LANGMUIR
·
2025
·
IF 3.9
Yong Zhang,Xiangyang Yan,Qiao Li,Jie Qi,Xingyu Lin,Ziteng Yang,Li Wang,Hongsheng Lu,Zheng Zhang
The introduction of stimuli-responsive surfactants effectively avoids the contradiction between the stability of the emulsion and the rapid release of the drag reducer, but the single-tailed chain structure limits the storage stability and the release rate of the switching emulsion drag reducer. Adding response sites on gemini surfactants to enhance the release rate of drag reducers and strengthen the storage efficiency of the emulsions is an effective strategy. Herein, a dual dynamic covalently bonded-based gemini surfactant (DF-PEG200/OAC) was synthesized by poly(ethylene glycol) 200 (PEG200), 4-carboxybenzaldehyde (DF), and oleylamine (OAC). The two tails of DF-PEG200/OAC enhanced the stability of the switching emulsion drag reducer and provided sufficient response sites, thereby intensifying the release of the drag reducer. The reorganization and decomposition of the imine bond on DF-PEG200/OAC was realized at different pH, thus endowing the DF-PEG200/OAC-stabilized monomer emulsion with controllable stability. Using the monomer emulsion as the inverse emulsion polymerization template, a switching emulsion drag reducer was obtained without delamination or demulsification within 30 days. When the pH of deionized water is 4.7, the switching emulsion drag reducer was completely dissolved in 30 s. At a concentration of 0.05 wt % of the switching emulsion drag reducer, the drag reduction rate reached 69.64%. We believe that the construction of a switching emulsion is expected to provide a new option for the development of drag reducers.
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Yanxue Si,Ruitao Cha,Pai Zhang,Fengshan Zhou,Wenbing Yuan,Xingyu Jiang
5-Aminosalicylic acid (5-ASA) is the first-line drug for ulcerative colitis (UC), which encounters therapeutic constraints due to the poor water solubility and absorption by the upper gastrointestinal. Here, a cyclodextrin-based metal-organic framework (CD-MOF) is used as a carrier for 5-ASA (ASA@CM) to enhance its solubility. To improve the targeted release 5-ASA, ASA@CM is incorporated into sodium alginate/ L -arginine complex (SA-LA) to obtain the desired microspheres (ASA@CM/SL) by electrospray. ASA@CM/SL safeguards 5-ASA against the harsh gastrointestinal environment and provides favorable delivery to the colon. The anti-inflammatory and anti-oxidant activity is studied by measuring inflammatory factors and reactive oxygen species (ROS). The therapeutic effect of ASA@CM/SL on UC mice induced with dextran sulfate sodium is assessed. The biosafety by evaluating cytotoxicity and organ toxicity is studied. ASA@CM/SL shows excellent therapeutic effects for UC, as evidenced by its alleviation of inflammatory response and restoration of disrupted intestinal barriers. ASA@CM/SL features low cytotoxicity and low organ toxicity. This study provides a potential strategy for improving 5-ASA solubility and delivery efficiency, which may also be applied to broadly tackle various small hydrophobic molecules to treat UC and other intestinal diseases.
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Hanyu Yao,Ruixuan Ji,Xiaoyi Song,Bin Yang,Yin Lv,Zhong Wei
Ferroptosis, a recently recognized form of non-classical programmed cell death (PCD), leads to impaired cellular structure and integrity due to the accumulation of lipid peroxidation products (LPO). However, single treatment ferroptosis often fails to achieve optimal tumor treatment outcome. Therefore, we constructed a multi-synergistic treatment strategy based on ferroptosis, that is more conducive to tumor therapy. In this study, we constructed a metal organic framework (MOF) loaded with glucose oxidase (GOx) and doxorubicin (DOX), denoted as Fe(Ⅲ)-RSSR@DOX@PEG-GOx. Fe(Ⅲ)-RSSR@DOX@PEG-GOx was synthesized through coordination between Fe3+ and disulfide-containing ligands scavenged GSH and downregulate glutathione peroxidase 4 (GPX4), thereby triggering ferroptosis. The GOx catalyzes glucose into abundant H2O2, promoting the Fenton reaction which results in excessive ROS formation within tumors. The accumulation of ROS can further enhance the process of ferroptosis, while the massive consumption of glucose constitutes a synergistic situation of “starvation treatment”. The smart biomimetic nanoplatform integrates ferroptosis, chemotherapy, and starvation therapy, providing a potential anti-tumor strategy to achieving multi-effect synergistic tumor treatment.
