JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Bitao Peng,Yi Lu,Hui Liu,Jingxian Wei,Lei Wang,Hongxiang Zhu,Hui He
Understanding the interface regulation process of the core-shell structure is of great significance for tailoring single ligand-engineered gold nanoclusters (Au NCs) and achieving pH-responsive multi-color fluorescence control switching. In this study, multicolor fluorescence switchable Au NCs are synthesized using cysteine as a single ligand with varying pKa values, promoting gold ion growth on cellulose nanocrystals (CNCs). The shell layer of AuNCs is rich in thiol, carboxyl, and amino groups, which deprotonate gradually as the pH increases from 3 to 11, inducing a conformational reorganization of the outer layer of the AuNCs, altering the Au(0)/Au(I) ratio and causing a shift in the fluorescence emission. The AuNCs exhibits reversible pH-dependent fluorescence switching: from pink dual-emission at around 410 and 625 nm (pH = 3), to orange-yellow at around 610 nm (pH = 9), and green fluorescence at around 520 nm (pH = 11). CNCs act as templates and stabilizers, enhancing the fluorescence quantum yield and improving stability for up to 1.5 years. This work significantly enhances understanding of the pH induced core-shell structure reconstruction process of AuNCs, while stimulating innovations in controllable regulation of multi-color fluorescence dynamic switching of nanoclusters, with potential applications in dynamic information encryption.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Chen Yang,Dongyu Geng,Ying Sun,Aitong Li,Zengchao Zhou,Haiyue Hu,Yening Qiao,Yingrui Lu,Nanqing Xu,Lina Wang,Jianming Wang
Composite particles of oat protein isolate (OPI) and chitosan (CS) were fabricated under different pH and ratio to investigate their interactions, and then used as stabilizers to prepare emulsions for β-carotene delivery. The heat treatment of OPI yielded OPI′, and the binding of OPI′ to CS was enhanced due to the unfolding of its structure. With increasing OPI′:CS ratio and pH value, the particle size and turbidity initially increased and then decreased, accompanied by a shift in the dominant interaction from electrostatic to hydrophobic forces. The strongest hydrophobic interaction was observed at OPI′:CS = 5:1 and pH 7. The emulsion prepared under these conditions exhibited the smallest droplet size (1.55 μm), excellent storage stability, and a high bioaccessibility of β-carotene (36.78%) during in vitro digestion. Furthermore, the OPI′/CS emulsion markedly enhanced the retention of β-carotene under various storage temperatures and UV irradiation, demonstrating great potential for delivering lipophilic bioactive compounds.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2026
·Vol. 41
·期 3
·612-622
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IF 1.4
Zhu Liangliang,Yi Guoqiang,Chang Ying,Wei Zhishun,Xiong Yan,Chen Sha
Using (Na) 2 TiF 6 and CO(NH 2 ) 2 as raw materials, we proposed a simple one-pot hydrothermal method for synthesizing single-phase anatase TiO 2 across a broad pH range of the precursor solution. The results showed that, irrespective of whether the precursor solution was acidic (pH=1.43, 3.43, 5.37), neutral (pH= 7.23), or alkaline (pH=9.45, 11.18, 13.15) prior to the hydrothermal reaction, the post-reaction solution pH stabilized between 8 and 9, and all resultant TiO 2 materials were identified as single-phase anatase. This finding contrasted with previous reports where phase transformations among anatase, rutile, or brookite were observed under varying pH conditions of the precursor solution. This discrepancy was attributed to the continuous decomposition of urea during the hydrothermal process, which maintained the pH of the reaction solution within a relatively stable range. Comprehensive investigations revealed that anatase TiO 2 synthesized at pH 7.23 exhibited optimal light absorption ability, enhanced charge dynamics, and a larger electrochemically active surface area. As a result, TiO 2 (pH 7.23) showcased the highest photocatalytic activity toward tetracycline (TC), achieving a degradation efficiency of 97.7%. Mechanistic studies indicated that O 2 •− was the predominant reactive species accounting for TC degradation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xiang Li,Zilong Gao,Yurong Li,Weiyang Wang,Chenyu Wu,Mingfei Li,Guozheng Zhang,Yeshun Zhang
RHS hydrogel offers visual pH monitoring (yellow-red, pH 5-9), antibacterial & antioxidant properties, and promotes angiogenesis and healing in infected wounds. Bacterial-infected wounds often lead to prolonged inflammation and delayed healing, posing a significant challenge in clinical practice. To address this issue, this study developed a novel antibacterial sericin-based hydrogel (rhein-sericin hydrogel, RHS) with inherent pH monitoring property based on natural active components. The hydrogel was engineered via crosslinking between sericin, isolated from silkworm cocoons, and rhein, resulting in a homogeneous gel structure. Experimental results demonstrated that the RHS hydrogel exhibits suitable mechanical properties, controllable biodegradability, and good biocompatibility. The hydrogel also displayed effective hemostatic performance, achieving a hemostasis time of 66 s in a mouse tail amputation model, significantly shorter than the 316 s recorded in the untreated control. In vitro antibacterial assays revealed that the RHS hydrogel possessed potent antibacterial activity, with bactericidal rates of 