MATERIALS TECHNOLOGY
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2022
·
IF 3.297
Hualei Fan,Qinwei Yang,Deyang Zheng,Chunxia Gao,Peizhi Zhu
Beta-tricalcium phosphate (β-TCP) based cements are a popular bone filling material due to their good compatibility, biodegradation, osteoconductivity and osteoinductivity. However, several inherent limitations of current available formulations of β-TCP based cements restrict their applications in repairing of load-bearing bone defects. With the aim to improve mechanical properties and modify the hydration mechanism, a novel β-TCP based bone cement was developed by the modification with different proportions of bioglass (BG) nanospheres, wheat gluten (WG) and poly (γ-glutamic acid) (PGA). Effects of WG and PGA on the anti-washout ability, compressive strength, biodegradability, in vitro mineralisation capability and cytocompatibility of BG-modified β-TCP bone cements were investigated. Results indicated that the introduction of WG and PGA could greatly enhance the handling performances of 50 wt.% BG nanospheres modified β-TCP bone cements (denoted as 50BG-β-TCP). Meanwhile, compared with 50BG-β-TCP (8.8 ± 0.9 MPa), the compressive strength of WG-50BG-β-TCP (PGA) increased to 53.1 ± 4.1 MPa after setting for 5 days at 37℃. Furthermore, the extract solutions of these prepared cements exhibited good cytocompatibility to MC3T3-E1 cells. Therefore, the combination of WG and PGA was supposed to be a new strategy for developing injectable bone cement with good handling performances and mechanical and biological properties for repairing the load-bearing defects.
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Nutrients
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2022
·Vol. 14
·期 13
·2765
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IF 6.706
Xuejiao Zhang,Bowei Zhang,Bo Peng,Jin Wang,Yaozhong Hu,Ruican Wang,Shuo Wang
Sugar reduction and sugar control are advocated and gaining popularity around the world. Sucrose, as the widely consumed ingredient in our daily diet, has been reported a relation to gastrointestinal diseases. However, the role of sucrose in inflammatory bowel disease remains controversial. Hence, our study aimed to elucidate the potential role of three doses of sucrose on DSS-induced colitis in C57BL/6 mice and the underlying mechanisms. The results showed that low-dose sucrose intervention alleviated colitis in mice, reducing the expression of inflammatory cytokines and repairing mucosal damages. In contrast, high-dose sucrose intervention exacerbated colitis. Furthermore, three doses of sucrose administration markedly altered gut microbiota composition. Notably, the low-dose sucrose restored microbial dysfunction and enhanced the production of short chain fatty acids (SCFAs). Specifically, the abundance of SCFAs-producing bacteriaFaecalibaculum,Bacteroides,andRomboutsiawere increased significantly in the LOW group. Consistently, PPAR-γ, activated by SCFAs, was elevated in the LOW group, thereby inhibiting the MAPK/NF-κB pathway. Together, our study demonstrates the differential effects of sucrose on colitis at different doses, providing a scientific basis for measuring and modifying the safe intake level of sugar and providing favorable evidence for implementing sugar reduction policies.Keywords:sucrose;gut microbiota;SCFAs;PPAR-γ;MAPK/NF-κB
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PubMed
高影响因子
MOLECULAR NUTRITION & FOOD RESEARCH
·
2022
·Vol. 66
·期 11
·2100963
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IF 6.575
Xiaoyao Ma,Kaixin Liu,Yiman Han,Yongping Bai,Fukui Shen,Mukuo Wang,Wei Wei,Jianfeng Qin,Erwei Hao,Xiaotao Hou,Yuanyuan Hou,Gang Bai
Scope Glutamate (Glu) and γ-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitters that control information flow in the brain. GABA dysfunction is a general vulnerability factor for mental illness. Cinnamaldehyde (CA) is found to have sedation in a mental illness model. However, the specific targets and molecular mechanisms related to the sedative effects of CA have not been elucidated. Methods and Results Metabolomics analysis and target fishing showed CA could increase the expression of GABA in vivo, and α-enolase (ENO1) is the primary target protein of CA associated with sedation. CA mainly binds with ENO1 in the cerebellar granular layer of brain, which influences the first transformations of the input signals arriving in the cerebellar cortex. The α,β-unsaturated aldehyde group of CA blocks the hydroxy group of Ser40, which induces a loss in ENO1 activation. CA also disturbs the glycolysis pathway and influences the tricarboxylic acid cycle and oxidative phosphorylation, which activate gluconeogenesis to provide energy to the brain. This mechanism is verified in zebrafish with ENO1 or glutamic acid decarboxylase (GAD) deficiency. Conclusions CA demonstrates sedation and alleviates GABA dysfunction via covalent binding ENO1, which shows the potential to improve the therapy of mental illness.