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高影响因子
Advanced Sustainable Systems
·
2025
·
IF 6.1
Zizi Wang,Fengchen Zhou,Binxin Lv,Jiayue Yu,Junjun Zhang,Yifan Zhang,Yang Wu,Yong Wang,Wen Luo
The electrocatalytic nitrate reduction reaction (NO 3 RR) offers a sustainable route for ammonia synthesis, yet its practical implementation requires catalysts adaptable to pH fluctuations inherent in industrial wastewater systems. Herein, Cu 2 O nanocubes as a model catalyst is synthesized and decoupled the pH-dependent reaction mechanisms with systematic experimental investigations. In acid electrolytes, the catalyst exhibited 93.3% faradaic efficiency for NH 3 with a yield rate of 34.6 mg h −1 mg cat −1 at −0.7 V versus. RHE. In contrast, in alkaline and neutral electrolytes, NH 3 synthesis is impeded by the formation of NO 2 - which served as the predominant by-product. Through operando infrared spectroscopy analysis, proton availability as the pivotal regulator is identified: Acidic media facilitates the further conversion of * NO 2 intermediates into NH 3 via the NOH pathway, whereas H + -deficient environments in neutral/alkaline conditions divert reaction flux through the NHO pathway. This mechanistic elucidation establishes proton concentration as a key parameter for steering nitrate-to-ammonia conversion efficiency.
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高影响因子
PHYSICA B-CONDENSED MATTER
·
2026
·
IF 3.2
Chuanfang Wu,Zitao Yan,Yong Pu,Dachuan Zhu
A series of bimetallic-organic frameworks (MOFs), Dy x Gd 1-x -L 1 L 2 (x=0.005, 0.01, 0.015, 1), have been synthesized via solvent-thermal method using Gd 3+ as the matrix ion, Dy 3+ as the emission center, 1,10-phenanthroline(L 1 ) and 2-aminoterephthalic acid(L 2 ) as organic ligands, DMF and methanol as solvents. The XRD and FT-IR patterns indicated the concentration of Dy 3+ did not change the crystal structure and bonding, and the SEM morphologies demonstrated the MOFs as irregular flake-like particles. The PL spectra revealed two characteristic peaks of Dy 3+ (481 nm and 575 nm) arisen from transition of 4 F 9/2 → 6 H 15/2 and 4 F 9/2 → 6 H 13/2 appeared, with the highest intensity at x=0.01. Notably, the emission intensity of Dy 0.01 Gd 0.99 -L 1 L 2 increased linearly with the increase of pH within a range of 3.4-8.8, and the acidity coefficient (pKa) was calculated as 3.69, implying a good sensing for pH value, combined with a good cyclic stability and anti-interference, which was deduced from protonation/deprotonation with the variation of pH value.
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高影响因子
Energy Sources Part A-Recovery Utilization and Environmental Effects
·
2021
·
IF 3.447
Ding Ma,Hongwen Gao,Jin Wang,Zhengbo Yue
Although conductive materials (CM) gained increasing attention over the last decades to facilitate methane production, its influence on the whole process of anaerobic digestion was not clear yet, especially for the acidogenesis. The purpose of this study was to investigate the role of goethite on methane production and its effects on the volatile fatty acids (VFAs) in acidogenesis under different pH conditions. Results showed that the methane production and chemical oxygen demand (COD) removal efficiency in continuous stirring tank reactors (CSTRs) were increased with the addition of goethite. The promotion effects of goethite were particularly significant under acidic conditions. Microbial community analysis indicated that Clostridium and Syntrophic bacteria were enriched in goethite-dosed reactors, while methanogens community was mainly affected by pH. Goethite inhibited the generation of acetate and increased the butyrate production, which may benefit to keep the pH of the reactors stable. The results revealed the underlying mechanism of goethite to promote performances of anaerobic digestion and confirmed goethite was a potential additive under different pH conditions.
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高影响因子
NANO
·
2019
·
IF 1.293
Shuai Wang,Fang Xiang Song,Li Zhang,Xue Zhang,Yan Li
Mesoporous silica (MS) spheres of different sizes with pH-responsive characteristics were synthesized based on Stöber’s theory. Organic functionalization with aminopropyl and carboxyl groups resulted in different materials, namely, MS@NH 2 @COOH. MS@NH 2 @COOH were observed to have a large number of carboxyl groups and multiamine chains, and were grafted into pore channels and pore outlets through systematic characterization analyses. All modified samples demonstrated the controlling of the delivery rate of DOX from the siliceous matrix. We also compared the drug release behavior of the DOX-loaded materials at high pH (7.4) and low pH (5.5) and studied the cytotoxicity on A549 cells. The experimental results indicated that the drug delivery system can better control drug release and have potential applications in the drug delivery field.