89.38% against E. coli , 94.9% against S. aureus , and 97.04% against MRSA . Furthermore, the hydrogel promoted HaCaT cell migration, achieving a migration rate of 64.48% at 24 h in a scratch wound assay. Notably, the hydrogel also displayed unique pH-responsive behavior, with the color varying according to pH changes, providing a visual indicator for real-time monitoring of wound status. In a S. aureus -infected wound model, the RHS hydrogel displayed outstanding antibacterial, anti-inflammatory, and pro-angiogenic capabilities, effectively modulating the wound microenvironment and promoting collagen deposition and re-epithelialization. After 12 days of treatment, the wound healing rate in the RHS group reached 97.71%, with near-complete wound closure. This study offers a promising strategy for the development of advanced hydrogel dressings based on natural components.
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Energy Sources Part A-Recovery Utilization and Environmental Effects
·
2021
·
IF 3.447
Ding Ma,Hongwen Gao,Jin Wang,Zhengbo Yue
Although conductive materials (CM) gained increasing attention over the last decades to facilitate methane production, its influence on the whole process of anaerobic digestion was not clear yet, especially for the acidogenesis. The purpose of this study was to investigate the role of goethite on methane production and its effects on the volatile fatty acids (VFAs) in acidogenesis under different pH conditions. Results showed that the methane production and chemical oxygen demand (COD) removal efficiency in continuous stirring tank reactors (CSTRs) were increased with the addition of goethite. The promotion effects of goethite were particularly significant under acidic conditions. Microbial community analysis indicated that Clostridium and Syntrophic bacteria were enriched in goethite-dosed reactors, while methanogens community was mainly affected by pH. Goethite inhibited the generation of acetate and increased the butyrate production, which may benefit to keep the pH of the reactors stable. The results revealed the underlying mechanism of goethite to promote performances of anaerobic digestion and confirmed goethite was a potential additive under different pH conditions.
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高影响因子
NANO
·
2019
·
IF 1.293
Shuai Wang,Fang Xiang Song,Li Zhang,Xue Zhang,Yan Li
Mesoporous silica (MS) spheres of different sizes with pH-responsive characteristics were synthesized based on Stöber’s theory. Organic functionalization with aminopropyl and carboxyl groups resulted in different materials, namely, MS@NH 2 @COOH. MS@NH 2 @COOH were observed to have a large number of carboxyl groups and multiamine chains, and were grafted into pore channels and pore outlets through systematic characterization analyses. All modified samples demonstrated the controlling of the delivery rate of DOX from the siliceous matrix. We also compared the drug release behavior of the DOX-loaded materials at high pH (7.4) and low pH (5.5) and studied the cytotoxicity on A549 cells. The experimental results indicated that the drug delivery system can better control drug release and have potential applications in the drug delivery field.
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JOURNAL OF FLUORINE CHEMISTRY
·
2016
·
IF 2.213
Jianquan Tan,Weiqu Liu,Zhengfang Wang
Novel amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains were designed and synthesized via radical polymerizaion of acrylic acid (AA), poly (ethylene glycol) methyl ether methacrylate (PEGMA) and homemade fluorinated macromonomer (PHFBMA-GMA) and the physicochemical properties of polymeric micelles prepared therefrom were investigated. GPC, FTIR and 1 H NMR were employed to characterize the structures of the copolymers. Potentiometric titration measurement confirmed that the pH-sensitive segments were successfully incorporated and the copolymer performed pKa similar to the reported values. A series of random copolymers with the same chemical composition were employed to make comparisons with the graft copolymers. The critical micelle concentrations (CMC) of the copolymers at different pH (5.0 and 9.0) were determined by fluorescence spectroscopy and surface tension measurements. CMC values showed a high degree of consistency between these two methods. The results showed that CMC values for random copolymers were one magnitude order higher than that of graft copolymers. Graft copolymers performed lower CMC larger particle size compared to random copolymers. No significant difference was observed among graft or random copolymers. CMC values and particle size increased while zeta potential values showed significant decrement with increasing pH, indicating significant pH-sensitivity of the copolymers. With regard to the influence of the amount and the molecular weight of PHFBMA-GMA on the properties, increasing the amount and molecular weight of PHFBMA-GMA was prone to lower CMC, larger particle size while zeta potential performed no significant change. Transmission electron microscopy (TEM) showed that the morphological shapes of the copolymers performed spherical micelles. The cytotoxicity test showed that the comb-shaped copolymers performed extremely low cytotoxicity.The pH-sensitive self-assembled amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains could be potential candidates for nanotanks, hydrophobic drug carriers or surfactants and their facile preparation might fit for large scale industrialization.
