European Journal of Integrative Medicine
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2023
·
IF 2.5
Xuelin Duan,Tiejian Zhao,Jiaru Wang,Jiahui Wang,Yang Zheng
Introduction : Curcuma is used as an herbal remedy for the treatment of chronic liver diseases, and its main active ingredient is curcumol. This study explored the molecular mechanism of curcumol in regulating glutamine metabolism. Methods : The current investigation used lipopolysaccharide(LPS) to activate hepatic stellate cells (HSCs) and then analyzed the effects of curcumol on glutamine metabolism and cell proliferation. The effects of curcumol on glutaminase 1 (GLS1), senescence-related proteins, and extracellular matrix (ECM) expression were examined by western blotting and reverse transcription-quantitative polymerase chain reaction(RT-PCR). The effect of curcumol on the cell cycle was detected by flow cytometry. Furthermore, after overexpression of GLS1, we observed the effects of curcumol on glutamine metabolism, the expression of related molecules, and the cell cycle. Results : Curcumol significantly inhibited cell proliferation, glutamine metabolism, and GLS1 and ECM expression, and also significantly promoted cell senescence. With GLS1 overexpression, the inhibitory effects of curcumol on glutamine metabolism and on promoting cell senescence were rescued. Conclusion : Curcumol targets GLS1, inhibits glutamine metabolism, and induces senescence in HSCs. GLS1 may be an important target for the pharmacological effects of curcumol.
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JOURNAL OF MOLECULAR STRUCTURE
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2023
·
IF 3.8
Ahmed M. Senan,Muhammed Tilahun Muhammed,Laila A. Al-Shuraym,Sadeq K. Alhag,Niyazi A.S. Al-Areqi,Senem Akkoç
1-Phenyl ethanol derivatives are well-known classes of drug molecules that play an important role as effective substitute analogs to anticancer and antiviral agents. In this work, phenylacetylene was selected as a simple alkyne in the presence of iron (II) phthalocyanine with NaBH 4 as a catalyst. This reaction has been proven that it is a significantly efficient catalyzed conversion of terminal and internal alkynes to 1-phenyl ethanol derivatives as secondary alcohols followed by the addition and elimination mechanism. However, such drug design by compiling the redox reaction and its sequence essentially requires exact stoichiometry of iron phthalocyanine to alkynes. The products were characterized using flash column chromatography with an eluent ratio of PE: EA (5: 1 / V: V), gas chromatography, 1 H, and 13 C NMR spectroscopy. The potential of the synthesized compounds to bind to protein kinase B was investigated through molecular docking to dig out their probable anticancer activity. Compound 7 (1-(4-bromophenyl) ethan-1-ol) exhibited the highest binding potential. However, the binding potential of all the compounds was less than the standard parent compound. In addition, the density functional theory (DFT) studies of the compounds were also applied which revealed that compound 1 might have the highest chemical stability.
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Weilong Hou,Kehang Lin,Xiangyu Zhang,Bowen Xu,Yuexia Wang,Xinqing Lu,Yijing Gao,Rui Ma,Yanghe Fu,Weidong Zhu
Nonoxidative propane dehydrogenation (PDH) has been regarded as an economic and efficient route to meet constantly increasing global demands for propylene. However, over industrially applied catalysts, thermally induced deactivation including coke formation and sintering of the active species occurs and simultaneously hydrocarbon cracking significantly reduces the selectivity for propylene. In the present work, titanosilicate-1 (TS-1) zeolite supported catalysts (Pt/TS-1) were developed for PDH. The results on the extensive characterizations of the prepared materials, in combination with density functional theory (DFT) calculations, verify that the framework Ti species in Pt/TS-1 can increase the dispersion and electron density of Pt, which significantly enhances the catalyst stability and selectivity for propylene. Utmost importantly, no sintering of the Pt active species in Pt/TS-1 occurs at the high temperatures required for the reaction and catalyst regeneration processes. Therefore, the current investigation provides a strategy for developing efficient PDH catalysts for practical applications.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Hailin Pan,Jie Wang,Zhi Chen,Ziqi Su,Zheng Tang,Zaifei Ma
Developing transparent conductors to replace indium tin oxide (ITO) is a critical objective in the field of organic optoelectronics. Non-atomically doped (NAD) ZnO thin films, while currently exhibiting limited conductivity, are highly promising candidates due to their unique advantages, such as having complete transparency in both the visible and near-infrared spectral regions, solution processability, and the desired surface electronic properties. In this work, the impact of surface modification by insulating polymers on the ultraviolet-enhanced conductivity of NAD-ZnO films is investigated. It was found that polymer modifiers that are rich in amino and hydroxyl groups are effective at increasing the concentration of oxygen vacancies and the conductivity of NAD-ZnO films. The highest conductivity of over 1000 S cm–1, which is more than twice as high as the previous record for NAD-ZnO films, is achieved using polyethylenimine ethoxylated (PEIE) to modify NAD-ZnO films. Subsequently, the replacement of ITO in organic photovoltaic devices by a ZnO/PEIE electrode is realized. The ZnO/PEIE-based OPV devices that were created exhibit performances comparable to those of ITO-based devices under simulated solar illumination and performances better than those achieved with ITO-based devices under simulated indoor illumination. These results make NAD-ZnO a promising candidate for the widespread replacement of ITO in optoelectronic devices.
