COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
·
IF 5.9
Peixin Dong,Yangkai Liu,Fulin Deng,Anning Zhao,Min Ren,Linjie Song,Yuanzhen Zhou,Yumeng Dong,Yunjie Xiang,Ugo D‘ Amora,Liqun Xu,Xi Rao
In 2 S 3 forms a Z-scheme heterojunction with TiO 2 , broadening the light response range, improving ROS generation. • Photothermal-photodynamic synergy reduces the required photothermal temperature. • The TiO 2 / In 2 S 3 /Chitosan composite coating exhibits enhanced antibacterial activity. • The composite coating exhibits excellent biocompatibility. Implant-associated bacterial infections remain a major challenge in orthopedic and dental applications, often compromising implant integration and longevity. For this reason, the synergistic antibacterial strategy of photothermal and photocatalysis has become one of the important methods in the field of antibacterial. To synthesize high-efficiency near-infrared (NIR) light-responsive catalysts, a titanium oxide/indium sulfide (TiO 2 /In 2 S 3 ) heterojunction antibacterial coating was prepared on the titanium-based surface using anodic oxidation and wet chemical deposition methods. Compared with titanium alloy, the TiO 2 /In 2 S 3 heterojunction showed a suitable energy band structure, improved light absorption, and enhanced carrier separation capability, thus enhancing photothermal catalytic activity and promoting the production of bacterial reactive oxygen species under NIR light. Indeed, the TiO 2 /In 2 S 3 heterojunction narrowed the bandgap (~2.5 eV) and efficiently generated reactive oxygen species (•O₂⁻ and •OH) under NIR irradiation. Furthermore, the successful deposition of chitosan (CS) endowed the TiO 2 /In 2 S 3 heterojunction with osteogenic activity, promoting the proliferation and differentiation of osteoblasts. In vitro , results demonstrated effective antibacterial performance against Escherichia coli and S taphylococcus. aureus , inhibited biofilm formation, and supported collagen secretion and mineralization. In vivo , NIR irradiation raised the implant site temperature to below 50 °C, enabling safe and efficient sterilization, and showing no organ toxicity. These results highlight CS-coated TiO 2 /In 2 S 3 heterojunction as a promising multifunctional coating that combines infection control with osteogenic support, providing a potential strategy for improving the safety and longevity of titanium-based implants. Download: Download high-res image (156KB) Download: Download full-size image
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高影响因子
Regenerative Biomaterials
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2025
·
IF 8.1
Feng Xinyu,Liu Ruihan,Zhang Cai,Cheng Ran,Fu Dianxun,Sun Shaokai,Wang Junping,Wang Guohe
Bioadhesives are being increasingly used in clinical practice, but pose significant health risks due to their uncontrollable intraoperative leakage. Nevertheless, there is currently a critical lack of effective solutions. Herein, we propose a second near-infrared window (NIR-II) fluorescence-visible indocyanine green (ICG)-BioGlue adhesive for precision surgical adhesion with intraoperative leakage prevention. The fabricated ICG-BioGlue adhesive based on the non-covalent interaction exhibits nearly 100% fluorescence labeling efficiency and maintains long-term stable NIR-II fluorescence for up to 3 months. During surgery, ICG-BioGlue adhesive enables real-time visualization of wound adhesion in various fields such as aortic dissection adhesion and liver or kidney wound hemostasis, preventing leakage into surrounding tissues. Moreover, the stable fluorescence of ICG-BioGlue adhesive allows effective imaging-guided removal of long-term adhesive fragments in the body when they cause compression symptoms after surgery. Considering it consists solely of Food and Drug Administration-approved drugs ICG and BioGlue, with a straightforward synthesis method and versatile applicability, ICG-BioGlue adhesive holds excellent potential for clinical translation. Our study provides a leakage-preventing strategy to enhance biosafety and promote the widespread application of bioadhesives in clinical settings.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Jianghui Zhao,Zhaoyang Pan,Ping Liu,Jingjuan Huang,Wei Li,Ke Zhang,Xiaohong Chen,Fengcang Ma
