INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Abid Naeem,Yu Chengqun,Hetonghui,Zang Zhenzhong,Zhu Weifeng,Guan Yongmei
Gallic acid is an important phenolic compound with extensive applications in the food and pharmaceutical industries due to its health-promoting properties. However, due to its poor solubility and bioavailability, it is rapidly excreted from the body. Therefore, β-cyclodextrin/chitosan-based (polyvinyl alcohol- co -acrylic acid) interpenetrating controlled release hydrogels were developed to improve its dissolution and bioavailability. pH, polymer ratios, dynamic and equilibrium swelling, porosity, sol-gel, FTIR, XRD, TGA , DSC , SEM and structural parameters like an average molecular weight between crosslinks, solvent interaction parameters, and diffusion coefficient affecting release behavior were investigated. The highest swelling and release were observed at pH 7.4. Furthermore, hydrogels showed good antioxidant and antibacterial properties . Hydrogels improved the bioavailability of gallic acid in a pharmacokinetics study in rabbits. In vitro biodegradation showed that hydrogels were more stable in blank PBS than lysozyme and collagenase . Hydrogels were safe for rabbits (3500 mg/kg) without causing hematological or histopathological changes. The hydrogels showed good biocompatibility, and no adverse reactions were observed. Moreover, the developed hydrogels can be used to improve the bioavailability of various other drugs.
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JOURNAL OF MEMBRANE SCIENCE
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2023
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IF 9.5
Huange Zhen,Mengyuan Wu,Zhijie Yuan,Zhibo Qi,Yingshuang Meng,Xihong Zu,Dan Liu,Gaohong He,Xiaobin Jiang
Nanofiltration (NF) is a promising technique to achieve sustainable and efficient separation of antibiotics with high industrial value. In this work, carboxymethyl- β -cyclodextrin (CM- β -CD) modified nanofiltration membrane was fabricated through interfacial polymerization (IP) for high concentration cephalexin solution separation, which is a classic antibiotic pharmaceutical wastewater. In principle, CM- β -CD can slow down the diffusion of amine monomers via electrostatic attraction, steric effect, hydrogen bonding and adsorption of the piperazine (PIP) monomer onto the hydrophilic surface, which renders amine monomer the high local concentration. The fabricated NF membranes possessed a larger proportion of dense primary layer on the surface. In addition, the accumulation of CM- β -CD between the substrate membrane and polyamide (PA) layer played the role as a barrier with specific cavity structure and bulk carboxylate to enhance the rejection of cephalexin. The cavity structure and stacking gap of CM-β-CD simultaneously rendered the membrane interlayer highly permeable. The optimal CM- β -CD modified membrane exhibited high rejection of cephalexin (94.7%) and water permeability of 122.4 L m −2 h −1 MPa −1 when the concentration of cephalexin was 3473.9 ppm (10 mmol/L). This work furnished an available way to prepare a novel nanofiltration membrane with efficient separation performance for relevant pharmaceutical production wastewater.
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ANALYTICAL CHEMISTRY
·
2022
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IF 8.008
Guojuan Zhang,Yujie Han,Zhiguang Liu,Lifang Fan,Yujing Guo
A triple-amplified and ratiometric electrochemical aptasensor for CA125 was designed based on hemin–graphene/SH-β-cyclodextrin@PdPt nanoflower (H-Gr/SH-β-CD@PdPtNF) composites and an exonuclease I (Exo I)-assisted strategy. In the nanocomposite, hemin acts as an internal reference signal owing to the reversible heminox/heminred pair. PdPtNFs can significantly improve the electron transfer rate. SH-β-CD can efficiently enrich quercetin probes through host–guest recognition and increase the second indicator signal. In the presence of CA125, due to the specific binding between the aptamer and CA125, the conformational change of dsDNA (designed by the CA125 aptamer and its complementary DNA) results in the release of quercetin embedded in dsDNA. Subsequently, the free quercetin and DNA fragments are enriched on the H-Gr/SH-β-CD@PdPtNF-modified electrode. Thus, an enhanced oxidation peak from quercetin (IQ) and a reduced peak from hemin (Ihemin) can indicate the same biological identification event. In addition, the recycling amplification of CA125 by Exo I can effectively assist the increase of the quercetin signal. The value of IQ/Ihemin is linear with the concentration of CA125 in the range from 6.0 × 10–4 to 1.0 × 103 ng/mL, and the limit of detection is 1.4 × 10–4 ng/mL. The recovery of CA125 in human blood serum samples was from 99.2 to 104.4%. The proposed sensor is sensitive and reliable, which provides an avenue for the development of triple amplification and ratiometric signal strategies for detecting tumor markers in clinical diagnostics.
