SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Meng Luo,Hongrui Huang,Xiao Liu,Danheng Gao,Qiegen Liu,Jin Li,Lianfu Li,Shichuan Xi,Yu Shi,Yuanyuan Song,Shuxuan Li
Novel integrated optofluidic in-fiber SERS probe based on 4-MBA/Ag NPs for high-stability, label-free detection of PYO. • Ultrafast PYO fingerprint identification within 5 s via a competitive coordination recognition strategy. • Quantitative evaluation of PAHs-triggered bacterial virulence enhancement, providing reliable technical support for marine environmental risk assessment and coastal public health early warning. The activation of virulence in Pseudomonas aeruginosa under environmental stress is of great significance for studying the mechanism of bacterial-environment interaction. Pyocyanin (PYO), a key phenazine virulence factor secreted by P. aeruginosa , serves as a direct indicator of bacterial pathogenicity. Herein, we developed a highly integrated optofluidic in-fiber surface-enhanced Raman scattering (SERS) biosensor for rapid, label-free detection of PYO secretion by Pseudomonas aeruginosa under environmental stress. 4-Mercaptobenzoic acid (4-MBA) serves as a molecular recognition linker anchored onto silver nanoparticle (Ag NPs) surfaces, which can undergo competitive coordination with pyocyanin to suppress non-specific interference from coexisting impurities. The nitrogen atoms on the phenazine ring of PYO form Ag–N coordination bonds along with π–metal coupling interactions with Ag NPs. This competitive substitution displaces the Ag–S bonds between 4-MBA and Ag NPs, leading to a concentration-dependent reduction in the characteristic peak intensity of 4-MBA at 1077 cm⁻¹ . The sensor specifically identifies PYO via its characteristic peak at 1345 cm⁻¹ within 5 s, and exhibits a linear range of 10 −5 M to 10 −14 M. The limit of detection (LOD) was calculated as 1.0 × 10⁻ 14 M. Through the sampling tests, we confirm that 50 μM PAHs stress triggers a 1.5-fold increase in PYO secretion of P. aeruginosa , verifying PAHs-induced bacterial virulence enhancement. Benefiting from the specific competitive recognition between 4-MBA and PYO, the sensor exhibits robust anti-interference performance in complex natural seawater matrices. This work provides a sensitive, rapid, and cost-effective SERS platform for bacterial virulence monitoring, offering valuable insights into pollutant-bacterium interactions and public health early warning. Download: Download high-res image (164KB) Download: Download full-size image
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MOLECULES
·
2026
·Vol. 31
·期 17
·3096
·
IF 5.1
Haixia Wu,Dianheng Yu,Jinliang Hu,Fang Wang,Songtao Zhang,Kailu Guo,Huan Pang
Metal–organic frameworks (MOFs) have significant potential in electrochemical sensors, but the guest molecules and residual solvents in the pores often block the active sites and limit the reaction kinetics. One-dimensional nanostructures can provide direct conduction pathways and shorten ion diffusion distances, thereby enhancing electron transport and electrode contact. Meanwhile, fluorine-incorporated MOF materials leverage the high electronegativity of fluorine to substitute oxygen, suppress oxidation to widen the voltage window, and improve stability through enhanced hydrophobicity. In this work, 4-fluorosalicylic acid (4FSA) was used as the ligand and benzimidazole (Bim) was introduced to adjust the coordination environment, and one-dimensional Bim4FSA-MOF nanorods were successfully constructed. While the guest molecules were largely removed, the nickel sites were thereby activated and the pore size was enlarged. Due to the synergistic effect of one-dimensional nanostructure-promoted electron transport and the Ni(OH)2/NiOOH dynamic active center, the B-250 composite exhibited excellent performance in a glucose electrochemical sensor. The optimized sensor delivered a detection limit of 0.022 μM and a detection time of 0.9 s, along with a sensitivity value of 2986.45 μA mM−1cm−2, which provides a new strategy for the design of efficient MOF-based electrochemical sensor interface.
