COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Tengfang Zhang,Ziqi Wu,Huafeng Zhu,Zhikun Wang,Shuangqing Sun,Songqing Hu
Hypothesis Natural polymer chitosan (CS) has been widely used as emulsifier due to its good stability, salt-resistant, and stimuli-responsive demulsification . However, chitosan is a hydrocarbon structure molecule containing -NH 3+ and -OH with low surface activity, which is mainly suitable for some specific oil-water systems such as corn oil and sunflower oil . Appropriate hydrophilic-hydrophobic modification of chitosan by PNIPAM not only increases its surface activity but also introduces a temperature response on chitosan. Experiments Pickering emulsions (O/W) formed by CS-PNIPAM were prepared. The stability and response performance of the emulsions were investigated by observing the macroscopic states, microscopic images, droplet size distributions, emulsion emulsification indices, water partition rates, etc. Molecular dynamics and dissipative particle dynamics simulations were used to reveal the distribution pattern of the emulsifiers at the water-oil interface and clarify the stabilization and pH/temperature response mechanism of the emulsions. Findings CS-PNIPAM performs excellent emulsification in various oil phases. The addition of salt ions enhances the stability performance of the emulsion. At low pH, CS will be protonated to break the emulsion, while increasing the pH will deprotonate CS and reform the emulsion. Also, the increase of temperature to 80 °C leads to emulsion breakage due to the agglomeration of PNIPAM.
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JOURNAL OF POROUS MATERIALS
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2022
·Vol. 30
·期 3
·767-774
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IF 2.523
Lin Yonghui,Zhao Xiaojun,Jin Qi,Chen Yang,Yang Weiting,Pan Qinhe,Chen Yan,Wang Fuxiang
The shortage of fresh water resources is becoming more and more serious, which endangers human survival and social progress. Atmospheric water harvesting technology is expected to be one of the ideal ways to break through this predicament. However, in the special circumstances such as offshore place or island, the equipment of atmospheric water harvesting is required not only to have good capture ability of water molecules, but also to have the advantages of stable performance, low energy consumption, and simply employment. We designed and prepared a composite of microtube-filled vesicle-like PEDOT wrapped into honeycomb chitosan by vaper-phase polymerization. Under the static adsorption, it reaches high water molecules uptake of 154.0 wt% at 98% relative humidity, and captured water molecules aggregate into droplets to achieve the direct collection without any external force. Moreover, this composite has low density and good stability under high humidity, which indicates its promising application for atmospheric water harvesting in the coastal and offshore areas.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Xiaoxiao Wan,Zhihao Rong,Kaixuan Zhu,Yumin Wu
With the rapid development of the textile industry, a large amount of dyeing wastewater discharge has caused great harm to the ecological environment. In this work, a dual-network, composite hydrogel adsorbent with excellent mechanical properties, good reusability, and large adsorption capacity was prepared by introducing chitosan cross-linked polyvinylamine into the N , N ′-methylenebisacrylamide cross-linked polyacrylic acid network. The dual cross-linking network gave the hydrogel excellent mechanical properties with maximum tensile stress and strain up to 1.9 MPa and 920 %. The adsorption capacity of methylene blue on hydrogel was up to 596.14 mg/g. In addition, the prepared hydrogel exhibited good reusability, and their adsorption efficiency remained above 85 % in five consecutive cycles. The adsorption behavior was well fitted by Pseudo-second-order kinetics and the Langmuir equation, indicating that the hydrogel was chemisorbed to the dye as a monolayer. The adsorption mechanism analysis showed that the electrostatic interactions and hydrogen bonding between the functional groups of the hydrogels and methylene blue molecules contributed to the good adsorption capacity. Overall, the synthesized composite hydrogels could be used as an efficient adsorbent for the removal of methylene blue dye, particularly from textile industry wastewater.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Yanzhen Sun,Xiaodong Jing,Yang Liu,Bing Yu,Hao Hu,Hailin Cong,Youqing Shen