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PROGRESS IN ORGANIC COATINGS
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2022
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IF 6.206
Zhuanghua Yu,Zhangyin Yan,Fuhao Zhang,Junxiang Wang,Qian Shao,Vignesh Murugadoss,A. Alhadhrami,Gaber A.M. Mersal,Mohamed M. Ibrahim,Zeinhom M. El-Bahy,Yifan Li,Mina Huang,Zhanhu Guo
The waterborne acrylic resin modified by both itaconic acid (IA) and γ-methacryloxypropyl triisopropoxidesilane (KH571) was successfully synthesized by the seeded emulsion polymerization . The effects of IA and KH571 on the properties of waterborne acrylic resin, including mechanical properties , water resistance, thermal stability, storage stability and corrosion resistance , were studied. Fourier transform infrared spectroscopy analysis showed that IA and KH571 were successfully copolymerized with acrylic monomers . Compared with the unmodified resin, the introduction of IA and KH571 greatly improved the water resistance of the resin coating. When 2 wt% IA and 4 wt% KH571 were added, the contact angle of the resin coating increased from 78.91° to 90.49°. The water resistance time of the resin coating was improved from one day to 17 days. Additionally, the modified resin showed better mechanical properties, thermal stability, storage stability and corrosion resistance. The waterborne acrylic resin modified with IA and KH571 has a potential application prospect in the fields of waterproof and anticorrosive coating.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
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IF 3.764
Zhongwen Dong,Xinyi Wang,Weifeng Chu,Chuanyu Yang,Yanan Wang,Lin Mei,Dongpu Zhao,Wenjie Xin,Shenglin Liu,Hongxia Wang,Yongchen Shang,Longya Xu
A fast synthetic methodology of β-zeolite with the assistance of γ-butyrolactone (GBL) has been developed in this paper, and the synthetic parameters are systematically investigated to obtain β-zeolite efficiently. Compared to the conventional synthetic system with a crystallization time of 120 h, GBL promotes the crystallization of β-zeolite in a much shorter time of 24 h. An accelerated nucleation mechanism of β-zeolite assisted by GBL is unraveled by X-ray diffraction, scanning electron microscopy, thermogravimetry–differential thermal analysis, Fourier transform infrared spectroscopy, and NMR techniques. The results demonstrate that GBL can adjust the pH value of the initial gels and enhance the combination of TEA+ with aluminosilicate species; in the meantime, the Hoffmann degradation of TEAOH is suppressed. In addition, the β-catalyst obtained with the assistance of GBL exhibits both a higher selectivity of tert-butylbenzene and excellent catalytic stability in the alkylation of benzene with isobutylene compared with the commercial β-catalyst with a similar SiO2/Al2O3 molar ratio.
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高影响因子
LIFE SCIENCES
·
2023
·
IF 6.1
Kang Du,Qun Zhou,Ziwen Wang,Chou Mo,Wanwen Dong,Ning Wei,Wenshen Zhong,Yuejiao You,Yifei Wang,Zhiping Wang
Aims Polygonum cuspidatum Sieb. et Zucc is one of the commonly used herbs for the treatment of gouty arthritis, and polydatin is one of its main effective components. This study evaluated the therapeutic potential of polydatin for the treatment of gout. Main methods The ankle joint of C57BL/6 mice were injected with MSU suspensions to simulate human gouty arthritis, and oral treatment with polydatin (25, 50, and 100 mg/kg body weight) was performed at 1 h after MSU crystal injection. The effect of polydatin on model mice was evaluated by measuring ankle swelling, gait, histopathological analysis, proinflammatory cytokine expression, as well as the contents of NO, MDA and GSH. The targets of polydatin were explored by Real-Time PCR and IHC. Key findings Treatment with polydatin inhibited ankle swelling, improved abnormal gait, and reduced ankle lesions dose-dependently. Moreover, polydatin decreased pro-inflammatory cytokine expression, and promoted expression of anti-inflammatory cytokine. In addition, polydatin inhibited MSU-induced oxidative stress by decreasing oxidative product (NO, MDA) generation and promote the antioxidant (GSH). Further, we found that polydatin reduced inflammation by decreasing the expression of NLRP3 inflammasome component via activating PPAR-γ. Moreover, polydatin can protect against iron overload and attenuate oxidative stress by promoting the activation of ferritin. Significance Our findings indicates that polydatin ameliorates MSU-induced inflammation and oxidative stress by regulating PPAR-γ and ferritin activation in gouty arthritis model mice, and this research result suggests that polydatin has therapeutic potential for the treatment of gout in humans through multiple targets.
