FOOD CHEMISTRY
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2023
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IF 8.8
Yanjie Wang,Xiaofeng Wei,Yu Su,Rui Xu,Daqian Song,Lan Ding,Yanhua Chen
In this manuscript, we synthesized CDs@ZIF-8 through a one-step, in-situ method by integrating green-emitting carbon dots (CDs) with zeolitic imidazolate framework-8 (ZIF-8). The resulting CDs@ZIF-8 was utilized as an ultrasensitive probe for detection, leveraging the inner filter effect. The analysis demonstrated the capability to detect Sudan dyes. Sudan I, for example, could be detected within a concentration range spanning from 0.25 to 70 μM, achieving a remarkable detection limit of 76.56 nM. This established method was effectively employed for detecting Sudan I in paprika. Compared with CDs, CDs@ZIF-8 exhibited a 3.32-fold increase in sensitivity and a wider detection range. This enhanced performance was attributed to the porous ZIF-8, which allowed for the enrichment of targets around CDs and avoided the aggregation of CDs. Additionally, embedding the CDs in ZIF-8 improved their pH stability. Our study provides a new approach for using CDs under limited conditions by leveraging metal–organic frameworks.
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Journal of Industrial Textiles
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2023
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IF 3.2
Xu Yang,Sarkodie Bismark,Dengbing Wang,Zuyi Liu,Yun Tao,Ziwei Sun,Xu Han,Quan Feng
Antibiotics released in the water pose a serious threat to human and ecological health. Therefore, it is of great importance to effectively remove antibiotics from wastewater. In this study, recyclable bacterial cellulose/sodium alginate/zeolitic imidazolate framework-8 (BC/SA/ZIF-8) aerogel composites were prepared by chemical cross-linking and in situ growth in freeze-drying. The successful preparation of the composite aerogel was confirmed by scanning electron microscope (SEM), Fourier Transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis. The results reveal that BC/SA/ZIF-8 aerogel composite has significantly high BET specific surface area of 165.24 m2/g than that of BC/SA at 7.39 m2/g. The BC/SA/ZIF-8 composite aerogel exhibited excellent adsorption performance for tetracycline hydrochloride, with a maximum adsorption capacity of 746.27 mg/g. The adsorption process followed the pseudo-second-order kinetic model and Langmuir adsorption isotherm model. Moreover, the reusability test on BC/SA/ZIF-8 composite aerogel revealed an insignificant decline in adsorption after six cycles. Therefore, BC/SA/ZIF-8 composite aerogel has a high potential as a novel and recyclable adsorbent for efficient removal of tetracycline hydrochloride from water.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2023
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IF 3.4
Xueqiang Sun,Fuxin Li,Lingyan Yuan,Zhitong Bing,Xun Li,Kehu Yang
Resveratrol (Res) is known for its potential in treating various types of cancers, with a particular advantage of causing minimal toxic side effects. However, its clinical application is constrained by challenges such as poor bioavailability, low water solubility, and chemical instability in neutral and alkaline environments. In light of these limitations, we have developed a pH-responsive drug delivery nanoplatform, Res@ZIF-8/TA NPs, which exhibits good biocompatibility and shows promise for in vitro cancer therapy. Benefiting from the mild reaction conditions provided by zeolitic imidazolate frameworks (ZIFs), a “one-pot method” was used for drug synthesis and loading, resulting in a satisfactory loading capacity. Notably, Res@ZIF-8/TA NPs respond to acidic environments, leading to an improved drug release profile with a controlled release effect. Our cell-based experiments indicated that tannic acid (TA) modification enhances the biocompatibility of ZIFs. 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT assay), Hoechst 33342/PI staining, cell scratch assay, Transwell and Reverse Transcription quantitative PCR (RT-qPCR) assays further demonstrated that Res@ZIF-8/TA NPs inhibited colon cancer cell migration and invasion, and promoted apoptosis of colon cancer cells, suggesting a therapeutic potential and demonstrating anti-cancer properties. In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.