Nucleic acid-based agents have advantages in therapeutic efficacy and biological safety. However, due to its facile degradability, it lacks an effective route of administration in wound treatment. Designing smart hydrogels for the spatiotemporally controllable delivery of nucleic acids is of great significance for clinical applications. Here, a near-infrared (NIR)-responsive nanocomposite hydrogel was prepared using methyl methacrylate (GMA)-modified chitosan as the macromolecular cross-linker, N-isopropylacrylamide (NIPAAm) as the backbone, and molybdenum disulfide nanosheets (MoS 2 NSs) as the nanocomponents. The polydeoxyribonucleotide (PDRN), a nucleic acid-based agent that promotes tissue regeneration , was loaded and delivered. The photothermal conversion capability of MoS 2 NSs enables customized care of PDRNs and antibacterial enhancement. In a full-thickness skin defect model, high-quality wound healing effects were demonstrated under the action of nanocomposite hydrogels. The proposed nanocomposite hydrogel provides a new reference for local delivery of nucleic acid-based agents.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Tao Liu,Zhuoran Zhang,Jiacheng Liu,Peijie Dong,Feng Tian,Fan Li,Xin Meng
Development of chitosan-based hemostatic products and their application in wound healing has always been a research hotspot in the field of emergency treatment and biomedicine . In this study, the classic hemostatic chitosan and the most well-known inorganic hemostatic agent—kaolin were tried to combine to form a more excellent dressing. Together with the aid of non-toxic, harmless and good hydrophilic polyethylene oxide, chitosan/polyethylene oxide (PEO)/kaolin nanofiber membranes (CPKs) were prepared by electrospinning technology. Such membranes exhibited adjustable mechanical properties and good biocompatibility. Furthermore, a series of in vitro coagulation experiments proved that CPKs with 10 % ratio of kaolin (CPK10) has excellent hemostatic ability. Especially, in the whole blood coagulation time (WBCT) assay, the hemostatic time of CPK10 (43 ± 1.4 s) was significantly lower than that of chitosan/polyethylene oxide (CPK0) nanofiber membrane (61 ± 2.2 s) and QuikClot® Combat Gauze (55.7 ± 1.2 s). The further rat liver injury test reconfirmed that CPK10 can stop bleeding better and faster compared to other groups. In addition, CPKs could promote back wound healing in rats within 14 days without significant inflammatory response. This safe and effective hemostatic CPKs is expected to be a promising candidate hemostat in pre-hospital medical care.
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JOURNAL OF BIOMATERIALS APPLICATIONS
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2022
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IF 2.712
Junjing Zhou,Xinglian Wu,Chaochen Zhao
Hepatocyte scaffold is an essential part in bioartificial liver device. We have designed a novel hepatocyte scaffold based on porcine liver extracellular matrix (ECM) and chitosan (CTS) fabrics. This CTS-ECM scaffold can improve cell adhesion and proliferation. In the present study, an orthogonal test was designed to optimize the CTS/ECM composite scaffold, in which ECM concentration, EDC concentration and EDC to NHS ratio were taken as factors, proportion of nitrogen element and hydroxyproline content as indicators. The cytocompatibility of the novel scaffold for C3A hepatocytes was analyzed in vitro. The orthogonal test demonstrated that the optimal scaffold should be based on ECM concentration of 5 mg/mL, EDC concentration of 5 mg/mL, and EDC to NHS ratio 1:1. C3A hepatocytes cultured on the optimized CTS-ECM scaffolds showed stronger proliferation and functionality than those on Cytodex3 microcarriers (p < 0.05). The CTS/ECM composite scaffold may be widely used as a promising hepatocyte culture carrier, especially in bioartificial liver support systems.