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Solar RRL
·
2026
·Vol. 10
·期 9
·e70362
·
IF 4.8
Yingjun Zhou,Chuanhe Ma,Shulei Liang,Yujun Li,Hailong Wang
In Cu 2 ZnSn(S, Se) 4 (CZTSSe) solar cells, the conventional magnetron-sputtered ZnO (ZnO-SP) suffers from high cost, low efficiency, and interface damage. This study systematically compares sol–gel ZnO (ZnO-SG) and 18C6 crown ether-modified sol–gel ZnO (ZnO-SG-18C6) as interfacial layers. X-ray diffraction (XRD), scanning electron microscope (SEM), AFM, and X-ray photoelectron spectroscopy (XPS) show ZnO-SP has a uniform hexagonal wurtzite structure, whereas ZnO-SG displays an amorphous fibrous morphology with bright/dark striations. Both exhibit similar UV absorption peaks, but ZnO-SG shows broader absorption and double-exponential decay. Density–voltage ( J – V ) tests reveal that ZnO-SG-18C6 increases PCE from 8.5% to 10.6%, surpassing the 9.5% achieved with ZnO-SP. Electrochemical impedance spectroscopy (EIS) analysis shows that the ZnO-SG-18C6 layer reduces carrier recombination, with the charge transfer resistance ( R ct ) increasing by 30%. Transient photocurrent measurements further reveal that it enhances the photocurrent response, achieving a 1.8-fold increase in the peak, which rises to four times under a 70% high duty cycle.This work demonstrates ZnO-SG-18C6 as a low-cost, high-efficiency alternative to ZnO-SP in CZTSSe solar cells.
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ACS Applied Nano Materials
·
2026
·
IF 5.8
Guanglin He,Jing Guo
We report a plasmon-mediated route to drive the azo coupling of 4-aminothiophenol to 4,4′-dimercaptoazobenzene on a gold nanostructure on a nanoelectrode (NSoNE) platform. Gold nanostructures were grown on electrochemically etched gold nanoelectrodes to form NSoNE substrates. The curved tip showed a larger enhancement factor than the planar rear surface, with values of 1.31× 104 and 3.08 × 103. Surface-enhanced Raman spectra tracked the azo coupling reaction in real time. At 88 μW μm–2, the curved tip reached a steady state in 37.5 s, while the planar region required 108.4 s. Reducing the power to 44 μW μm–2 slowed the process. Phenyl isocyanide (PIC) served as a molecular thermometer. The C≡N peak of PIC showed a linear red shift with temperature, with a slope of −0.246 cm–1 °C–1. Calibrated maps revealed a nonuniform thermal field that peaked at the tip. Potassium bromate was used to consume hot electrons. The reaction still proceeded in 0.8 mmol L–1 of KBrO3 but with longer steady-state times of 56.4 s at the curved tip and 109.3 s at the planar region. Dark-field heating experiments indicate that thermal effects can effectively activate the 4-ATP coupling reaction, yet they are insufficient to achieve the maximum reaction state. Overall, the results demonstrate that thermal effects can activate and accelerate the reaction process, with the most pronounced influence near the tip; moreover, electron-related reaction pathways also play a certain role.
