CRYSTENGCOMM
·
2019
·Vol. 22
·期 3
·587-592
·
IF 3.382
Chunli Jiang,Qianqian Luo,Hanmei Fu,Hechun Lin,Chunhua Luo,Jianlu Wang,Xiangjian Meng,Hui Peng,Chun-Gang Duan,Junhao Chu
Great attention has been paid to organic–inorganic hybrids in searching for single-phase multiferroics because of their flexible structure design. Here, a new [CuCl4]2− based organic–inorganic hybrid, (bix)CuCl4·H2O (bix = 1,4-bis(imidazol-1-ylmethyl)benzene), is synthesized via a simple solution method. Different from most [CuCl4]2− based organic–inorganic hybrids, tetrahedral [CuCl4]2− units in (bix)CuCl4·H2O are connected to each other through water molecules and form one dimensional chains. The coexistence of ferroelectric and antiferromagnetic ordering in (bix)CuCl4·H2O is demonstrated. Its spontaneous polarization and coercive field at room temperature are 2.03 μC cm−2 and 0.32 kV cm−1, respectively. Furthermore, (bix)CuCl4·H2O films with high quality can be easily prepared, which makes them suitable for application in device fabrication.
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FUEL
·
2022
·
IF 8.035
Xiaojie Wang,Yingjie Ma,Jianing Huo,Jidong Liu,Shizhao Wang,Lide Fang,Zhiyue Zhao
Alcohols are commonly used as additives in biodiesel to improve its viscous and dense properties for better applicability in the industrial field. In this work, experimental investigations are conducted on the dynamic viscosities for the binary mixture of methyl octanoate (one component of biodiesel) with one 1-alcohol containing 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, and 1-heptanol from 293.15 to 333.15 K at atmospheric pressure. The excessive viscosity shows negative deviation from the ideal solution for each binary system and is fitted with the Redlich-Kister equation. The McAllister three-body model is used for the kinematic viscosity correlation of binary mixtures. To acquire dynamic viscosity, the experimental density is measured and correlated as a function of temperature and mole fraction of methyl octanoate. Meanwhile, the McAllister three-body model, Heric's model, Frenkel model, and Grunberg-Nissan model are used to correlate the viscosities of the mixtures. Furthermore, some research has also been done on the improvement of the prediction performance for McAllister three-body model based on the studied systems.
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Frontiers in Pharmacology
·
2023
·
IF 5.6
Jing Zhu,Zhenyao Li,Fengli Yin,Xiaoting Yu,Yuanfan Lu,Tong Zhou,Fanghua Gong,Zhangye Xu
Background : Thin endometrium is a reproductive disorder that affects embryo implantation. There are several therapies available for this disease, however they are not so effective. Fibroblast growth factor 1 (FGF1) is a member of fibroblast growth factor superfamily (FGFs), and it has been demonstrated that FGF1 expression was altered in samples collected from patients with thin endometrium. However, it is unclear if FGF1 could improve thin endometrium. The aim of this study was to investigate whether FGF1 have a therapeutic effect on thin endometrium. Methods: A model of thin endometrium induced by ethanol was constructed to investigate the effect and mechanism of action of FGF1 in thin endometrium. In the characterization experiments, 6–8 weeks female rats (n = 40) were divided into four groups: i) Control group; ii) Sham group; iii) Injured group; (iv) FGF1 therapy group. Endometrial tissues would be removed after three sexuel cycles after molding. Morphology and histology of the endometrium were evaluated by visual and hematoxylin and eosin staining. Masson staining and expression of α-SMA in endometrium showed the degree of endometrial fibrosis. Western blotting (PCNA、vWF and Vim) and immunohistochemistry (CK19 and MUC-1) demonstrated the effect of FGF1 on cell proliferation and angiogenesis. Moreover, immunohistochemistry (ER and PR) was used to explore the function of endometrium. The remaining rats (n = 36) were divided into three groups: i) Injured group; ii) FGF1 therapy group; and iii) 3-methyladenine. Western blotting (p38、p-p38、PI3K 、SQSTM1/p62、beclin-1 and LC3) was used to explore the mechanisms of FGF1. Results: In FGF1 therapy group, the morphology and histology of endometrium improved compared with the model group. Masson staining and the expression level of α-SMA showed that FGF1 could decrease the fibrotic area of endometrium. Besides, changes in ER and PR expression in the endometrium suggested that FGF1 could restore endometrium-related functions. Western blotting and immunohistochemistry revealed that PCNA, vWF, Vim, CK19 and MUC-1 were significantly increased after FGF1 treatment compared with the thin endometrium. In addition, Western blotting showed that p38, p-p38, PI3K, SQSTM1/p62, beclin-1 and LC3 levels were higher in FGF1 group than in the injured group. Conclusion: FGF1 application cured the thin endometrium caused by ethanol through autophagy mechanism.
