH 7.4, the fluorescence is quenched due to the photo-induced electron transfer (PET) process. After the photosensitizer is protonated in tumor cell lysosomes (pH 4.0–5.5), the PET process is inhibited and the fluorophore emission capacity is restored (fluorescence enhancement up to 10-fold), resulting in near-infrared fluorescence with the OFF/ON transition inside the tumor and enhanced singlet oxygen production for lysosome targeting capability. Due to the substitution of heavy atom iodine, the compound has a high singlet oxygen quantum yield of 81.8% in dichloromethane. In addition, using a pH-sensitive amphiphilic polypeptide (POEGMA23-PE9) as a carrier to wrap the photosensitizer BDPI can release enough drug in the acidic environment (pH 5.5–6.5) of intracellular endosomes/lysosomes, which is conducive to more adequate interactions of the photosensitizer with H+ and more effective enhancement of fluorescence emission and 1O2 production, achieving precise fluorescence imaging capability and extremely low background toxicity.
研究领域:
生物医学工程
·
癌症研究
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材料科学
·
分子影像
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DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Depeng Liu,Yang Zhang,Guohua Jiang,Weijiang Yu,Bin Xu,Jiangyin Zhu
This study described near-infrared (NIR) light-responsive polymer-nanodot composite microneedles (MNs) used for on-demand transdermal drug delivery. Bismuth (Bi) nanodots stabilized by poly(vinylpyrrolidone) (PVP) as a photothermal conversion agent and metformin as an antidiabetic drug were introduced into the dissolving MNs coated with lauric acid (LA). When the MNs were irradiated with NIR light, light-to-heat transduction induced by the Bi nanodots caused the LA to melt. As a result, the polymer matrix was dissolved after absorbing the interstitial fluid, enabling the encapsulated metformin release from the MNs into skin tissue. Compared with subcutaneous injection of metformin, the administration using the Bi nanodots-induced NIR responsive MNs developed in the current research exhibited a remarkable hypoglycemic effect in vivo. This work indicates that the as-fabricated Bi nanodot-induced NIR responsive and LA-coated MNs have potential applications in diabetes treatment. Additionally, these artificial MNs also present a promising platform for delivering other therapeutic drugs.
研究领域:
药剂学
·
药物递送系统
·
生物医学工程
·
糖尿病治疗
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）