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高影响因子
JOURNAL OF FLUORINE CHEMISTRY
·
2016
·
IF 2.213
Jianquan Tan,Weiqu Liu,Zhengfang Wang
Novel amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains were designed and synthesized via radical polymerizaion of acrylic acid (AA), poly (ethylene glycol) methyl ether methacrylate (PEGMA) and homemade fluorinated macromonomer (PHFBMA-GMA) and the physicochemical properties of polymeric micelles prepared therefrom were investigated. GPC, FTIR and 1 H NMR were employed to characterize the structures of the copolymers. Potentiometric titration measurement confirmed that the pH-sensitive segments were successfully incorporated and the copolymer performed pKa similar to the reported values. A series of random copolymers with the same chemical composition were employed to make comparisons with the graft copolymers. The critical micelle concentrations (CMC) of the copolymers at different pH (5.0 and 9.0) were determined by fluorescence spectroscopy and surface tension measurements. CMC values showed a high degree of consistency between these two methods. The results showed that CMC values for random copolymers were one magnitude order higher than that of graft copolymers. Graft copolymers performed lower CMC larger particle size compared to random copolymers. No significant difference was observed among graft or random copolymers. CMC values and particle size increased while zeta potential values showed significant decrement with increasing pH, indicating significant pH-sensitivity of the copolymers. With regard to the influence of the amount and the molecular weight of PHFBMA-GMA on the properties, increasing the amount and molecular weight of PHFBMA-GMA was prone to lower CMC, larger particle size while zeta potential performed no significant change. Transmission electron microscopy (TEM) showed that the morphological shapes of the copolymers performed spherical micelles. The cytotoxicity test showed that the comb-shaped copolymers performed extremely low cytotoxicity.The pH-sensitive self-assembled amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains could be potential candidates for nanotanks, hydrophobic drug carriers or surfactants and their facile preparation might fit for large scale industrialization.
研究领域:
高分子化学
·
材料科学
·
纳米技术
·
药物递送
·
胶体与界面科学
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DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.1
Xiyuan Guo,Yuanfeng Pan,Yuanjian Xie,Pingxiong Cai
Pesticides are essential for agricultural production; however, their improper application can result in ecological damage and potential threats to human health. Therefore, the development of pesticide-controlled-release systems is crucial for the sustainable progress of agriculture and society. This work presents a novel strategy for fabricating a polyelectrolyte hydrogel bead-based pesticide-controlled-release system. The process involves blending a sodium alginate/carboxymethyl chitosan (SA/CMCS) solution with cystine dihydrochloride (CYS), followed by introducing the mixture into a citric acid (CA) solution. The abundant protonated amino groups (-NH 3+ ) and carboxylate anions (-COO-) within the system facilitate the formation of CMCS/SA-CYS/CA composite hydrogel beads (CHGB), subsequently loaded with thiamethoxam (TMX) to create TMX-loaded CHGB (TCHGB) for investigations into drug loading and responsive release. The CHGB exhibits remarkable swelling properties (up to 4200%), along with pH and redox sensitivity. And the release of TMX from TCHGB displays favorable responsiveness to pH and redox stimuli. Under alkaline conditions (pH 9.0) and reductive surroundings (containing glutathione), the cumulative release ratio of TMX surpasses 95%. Furthermore, it has been demonstrated that the release kinetics of TMX comply with Fickian diffusion described by the Korsmeyer-Peppas model. The discoveries of this study hold considerable research and practical value in the domain of controlled-release agricultural chemicals.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Nian Xiang,Chuanyang Chen,Yuming Lin,Wang Li,Zuzeng Qin,Yiheng Ruan,Tongming Su,Xuan Luo,Xinling Xie