研究领域:
高分子化学
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材料科学
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纳米技术
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药物递送
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胶体与界面科学
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Min Du,Jing Jin,Feng Zhou,Jiayue Chen,Wei Jiang
Antibacterial and hemostatic properties are essential for wound healing dressing. In this study, a new type of hydrogel composed of gelatin methacryloyl (GelMA) and hyaluronic acid-aldehyde (HA-CHO) is fabricated by photo-crosslinking and respectively loaded with a single drug gentamicin sulfate (GS), and two drugs of GS and lysozyme (LZM). The composite hydrogel of GelMA and HA-CHO is successfully synthesized by the aldehyde and Schiff base reactions. The structures and compositions of the hydrogels with and without drug loaded are characterized by FT-IR, 1 H NMR, and XPS. Furthermore, the microstructure and swelling behaviour of hydrogels prove that the content of HA-CHO has a significant role in the formation of hydrogels with dense porous structures and super absorbent. pH 7.4 and pH 5.0 conditions are used to evaluate the drug release behaviour of the obtained hydrogels. The released amount of GS of the drug-loaded hydrogels in the acidic buffer is more than that of the physiological environment because of the cleaved Schiff base bonds and the electrostatic interaction. Especially for the dual drug-loaded hydrogel GelMA/HA-CHO/GS/LZM, the released ratio of GS is elevated from 59 % in pH 7.4 buffer to about 78 % in pH 5.0 buffer within the first 6 h, which verifies the excellent pH-stimulus responsiveness. These endow the GS-LZM dual drug-loaded hydrogels with superior antibacterial efficiencies to that of the single GS drug-loaded hydrogels, no drug-loaded hydrogels, and SEBS control, especially in inhibiting S. aureus in a lower concentration of 10 6 CFU mL −1 , which can be attributed to the synergistic effect of LZM and GS. For S. aureus at 10 6 CFU mL −1 , the bacterial survival of GelMA/HA-CHO/GS/LZM is 1.1 %, which shows outstanding antibacterial effect . Hence, the drug-loaded hydrogels, especially the dual drug-loaded hydrogels with pH-responsive, antibacterial, and hemostatic properties have great potential as wound healing materials.
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MACROMOLECULAR RAPID COMMUNICATIONS
·
2023
·Vol. 44
·期 8
·2200928
·
IF 4.6
Xiaotong Wei,Jie Li,Zhirui Hu,Chen Wang,Zhiqiang Gao,Yang Cao,Jing Han,Yingchun Li
In recent years, hydrogels have attracted extensive attention in smart sensing owing to their biocompatibility and high elasticity. However, it is still a challenge to develop hydrogels with excellent multiple responsiveness for smart wearable sensors. In this paper, a facile synthesis of carbon quantum dots (CQDs)-doped cross-linked chitosan quaternary/carboxymethylcellulose hydrogels (CCCDs) is presented. Designing of dual network hydrogels decorated with CQDs provides abundant crosslinking and improves the mechanical properties of the hydrogels. The hydrogel-based strain sensor exhibits excellent sensitivity (gauge factor: 9.88), linearity ( R 2 : 0.97), stretchable ability (stress: 0.67 MPa; strain: 404%), good cyclicity, and durability. The luminescent properties are endowed by the CQDs further broaden the application of hydrogels for realizing flexible electronics. More interestingly, the strain sensor based on CCCDs hydrogel demonstrates photo responsiveness (Δ R / R 0 ≈20%) and pH responsiveness (pH range ≈4–7) performance. CCCDs hydrogels can be used for gesture recognition and light sensing switch. As a proof-of-concept, a smart wearable sensor is designed for monitoring human activities and detecting pH variation in human sweat during exercise. This study reveals new possibilities for further applications in wearable health monitoring.