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PubMed
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BIOORGANIC & MEDICINAL CHEMISTRY
·
2017
·
IF 2.93
Juan Sun,Han-Yu Liu,Ruo-Fei Xu,Hai-Liang Zhu
Recent progress in the development of small molecular skeleton-derived polo-like kinase (PLK1) catalytic domain (K D ) inhibitors has led to the synthesis of multiple ligands with high binding affinity. However, few systematic analyses have been conducted to identify key PLK1-PBD domain and characterize their interactions with potent PLK1 inhibitors. Therefore, we designed a series of PLK1-PBD inhibitors with an in silico scaffold modification strategy. A docking simulation combined with a primary screen in vitro were performed to filter for the lead compound, which was then substituted, synthesized and evaluated by a variety of bioassays. The biological profile of 4v suggests that this compound may be developed as a potential anticancer agent.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2022
·
IF 7.088
Xiaona Sun,Yujin Wang,Zhichao Lei,Shasha Yue,Li Chen,Jianbo Sun
A series of novel 5-hydroxyl-1-azabenzanthrone derivatives were designed, synthesized and evaluated as dual binding site acetylcholinesterase inhibitors for the treatment of Alzheimer's disease (AD). The most effective Compound 16 showed selective inhibition of acetylcholinesterase ( ee AChE IC 50 = 0.045 μM; ee BuChE IC 50 = 19.68 μM; SI = 437.33). Most of the compounds showed cytoprotective effects on PC12 cells damaged by hydrogen peroxide, which might be related to their antioxidant activity . Further experiments confirmed that 16 exhibited anti-apoptotic effects at low concentrations and reduced the relative level of ROS generation in PC12 cells. The expression level of proteins related to antioxidant stress pathway in PC12 cells was relatively increased after administrated with 16 , which may be beneficial to delay the progression of the disease. Moreover, 16 was evaluated to be safe in vivo and in vitro, and showed good overall pharmacokinetic performance and high bioavailability (Foral = 55.5%). Besides, 16 showed comparable performance in ameliorating the scopolamine-induced cognition impairment to donepezil . In addition, in vitro BBB permeability experiments confirmed that 16 had high BBB permeability.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Haiyan Zhou,Xiaolei Li,Yuanyuan Li,Xinying Zhu,Lei Zhang,Jing Li
As part of a continuing study, we designed and synthesized four series of 1-phenylimidazole-4-carboxylic acid derivatives as xanthine oxidoreductase (XOR) inhibitors, evaluated their in vitro inhibitory potencies against XOR and hypouricemic effects in mice, and determined their structure-activity relationships (SARs). Most of the compounds exhibited in vitro XOR inhibition at the nanomolar level. In comparison to febuxostat (half-maximal inhibitory concentration [IC 50 ] value of 7.0 nM), compounds Ie and IVa exhibited the most promising XOR inhibitory effects with IC 50 values of 8.0 and 7.2 nM, respectively. In the potassium oxonate/hypoxanthine-induced acute and long-term hyperuricemia mouse models, compounds Ie and IVa displayed significant hypouricemic potencies ( P < 0.05), that were slightly weaker than and similar to febuxostat, respectively. More interestingly, both compounds showed a capacity to improve kidney damage by decreasing creatinine and urea nitrogen levels compared to the long-term hyperuricemia mouse group ( P < 0.05), while febuxostat showed no significant effect.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Xiaolu Fan,Fumin Wang,Yi Zhai,Xubin Zhang,Yongwang Li,Kaiwei Wang,Zhibo Xu,Changhao Bing,Jinjin Zhang,Qi Shen,Xinyuan He,Guojun Lv