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ACS Omega
·
2026
·
IF 5.2
Huanyu Chen,Yuduo Wan,Wanlu Feng,Changjiang Wang,Yang Wang,Yue Chen,Takron Chantadee,Zibo Li,Li Wang
Nectin-4, a cell adhesion molecule frequently overexpressed in non-small cell lung cancer (NSCLC), has emerged as a promising target for theranostic applications due to its involvement in tumor progression and association with poor prognosis. This study aimed to develop radiolabeled agents based on bicyclic peptides for both imaging and targeted therapy for Nectin-4 positive tumors. We designed and synthesized 68Ga-labeled probes ([68Ga]Ga-3 and [68Ga]Ga-5) for PET imaging and 177Lu-labeled agents ([177Lu]Lu-6) for targeted radionuclide therapy. Radiochemical yields and purity were optimized, and the agents were evaluated for cellular uptake, internalization, and biodistribution in Nectin-4-expressing cell lines (H1975, ABC-1, HEK293nectin4) and xenograft models. Target specificity was confirmed through blocking studies with the Nectin-4 specific inhibitor peptide N188. The 68Ga-labeled probes exhibited high radiochemical yields (78–81%) and purity (>95%), with specific uptake observed in Nectin-4-positive cells (e.g., 69.20 ± 2.31%ID/106 cells for [68Ga]Ga-3 at 120 min) and tumors. Blocking studies resulted in significant reductions in uptake, with 39-fold and 22-fold decreases for [68Ga]Ga-3 and [68Ga]Ga-5, respectively, confirming Nectin-4 specificity. [177Lu]Lu-6 showed superior tumor retention (13% uptake) and internalization (3.5%) compared to [177Lu]Lu-FAP-2286/N188, with sustained tumor growth suppression in xenograft models. PET/SPECT imaging revealed high tumor-to-background ratios and favorable pharmacokinetics, highlighting the potential of these agents for clinical application.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·
IF 7.5
Jin-Xing Zheng,Min-Hua Cui,Yan Zhang,Jing Wu,He Liu,Zhi-Yong Zheng
Nitrophenols are toxic and recalcitrant organic pollutants, posing a major challenge for wastewater treatment. Herein, a Fe-doped cyanobacterial biochar catalyst (Fe 3 /C 1 -800) was fabricated via a one-step impregnation pyrolysis strategy using lake-harvested cyanobacterial biomass as the carbon matrix and FeCl 3 ∙6H 2 O as both the in-situ activator and Fe source realizing the 'waste-to-treat-waste' concept. When applied to the catalytic reduction of 4-nitrophenol (4-NP), the Fe 3 /C 1 -800/NaBH 4 system achieved nearly complete reduction of 4-NP within 5 min, with a high turnover frequency (TOF) of 0.67 mmol·g -1 ·min -1 , surpassing most reported transition-metal catalysts and approaching noble-metal activity. The catalyst exhibited high efficiency over a wide pH range (3-11) and temperature range (15-45 ℃), resisted interference from Cl - and NO 3 - , and retain 93.7% of its activity after four consecutive cycles. In real water matrices (Lake Taihu water and secondary effluent from a sewage treatment plant), the 4-NP removal efficiency reached 95.4% and 88.1%, respectively. Mechanistic investigations revealed a synergistic effect between the catalyst’s large specific surface area (802.16 m 2 ·g -1 ) for 4-NP adsorption and the Fe 2+ /Fe 3+ redox cycle for accelerated electron transfer. This synergy promotes BH₄⁻ dissociation to generate active hydrogen species, enabling the selective reduction of 4-NP to 4-aminophenol (4-AP) with 97% selectivity. Furthermore, Fe 3 /C 1 -800 displayed broad-spectrum catalytic activity toward diverse nitrophenol contaminants (e.g., o -nitrophenol, p -nitrotoluene) with conversion rates >90%. This work not only offers a low-cost, eco-friendly pathway for cyanobacterial valorization but also offers a novel design principle of high-performance biochar-based catalysts, advancing the development of sustainable reduction systems for refractory organic wastewater.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Zeng-Yang Wang,Xin-Jie Zhao,Shuo Gao,Yuan-Xin Liao,Hao-Cheng Chen,Meng-Ge Zhang,Cheng-Cheng Li,Zhi-Jie Sun,De-Li Dong