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International Journal of Polymeric Materials and Polymeric Biomaterials
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2022
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IF 3.221
Yuting Zhang,Chenlu Dai,Jiugang Yuan,Ping Wang
Maintaining a moist wound environment facilitates the wound healing process. However, traditional dressings such as medical gauze are difficult to meet this condition and easy to cause wound infection when the gauze is replaced. In this paper, a novel multifunctional medical dressing based on keratin porous materials was prepared by the freeze-drying method. Keratin was first modified by poly (ethylene glycol) dimethacrylate (PEGDMA) to increase its hydrophilicity. Then, the carboxymethyl chitosan (CMCS) was mixed with keratin solution to further improve the pore-forming properties, and finally, the solution was dried through the freezing method to obtain the porous dressing. The performance of the dressing was detailed and studied using DPPH free radical scavenging ability, water retention, blood coagulation, and bacteriostasis tests. The results showed that PEGDMA grafting greatly improved moisture retention from 22 to 43. CMCS blending not only improved the uniform and compact of the pore structure, but also effectively improved blood coagulation and antibacterial properties. After blending with CMCS, the performance of the keratin porous material was greatly improved. Carboxymethyl chitosan is positively charged, which makes the negatively charged platelets easy to aggregate, so the coagulation performance is greatly improved, and the BCI decreased to 15%. At the same time, the antibacterial performance against Staphylococcus aureus was greatly improved, and the optimal condition was PEG-g-KR:CMCS = 6:4. The PEG-g-KR/CMCS dressing prepared in this method had the characteristics of promoting wound healing, good moisture absorption and water retention, excellent blood coagulation performance and strong bacteriostasis. It is of great significance to the research and application of composite dressings.
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FOOD HYDROCOLLOIDS
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2022
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IF 11.504
Shuang Liu,Jiayi Lian,Zhengming Xu,Yue Ning,Minyu Shi,Zhengang Zhao,Zhanying Zhang
Betanin is a high-value health-promoting food ingredient. However, the bioavailability of betanin is constrained by its low stability. In this study, for the first time, betanin was stabilized and delivered using chitosan-coated nanoliposomes (CC-NLs). The CC-NLs were firstly synthesized and characterized. The results showed that increasing chitosan concentration from 0% to 1.0% increased particle size of CC-NLs from 156.4 nm to 217.2 nm. With the use of CC-NLs prepared with 0.6% chitosan, it was found that increasing pH from 1.5 to 9.0 reduced zeta potential of CC-NLs from 8.62 mv to-9.65 mv while the average size of CC-NLs of 221.40 nm peaked at pH 5.5. In aqueous solution, 29.0% of loaded betanin was released from NLs compared to 15.8% from CC-NLs. The in vitro digestion analysis indicated that uncoated NLs and CC-NLs had similar stabilities and relatively stable in oral and gastric fluids. However, in intestinal fluid, the average size of both NLs and CC-NLs were significantly reduced due to bile salt and trypsin. Furthermore, in vitro antioxidant activity assay results showed that betanin delivered by CC-NLs had the highest ORAC and PSC values. This study demonstrated that betanin could be efficiently delivered by CC-NLs with improved stability and bioavailability. The information generated from this study is very useful for the applications of betanin in functional food, pharmaceutical and cosmetics industry.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Jun Wang,Justin Liu,Dao-Qiang Lu,Lijing Chen,Rujia Yang,Dahai Liu,Bin Zhang
In this paper, we report a simple approach to fabricate diselenide-crosslinked carboxymethyl chitosan nanoparticles (DSe-CMC NPs) for doxorubicin (DOX) delivery, with disulfide analogs (DS-CMC NPs) as control. DS-CMC NPs and DSe-CMC NPs featured a spherical morphology and narrow size distribution with the average size about 200 nm. Carboxymethyl chitosan (CMC) as the starting material not only improved the biocompatibility of the nanocarriers but also enhanced physiological stability. Due to electrostatic interactions between DOX and CMC, the nanoparticles had high drug encapsulation efficiency (∼25 %). The nanoparticles disintegration and drug release were accelerated by the cleavage of diselenide bonds through oxidation by H 2 O 2 or reduction by GSH. In vitro cell experiments revealed that DOX-loaded DSe-CMC NPs possessed the highest drug accumulation and cytotoxicity in tumor cells. Moreover, DOX-loaded DSe-CMC NPs performed the enhanced growth inhibition in vivo than that of DS-CMC NPs. Thus, the diselenide-crosslinked nanoparticles possess great potentials for DOX delivery.