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ACS Applied Nano Materials
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2023
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IF 5.9
Nahar Jannatun,Yuqian Zhang,Ben Wu,Qingle Song,Guoli Cao,Wenhe Luo,Feng Yuan,Qi Li,Yanqiao Zeng,Guofang Zhang,Guocheng Wang,Yang Li
Epigallocatechin-3-gallate (EGCG), the most abundant tea polyphenol, possesses excellent anti-inflammation properties. Emerging studies proved its potent potential as an immune checkpoint (ICP) inhibitor for anticancer therapy. However, the low bioavailability of EGCG reduces its treatment efficiency. In this work EGCG-based nanomedicine EGCG–ZIF-8@PDA–PEG (EZP) was developed via the coordination between ZIF-8 MOF and EGCG, followed by polydopamine and PEG functionalization for efficient tumor-targeting EGCG delivery. Results demonstrated that the EGCG loading rate in EZP reached up to 85%. Both in vitro and in vivo studies proved that the EZP nanoparticles were capable of inhibiting the expression of ICP molecules and modulating the inflammatory tumor microenvironment, evidenced by the suppression of PD-L1 expression, the reduction of inflammatory cytokines, and the resultant decline in the number of immunosuppressive cells, for instance, myeloid-derived suppressor cells, tumor-associated macrophages, and regulatory T cells. These synergistic effects significantly improved the infiltration of dendritic cells and T cells in tumors, realizing an inspiring antitumor effect.
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Biomedical Physics & Engineering Express
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2023
·Vol. 9
·期 3
·035027
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IF 1.4
Danni Wang,Xingming Wang,Ximing Pu,Guangfu Yin,Zhenrong Zhu,Xiaoran An,Wen Zhang
The high wastage rate and low survival rate of seed cells in conventional bone tissue engineering (BTE) are always a challenge for tissue regeneration. Constructing scaffolds that could continuously recruit endogenous stem cells is considered a novel way to promote tissue repair. In this study, a GelMA fiber hydrogel membrane loaded interleukin 8 (IL8) (IL8-GelMA), was prepared via electrostatic spinning technology. Compared with Gelatin fiber, GelMA fiber possessed a smooth morphology with nanoscale diameter and better physical properties including hydrophilicity, elastic modulus, swelling rate and degradation rate. In addition, IL8-GelMA fiber membranes could lead an osteogenic differentiation of BMSCs. Moreover, the results of chemotaxis experiment demonstrated that both IL8 and IL8-GelMA fiber membranes promote the migration of BMSCs in vitro. These results suggested that IL8-GelMA fiber membranes can be used for cell-free scaffold of bone repair, which can not only recruit endogenous BMSCs, but also promote osteogenic differentiation of BMSCs.
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Journal of Environmental Chemical Engineering
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2023
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IF 7.7
Na Yang,Hao Jiang,Longfei Zhang,Xiang Wang,Luhong Zhang,Yongli Sun,Bin Jiang
Spinel oxides can be considered effective heterogeneous catalysts in activating peroxymonosulfate (PMS) for wastewater decontamination . However, the intrinsic characteristics of agglomeration and metal ion leaching impede its further application. In this work, to further improve the catalytic efficiency and stability of the catalyst, ZIF-8 was employed as the candidate and further etched by tannic acid (TA) to obtain a core-shell structure with less mass transfer resistance. Following this, CoFe 2 O 4 was anchored on TA-ZIF-8 matrix via a hydrothermal method. Benefiting from the tailored core-shell structure and high activity of CoFe 2 O 4 , the as-prepared CoFe 2 O 4 @TA-ZIF-8 catalyst shortened the mass transfer distance of radical to target pollutant, thus realizing high radical utilization efficiency. Accordingly, 98.1% of tetracycline (TC) can be eliminated in 30 min with kinetic constants 3.15 times higher than pristine CoFe 2 O 4 . Besides, the TC degradation efficiency can still maintain 84.1% after five consecutive cycles with cobalt leaching lower than 0.306 mg/L, showing favorable stability compared with pristine CoFe 2 O 4 . Furthermore, electron paramagnetic resonance (EPR) and quenching experiments exhibited that singlet oxygen and sulfate radicals play dominant roles in TC degradation processes. This work fabricates an efficient CoFe 2 O 4 @TA-ZIF-8 heterogeneous catalyst for degrading refractory TC, which may possess potential applications in wastewater treatment .
