EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 4.7
Zhenshuai Zhang,Li Jiang,Lu Chen,Xinyan Cai,Yuteng Wang,Wenqian Xue,Kaijian Lei,Tianxiao Wang
Colorectal cancer (CRC) remains one of the most prevalent malignancies globally, with limited therapeutic options for advanced-stage patients due to acquired drug resistance and systemic toxicity. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target for CRC, while cystathionine γ-lyase (CSE)—a key enzyme in hydrogen sulfide (H 2 S) biosynthesis—plays a critical role in maintaining redox homeostasis and suppressing ferroptosis in cancer cells. Here, we synthesized a novel small-molecule compound, DPhA-EtOBz-TSC, and systematically evaluated its anti-CRC efficacy and underlying molecular mechanism. The chemical structure of DPhA-EtOBz-TSC was confirmed by 1 H nuclear magnetic resonance ( 1 H NMR), 13 C NMR, and high-resolution mass spectrometry (HRMS). In vitro studies using human CRC cell lines (HCT8 and SW480) demonstrated that DPhA-EtOBz-TSC specifically targeted and inhibited CSE: molecular docking and cellular thermal shift assay (CETSA) confirmed direct binding between DPhA-EtOBz-TSC and CSE (binding affinity ΔG = −29.07 ± 3. 85 kcal/mol), while Western blot analysis revealed a concentration-dependent reduction in CSE protein levels in SW480 and HCT8 cells treated with DPhA-EtOBz-TSC. Mechanistically, DPhA-EtOBz-TSC-induced CSE downregulation disrupted the CSE-H 2 S-GPX4 axis, leading to reduced glutathione (GSH) levels, decreased glutathione peroxidase 4 (GPX4) activity, and accumulation of lipid reactive oxygen species (ROS) and malondialdehyde (MDA)—hallmarks of ferroptosis. Additionally, Electron microscopy and JC-1 staining revealed that DPhA-EtOBz-TSC induced significant alterations in mitochondrial morphology and a marked reduction in mitochondrial membrane potential (ΔΨm). Functionally, DPhA-EtOBz-TSC exhibited potent in vitro anti-CRC activity with IC 50 values of 25.15 μM (HCT8) and 26.11 μM (SW480) respectively, and suppressed migration and invasion. In vivo, DPhA-EtOBz-TSC (10 mg/kg/day, i.p.) significantly suppressed the growth of CT26 cell-derived xenograft tumors in BALB/c mice without causing obvious histopathological abnormalities in major organs (heart, liver, spleen, lung, kidney). Immunohistochemical staining of tumor tissues confirmed increased lipid peroxidation and decreased CSE/GPX4 expression in DPhA-EtOBz-TSC-treated mice, consistent with in vitro findings. In conclusion, DPhA-EtOBz-TSC is a novel CSE-targeting compound that induces ferroptosis in CRC cells and inhibits tumor growth in vivo. Our findings identify DPhA-EtOBz-TSC as a potential lead compound for CRC therapy and highlight the CSE-H 2 S-GPX4 axis as a viable therapeutic target for ferroptosis-based anticancer strategies.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 24
·52335
·
IF 3.057
Hao Zhang,Ying Jun Li,Jun Zeng,Hui Ping Liu,Yuan Lin Zhou
In order to solve the problem of poor thermal conductivity of polymer-based radiation shielding composite materials, h-BN@PDA@PbWO 4 hybrid powders were prepared by combining h-BN with high thermal conductivity and PbWO 4 with γ shielding. With the assistance of polydopamine, PbWO 4 particles were synthesized in situ on the h-BN surface. The effects of h-BN@PDA@PbWO 4 on thermal conductivity, γ-ray shielding, and mechanical properties of chloroprene rubber were studied. The results showed that the hybrid particles had better dispersibility than the pure mixing of h-BN and PbWO 4 in chloroprene rubber and significantly improved the thermal conductivity gamma-ray shielding performance and mechanical properties of CR composites. When the filler content of the hybrid powder reaches 40 wt%, the thermal conductivity of the composite is about 3.16 times that of the pure CR. The γ shielding rates at 86.5 KeV and 105.3 KeV photon energies increase by 14.14% and 17.61% compared with the pure CR. Compared with pure CR, the tensile strength of the composites increased by 4.79 MPa, and the elongation at break decreased slightly. These were because h-BN@PDA@PbWO 4 shows had an excellent synergistic effect in CR substrate. The new kind of CR/h-BN@PDA@PbWO 4 composite can be used for thermal management and gamma shielding.