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CELLULOSE
·
2022
·Vol. 29
·期 15
·8265-8282
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IF 6.123
Chaudary Aneeba,Patoary Mohammed Kayes,Zhang Meiling,Chudhary Tayba,Farooq Amjad,Liu Lifang
Aerogels are materials comprising hierarchical designs and are of growing significance to acquire advanced structure-based functionality in future technical applications. Since the researchers have previously focused on a single freeze-casting strategy in the fabrication of aerogels, the correlation between processing routes and their integrated characteristics could not be determined. Herein, we constructed cellulose nanofiber (CNF)/chitosan (CS) based composite aerogels (CCSA) by employing random and directional freeze-casting strategies. The effect of such techniques has been explored as a source of an integrated freeze-cast dried porous structure. Random freeze-dried aerogels (r-CCSA) exhibited isotropic properties with high porosity (99.6%) and large pore volume (2.71 mL/g). Whereas, controlled freeze ice-cast nucleation endowed the directional aerogels with ultra-low thermal conductivity (0.027 Wm −1 K −1 ) in the radial direction and about 20% greater (0.033 Wm −1 K −1 ) in the axial direction. Moreover, high BET-specific surface area (342 m 2 /g) and 60% strain adherence was observed for these anisotropic aerogels. This composite bio-mass aerogel preparation approach can offer a clear insight into the adoption of the right methodology considering the potential applications and environmental safety. Graphical abstract
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ACS Applied Nano Materials
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2022
·
IF 6.14
Tongyao Lin,Jinglin Zhang,Hui Long,Fengjuan Yang,Langhuan Huang,Sui-Ping Deng,Jingxian Zhang,Xiang Cai,Yunhua Yang,Shaozao Tan
To improve the environmental response and drug loading/release performance of hydrogels, carboxylated chitosan-modified carbon nanotubes (CCS/CNT) were synthesized as a reinforcer. Moreover, diethylacrylamide (DEA) and N-hydroxymethylacrylamide (NHMAA) acted as a temperature-sensitive monomer and a hydrophilic comonomer, respectively. Thus, a novel micro-nanomodified temperature-sensitive hydrogel (DEA-NHMAA-CNT/CCS) was fabricated via polymerization and cross-linking reactions. The results showed that DEA-NHMAA-CNT/CCS with a uniform and complete pore structure exhibited improved temperature-responsive speed, compression property, and photothermal performance. Furthermore, DEA-NHMAA-CNT/CCS owned an enhanced drug loading/release ability, displaying good temperature-controlled drug release behavior and satisfactory antibacterial activity. The advantages combining facile preparation and good overall performance suggested the great potential application of DEA-NHMAA-CNT/CCS in the fields of drug delivery, wound dressing, and tissue engineering scaffolds.
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AAPS PHARMSCITECH
·
2022
·Vol. 23
·期 6
·1-11
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IF 4.026
Zou Linghui,Zhang Zhongbin,Chen Jinqing,Yang Xu,Li Yuyang,Tang Jing,Du Xiaolu,Tang Ling,Liang Dan,Zhu Xiaoyong,Feng Jianfang,Ding Wenya
β-Cyclodextrin (CD) and chitosan (CS) have attracted great attention due to their unique properties and structures. β-Cyclodextrin-grafted chitosan (CD-CS) has been widely used as a drug carrier to prepare nano-formulations for drug delivery. However, few researches have been conducted to investigate the effect of CD-CS as an excipient on cellular uptake and intestinal absorption. Herein, Caco-2 cells were used to investigate the influence of CD-CS on cellular uptake. The MTT assay showed that CD-CS was non-toxic to Caco-2 cells in concentrations ranging from 15.62 to 125 μg/mL. Confocal laser microscopy and flow cytometry measurements indicated that the uptake ability of Caco-2 cells was significantly enhanced after being treated with CD-CS at a concentration of 31.25 μg/mL or incubation for 0.5 h, and the uptake enhancement gradually increased with increasing CD-CS concentration and incubation time. The Caco-2 monolayer cell model and the everted intestinal sac method were employed to preliminarily explore the mechanism of the improved intestinal absorption. The results demonstrated that CD-CS might open the tight junctions and enhance the clathrin-dependent endocytosis, macro-pinocytosis, and phagocytosis of the intestinal epithelial cells. Such findings can serve as references and inspiration for the design of absorption enhancers. Graphical abstract
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危险品化学品经营许可证（带存储）