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Hao Zhou,Yongheng Shi,Lingmei Dai,Dehua Liu,Wei Du
Pyrolyzing ZIF-8 into N-doped carbon is now inspiring new potential of ZIF-8 for extensive applications. However, the exploration of such ZIF-8-derived carbon for biotechnological applications has been rarely investigated, especially in this context that imidazole derivatives are of rich functionality in life science. Herein, we reported a facile temperature-dependent pyrolysis method to achieve the effective N-doping in ZIF-8-derived macroporous carbon, which was systematically investigated for the immobilization of lipase from Thermomyces lanuginosus (TLL) in biodiesel production. MNC-600 (macroporous N-doped carbon derived at 600 °C) exhibited the best immobilization performance, with the highest specific activity of 190.6 U mg −1 , a 36.9% increase than free TLL. Moreover, MNC-600@TLL showed superior effectiveness and robustness in biodiesel production. A much faster rate of conversion and the highest biodiesel yield of 87.4% were observed. After eight successive batches of recycling, MNC-600@TLL retained 93.4% of its initial activity. XPS analysis revealed the evolution of N species during the pyrolysis of ZIF-8. It was proposed that the abundant doping of pyrrolic N species played a major role in the surprising performance of MNC-600, mainly through hydrogen bonding interactions, which simultaneously realized the activation of reactants as well as the in-situ hydrophobization of biocatalyst. This report is anticipated to pave a way for the exploration of ZIF-8-derived N-doped carbon for extensive biotechnological applications.
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ACS Omega
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2023
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IF 4.1
Samreen Sadiq,Iltaf Khan,Muhammad Humayun,Ping Wu,Abbas Khan,Sohail Khan,Aftab Khan,Shoaib Khan,Amal Faleh Alanazi,Mohamed Bououdina
Toxic antibiotic effluents and antibiotic-resistant bacteria constitute a threat to global health. So, scientists are investigating high-performance materials for antibiotic decomposition and antibacterial activities. In this novel research work, we have successfully designed ZIF-8@ZIF-67 nanocomposites via sol–gel and solvothermal approaches. The ZIF-8@ZIF-67 nanocomposite is characterized by various techniques that exhibit superior surface area enhancement, charge separation, and high light absorption performance. Yet, ZIF-8 has high adsorption rates and active sites, while ZIF-67 has larger pore volume and efficient adsorption and reaction capabilities, demonstrating that the ZIF-8@ZIF-67 nanocomposite outperforms pristine ZIF-8 and ZIF-67. Compared with pristine ZIF-8 and ZIF-67, the most active 6ZIF-67@ZIF-8 nanocomposite showed higher decomposition efficacy for ciprofloxacin (65%), levofloxacin (54%), and ofloxacin (48%). Scavenger experiments confirmed that •OH, •O2–, and h+ are the most active species for the decomposition of ciprofloxacin (CIP), levofloxacin (LF), and ofloxacin (OFX), respectively. In addition, the 6ZIF-67/ZIF-8 nanocomposite suggested its potential applications in Escherichia coli for growth inhibition zone, antibacterial activity, and decreased viability. Moreover, the stability test and decomposition pathway of CIP, LF, and OFX were also proposed. Finally, our study aims to enhance the efficiency and stability of ZIF-8@ZIF-67 nanocomposite and potentially enable its applications in antibiotic decomposition, antibacterial activities, and environmental remediation.
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ChemNanoMat
·
2023
·Vol. 9
·期 10
·e202300310
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IF 3.8
Xin Cui,Jiachen Zhang,Yitong Liu,Wen Shao,Yawen Tang,Hanjun Sun
Graphical A Ru-ZIF-8 nanozyme with both esterase like and peroxidase like activities were prepared for acetylcholine (ACh) detection. On the basis of the Ru-ZIF-8 nanozyme, a portable nanozyme strip was developed as a novel biosensor for detecting ACh, which was conducive to promoting the development of multiple enzyme cascade assays. In the present study, the incorporation of Ru into the framework of ZIF-8 resulted in that a Ru-ZIF-8 nanozyme with both esterase-like activity and peroxidase-like activity. Owing to the dual nanozymatic activities of Ru-ZIF-8 nanozyme, the acetylcholine (ACh) detection process utilized only one natural enzyme (choline oxidase), which greatly simplified the detection procedure. In the detection process, nanozyme Ru-ZIF-8 showed esterase-like activity to catalyze the hydrolysis of ACh to choline. Then the generated choline was oxidized by choline oxidase to generate H 2 O 2 . Finally, Ru-ZIF-8 with peroxidase-like activity was used to catalyze H 2 O 2 to oxidize 2,2′-azino-bis (3-ethylbenzothiazo-line-6-sulfonic acid) ammonium salt with a color change. As a result, the linear range for ACh was from 0.01 μM-22 μM with the detection limit (DL) of 5.5 nM. In addition, Ru-ZIF-8 was utilized to fabricate a portable detection test strip. Our work provided a simple, portable, low-cost, highly sensitive and selective assay for the detection of ACh, which paved the way for the development of multi enzyme cascade assays.