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高影响因子
Scientific Reports
·
2026
·
IF 4.9
Dang Yanqing,Xiang Yanju,Abudula Adila,Hou Xujie,Pu Yunfeng
This study investigated the efficacy of γ-aminobutyric acid (GABA, 1.0 mM) and 1-methylcyclopropene (1-MCP, 1 µL L − 1 ), individually and in combination, in mitigating watercore disappearance, flesh browning, and postharvest quality in apples during 180 days storage. The results showed that the combined GABA + 1-MCP treatment outperformed individual applications, significantly delaying watercore disappearance by preserving sucrose and sorbitol while moderating glucose and fructose accumulation. Furthermore, the combined treatment significantly reduced flesh browning compared to the control, likely attributed to suppressed polyphenol oxidase activity and enhanced antioxidant capacity. This approach also minimized weight loss and maintained firmness and titratable acidity. Although total phenolics and total flavonoids increased progressively during storage, their levels were effectively regulated by the GABA + 1-MCP treatment. These results indicate that the combined exogenous application of GABA and 1-MCP is a potentially effective method to improve postharvest quality, and enhance storage efficiency of apple fruit.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Chan Li,Xue Yang,Yunfei Zou,Li Zhang,Chuhuan Wei,Yan Ran,E. Zhao,Jibiao Yuan,Keshan Wang,Yongguo Jin,Ying Zhou,Qiujin Zhu,Yuxin Cheng,Yuanyuan Liu
Egg white gel (EWG) is a highly important raw and auxiliary material in food industry. With the increasing demand of consumers for nutrition, developing a modification method for regulating the texture of traditional egg white gel while enhancing its nutritional efficacy has become a challenge. Herein, a hierarchical W/O/W double emulsion filled gel was fabricated via a two-level emulsification process. The primary W/O emulsion, stabilized by synthesized γ-cyclodextrin metal-organic frameworks (CD-MOFs) Pickering emulsifiers, was incorporated into an egg white solution, where the endogenous emulsifying properties of the proteins facilitated the formation of the secondary O/W interface. The stability and morphology of the CD-MOFs-stabilized W/O emulsion (CDME) were analyzed, and the gel properties, molecular interactions, and microstructure of the W/O/W emulsion filled EWG gel (CDME-EWG) was then evaluated. The results indicated that CD-MOFs at 6 mg/mL (CDME-6) significantly enhanced the stability of the Pickering emulsion. This effect was achieved through the formation of a dense interfacial film at the oil/water boundary, which effectively promoted droplet dispersion and suppresses coalescence. Furthermore, the emulsion filled gel with 6 mg/mL CD-MOFs (CDME-EWG6) promoted the cross-linking within the gel network, leading to a more compact structure, enhanced water retention (52.84%) and hardness (887.00 g), as well as the enhancement in encapsulation capability (81.77%) and bioavailability (41.18%) of lutein. This study proposed a novel strategy for improving the performance of protein gels, which also provided the potential for co-encapsulation of multi-component bio-actives via the porous CD-MOFs and compartmentalized chamber within the W/O/W emulsion
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EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Benshun Huang,Ting Shen,Zhuoyi He,Xi Yang,Zhen Wang,Limin Ji,Yujun Chen,Jiayi Luo,Jun Ling,Yougen Chen