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Materials Today Sustainability
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2023
·
IF 7.8
B. Putrakumar,Prem Kumar Seelam,G.S. Rao,N. Pethan Rajan,P. Bhanuchander,G. Raveendra,P. Vijayanand,U. Lassi,E.M. Bakhsh,S.B. Khan,S. Kim
This research work introduces highly dispersed Cu nanoparticles encapsulated into a nanoporous carbon (Cu@C) structure as an efficient catalytic system in selective hydrogenation of γ-valerolactone (GVL) to 1,4-pentanediol. The nanoporous carbon support and the catalysts were synthesized by sequential novel methods and characterized extensively by using a combination of different analytical techniques to determine the phase, textural, morphology, nanoparticles size, and distribution analysis, and redox behavior. The designed Cu@C embedded catalysts show moderately high activity in GVL hydrogenation with different Cu loadings. The effect of copper loadings was found to be a significant parameter in gaining the best performance in GVL conversion. The copper nanoparticles were uniformly distributed over the nano-scaled carbon structure with active metallic Cu(111) sites with high dispersion and promote GVL hydrogenation, efficiently. Over a 5Cu@C catalyst exhibited the highest GVL conversion (∼91%) and 1,4-pentanediol selectivity (∼97%) at 200 °C for a 5 h reaction time under a 5 MPa H 2 pressure. The dispersion of the active copper phase in combination with a smaller particle size and surface acidity is directly correlated with the catalytic performance activity. The effects of reaction parameters such as the reaction time, temperature, and H 2 pressure were systematically investigated. Overall, Cu@C is a promising non-noble metal-based catalytic system for the upgradation of biomass-based platform molecules via selective hydrogenation.
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高影响因子
FEBS Journal
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2021
·Vol. 289
·期 7
·1968-1983
·
IF 5.542
Ting-Ting Wei,Meng-Yuan Zhang,Xin-Hua Zheng,Tian-Hua Xie,Wenjuan Wang,Jian Zou,Yan Li,Hong-Ying Li,Jiping Cai,Xiaolu Wang,Jianxin Tan,Xusheng Yang,Yong Yao,Lingpeng Zhu
Retinal pigment epithelium (RPE) cell damage is implicated in the pathogenesis of age-related macular degeneration (AMD). An increase of interferon-γ (IFN-γ) levels was observed in patients with AMD, but whether inflammatory factors are causally related to AMD progression is unclear. Here, we demonstrate a direct causal relationship between IFN-γ and RPE cell death. IFN-γ induced human retinal pigment epithelial cell (ARPE-19) death accompanied by increases in Fe 2+ , reactive oxygen species, lipid peroxidation, and glutathione (GSH) depletion, which are main characteristics of ferroptosis. Mechanistically, IFN-γ upregulates the level of intracellular Fe 2+ through inhibiting Fe 2+ efflux protein SLC40A1 and induces GSH depletion by blocking cystine/glutamate antiporter, System xc-. At the same time, treatment with IFN-γ decreases the level of glutathione peroxidase 4 (GPx4), rendering the cells more sensitive to ferroptosis. JAK1/2 and STAT1 inhibitors could reverse the reduction of SLC7A11, GPx4 and GSH expression induced by IFN-γ, indicating IFN-γ induces ARPE-19 cell ferroptosis via activation of the JAK1-2/STAT1/SLC7A11 signaling pathway. The above results were largely confirmed in IFN-γ-treated mice in vivo . Finally, we used sodium iodate (NaIO 3 )-induced retinal degeneration to further explore the role of ferroptosis in AMD in vivo . Consistent with the role of IFN-γ, treatment with NaIO 3 decreased SLC7A11, GPx4 and SLC40A1 expressions. NaIO 3 -induced RPE damage was accompanied by increased iron, lipid peroxidation products (4-hydroxynonenal, malondialdehyde), and GSH depletion, and ferroptosis inhibitors could reverse the above phenomenon. Taken together, our findings suggest that inhibiting ferroptosis or reducing IFN-γ may serve as a promising target for AMD.
