SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Huanlin Li,Wei Shi,Yusong Zhang
Terahertz time-domain spectroscopy (THz-TDS) technology offers unique advantages for biomedical applications and non-destructive testing. Unlike X-rays, THz technology does not damage the materials being tested, especially active substances. However, traditional THz-TDS techniques still struggle to distinguish between chiral substances. This study presents a terahertz polarization time-domain spectroscopy system (THz-PTDS) that utilizes a 2 × 2 GaAs photoconductive array to detect the polarization of terahertz waves. This system enables the non-destructive and rapid identification of chiral forms of malic acid and its diethyl ester enantiomers. The results indicated that the polarization parameter curves for both solid and solution forms of malic acid showed significant chiral differences at frequency of 0.6 THz. Moreover, the polarization parameter curve of a malic acid diethyl ester-ethanol solution displayed significant chiral differences at 0.93 THz, while the pure malic acid diethyl ester showed significant chiral differences at 1.013 THz. Furthermore, the rotation direction of the polarization ellipse at the corresponding THz frequencies can be used to distinguish between enantiomers. This method provides an innovative approach for the rapid identification of chiral enantiomers in food and pharmaceuticals, with significant application prospects and potential benefits.
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IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION
·
2025
·
IF 3.1
Dazhi Su,Bowen Tang,Shuoyan Ren,Hengxin Zhong,Zhiqian Liu,Ju Tang,Fuping Zeng
With the development of wide bandgap power semiconductor devices represented by silicon carbide (SiC) to higher voltage levels and faster switching speeds, the reliability of packaging insulation is facing severe challenges. In this paper, the strategy of modifying silicone gel by nano boron nitride (BN) doping is proposed, and the breakdown characteristics of composite insulation materials under high du/dt voltage are studied. The experimental results show that the breakdown voltage of composite insulating materials with different BN doping mass fractions decreases significantly with the increase of voltage rise rate. The doping of BN can effectively improve the high du/dt breakdown voltage of the composite insulating medium, and the modification effect is the most significant when the doping mass fraction of BN is 2%. Further combined with molecular simulation studies, it is found that the change in energy level structure of composite insulating materials under the action of electric field will lead to an increase in the number of carriers, which will accelerate the initiation of avalanche breakdown under high du/dt conditions. The doping of BN changes the charge transport mechanism of the composite material, and enhances the polarization of the molecular chain, thus exhibiting better insulation performance under high du/dt conditions. This study provides important data support and theoretical basis for the development of new high-performance insulation materials for new generation power device packaging.
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MOLECULAR PHARMACEUTICS
·
2014
·
IF 4.787
Yuling Bao,Yuanyuan Guo,Xiangting Zhuang,Dan Li,Bolin Cheng,Songwei Tan,Zhiping Zhang
To overcome the multidrug resistance (MDR) of P-glycoprotein (P-gp) substrate anticancer drugs, such as paclitaxel (PTX), a novel dual-functional prodrug, D-α-tocopherol polyethylene glycol succinate (TPGS) based PTX prodrug (TPGS-S-S-PTX), was synthesized here to fulfill the synergistic effect of P-gp inhibiting and intracellular redox-sensitive release. The prodrug could self-assemble into stable micelles in physiological environment with a diameter of ∼140 nm, while it disassociated in reductive condition and released PTX and TPGS active derivatives rapidly. High cell cytotoxicity in PTX-resistant human ovarian cell line A2780/T was observed with enhanced PTX accumulation due to the P-gp inhibition by the TPGS moiety. The IC50 of TPGS-S-S-PTX was 55% and 91% more effective than that of Taxol (clinical formulation of PTX) and uncleavable TPGS-C-C-PTX prodrug, respectively. This was found to be related with the increased apoptosis/necrosis and cell arrest in G2/M phase. In vivo evaluation of the TPGS-S-S-PTX prodrug exhibited an extended half-life, increased AUC (area under the concentration–time curve), enhanced tumor distribution and significant tumor growth inhibition with reduced side effects as compared to Taxol and TPGS-C-C-PTX. This prodrug has great potential in improving efficiency in the treatment of MDR tumors.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Dijun Zhang,Jiaojiao Han,Yanyan Li,Bei Yuan,Jun Zhou,Lingzhi Cheong,Ye Li,Chenyang Lu,Xiurong Su
To discern whether tuna oil modulates the expression of brain proteins and the gut microbiota structure during aging induced by d-galactose, we generated an aging mouse model with d-galactose treatment, and the mice showed aging and memory deterioration symptoms according to physiological and biochemical indices. Treatment with different doses of tuna oil alleviated the symptoms; the high dose showed a better effect. Subsequently, brain proteomic analysis showed the differentially expressed proteins were involved in damaged synaptic system repairment and signal transduction system enhancement. In addition, tuna oil treatment restored the diversity of gut microbiota, 27 key operational taxonomic units, which were identified using a redundancy analysis and were significantly correlated with at least one physiological index and three proteins or genes. These findings suggest that the combination of proteomics and gut microbiota is an effective strategy to gain novel insights regarding the effect of tuna oil treatment on the microbiota–gut–brain axis.