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Separations
·
2023
·Vol. 10
·期 2
·111
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IF 2.6
Zexing Xie,Meiying Xie,Tingting Tang,Fan Yang,Liyan Xue,Zhengming Jiang
6Li and7Li are strategic resources. Because Li+ions have no outermost electrons and the radii of6Li and7Li differ by only one neutron, the separation of the naturally stable isotopes of Li, especially by solvent extraction, is recognized as a difficult problem worldwide. Therefore, in this paper, an advancedβ-diketone-driven deep eutectic solvent (DES) extraction system containing 2-thenoyltrifluoroacetone (HTTA) and tri-n-octyl phosphine oxide (TOPO) is introduced to the extraction and separation of6Li+and7Li+ions. Compared with those of reported HTTA extraction systems and crown ether extraction systems, the separation coefficient (β7Li/6Li) of theβ-diketone-driven DES extraction system can reach the best value of 1.068, which is now the highest knownβ-value reported in the extraction system. From the intramolecular hydrogen bond of HTTA to the intermolecular hydrogen bond of DES, the bond energy increases by 47.8%. Because the active site of the proton in DES provides a higher energy barrier for the separation of7Li, theβ7Li/6Liis significantly increased. The extractions were characterized by spectrum, using1H nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, and X-ray photoelectron spectroscopy (XPS). The mechanism was determined on the basis of the reaction kinetics and density functional theory (DFT). The DES extractant shows excellent cycle performance with regard to stripping and reusability. In conclusion, the highly efficient, economical, and stableβ-diketone-driven DES extraction system can be used for the separation of naturally stable Li isotopes, which provides good industrial application prospects.Keywords:β-diketone;Lithium-7;separation of isotopes;deep eutectic solvent (DES);solvent extraction
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Science China-Life Sciences
·
2022
·Vol. 66
·期 7
·1569-1588
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IF 10.372
Ma Ning,Guo Pingting,Chen Jingyu,Qi Zengkai,Liu Chunchen,Shen Jiakun,Sun Yiwei,Chen Xiyue,Chen Guo-Qiang,Ma Xi
Maintainance of sulfomucin is a key end point in the treatment of diarrhea and inflammatory bowel disease (IBD). However, the mechanisms underlying the microbial sense to sulfomucin are poorly understood, and to date, there are no therapies targeting the secretion and maturation of sulfomucin in IBD. Herein, we biosynthesized poly-β-hydroxybutyrate (PHB) and found that PHB could alleviate inflammation caused by diarrhea and colitis by enhancing the differentiation of sulfomucin. Microbiota transplantation and clearance together demonstrate that PHB promoting sulfomucin is mediated by Lactobacillus johnsonii ( L. johnsonii ). Further studies revealed that PHB provides a favorable niche for L. johnsonii biofilm formation to resist disturbance and support its growth. L. johnsonii -biofilm alleviates colitis by regulating fucose residues to promote goblet cell differentiation and subsequent sulfomucin maturation. Importantly, PHB alleviates colitis by enhancing sulfomucin secretion and maturation in a L. johnsonii -dependent manner. PHB represents a class of guardians, acting as a safe probiotic-biofilm delivery system that significantly promotes probiotic proliferation. Altogether, this study adds weight to the possible role of probiotics and functional materials in the treatment of intestinal inflammation. The application of PHB and biofilm self-coating L. johnsonii carries high translational potential and may be of clinical relevance.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Lixi Cai,Yanqi Gao,Yunmeng Chu,Yuanqing Lin,Lixing Liu,Guangya Zhang