The long-term clinical success of titanium-based implants is perpetually compromised by post-operative infection and suboptimal osseointegration. To address this dual challenge, we developed a defect-engineered, zinc-doped titania (Zn-TiO 2-x ) coating through a two-step process of micro-arc oxidation and subsequent alkaline reduction. This process endows the material with a profusion of oxygen vacancies (OVs), imparting significant absorbance in the near-infrared (NIR) spectrum. Upon 808 nm laser irradiation, this property translates into highly efficient photothermal conversion, which orchestrates a formidable, multi-modal antibacterial assault. The coatings exhibited exceptional bactericidal efficacy, achieving eradication rates of over 89% against S. aureus and 98% against E. coli . This potency stems from a synergistic trinity of hyperthermia via photothermal therapy (PTT), cytotoxic reactive oxygen species (ROS) generated through photodynamic therapy (PDT), and the intrinsic antimicrobial activity of released Zn 2+ . Concurrently, beyond antimicrobial prowess, the hierarchical porous microarchitecture acts in concert with the pro-osteogenic bioactivity of Zn 2+ to markedly enhance the adhesion, proliferation, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). This study presents a versatile coating strategy for endowing titanium implants with dual therapeutic capabilities, opening new avenues for smart implants that actively combat infection and promote tissue regeneration.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Arsalan Ahmed,Mehar Muhammad Hamza Maqbool,Weiping Zhou,Nosherwan Adil,Anam Zulfiqar,Yanjie Zhu,Di He,Yongjian Zhuang,Oleg G. Sinyashin,Asiya R. Mustafina,Rustem R. Zairov,Naeem Akhtar,Cong Yu
Machine learning optimized nanocrystals with narrow band in the NIR-I region were synthesized. • DBT-F 4 TCNQ derive nanocrystals offer excellent photothermal and sensing performance. • Designed theranostic platform integrates cancer therapy with precise electrochemical sensing. • DBT-F 4 TCNQ derive nanocrystals demonstrated effective glutathione depletion. Despite significant advances in near-infrared (NIR) photothermal agents, most current systems face challenges including large band gaps and poorly defined crystalline morphology, compromised responsiveness in the tumor microenvironment due to inefficient and time-consuming optimization, and dependence on separate, cancer type-specific diagnostic platforms for effective treatment. To overcome these challenges, we rationally synthesized a novel class of charge transfer complex-derived nanocrystals (CTNs) with well-defined morphology and a significantly reduced band gap in the NIR-I region, achieved for the first time through the unique combination of DBT as the electron donor with F 4 TCNQ, TCNB, and DTTCNQ as acceptors. Additionally, we employed machine learning (ML) to systematically optimize donor-to-acceptor ratios in CTNs, ultimately identifying DBT-F 4 TCNQ as the most effective formulation, with strong NIR absorption, excellent photothermal conversion, and superior electrocatalytic efficiency. Interestingly, ML-optimized DBT-F 4 TCNQ derived from CTNs demonstrated effective cysteine-triggered intracellular depletion of glutathione (GSH), thereby promoting reactive oxygen species (ROS) accumulation and inducing ferroptosis. Additionally, the in vivo antitumor efficacy was validated through NIR-triggered photothermal therapy combined with ROS-mediated ferroptosis, while the diagnostic potential of the designed CTNs was demonstrated via in-direct electrochemical monitoring of choline released from 4T1 cancer cells. Thus, the designed ML-optimized CTNs derived from the novel DBT-F 4 TCNQ combination hold great promise as a next-generation theranostic platform by integrating therapeutic efficacy with diagnostic precision.