The current study explores the organocatalytic ring-opening polymerization (ROP) of γ - n -butoxyl- ε -caprolactone (BCL) and its one-pot block copolymerization with a strained bridged ester N -Boc-substituted proline lactone (N Boc PL), using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The TBD-catalyzed ROP of BCL in toluene demonstrates the first-order polymerization kinetics and exhibits living polymer characteristics within moderate monomer conversion. It effectively suppresses inter- and intramolecular transesterification side reactions to the minimum, which are commonly observed in base-promoted ROP of lactone monomers. It provides acceptable control over the molecular weight of poly( γ - n -butoxyl- ε -caprolactone) (PBCL) by simply tuning the initial monomer-to-initiator molar ratio and controlling the monomer conversion. For instance, the polymerization using bifunctional 1,4-butanediol as the initiator can produce narrowly distributed PBCL with M n,SEC up to 34.5 kg mol −1 and M w / M n of less than 1.20. The TBD-catalyzed copolymerization of BCL with N Boc PL is successful to synthesize block copolymers. Notably, the one-pot copolymerization of the two monomers demonstrates a strictly sequential monomer consumption with N Boc PL polymerizing first followed by BCL. This unique copolymerization behavior enables the synthesis of block copolymers via a one-pot procedure, and tri-, penta-, and heptablock copolymers are accordingly synthesized by introducing monomers simultaneously or in multiple steps. The polymer structures are characterized using NMR, FT-IR spectroscopy, MALDI-TOF MS, and SEC. The thermal characteristics and self-assembly behavior of the polymers in aqueous solutions are further evaluated using TGA, DSC, and DLS. Additionally, the cytotoxicity of the Boc-deprotected triblock copolymers towards mouse fibroblasts (3T3 cells) and their hemolytic effects on rat red blood cells are further investigated, with the detailed results presented in subsequent sections.
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高影响因子
ACS Materials Au
·
2026
·
IF 9.1
Yuhan Li,Zhuoyang Du,Yongheng Shi,Zeqing Liu,Lingmei Dai,Dehua Liu,Wei Du
Enzyme immobilization on solid supports enhances stability and reusability, yet nanoscale carriers such as metal–organic frameworks (MOFs) still face challenges in efficient recovery. While pyrolysis can magnetize Fe-MOFs, conventional methods often compromise either enzyme activity or structural integrity. This study presents a rational two-step oxidation–reduction (O–R) pyrolysis strategy to convert Meso-MIL-88A into a magnetically recyclable, mesoporous biocatalyst support (O-R500). Unlike one-step carbonization, which generates enzyme-incompatible Fe3O4, or carbonization-oxidation routes that collapse the framework, our approach first transforms the MOF into a robust α-Fe2O3 template while preserving its morphology. Citric acid then acts as a mild, slow-releasing reductant, selectively producing a γ-Fe2O3-rich phase without damaging the mesostructure. The resulting O-R500 exhibits well-defined mesopores (∼13 nm), sufficient magnetization (16 emu/g) for rapid separation, and a biocompatible surface that maintains the native conformation of immobilized Candida antarctica lipase B (CalB). In the synthesis of phosphatidyl EPA/DHA, CalB@O-R500 achieved 84.5% incorporation and retained 90.3% activity over five cycles, outperforming nonmagnetic counterparts. This work not only provides a high-performance magnetic biocatalyst but also establishes a generalizable design principle for converting Fe-MOFs into structured, biocompatible, and functionally integrated carriers.