Tailoring magnetic nanocarriers with tunable properties is of great significance for the development of multifunctional candidate materials in numerous fields. Herein, we report a one-pot biomimetic silicification-based method for the synthesis of silica-coated magnetic nanoparticles. The synthesis process was mild, low cost, and highly efficient, which took only about 21 min compared with 4.5–120 h in other literature. Then, the carriers had been characterized by VSM, SEM, TEM , XRD, FT-IR, and EDS to confirm their function. To evaluate the usefulness of the carriers, they were adopted to couple the purification and immobilization of β-1,3-xylanase from the cell lysate in a single step with high immobilization yield (92.8 %) and high activity recovery (82.4 %). The immobilized enzyme also retained 58.4 % of the initial activity after 10 cycles and displayed good storage properties, and improved thermal stability , which would be promising in algae biomass bioconversion as well as other diverse applications.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yu Zhang,Qiang Xie,Zhi Xia,Guofeng Gui,Ping Zhang,Lifen Meng,Ling Pan
In this study, a rapid and sensitive electrochemical sensor based on amino β-cyclodextrins (NH 2 -β-CD) functionalized graphene and multi-walled carbon nanotubes (MWCNTs) nanohybrids was successfully constructed for the simultaneous determination of p -aminophenol ( p -AP) and acetaminophen (AC). Graphene and MWCNTs were oxidized with strong acid to give carboxyl groups (COOH-f-GS/MWCNTs). Then, the NH 2 -β-CD was immobilized on its surface by EDC and NHS to prepare a porous hybrid nanocomposite (β-CD-NHCO-f-GS/MWCNTs). The composite material displays a well synergistic effect of high electrocatalytic activity and excellent conductivity of COOH-f-GS/MWCNTs and high supramolecular recognition capability of NH 2 -β-CD. The electrocatalytic mechanism and catalytic process are discussed. Under the optimum conditions, the detection limits of the as-prepared electrochemical sensor are 0.11 mM and 0.15 mM for p -AP and AC, respectively. The linear ranges are 1.0 mM to 1.32 mM for p -AP and 0.6 mM to 0.44 mM for AC. More importantly, this result was measured in the presence of each other. The electrochemical sensor can simultaneously display obvious and accurate response to p -AP and AC at different potentials with high sensitivity and less interferences.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Bo Zhu
PEDOT is a conductive polymer with a conjugated structure, which has great steric hindrance and ion exchange capacity, but its compatibility is poor. Herein, a novel PEDOT-hydroxypropyl-β-cyclodextrin (P-CD) inclusion complex was synthesized and was used as an additive for anticorrosive epoxy coating. UV, FTIR, Raman and XRD spectra demonstrated that the HP-β-CD was successfully attached with the PEDOT and enhanced the solubility and dispersion of PEDOT. The epoxy coatings without and with a small content of P-CD (0.5 wt.%, 1 wt.%) were prepared and the anticorrosion properties were assessed by electrochemical impedance spectroscopy (EIS) and corrosion product analysis. The results indicate that the composite coating exhibits a higher impedance modulus compared to the pure epoxy coating. The main reason is the barrier performance of P-CD, which increases the diffusion path of corrosive media, and P-CD can enhance corrosion resistance by promoting the formation of Fe 3 O 4 passivation layer on the surface of steel.
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Inorganic Chemistry Frontiers
·
2023
·Vol. 10
·期 15
·4496-4502
·
IF 7
Lei Wu,Ruixin Zhang,Qun Jing,Hongyu Huang,Xianmeng He,Zhongchang Wang,Zhaohui Chen
As nonlinear optical (NLO) materials, phosphates often suffer from weak second harmonic generation (SHG) response and low birefringence. Here, we report the successful synthesis of a new UV NLO orthophosphate, β-Li2RbBi(PO4)2, by the high temperature solution method, and demonstrate that it crystallizes in a polar space group of P21 and is composed of 1D 1[Bi4(PO4)8]∞ infinite chains that are constructed from 1[Bi2O11]∞ chains and [PO4] clusters. The optical functional motifs 1[Bi4(PO4)8]∞ are arranged in a parallel mode, which greatly improves the polarizability of the phosphate. As a result, β-Li2RbBi(PO4)2 presents the largest SHG response, 5.2 × KH2PO4 (KDP), at 1064 nm incident radiation among all the Bi-based phosphates. Furthermore, first-principles calculations reveal that the synergistic effect of P–O and Bi–O groups contributes significantly to the optical properties of the title compound.