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高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2022
·Vol. 194
·期 11
·5274-5291
·
IF 3.094
Lei Jiping,Tang Kexin,Zhang Ting,Li Yan,Gao Zhen,Jia Honghua
2-O-α-D-Glucosyl glycerol (2-αGG) can be used as a multipurpose anti-aging, cell-stimulating, and skin moisturizing agent in the cosmetic industry. Sucrose phosphorylase (SPase) has been widely used in the production of 2-αGG. In this paper, the gene encoding sucrose phosphorylase from Bifidobacterium longum (BlSP) was inserted into pRSF-Duet-1 to construct the recombinant plasmid pRSF-BlSP and was functionally expressed in E. coli BL21(DE3) to be used as a biocatalyst for the synthesis of 2-αGG firstly. The mutations of BlSP were carried out based on alanine scanning, and a positive mutant G293A with a 50% increase in activity for 2-αGG production was identified. Mutant G293A has less K m and bigger k cat / K m towards glycerol than the parental BlSP. Subsequently, the production of 177.6 g/L 2-αGG was attained from 1 M sucrose and 1.2 M glycerol catalyzed by 17 mg/mL G293A mutant. This study indicated that BlSP has good potential in the production of 2-αGG.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 46
·期 2
·592-598
·
IF 3.591
Rui Wang,Wei Zhang,Ying Tang,Ze-Hui Qi,Yuan-Hui Yu,Hong-Bo Tan,Dian-Yong Tang,Zhi-Gang Xu,Zhong-Zhu Chen
An efficient one-pot four-component reaction for the synthesis of a new family of novel bridgehead nitrogen-containing pyrido[1,2-d][1,4]diazepines has been described and its mechanism has been proposed, which follows a ring-closure and ring-cleavage pathway. The protocol involved a cyclization through γ-selective C–C bond formation, an intramolecular Michael addition and a ring-opening of a pyranone ring under refluxing conditions with high to excellent yields. The advantages of this methodology, including the use of easily available raw materials and an inexpensive catalyst, an open-air reaction setup, wide functional group tolerance, and gram-scale synthesis, make the developed methodology a practical way to access novel pyrido[1,2-d][1,4]diazepines and functionalized tricyclic or polycyclic fused 1,4-diazepines as well as novel analogs of important biologically active molecules.