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高影响因子
ACS Catalysis
·
2026
·
IF 13.6
Ruan Yuhao,Liu Peng,Liu Jianqiao,Yang Yiwei,Shen Zhangfeng,He Jiehua,Huang Chen,Zhang Siqian,Ge Zhigang,Pan Yun-Xiang,Wang Yangang
Catalytic CO 2 methanation converts CO 2 with hydrogen into methane, enabling carbon recycling and chemical energy storage. However, the precise roles and synergy of critical active sites, oxygen vacancies and metal–support interfaces remain elusive in CO 2 methanation, impeding the development of highly active and selective low-temperature catalysts. Based on density functional theory calculations, herein, Ni-doped CeO 2 supports were designed to load Ni nanoparticles for constructing Ni/Ni x CeO 2-γ catalysts. With 2 mol % Ni doping, the Ni/Ni 0.02 CeO 2-γ catalyst exhibited 75.5% CO 2 conversion and 100% CH 4 selectivity at 250 ° C, and maintained its activity over 200 h at 300 ° C. Compared to Ni/CeO 2 , Ni/Ni 0.02 CeO 2-γ features smaller CeO 2 nanoparticles, higher oxygen vacancy concentration, and stronger metal–support interaction. The abundant oxygen vacancies create frustrated Lewis pairs with adjacent basic sites (e.g., hydroxyls and lattice oxygen) for effective CO 2 adsorption and activation, while the strong metal–support interaction facilitated the adsorption and dissociation of H 2 on the metallic Ni sites. Consequently, the above synergy boosted key steps including hydrogen spillover and intermediate hydrogenation, resulting in a marked improvement in the CO 2 methanation rate at low temperatures. The in situ diffuse-reflectance infrared Fourier transform spectroscopy revealed that the formate pathway served as the principal reaction mechanism for CO 2 methanation over Ni/Ni 0.02 CeO 2-γ . This study elucidates the role of oxygen vacancy-mediated synergy in low-temperature CO 2 methanation and offers a strategy for designing CO 2 hydrogenation catalysts.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 21
·10455-10462
·
IF 3.3
Mengting Chen,Qifeng Zhong,Jiao Ma,Zhiyang Zhang,Yingxin Liu,Zuojun Wei,Shuguang Deng
Hydrogenation of levulinic acid (LA) to γ-valerolactone (GVL) is a key reaction in the conversion of biomass to renewable fuels and value-added chemicals. Developing low-cost, highly efficient and reusable non-noble metal-based heterogeneous catalysts is vital but challenging. Herein, non-noble Ni–Mn/SiO2 catalysts with a low Ni loading (2.0 wt%) were designed for the selective hydrogenation of LA to GVL. The results showed that the optimal Ni–Mn/SiO2 (Ni/Mn = 2) catalyst with well-dispersed and small-sized metal nanoparticles (2.21 nm) and moderate acid sites exhibited excellent activity and selectivity and achieved a 100% yield of GVL in a 1,4-dioxane solvent under mild reaction conditions (e.g., 0.8 mol% Ni, 140 °C and 2.0 MPa H2) for 5.5 h and a 100% GVL yield at 180 °C for 2 h with a turnover frequency (TOF) of 190.2 h−1, which is better than most non-noble metal catalysts reported. Furthermore, the catalyst exhibited excellent reusability and could be recycled at least five times with only slight activity loss. This work provides new insights for the rational design of highly efficient and stable non-noble metal catalysts for the conversion of LA to GVL.
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高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 7
·2312-2321
·
IF 3.4
Peng Cai,Hefeng Zhang,Yifu Huang
Organic long afterglow materials can be incorporated into commercial polar polymer in very small amount to significantly reduce cost for application, while gaining excellent mechanical deformability attractively. Their luminescence can be usually enhanced, as the polar polymer can block oxygen diffusion and inhibit inclusion aggregation. However, due to thermal instability of most afterglow materials at high temperature, it is still a great challenge when they are applied for widely used polymer melt in material industry. Herein we report a new afterglow material of doped polymer system by blending a new luminescent, two-dimensional polyamide sheet (TIB-3CPBA-TAPA) with a high-temperature polyamide 6 (γPA6) melt. The excellent thermal stability of TIB-3CPBA-TAPA results from the amide bond-linked, imidazolium salted and conjugated structure. Interestingly, TIB-3CPBA-TAPA/γPA6 is found to emit greenish afterglow luminescence that can last for 4 s at room temperature, only under a loading of 0.1 wt% that harvests the UV exposure efficiently. Different from converting non-afterglow γ crystal (γPA) into afterglow α crystal (αPA), our facile strategy achieves longer afterglow with a higher melting point (220°C) and a tripled quantum yield (1.8%). In addition, the viscoelasticity of the polymer melt is improved by TIB-3CPBA-TAPA with a mechanical toughening effect.