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JOURNAL OF CHEMICAL RESEARCH
·
2023
·
IF 1.4
Bin Gao,Yanhua Wang
The selective hydrogenation of chalcone to dihydrochalcone under atmospheric hydrogen pressure is investigated using a thermoregulated phase-transfer ruthenium nanocatalyst, representing the first ruthenium nanocatalyst used for this reaction. Under the optimal conditions, the conversion of chalcone into dihydrochalcone and the selectivity are 98% and >99%, respectively. The ruthenium catalyst can be easily separated from the product and recycled three times without any decrease in the conversion or selectivity. The turnover frequency is higher than that of a reported ruthenium complex catalyst. The thermoregulated phase-transfer ruthenium nanocatalyst is also applied for the atmospheric hydrogenation of other α,β-unsaturated ketones.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Zihui Tang,Xiaojuan Li,Le Tian,Yuhao Sun,Xinyan Zhu,Fei Liu
Early intervention of liver fibrosis can prevent its further irreversible progression. Both excess reactive oxygen species (ROS) and transforming growth factor beta(TGF-β)/drosophila mothers against decapentaplegic protein (SMADS) pathway balance disorder promote the progression of hepatic stellate cell (HSC) activation, but existing therapeutic strategies failed to focus on those two problems. A new biomimetic mesoporous polydopamine nandrug (MPO) was constructed for liver fibrosis therapy with multiple targets and reliable biosafety. The MPO was formed by mesoporous polydopamine (mPDA) which has the effect of ROS elimination and encapsulated with anti-fibrotic drug -oxymatrine (OMT) which can intervene liver fibrosis targeting TGF-β/SMADSpathway. Particularly, the nanodrug was completed by macrophage-derived exosome covering. The MPO was confirmed to possess a desired size distribution with negative zeta potential and exhibite strong ROS scavenger ability. Besides, in vitro studies, MPO showed efficient endocytosis and superior intracellular ROS scavenging without cytotoxicity; in vivo studies, MPO effectively cleared the excessive ROS in liver tissue and balanced the TGF-β/SMADS pathways, which in turn inhibited HSC activation and showed superior anti-liver fibrosis therapeutic efficiency with good biological safety. Taken together, this work showed highlights the great potential of the MPO for ameliorating liver fibrosis via ROS elimination and TGF-β/SMADS balancing.
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INFLAMMATION
·
2023
·
IF 5.1
Huang Yina,Zhang Lu,Tan Lingping,Zhang Chi,Li Xiting,Wang Panpan,Gao Li,Zhao Chuanjiang
Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues. The gingival epithelium is the first barrier of periodontal tissue against oral pathogens and harmful substances. The structure and function of epithelial lining are essential for maintaining the integrity of the epithelial barrier. Abnormal apoptosis can lead to the decrease of functional keratinocytes and break homeostasis in gingival epithelium. Interleukin-22 is a cytokine that plays an important role in epithelial homeostasis in intestinal epithelium, inducing proliferation and inhibiting apoptosis, but its role in gingival epithelium is poorly understood. In this study, we investigated the effect of interleukin-22 on apoptosis of gingival epithelial cells during periodontitis. Interleukin-22 topical injection and Il22 gene knockout were performed in experimental periodontitis mice. Human gingival epithelial cells were co-cultured with Porphyromonas gingivalis with interleukin-22 treatment. We found that interleukin-22 inhibited apoptosis of gingival epithelial cells during periodontitis in vivo and in vitro , decreasing Bax expression and increasing Bcl-xL expression. As for the underlying mechanisms, we found that interleukin-22 reduced the expression of TGF-β receptor type II and inhibited the phosphorylation of Smad2 in gingival epithelial cells during periodontitis. Blockage of TGF-β receptors attenuated apoptosis induced by Porphyromonas gingivalis and increased Bcl-xL expression stimulated by interleukin-22. These results confirmed the inhibitory effect of interleukin-22 on apoptosis of gingival epithelial cells and revealed the involvement of TGF-β signaling pathway in gingival epithelial cell apoptosis during periodontitis.
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