PDE4 inhibitors roflumilast and rolipram extend lifespan and improve fitness in C. elegans ; roflumilast attenuates cellular senescence in mouse embryonic fibroblasts. • Roflumilast and rolipram enhance mitochondrial function and reduce ROS levels by activating PKA signaling. • PDE4/cAMP/PKA signaling pathway-mediated anti-aging effects are conserved. Aging is driven by multiple factors such as mitochondrial dysfunction and oxidative stress, leading to various age-related diseases. Phosphodiesterase-4 (PDE4) is a subfamily of phosphodiesterases and specifically hydrolyzes cAMP. PDE4 inhibitors have been approved for the treatment of several diseases and shown to improve aging-related conditions. However, the precise effects and underlying mechanisms of PDE4 inhibitors on lifespan and cellular senescence remain unclear. Here, we report that two PDE4 inhibitors (roflumilast and rolipram) extend C . elegans lifespan and that roflumilast attenuates passage-induced cellular senescence in mouse embryonic fibroblasts (MEFs). We further demonstrate that protein kinase A (PKA) activation mediates PDE4 inhibitors’ anti-aging effects by improving mitochondrial function and alleviating oxidative stress, and that the mechanism is conserved in C. elegans and MEFs. Our findings provide evidence that PDE4 inhibitors possess anti-aging potential. Download: Download high-res image (205KB) Download: Download full-size image
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Qiulian Luo,Jing Li,Jianwu Wei,Binbin Luo,Liya Zhou,Peican Chen,Jie Tian,Jiahong Pan,Alexei V. Emeline,Qi Pang
Metal halide species with multimeric anionic frameworks exhibit outstanding coordination chiralities and intriguing photophysical properties, making them highly promising for emerging photonic applications. However, their chiroptical activities remain largely unexplored to date. Herein, lead-free chiral hybrid 0D materials composed of edge-sharing [Sb2Cl10]4– dimers were synthesized via a natural cooling crystallization. The 0D chiral crystals R/S-1 [(R/S-MBA)4Sb2Cl10] show broad yellow photoluminescence stemming from self-trapped exciton states with a PL peak at 596 nm. R/S-1 exhibits strong circular dichroism (|gCD| ≈ 7 × 10–3) and efficient circularly polarized luminescence (|glum| ≈ 5 × 10–3). This is attributed to the chiral organic cations inducing inorganic sublattice chirality through asymmetric hydrogen-bonding interactions, while the inorganic lattice components adopt a helical arrangement following a 21 symmetry operation. Density functional theory calculations verify a Rashba-type band splitting for R/S-1, confirming the noncentrosymmetric structural distortion and substantial spin–orbit interaction induced by chiral organic cations. Furthermore, we applied chiral scintillators R/S-1 to achieve X-ray-driven asymmetric photopolymerization using circularly polarized emission. This study offers a pathway for the exploration and development of novel lead-free chiral metal halides.
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PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2020
·Vol. 39
·期 3
·327-336
·
IF 3.154
Shi Zhen,Wang Qi,Li Gui-Fei,Shou Yu-Feng,Zong Hong-Jie,Yan Shi-Feng,Zhang Kun-Xi,Yin Jing-Bo
Self-healing hydrogels with the shear-thinning property are novel injectable materials and are superior to traditional injectable hydrogels. The self-healing hydrogels based on 2-ureido-4[1 H ]-pyrimidinone (UPy) have recently received extensive attention due to their dynamic reversibility of UPy dimerization. However, generally, UPy-based self-healing hydrogels exhibit poor stability, cannot degrade in vivo and can hardly be excreted from the body, which considerably limit their bio-application. Here, using poly (l -glutamic acid) (PLGA) as biodegradable matrix, branching α-hydroxy- ω -amino poly(ethylene oxide) (HAPEO) as bridging molecule to introduce UPy, and ethyl acrylate polyethylene glycol (MAPEG) to introduce double bond, the hydrogel precursors (PMHU) are prepared. A library of the self-healing hydrogels has been achieved with well self-healable and shear-thinning properties. With the increase of MAPEG grafting ratio, the storage modulus of the self-healing hydrogels decreases. The self-healing hydrogels are stable in solution only for 6 h, hard to meet the requirements of tissue regeneration. Consequently, ultraviolet (UV) photo-crosslinking is involved to obtain the dual crosslinking hydrogels with enhanced mechanical properties and stability. When MAPEG grafting ratio is 35.5%, the dual crosslinking hydrogels can maintain the shape in phosphate-buffered saline solution (PBS) for at least 8 days. Loading with adipose-derived stem cell spheroids, the self-healing hydrogels are injected and self-heal to a whole, and then they are crosslinked in situ via UV-irradiation, obtaining the dual crosslinking hydrogels/cell spheroids complex with cell viability of 86.7%±6.0%, which demonstrates excellent injectability, subcutaneous gelatinization, and biocompatibility of hydrogels as cell carriers. The novel PMHU hydrogels crosslinked by quadruple hydrogen bonding and then dual photo-crosslinking of double bond are expected to be applied for minimal invasive surgery or therapies in tissue engineering.