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高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Yutong Wang,Mengxin Chen,Enrui Zhang,Sichen Liu,Hang Zhao,Gopika M. Gopakumar,Ruttiya Chaepratoom,Suwit Suthirakun,Anurak Weahayee,Wanwisa Limphirat,Theeranun Siritanon,M.A. Subramanian,Peng Jiang
The emission peak of Mn 5+ lies in the second near-infrared window (NIR-II) biological transparency window, and it exhibits outstanding application prospects in deep-tissue bioimaging, non-contact optical thermometry, and related fields. In this work, a novel Mn 5+ -activated Ba 1.9 Sr 0.1 TiO 4 NIR-II phosphor is designed and synthesized via a high-temperature solid-state reaction, where partial Sr 2+ substitution for Ba 2+ enables precise crystal field modulation around Mn 5+ ions. Mn K-edge X-ray absorption near-edge structure (XANES) spectroscopy confirms that Mn ions are stabilized in the +5 oxidation state. The optimized BSTO: 0.1 % Mn 5+ phosphor shows efficient 680 nm red light excitation and a characteristic narrowband NIR-II emission at 1190 nm from the 1 E → 3 A 2 transition of Mn 5+ , with a long luminescence lifetime of 184.9 μs and excellent thermal stability. Density functional theory with Hubbard U correction (DFT + U) calculations further reveal that Sr 2+ substitution induces controllable lattice contraction and local structural distortion, which modulates the host electronic structure and enhances the stability of Mn 5+ luminescent centers. Furthermore, the phosphor delivers a maximum relative temperature sensitivity of 2.24 % K −1 via the luminescence intensity ratio technique. A proof-of-concept NIR phosphor-converted light-emitting diode fabricated with the as-prepared phosphor realizes clear NIR penetration imaging.
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高影响因子
Food Packaging and Shelf Life
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2025
·
IF 10.6
Yiya Ping,Liang Zhang,Mengyi Wang,Bingzhi Li,Linpin Luo,Wenze Wang,Yuechun Li,Wentao Zhang,Mingqiang Zhu,Jianlong Wang
In this study, a nano-platform driven by the microenvironment and photo-controlled catalytic activity was meticulously designed, and a CaO 2 @CAFe functional filler was constructed by using chlorogenic acid as a phenolic ligand and ferric ion to co-encapsulate calcium peroxide, creating an antibacterial packaging system (CCF-CS) with in situ self-activation cascade catalytic activity and intelligent enhancement effect of near-infrared light response. In this system, the acidic microenvironment provided by the chitosan (CS) film matrix triggers the CaO 2 @CAFe particles to continuously release H 2 O 2 , the catalytic substrate in which peroxidase plays a role, and "substrate self-supply" is achieved through a cascade reaction. Moreover, the catalytic efficiency of the nanozymes can be positively modulated by the "smart switch" of near-infrared light, enabling a dual-mode antibacterial behavior of "on-demand burst and routine protection". The CCF 0.20 -CS film was 99.9 % effective in killing both bacteria and fungi, and significantly extended the shelf life of cherry tomatoes by 10 days. Furthermore, the film exhibits enhanced UV-shielding capability and improved mechanical strength, alongside validated biosafety. These optimal properties underscore the innovative potential and practical superiority of the CCF 0.20 -CS packaging system in addressing microbial contamination challenges in food preservation.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Maoyu Liu,Jindong Zhang,Shuning Chen,Jiao Zheng,Linlin Xiao,Xiaoli Liu,Yang Cao,Shenyin Zhu,Shufang Chang
HPV-associated malignancies consistently express E6/E7 oncoproteins, making these viral antigens prime targets for therapeutic vaccination. However, insufficient antigen exposure and presentation remain major obstacles for potent immunotherapy. Here, a novel metal-polyphenol network-coated human serum albumin nanoplatform (IMT@H) is engineered to co-deliver IR780 and manganese ions (Mn 2+ ) to achieve enhanced immunogenic cell death (ICD) and cGAS-STING-dependent antigen presentation. The metal-polyphenol nanostructure facilitates the pH-responsive release of Mn 2+ , which subsequently initiates Fenton-like reactions to generate hydroxyl radicals (·OH). Meanwhile, under near-infrared (NIR) light irradiation, IR780 induces mitochondrial-targeted phototherapy and concurrently produces reactive oxygen species (ROS). These processes act synergistically to amplify the oxidative damage and ICD in TC-1 tumors, leading to the release of damage-associated molecular patterns (DAMPs). These ICD-derived DAMPs cooperate with Mn 2+ to sustain activation of the cGAS-STING pathway in dendritic cells. This combinatorial strategy successfully transforms tumor antigens into endogenous vaccines, eventually inhibiting the growth of primary tumors and producing strong abscopal effects. Notably, mice primed with nanovaccines exhibit strong anti-HPV16 E7-specific immune responses and tumor resistance. With its dual therapeutic and preventive functionality, IMT@H represents a paradigm-shifting strategy for virus-driven malignancies and offers a blueprint for engineering self-adjuvanting nanovaccines against viral oncogenesis.