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AAPS PHARMSCITECH
·
2021
·Vol. 22
·期 7
·1-7
·
IF 3.246
Wang Beilei,Shan Xiaoxiao,Lv Shujie,Zha Liqiong,Zhang Caiyun,Dong Qiannian,Chen Weidong
3-O-β-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-β-D-galactose (Gal) in our previous study. In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were prepared using polydopamine (PDA) as a drug carrier. The drug loading (DL %) and entrapment efficiency (EE %) of Gal-Res NPs were 46.80% and 88.06%. The average particle size, polydispersity index (PDI), and Zeta potential of Gal-Res NPs were 179.38 ± 2.83 nm, 0.129 ± 0.013, and − 28.05 ± 0.36 mV, respectively. The transmission electron microscope (TEM) showed that Gal-Res NPs had uniform spherical morphology. Compared with the fast release of raw Gal-Res, the in vitro release of Gal-Res NPs was slow and pH-sensitive. The results of the blood vessel irritation and hemolysis test demonstrated that Gal-Res NPs had good hemocompatibility. The pharmacokinetics study in rats showed that area under the curve of plasma drug concentration time (AUC 0→600 ) and half-life (t 1/2 ) of Gal-Res NPs were enhanced 1.82-fold and 2.19-fold higher than those of raw Gal-Res. The in vivo biodistribution results showed that Gal-Res NPs were more distributed in liver tissue than Gal-Res. Gal-Res NPs with high bioavailability and liver accumulation were hopeful drug delivery systems (DDS) to treat liver diseases. Graphical abstract
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Nanomaterials
·
2021
·Vol. 11
·期 6
·1595
·
IF 5.076
Jing Qi,Tianli Wu,Mengyao Xu,Dan Zhou,Zhubing Xiao
To address the challenge of highly efficient water splitting into H2, successful fabrication of novel porous three-dimensional Ni-doped CoP3nanowall arrays on carbon cloth was realized, resulting in an effective self-supported electrode for the electrocatalytic hydrogen-evolution reaction. The synthesized samples exhibit rough, curly, and porous structures, which are beneficial for gaseous transfer and diffusion during the electrocatalytic process. As expected, the obtained Ni-doped CoP3nanowall arrays with a doping concentration of 7% exhibit the promoted electrocatalytic activity. The achieved overpotentials of 176 mV for the hydrogen-evolution reaction afford a current density of 100 mA cm−2, which indicates that electrocatalytic performance can be dramatically enhanced via Ni doping. The Ni-doped CoP3electrocatalysts with increasing catalytic activity should have significant potential in the field of water splitting into H2. This study also opens an avenue for further enhancement of electrocatalytic performance through tuning of electronic structure andd-band center by doping.Keywords:transition-metal phosphide;electrocatalyst;hydrogen-evolution reaction;density-functional theory
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Small
·
2024
·Vol. 20
·期 40
·2402725
·
IF 13
Mengyu Liu,Ruohan Hou,Pengpeng Zhang,Yukun Li,Guosheng Shao,Peng Zhang
Unveiling the inherent link between polysulfide adsorption and catalytic activity is key to achieving optimal performance in Lithium-sulfur (Li-S) batteries. Current research on the sulfur reaction process mainly relies on the strong adsorption of catalysts to confine lithium polysulfides (LiPSs) to the cathode side, effectively suppressing the shuttle effect of polysulfides. However, is strong adsorption always correlated with high catalysis? The inherent relationship between adsorption and catalytic activity remains unclear, limiting the in-depth exploration and rational design of catalysts. Herein, the correlation between “d-band center-adsorption strength-catalytic activity” in porous carbon nanofiber catalysts embedded with different transition metals (M-PCNF-3, M = Fe, Co, Ni, Cu) is systematically investigated, combining the d-band center theory and the Sabatier principle. Theoretical calculations and experimental analysis results indicate that Co-PCNF-3 electrocatalyst with appropriate d-band center positions exhibits moderate adsorption capability and the highest catalytic conversion activity for LiPSs, validating the Sabatier relationship in Li-S battery electrocatalysts. These findings provide indispensable guidelines for the rational design of more durable cathode catalysts for Li-S batteries.