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Molecular Systems Design & Engineering
·
2023
·Vol. 8
·期 6
·767-774
·
IF 3.6
Zuobing Xiao,Chengjing Wu,Xinyu Lu,Yunwei Niu,Peiran Yu,Xiaojie Ma
Fragrance precursors are an assorted class of pro-fragrances that could realize the controlled release of aromatic compounds. Herein, nicotinoylhydrazone-based pH-triggered fragrance precursors (NTA1–NTA4) have been prepared by reacting nicotinoylhydrazine with a series of aromatic benzaldehydes bearing different electron-donating groups. The chemical structures and substituent effects have been confirmed by FT-IR, NMR, mass and ultraviolet-visible (UV-vis) spectroscopies. Controlled release studies in an acidic environment revealed that a strong electron-donating substituent accelerates the release rate, while weak electron donor groups favor the deceleration of fragrance release. Surprisingly, intramolecular hydrogen bond formation (–OH⋯NC–) has a positive impact upon the stability of the hydrazone bridge in precursor NTA4, consistent with the simulation of the molecular electrostatic potential (MEP) results. In addition, the release kinetics were also investigated and the release rate constant could be estimated with a first-order kinetic model (R2 > 0.98). Furthermore, it was demonstrated that fragrance precursors on cotton fabrics could be an efficient controlled release strategy for fragrant aldehydes after exposure to an ambient atmosphere for several days, compared to a reference sample containing the raw aroma chemicals.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 3
·1214-1228
·
IF 4.5
Qian Guowen,Wang Junzhe,Yang Liuyimei,Zeng Zhikui,Zhao Zhenyu,Peng Shuping,Shuai Cijun
The insufficient of H 2 O 2 restricts the efficacy of chemodynamic therapy in tumor microenvironment. Calcium peroxide (CaO 2 ) is expected to solve this problem due to its H 2 O 2 -evolving ability. However, it prematurely decomposes in the moist air or water before reaching tumor site. In this study, zeolitic imidazolate framework-67 (ZIF-67) was in-situ grown on the surface of CaO 2 to construct a pH-responsive CaO 2 @ZIF-67 system and then incorporated into poly-L-lactic acid (PLLA) to prepare PLLA/CaO 2 @ZIF-67 scaffold by selective laser sintering technology. On the one hand, ZIF-67 is used as a chemodynamic therapy agent due to the release of cobalt ions after degradation. On the other hand, ZIF-67 can serve as protective layers to prevent premature decomposition of CaO 2 due to its hydrophobic properties, and then CaO 2 is exposed and reacts with water to form H 2 O 2 after the pH-responsive degradation of ZIF-67 under tumor acidic microenvironment. Results showed that the PLLA/CaO 2 @ZIF-67 scaffold could sustainedly produce H 2 O 2 under acidic pH and achieve 84.64% antitumor ratio against MG-63 cells. In addition, the scaffold also promoted proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells due to the release of calcium ions. The prepared PLLA/CaO 2 @ZIF-67 scaffold with chemodynamic antitumor and osteogenic effects has great potential to treat tumorous bone defect.
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CHINESE JOURNAL OF CATALYSIS
·
2022
·
IF 12.92
Qixian Xie,Dan Ren,Lichen Bai,Rile Ge,Wenhui Zhou,Lu Bai,Wei Xie,Junhu Wang,Michael Grätzel,Jingshan Luo
Nickel iron layered double hydroxide (NiFe LDH) is one of the best oxygen evolution reaction (OER) catalysts in alkaline electrolytes. However, it performs poorly in neutral electrolytes, and the detailed mechanism is still unclear. Herein, we introduce electrochemical measurements, operando surface enhanced Raman spectroscopy and operando 57 Fe Mössbauer spectroscopy to elucidate the mechanism of NiFe LDH for OER process in different pH electrolytes. Our results show that even though there exist Ni 3+ and Fe 4+ species, the NiFe LDH based electrocatalysts still show worse OER performance in neutral electrolytes than in alkaline conditions. Combining the electrochemical measurements with spectroscopic investigations, we demonstrated that the rate-determining step (RDS) of OER on NiFe LDH based electrocatalysts is from *O to *OOH in alkaline medium while *OH formation is the RDS in neutral conditions. Our work provides new insights into elucidating the OER mechanism in different pH electrolytes.
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危险品化学品经营许可证（带存储）