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高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Ranran Guo,Ruixun Chen,Zhenhang Rao,Lugui Wang,Jianing Xi,Yu Zhang,Weisheng Guo,Ye Tian
Immune checkpoint blockade therapy has revolutionized clinical oncotherapy by intercepting immunosuppressive pathways in tumor tissues. Nevertheless, the therapeutic efficacy is limited by a multidimensional immunosuppressive tumor microenvironment, which impedes the activity of tumor-infiltrating immune cells and undermines treatment outcomes. In this study, a zwitterionic polymer is designed for the conjugation and traceless release of a checkpoint inhibition antibody (Atezolizumab), while concurrently enabling the restoration of membrane redox homeostasis on T cell membranes within the oxidative tumor microenvironment. Contrast-enhanced fluorescence imaging in the near-infrared II spectral region with a deep learning network is employed to visualize in vivo dynamics of the antibody conjugates. The antibody conjugates demonstrate enhanced and accelerated tumor accumulation, thereby promoting T cell proliferation and augmenting the antitumor efficacy. Mechanistic investigations reveal that the conjugate-mediated regulation of the T cell surface redox state protects against damage induced by extracellular reactive oxygen species, subsequently mitigating ferroptosis of T cells. In murine models, the antibody conjugates effectively suppressed colorectal tumor growth and recurrence, leading to a significant extension of animal survival. This work thus realizes reversing suppressive immune microenvironment from multiple dimensions with a simple checkpoint inhibitor conjugate, promising for clinical translation and next-generation immune checkpoint blockade therapy.
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高影响因子
BIOMATERIALS
·
2024
·
IF 12.8
Zhuangzhuang Chu,Xingdan Liu,Tong Zhao,Dongya Jiang,Jing Zhao,Xiaohua Dong,Kelvin W.K. Yeung,Xuanyong Liu,Yun Liao,Liping Ouyang
Non-healing diabetic foot ulcers are the knotty public health issue due to the uncontrolled bacterial infection, prolonged inflammation, and inferior vessel remodeling. In this work, polypyrrole (Ppy) was added into the hybrid hydrogel containing polyvinyl alcohol (PVA), polyethylene glycol (PEG), and hyaluronan (HA) to acquire superior mechanism and photothermal ability. The Ppy composited hybrid hydrogel could effectively kill bacteria through accumulating heat on the hydrogel surface. RNA-Seq analysis shows that the heat accumulation could enhance phagosome of macrophage and M1 activation, which further accelerate bacteria clearance. Benefitting from the bacteria clearance, macrophage could transform its phenotype to M2 in Ppy composited hybrid hydrogel group with near infrared light (NIR) stimulation. The related genes expression in keratinization, keratinocyte differentiation, and establishment of the skin barrier in the skin were up-regulated and collagen and vascular endothelial growth factor (VEGF) expression level are also enhanced. In summary, Ppy composited hybrid hydrogel could effectively solve the issues of infection and poor wound healing in diabetic foot ulcers, making it an ideal candidate dressing for the treatment of chronic wounds.
研究领域:
生物医学工程
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伤口愈合
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组织工程
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材料科学
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光热治疗
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感染控制
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免疫学
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高影响因子
Polymer Chemistry
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2016
·Vol. 7
·期 26
·4411-4418
·
IF 5.687
Zheng Ruan,Le Liu,Liyi Fu,Tao Xing,Lifeng Yan
A carborane-containing triblock copolymer conjugated with a near infrared (NIR) fluorescence probe has been synthesized via reversible addition fragmentation chain transfer (RAFT), ring open polymerization (ROP), and conjugations of a cyanine NIR dye. Reactions were traced by means of 1H-NMR, GPC and FT-IR. The NIR amphiphilic copolymer with polycaprolactone and polycarborane as hydrophobic segments and poly(ethylene glycol)methyl ether methacrylate as the hydrophilic segment could self-assemble into micelles in aqueous solution, and was characterized by means of DLS and TEM. In the copolymer, carborane works as a boron neutron capture therapy (BNCT) agent while the aminocyanine (Cy) dye works as a NIR bioimaging agent, and the nanoparticles of the copolymers are a potential theranostic BNCT system for cancer therapy, which was supported by MTT experiments and in vitro fluorescence microscopy studies.