研究领域:
电化学
·
材料科学
·
能源化学
·
纳米催化
·
电池技术
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高影响因子
FUEL
·
2022
·
IF 8.035
Yongtao Zhang,Fulin Chen,Yan He,Fei Wang
CO 2 sequestration based on hydrate technology is considered to be the most promising long-term CO 2 sequestration technology. In this study, a method of using initial stirring to activate CO 2 hydrate formation process was proposed in the aim of saving energy and avoiding the problem of stirring shaft stuck, where the stirring only played a role in activating hydrate formation process. Two amino acids, l -Methionine and d -leucine, were chosen as promoters for improving the formation kinetics of CO 2 hydrates, and l -Methionine presents better than d -leucine. When the concentration of l -methionine solution is equal to or greater than 4 mmol/L, even with the initial stirring of 10 rpm within 8 min, T 90 can be shortened to close to or less than 40 min with a high gas consumption of more than 7.3 mmol gas/mL water, where the promoting effect is similar to the condition of continuous stirring of about 100 min, indicating that about 90 % of the energy consumed for mechanical stirring can be saved. Moreover, an interesting phenomenon was observed that CO 2 hydrates firstly nucleated inside the l -methionine solution, and a large number of small hydrate floccules rapidly formed and filled the entire solution under the action of magnetic stirring, which proved the instantaneous excitation effect of stirring on hydrate formation. This work contributes to rethinking the promoting roles of stirring and promoters in CO 2 hydrate formation.
研究领域:
环境科学
·
能源化学
·
物理化学
·
气体水合物
·
碳捕集与封存
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高影响因子
TALANTA
·
2013
·
IF 3.498
Zhiwei Sun,Xiaoxiang Wang,Yiping Cai,Junqing Fu,Jinmao You
A new pair of derivatization reagents, d 0 -4-(1-methyl-1 H -phenanthro[9,10- d ]imidazol-2-yl)phenlamine (d 0 -MPIA) and d 3 -4-(1-methyl-1 H -phenanthro[9,10- d ]imidazol-2-yl)phenlamine (d 3 -MPIA) have been designed and synthesized. It was successfully used to label aliphatic aldehydes and the aldehyde derivatives were analyzed by high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). The new isotope-coded reagents could easily label aldehydes under acidic conditions in the presence of NaCNBH 3 . The target derivatives exhibited intense [M+H] + and regular product ions with electrospray ionization source in positive mode. The d 0 /d 3 -MPIA-aldehydes were monitored by the transitions of [M+H] + → m/z 322 and [M+H] + → m/z 165, and the obtained detection limits were in the range of 0.18–15.9 pg/mL at signal to noise ratio of 3. The global isotope internal standard technology was employed for quantification analysis with d 3 -MPIA-aldehyde as internal standard for corresponding d 0 -MPIA-aldehyde. Excellent linear responses for relative quantification were observed in the range of 1/10–10/1 with coefficients >0.998. The developed method has been applied to the quantification of aliphatic aldehydes in selected aquatic products with RSD<3.6% and recoveries >85.2%.
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FUEL
·
2019
·
IF 5.128
Yiming Zhang,Xiefei Zhu,Liqiang Zhang,Xifeng Zhu
In this study, a bio-oil model compound of walnut shell pyrolysis oil was selected. The microemulsions of diesel and model compound were produced using Span80 and Tween 80 as surfactants. The microemulsions were quantificationally analyzed to investigate the solubilization capacity of bio-oil characteristic components in diesel. The effects of surfactant concentration and initial volume ratio of bio-oil model compound to diesel (B/D ratio) on the solubilization capacity of bio-oil characteristic components in diesel were investigated. The heating value, kinematic viscosity, elemental analysis and thermogravimetric analysis of microemulsion were also conducted. Experimental results indicated that the suitable concentration of surfactant was 0.3 mol/L–0.45 mol/L, and the optimum B/D ratio was 4:12 for the bio-oil model compound. The dissolubility of m-cresol and guaiacol in microemulsion was much better than that of water and acetic acid. The heating value and the kinematic viscosity of microemulsion decreased slightly as the B/D ratio increased. Increasing the surfactant concentration contributed to a more pronounced increase in the kinetic viscosity and a significant decrease in the heating value. The influence of surfactant concentration on the fuel properties and thermogravimetric characteristics was stronger than that of B/D ratio.
研究领域:
能源科学
·
化学工程
·
生物质能
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