Stimuli-responsive fertilizers show great potential for precision nutrient delivery but are often limited by single responsiveness and unsynchronized release with plant growth demands. This study developed a novel polysaccharide-based thermo-pH dual stimuli-responsive gating microcapsule (CSMC-g-PNM) via atom transfer radical polymerization (ATRP). N-isopropylacrylamide (NIPAM) and methacrylic acid (MAA) were sequentially grafted into the chitosan microcapsules (CSMC), with thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM) acting as a macromolecular initiator for the subsequent grafting of MAA by reactivating dormant chain ends. Independent chain lengths of PNIPAM and PMAA were achieved by controlling grafting time, endowing the microcapsules with reversible and dual-responsive gating properties. The PNIPAM and PMAA chains acted as dual-responsive gating mechanisms, extending below the low critical solution temperature (LCST) (25 °C) or above pKa (pH 8), closing the gates to slow release. Conversely, when the temperature exceeds 40 °C or is below the pKa (pH 3), the chains contract, opening the gates to accelerate release. CSMC-g-PNM demonstrated sustained urea release (cumulative release 80.79% over 168 h), following First-order kinetics and Korsmeyer-Peppas diffusion-erosion mechanisms. Biodegradation studies affirmed the system’s environmental compatibility, showing a controlled weight loss of up to 19.74% after 35 days in soil. Furthermore, pot experiments demonstrated significant agricultural efficacy, with maize seedlings treated with CSMC-g-PNM-6 in acidic soil achieving a plant height of 44.1 cm, significantly outperforming the 33.1 cm observed with unmodified microcapsules. This work provides a robust and sustainable strategy for designing intelligent nutrient delivery systems, advancing the development of solutions for precision agriculture.
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高影响因子
SENSORS
·
2026
·Vol. 26
·期 13
·4205
·
IF 4
Xiao Wu,An Wang,Xiao Cai,Fan-Li Zhang,Bing Pei
Urine pH is an important biomarker related to metabolic status and urinary system health, but reliable SERS quantification in real urine remains limited by matrix interference, heterogeneous hotspot distribution, and the narrow response range of single pH-responsive molecules. Here, we report a core–gap–shell Au@1,4-BDT@Au@4-MBA/MPY nanoprobe for ratiometric SERS detection of urine pH. 1,4-BDT was confined within the gap between the gold core and shell as an internal standard, while 4-MBA and 4-MPY were co-assembled on the outer gold shell to provide complementary protonation/deprotonation responses. The internal standard-corrected ratio I1004/I1400/I731reduced signal fluctuation and enabled segmented linear fitting over pH = 1.0–7.0 and pH = 7.0–10.0, with coefficients of determination of 0.98806 and 0.99989, respectively. The sensing platform also maintained stable ratiometric responses under different interference conditions. In real urine samples from five volunteers, SERS-predicted pH values agreed well with commercial pH meter measurements, with relative accuracies of 98.71–101.9% and RSD values below 2.1%. This confined internal standard and dual-molecule ratiometric strategy provides a feasible approach for urine pH sensing in complex biofluid matrices.
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PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Boning Su,Xiangjie Zhao,Ziyao Li,Bin Gao,Denglun Cheng,Junyin Li,Zekun Wang,Jiahui Liu,Chenghao Liu,Tianlin Shen,Yuanyuan Yao,Shugang Zhang,Yuechao Yang
Biobased controlled-release fertilizers (CRFs) contribute to sustainable agricultural development. However, their nutrient release often lacks sufficient responsiveness to environmental fluctuations, limiting overall fertilizer use efficiency. This study aimed to develop smart and green CRFs capable of modulating nutrient release in response to soil pH variations. A low-cost dehydrated castor oil (DCO)-based or castor oil (CO)-based alkyd resin (DCOCA/COCA) was used as the foundation for polyurethane (PU) reactions to prepare a DCOCA/COCA-coated CRF (DCOCAPF/COCAPF). Next, a one-step polymerization reaction was performed between HDI and differing amounts of 3-dimethylamino-1,2-propanediol (DMAPD), which contains a tertiary amine group with pH-responsive properties. The resulting products (DMAPDIs) were then subjected to a further polyurethane reaction with COCA to produce pH-responsive CRFs (DMAPDIPFs). The DMAPDIPFs exhibited excellent pH responsiveness with approximately 29% increase in the nitrogen release rate and 7-day reduction in the nitrogen release longevity under acidic conditions compared to that under neutral conditions, requiring only 1% of DMAPDI by total mass of the coating materials. This work provides valuable insights for developing smart CRFs that can autonomously adjust their nutrient release characteristics in response to environmental stimuli to increase the fertilizer utilization rate and thereby promote sustainable agricultural development.
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高影响因子
危险品化学品经营许可证（带存储）