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高影响因子
CHEMOSPHERE
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2023
·
IF 8.8
Zilong Zhao,Shuyu Qi,Jianli Zhou,Yatao Ren,Kaiyun Zheng,Jin Zhang,Wenyi Dong,Hongjie Wang
To enhance the polarization distribution of electron cloud density on the catalyst surface, we have introduced a novel bimetallic-substituted dual-reaction center (DRC) catalyst (FeCo-γ-Al 2 O 3 ) comprising iron (Fe) and cobalt (Co) for the decomplexation and mineralization of heavy metal complex Ni-EDTA in this study. Compared to the catalysts doped solely with Fe or Co, the bimetal-doped catalyst offered several advantages, including enhanced electron cloud polarization distribution, additional electron transfer pathway, and improved capacity of free radical generation. Through DFT calculations and EPR tests, we have elucidated the influences of the catalyst's adsorption toward Ni-EDTA and its decomplexation products on the electron transfer between the pollutant and the catalyst. The competition between the pollutants and H 2 O 2 affects the generation of free radicals in both electron-rich Fe and Co centers as well as electron-deficient Al center. Building on these findings, we have proposed a plausible removal mechanism of Ni-EDTA using the heterogeneous Fenton-like catalyst FeCo-γ-Al 2 O 3 . This study sheds light on the potential of FeCo-γ-Al 2 O 3 as a DRC catalyst and emphasizes the significance of pollutant characteristics in determining the catalyst's performance.
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高影响因子
Surfaces and Interfaces
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2023
·
IF 6.2
Tingyu Chen,Shuaiqi Zhao,Jiajin Lin,Yanan Chong,Yifei Li,Yun Zhao,Guangxu Chen,Yongcai Qiu
As a nontoxic and cheap catalyst, the Al 2 O 3 catalyst can be used to catalyze the propane dehydrogenation (PDH) process. However, due to its poor activity, it has been used as a catalyst carrier rather than catalysis. In this work, the experimental results indicate that γ- Al 2 O 3 -(110)-S catalysts can improve the yield of propane dehydrogenation more effectively than γ-Al 2 O 3 -(110) catalyst. We investigate the potential barrier of propane dehydrogenation reaction catalyzed by Al 2 O 3 -(110) under different conditions and found that the substitution of the S atom for partial O atom can modify the acid-base properties of the surface active site of γ-Al 2 O 3 -(110), thus reducing the reaction energy barrier. In particular, the yield of the reaction can be further improved by the active sites of oxygen vacancies generated by removing partial S atoms in γ-Al 2 O 3 -(110)-S, which is consistent with our theoretical calculation results. At the same time, theoretical calculation shows that Cu clusters can effectively remove the S atoms on the surface of γ-Al 2 O 3 -(110)-S and form oxygen vacancies. This strategy provides a new path to form oxygen vacancies on γ-Al 2 O 3 -(110), which opens up a new way for the study of propane dehydrogenation.
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MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2020
·Vol. 221
·期 18
·2000157
·
IF 2.335
Ming Gao,Hang Lu,Rong-Hao Song,Lin Ye,Ai-Ying Zhang,Zeng-Guo Feng
To highlight whether γ-cyclodextrins (CDs) facilitate propargylamine monosubstituted β-CDs (PA-β-CDs) as end stoppers to get threaded onto a distal azide terminated poly(2-hydroxyethylmethacrylate) (PHEMA) homopolymer (PH-46-2N 3 ) to create linear and hyperbranched polyrotaxanes (PRs) via the in situ copper-catalyzed azide/alkyne cycloaddition (CuAAC), PH-46-2N 3 is self-assembled with a varying amount of γ-CDs in water and then subjected the CuAAC with PA-β-CDs to end-cap the resulting γ-CD-PHEMA polypseudorotaxanes (PPRs) into the γ-CD-PHEMA PRs. It demonstrates that γ-CDs cannot promote PA-β-CDs to be entrapped on the PHEMA chain most likely due to their different cavity size and molecular framework and linear PRs are always formed with up to 29% γ-CD coverage ratio along the PHEMA axis thereof.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Guangyue Xu,Chuang Li,Tianyu Deng,Chenguang Wang,Ying Zhang,Yao Fu
The conversion of levulinic acid (LA) to γ-valerolactone (GVL) is one of the most important reactions from biomass-derived platform chemicals to value-added chemicals. In this work, bimetallic PdRu/TiO2 catalyst compared to monometallic Ru/TiO2 was designed for the conversion of LA to GVL at ambient H2 pressure. The highly dispersed Pd affected the reaction by two antagonistic effects: (I) increasing the reaction rate by promoting the activation of H2; (II) decreasing the reaction rate by lowering the activation ability of carbonyl group over Ru. The kinetic analysis refined by H2 concentration showed much lower apparent activation energy over 0.2Pd1Ru/TiO2 than that over Ru/TiO2. Finally, the catalysts were evaluated by both GVL productivity and catalyst cost to show increasing benefit of Pd addition at lower H2 pressure. This study offers both theoretical foundation and application instructions for high efficiency conversion of LA to GVL under mild conditions, especially ambient H2 pressure.
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