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Frontiers in Chemistry
·
2023
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IF 5.5
Jia Liu,Su-Hang He,Hugues Lambert,Tung-Chun Lee
Resazurin (Alamar Blue, RZ) is a widely utilized fluorescent probe for biological sensing, whose fluorescent intensity can be modulated by changing its redox states; thereby, electrochemical reactivity of RZ is of significance when designing a sensing assay. Herein, we report novel two-way electrochemical reactivity modulation of RZ using host-guest complexation with rigid molecular containers cucurbit[ n ]uril (CB n , n = 7, 8). The complexation between CB n and RZ is confirmed by 1 H NMR measurements and supported by computational simulation, and the binding constants are determined via UV-vis titration. Notably, the voltametric data highlights that the redox reactivity of RZ can be activated or deactivated upon encapsulation by CB8 or CB7, respectively. This two-way reactivity modulation is hypothesized to be mediated by the difference in cavity volume that favors or hinders the approach of water molecules to the encapsulated reaction center during the reduction process. Despite the similar cavity size to CB, molecular containers such as cyclodextrins (CDs) exhibit considerably weaker modulation effects. Our approach can potentially be applied to other redox processes that involve proton transfer, and open new possibilities in supramolecular electrochemistry.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2023
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IF 3.8
Yanhuai Ding,Cong Zhang,Hao Zheng,Yi Han
As one of the most stable metal-organtic framework (MOF), zeolitic imidazolate framework-8 (ZIF-8) has been widely studied for applications in the field of energy storage, catalysis, and environment protection. In this paper, ZIF-8 was employed to enhance the electrochemical properties and thermal stability of the electrospun poly(vinylidene fluoride- co -hexafluoropropylene)/polyacrylonitrile (PVDF-HFP/PAN) composite separator. The results indicate that the test cells assembled with the composite separators show improved rate capability, high discharge capacity, and stable cycling performances. The addition of ZIF-8 can improve the affinity of PVDF-HFP/PAN toward liquid electrolytes, and further enhance the ionic conductivity of the composite separators. In addition, the thermal stability of the PVDF-HFP/PAN separator has been improved by ZIF-8 nanoparticles . This work can provide insight into the application of MOF materials in Li-ion batteries.
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JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
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2023
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IF 4
Heng Wang,Xianjin Qi,Guizhi Yan,Jiahao Shi
Arsenic pollution is an international problem that must be urgently controlled. Therefore, this study is based on a one-pot precipitation method, in which copper ions were added to a zinc organic metal framework (ZIF-8) to partially replace the zinc ions and the obtained adsorbent (Cu-ZIF-8) used to effectively remove As(V) ions from water. The successful synthesis of the Cu-ZIF-8 adsorbent and its adsorption mechanisms were confirmed using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and X-ray photoelectron spectroscopy (XPS). In addition, the effects of pH (3–11), initial arsenic concentration (10–350 mg/L), and reaction time on the adsorption performance were also characterized. Our findings demonstrate that Cu-ZIF-8 had a high As(V) adsorption capacity of 238.11 mg/g, which was significantly higher than that of most adsorbents previously reported in the literature. Moreover, this material maintained >75% of its initial adsorption capacity after four adsorption-desorption cycles. The adsorption kinetics of Cu-ZIF-8 were accurately described using the pseudo-second-order kinetic model, whereas the adsorption isotherm was fitted using the Langmuir model. Collectively, our findings have demonstrated that doping organic metal frameworks with metal ions can substantially improve their adsorption performance without changing their structural properties. Therefore, Cu-ZIF-8 is a promising adsorption material for the treatment of As(V)-contaminated water.
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