Vanadium-MFI zeolites possess phenomenal potential for catalytic oxidation , while their application is constrained by vanadium content and species distribution. Here, we constructed Vanadium Silicate-1 (VS-1) with enhanced content and preferable distribution by the addition of citric acid in tandem with a temperature-program strategy. Citric acid could modulate the pH in the initial gel and coordinate with vanadium, inhibiting the hydrolysis of vanadium and promoting vanadium incorporation. Moreover, a temperature program was employed to generate unsaturated silicon species, overcoming the tendency of aggregation in vanadium precursor and further promoting vanadium insertion. Furthermore, the effects of the first-stage crystallization temperature and time on the properties of zeolite have been investigated in detail. The sample synthesized through the optimal temperature program achieved 99.9 % dibenzothiophene conversion in 2 h, 10.4 times that of conventional synthesis. To explain the excellent reaction activity, the relationship between different vanadium species and reaction results was investigated. Through linear fitting, V=O(OSi) 2 (OH) was considered as the dominant active species in oxidative desulfurization (ODS) reaction. Notably, the recycled zeolite proved good reusability, further enhancing its promising application prospect.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xian Zhang,Cheng-Ye Zhu,Wangbei Cao,Zhao-Yu Ma,Hao-Nan Li,Hong-Qing Liang,Chuan-Jie Fang,Xiao-Jun Huang,Zhi-Kang Xu
Poly(propylene-co-1-butene) (PP-co-BT) is a promising material for membrane separation, due to its greater flexibility, reduced melting point and lower crystallinity relative to other polyolefins including polypropylene and poly(4-methyl-1-pentene). Nevertheless, employing PP-co-BT in membrane separation poses a challenge due to the limited understanding of its thermodynamic and kinetic behavior in solution, as well as the lack of the appropriate means of optimizing membrane morphologies for specific applications. In this study, we aim to address these challenges by reporting the preparation of PP-co-BT membranes via the thermally induced phase separation (TIPS) process using soybean oil and dibutyl phthalate as mixed diluent. The thermodynamic phase diagram demonstrates a liquid–liquid phase separation mechanism. By employing an isotropic cooling condition, we fabricate symmetric membranes with uniformly distributed bi-continuous pores. These membranes are subsequently coated with a mussel-inspired coating to achieve Janus wettability, enabling efficient separation of oil-in-water emulsions. Furthermore, we demonstrate the ability to produce PP-co-BT membranes with gradient or asymmetric porous structures by subjecting the TIPS process to temperature or concentration gradients. These gradient or asymmetric membranes hold promise for specific applications such as the removal of microplastics from water or as oxygenation membranes. This study showcases the potential of PP-co-BT in membrane separation, offering insights into the fabrication techniques and the versatility of PP-co-BT for various applications.
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高影响因子
FUEL
·
2023
·
IF 7.4
Meiyu Liu,Xinyu Sun,Yiming Zhang,Ye Yang,Yucai Qin,Binbin He,Yi Mei,Yun Zu
Propane dehydrogenation (PDH) is one of the most effective methods for intentional (“on-purpose”) propylene production. Isolated Sn sites on open supports exhibit considerable PDH performance comparable to that of industrial Pt- and Cr-based catalysts, but the loss of Sn is inevitable. Herein, highly dispersed and stable NiSn subnanoclusters encapsulated within the channels of silicalite-1 zeolite are fabricated through a one-step hydrothermal synthesis in this work. The as-prepared Ni 1 Sn 1 @S-1 zeolite catalyst exhibits outstanding PDH performance with considerable propylene formation rate (ca. 12.3 mmol∙g cat -1 ∙h −1 ) and high propylene selectivity (>88 %). Most significantly, no Sn loss is detected after three regeneration cycles. Structural elucidation of NiSn sites on catalysts, by HRTEM, H 2 -TPR, FTIR and XPS characterizations confirms that the Ni sites embedded in the geminal silanols of zeolitic framework play a vital role in anchoring Sn species and preventing the active sites from losing and sintering. The cooperative action of robust NiSn subnanoclusters is conducive to the selective C–H activation and the propylene desorption. A plausible dehydrogenation mechanism is revealed by in situ infrared spectroscopy. This study on siliceous zeolite confined NiSn catalysts delivers an insight into the nature of selective and stable NiSn sites involved in the PDH reaction.