研究领域:
生物材料学
·
组织工程学
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JOURNAL OF SOLID STATE CHEMISTRY
·
2023
·
IF 3.3
Liqiang Ma,Pengpeng Wei,Jingfang Li,Liye Liang,Guangming Li
To develop efficient and reusable catalysts for biodiesel production, quaternary heteropolyacid H 4 PVMo 2 W 9 O 40 (PVMo 2 W 9 ) was effectively wrapped inside rht -MOF-1 { rht -MOF-1 = [Cu 6 O(TZI) 3 (H 2 O) 6 ] 4 ⋅nH 2 O}, affording a crystalline H 4 PVMo 2 W 9 O 40 @ rht -MOF-1 ( 1 ) by one-pot hydrothermal method. The identification of the crystal structure of 1 was achieved through the utilization of X-ray crystallography. Nano-size crystals of 1 ( n-1 ) were prepared with the assistance of surfactant Tween 20. Notably, crystal n-1 was of cube shape grown along {100} facets rather than octahedral shape for 1 . When n-1 was applied as the catalyst for the esterification reactions, high conversion rates were achieved. E. g. about 97 % conversion for oleic acid to the corresponding monoalkyl esters and about 87 % for rapeseed oil to biodiesel. The catalyst was heterogeneous and recyclable 7 times without obvious attenuation. Further, the correlation between the catalytic activity and structure of n-1 was investigated in terms of the distribution of active sites, various pores in rht -MOF-1, and the accessibility of catalytic sites on the {100} facets.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Zhichao Zhang,Xiaoqi Wang,Li Wang,Renan Wu,Yan Jin,Ziyuan Duan
The characteristic ‘mutton flavor’ primarily emanated from subcutaneous adipose tissue and was associated with the levels of three branched-chain fatty acids (BCFAs). This study focused on assessing the quantitative distribution of BCFAs in four sheep breeds from northern China and initially explored the influence of genetic and feeding factors through systematic GC-MS analyses and multidimensional statistics. A total of 164 samples were procured from four breeds of Chinese indigenous sheep, including small-tailed Han sheep (SHS, n = 30; rams 12, ewes 18), Altay sheep (AS, n = 30; rams 15, ewes 15), Short-tailed Steppe sheep (STSS, n = 44; rams 14, ewes 30), and HulunBuir sheep (HBS, n = 60; rams 30, ewes 30), all 8 months old. The results indicated that SHS exhibited the highest levels of BCFAs, followed by AS. No significant difference between STSS and HBS, both with notably lower levels of mutton flavor-related BCFAs. Additionally, rams generally harbored higher levels of BCFAs in comparison to ewes. Collectively, this study provides valuable insights for improving the mutton flavor.
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高影响因子
Energetic Materials Frontiers
·
2026
·
IF 4.7
Hua Fang,Peng-fei Zhu,Jin-xiang Yang,Xiao-le Sun,Xiong Cao,Xue-yong Guo
The DAP-4/RDX mixture was prepared by solvent suspension method. The thermal decomposition, combustion and micro-explosion experiments were carried out. The results showed that the thermal decomposition peak temperature of DAP-4/RDX was lower than that of DAP-4. RDX reduces the activation energy required for the thermal decomposition of DAP-4, reduces the maximum flame temperature but prolongs the combustion duration. The combustion peak pressure and pressurization rate of DAP-4/RDX samples are lower than those of DAP-4, and the maximum is reduced from 415.65 kPa and 68.95 kPa·ms -1 to 322.58 kPa and 23.07 kPa·ms -1 . The intensity of laser-loaded shock wave is increased after the introduction of RDX under the same conditions. The detonation heat and detonation velocity of DAP-4/RDX measured by micro-explosion are higher than those of DAP-4, the increased intensity of laser-loaded shock wave is consistent with the improved detonation heat and velocity, jointly reflecting the enhanced detonation performance of RDX to DAP-4/RDX.
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