研究领域:
生物材料学
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肿瘤学
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放射医学
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纳米医学
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高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Yulin Xie,Man Wang,Qianqian Sun,Dongmei Wang,Shuiping Luo,Chunxia Li
Combined photothermal/photodynamic therapy is a promising strategy to achieve an enhanced anticancer effect. However, hypoxia is one of the representative characteristics of the microenvironment of solid tumors, which not only attenuates the therapeutic effects but also promotes tumor invasion and metastasis. Herein, a PtBi-β-CD-Ce6 nanoplatform for the generation of sustained O2 was constructed for more effective tumor therapy. In detail, the catalase (CAT)-like nanozyme, PtBi, which could decompose H2O2 to produce O2, was modified with β-cyclodextrin (β-CD). O2 would be converted into 1O2 by PtBi-β-CD-Ce6 for enhanced photodynamic therapy (PDT) under 650 nm laser irradiation. In addition, by reason of excellent absorption in the near-infrared-II (NIR-II) region, PtBi-β-CD-Ce6 was used for photoacoustic imaging (PA) and photothermal imaging (PT)-guided photothermal therapy (PTT) in the NIR-II biowindow. Furthermore, PtBi-β-CD-Ce6 could be elected to serve as a contrast agent for X-ray computed tomography (CT) imaging due to the apparent X-ray attenuation capability of the Pt and Bi elements themselves. Therefore, by integrating the advantages of overcoming the hypoxia function and photothermal effect into a single nanoplatform, PtBi-β-CD-Ce6 showed an immense possibility in multimodal imaging-guided combined PDT/PTT.
研究领域:
生物医学工程
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肿瘤学
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纳米医学
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Feifei Li,Xinyu Lu,Dongbo Xu,Di Li,Yuanyong Huang,Weidong Shi
Despite extensive efforts over four decades, the development of efficient NIR-driven photocatalysts for solar H 2 production remains elusive. Current NIR-activated systems are limited by inferior performance, significant photocorrosion, and reliance on scarce noble metals or toxic dyes. Notably, NIR-activated systems based on non-noble metals that simultaneously exhibit high activity and long-term stability represent a critical gap. In this work, we present a Te-doping-induced band-structure optimization strategy, whereby Te-doped ZnIn 2 S 4 nanoflowers are synthesized via a one-step hydrothermal method, enabling a narrow-bandgap semiconductor to achieve efficient NIR-driven (λ > 800 nm) H 2 production without noble-metal co-catalysts through Urbach‑tail absorption. Te atom incorporation not only broadens light absorption and effectively narrows the bandgap through the formation of intermediate gap states, but also induces a redistribution of local charges, which facilitates the separation and transport of charge carriers. As expected, the optimized Te–ZnIn 2 S 4 catalyst delivers a remarkable hydrogen evolution rate of 128 μmol·g ‒1 ·h ‒1 under NIR irradiation (λ > 800 nm), which is 10 times higher than that of its pristine counterpart and outperforms all previously reported non‑noble‑metal NIR‑responsive photocatalysts under the same conditions. Impressively, the optimally Te-doped ZnIn 2 S 4 retains a considerable H 2 evolution rate of 8.57 μmol·g ‒1 ·h ‒1 under extended-wavelength NIR light (λ = 940 nm), demonstrating its exceptional capability to harvest low-energy photons for water splitting. This work highlights that rational band‑structure engineering through element doping can effectively extend the photoresponse of ZnIn 2 S 4 into the deep NIR region via Urbach‑tail absorption, thereby enabling efficient H 2 evolution without the need for noble‑metal co‑catalysts.
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