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DESALINATION
·
2023
·
IF 9.9
Yingying Liu,Xinyu Dong,Ming Wang,Shujie Guo,Haifeng Zhang,Zhi Wang
Nanofiltration (NF) membrane technology has become the most critical alternative to resolve fresh water resources shortage and water pollution . Preparing polyamide (PA) NF membrane with excellent water permeance and mono/multivalent salts selectivity is highly desired. Herein, we introduced 1-methylimidazole (1-MI) as a reactive additive into interfacial polymerization (IP) to prepare NF membrane and attempted to improve the NF membrane performance . 1-MI modified NF membranes exhibited enlarged pore size and thickness of PA layer, as well as a smooth and hydrophilic membrane surface , the water permeance improved from 7.7 L/(m 2 ·h·bar) of Virgin-NF to 13.1 L/(m 2 ·h·bar) of 1-MI-0.05-NF. The Na 2 SO 4 rejection was maintained at 95.01% while NaCl rejection dramatically reduced from 25.79% to 13.29%, and the Cl − /SO 4 2− selectivity slightly increased from 21.47 to 23 under the mixed salts solution as feed. The enhancement of water permeance was ascribed to the looser PA layer and enhanced hydrophilicity . The retaining Na 2 SO 4 rejection was attributed to electrostatic repulsion caused by more carboxylic acid groups, and the decreased NaCl rejection was ascribed to the looser PA layer. Besides, the modified membrane had an acceptable pH stability. In summary, 1-MI modified NF membrane was suitable for the separation of monovalent/divalent anionic salts.
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DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 39
·13955-13961
·
IF 4
Xiaorui Yan,Lele Chen,Haisheng Wei,Tiantian Liu,Kairui Li,Jing Li
The stability of Rh-based heterogeneous catalysts is a key issue in the hydroformylation of olefins. Confinement of active Rh species has been considered an effective strategy to achieve stable catalysts. In this work, a phosphine ligand was successfully confined in ZIF-8 material and coordinated with Rh metal by a reduction procedure to develop an efficient and stable Rh-based catalyst for hydroformylation of 1-octene. The results indicate that the catalyst reduced at 300 °C under H2 atmosphere exhibits better stability than that with NaBH4 as reductant and undoped P catalyst. Various characterization studies demonstrate that the superior performance is due to the strong interaction between Rh metal and P, which inhibits the leaching of active Rh species. This work reveals an effective strategy for the synthesis of highly stable catalysts for use in the hydroformylation reaction.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yaqiang Li,Chengzhi Li,Ruopeng Li,Xuesong Peng,Jinqiu Zhang,Peixia Yang,Guangzhao Wang,Bo Wang,Peter Broekmann,Maozhong An
A novel chlorinated functional group-modified triphenylmethane derivative leveler BB1 is used to achieve superconformal electrodeposition in microvias. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) are performed to study the suppressing effect of BB1, while the convection-dependent adsorption of BB1 on the copper surface is analyzed by galvanostatic measurement, and a BB1 concentration window between 100 and 200 mg/L is beneficial for superfilling. The interactions among BB1, bis-(sodium sulfopropyl) disulfide (SPS), and poly(ethylene glycol) (PEG) are also investigated. Density functional theory (DFT) calculation and in situ Raman spectroscopy are coupled to study the suppression mechanism and synergistic suppression mechanism, namely, the adsorption effect between BB1 and copper substrate, as well as the coordination effect between the modified chlorinated functional group and Cu2+, is proposed. The copper layer becomes smoother and more compact with an increase in BB1 concentration, according to scanning electron microscopy (SEM) and atomic force microscopy (AFM), while X-ray diffraction (XRD) analysis shows that the introduction of BB1 is conducive to the formation of the copper (220) plane. Besides, the solution wettability is boosted by BB1. A copper interconnecting layer with high quality is achieved with 150 mg/L BB1, while the surface deposition thickness (SDT) is about 34 μm and filling percentages (FPs) for microvias with diameters of 100, 125, and 150 μm are 81.34, 82.72, and 81.39%, respectively.
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