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高影响因子
CELLULOSE
·
2022
·Vol. 30
·期 3
·1791-1810
·
IF 6.123
Wang Yamei,Xiao Dongdong,Tang Yang,Xia Yezhong,Zhong Yi,Zhang Linping,Sui Xiaofeng,Wang Bijia,Feng Xueling,Xu Hong,Mao Zhiping
Overproduction of reactive oxygen species is one of the important reasons of non-healing wounds, such as diabetic wounds. Melatonin is well known as an antioxidant, while the poor solubility limits its use in many areas. In this study, the solubility of melatonin was improved by introducing γ-cyclodextrin to form the composite named MT-γ-CD through ultrasonic process. During this process, the molar ratio of melatonin and γ-cyclodextrin was 2:1, the temperature was set at 30 ℃, and the ultrasonic time was 40 min. The MT-γ-CD showed good antioxidant property in vitro with high free radical scavenging efficiency over 90%. Besides, an injectable self-healing hydrogel was prepared to load with MT-γ-CD to form the wound dressing, here, sodium carboxymethylated cellulose was oxidized to introduce aldehyde groups that could form Schiff base with amino groups in gelatin. This dressing with good biocompatibility could be injected into irregular wounds, suppress the level of reactive oxygen species, and accelerate wound healing of diabetic rats in vivo. Therefore, it has great potential to provide a new treatment strategy for diabetic wounds.
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高影响因子
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2023
·Vol. 54
·期 2
·712-733
·
IF 3
Zhang Xi,Na Hao,Liu Pengyao,Wang Yajun,Li Junguo,Meng Qian,Li Guopeng
Regulating the phase transformation of γ → β in dicalcium silicate (C 2 S) can effectively improve the hydration activity and recycling rate of AOD slag; however, the evolution law for γ → β in C 2 S has not been extensively investigated. In this study, a novel “two-step” γ → α ′ L → β phase transformation method in C 2 S was designed based on the study of the pure C 2 S phase at a nonequilibrium state in the low- and middle-temperature ranges. The “two-step” method can be used to realize the transformation from needle-like nanostructured γ -C 2 S grains to lamellar-structured β -C 2 S grains, exhibiting the trend of interlaminar peeling accompanied by expansion of the particle volume and leading to the appearance of macroscopic lamellar cracking in β -C 2 S particles. In addition, the β -C 2 S mass fraction in AOD slag treated by water cooling at 680 °C reaches a maximum value of 47.5 wt pct, while the treated AOD slag presents abundant holes and defects, which can effectively enlarge the hydration contact area.
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高影响因子
Molecular Catalysis
·
2022
·
IF 5.089
Fukun Li,Ronghe Yang,Ziting Du,Jinhang Dai,Xingmin Wang,Ning Li,Jie Zhang,Xianming Zhang,Yunqi Liu,Haifeng Gong,Hong Yin,Zhenping Cai
γ-Valerolactone (GVL) is considered as a versatile platform chemical obtained from biomass refinery. In this study, eco-friendly group III metal (Sc, Y, La) triflates were examined as homogeneous catalysts for microwave-assisted transfer hydrogenation of ethyl levulinate (EL) to GVL under mild conditions. Experimental results revealed that the selectivity of GVL has a positive relationship with the Lewis acidity of metal ion, which is related to effective charge density of the metal center (3.23, 2.81, 2.60 for Sc 3+ , Y 3+ , La 3+ , respectively). The stronger Lewis acidity of metal ion, the higher catalytic activity of MPV reduction. Among these catalysts, Sc(OTf) 3 exhibited the best catalytic activity, achieving 98.4% EL conversion and 92.4% GVL yield at 140 °C in 3.0 h. Furthermore, Sc(OTf) 3 showed high stability and recyclability for at least ten reaction cycles. In addition, a plausible reaction pathway and mechanism were proposed.
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