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MINERALS ENGINEERING
·
2023
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IF 4.8
Jiahui Wu,Longhua Xu,Donghui Wang,Kai Xue,Xinzhang Shi,Lin Peng,Jiushuai Deng
Removing calcite is a tricky problem in smithsonite flotation because of its better floatability. 1-Hydroxyethylidene-1,1-diphosphonic acid (HEDP), a scale inhibitor in water treatment industry, was chosen as a calcite depressant. This study validated the effectiveness of HEDP in separating smithsonite from calcite by flotation using sodium oleate (NaOL) as the collector, and obtained a 70% recovery difference in a single mineral flotation. Artificial mixed mineral flotation obtained a concentrate with a grade of 44% and a recovery of more than 80%. Zeta potential, Fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS) tests were conducted to obtained some crucial information on the adsorption of NaOL and HEDP, demonstrating that the adsorption of HEDP on calcite surfaces was stronger than smithsonite. The intense adsorption of HEDP on calcite surfaces was attributed to chelation with surface calcium sites. Quantum chemical calculations suggested that the selectivity of HEDP was closely related to the phosphate groups. HEDP was chemically adsorbed on calcite surface by complexing with calcium sites to form six-membered ring chelate. Partial oxygen atoms of phosphate groups dominated in the reaction with calcium sites, and the deprotonation of phosphate groups enhanced the reactivity.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-25
·
IF 16.6
Li Ting,Jiang Shuhui,Zhang Ying,Luo Jie,Li Ming,Ke Hengte,Deng Yibin,Yang Tao,Sun Xiaohui,Chen Huabing
The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling self-defenses to amplify antitumor potency remains unexplored. Herein, we demonstrate that nanoparticle-mediated transient receptor potential vanilloid member 1 (TRPV1) channel blockade potentiates thermo-immunotherapy via suppressing heat shock factor 1 (HSF1)-mediated dual self-defense pathways. TRPV1 blockade inhibits hyperthermia-induced calcium influx and subsequent nuclear translocation of HSF1, which selectively suppresses stressfully overexpressed HSP70 for enhancing thermotherapeutic efficacy against a variety of primary, metastatic and recurrent tumor models. Particularly, the suppression of HSF1 translocation further restrains the transforming growth factor β (TGFβ) pathway to degrade the tumor stroma, which improves the infiltration of antitumor therapeutics (e.g. anti-PD-L1 antibody) and immune cells into highly fibrotic and immunosuppressive pancreatic cancers. As a result, TRPV1 blockade retrieves thermo-immunotherapy with tumor-eradicable and immune memory effects. The nanoparticle-mediated TRPV1 blockade represents as an effective approach to dismantle self-defenses for potent cancer therapy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Changsheng Qiao,Guohang Sun,Hongbao Li,Weifeng Cao,Fei Shen,Rong Fan,Yinhua Wan
Poly (β-L-malic acid) (PMLA) is attracting industrial interest for its potential application in medicine and other industries, whose functions primarily depend upon its molecular size and chemical structure. Up to now, the fractionation and characterization of PMLA produced by Aureobasidium spp. were still unclear. In this study, the product from A. melanogenum ipe-1 was effectively fractionated using 300 and 50 kDa membranes. During the filtration, the mechanisms of membrane fouling were illegible since the PMLA can both reject and permeate the membrane, while the main fouling mechanism varied between standard blocking and complete blocking during the diafiltration . After fractionation, 14.0, 8.4 and 77.6 % of the PMLAs with M w s of 75,134, 21,344 and 10,056 Da were distributed in the 300 kDa retentate after diafiltrating, 50 kDa retentate after diafiltrating, and the 50 kDa permeate, respectively. The M w /M n s of the PMLAs were 4.12, 1.92, and 1.12 in the three fractions. Based on characteristic spectra of NMR, HPLC and FTIR, the product was not usual L-malic acid monomers, but glucose-terminated PMLA. The glucose was located at the terminal hydroxyl of PMLA. These results would serve as a valuable guide for process design and practical operation in subsequent industrial application.
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MATERIALS RESEARCH BULLETIN
·
2023
·
IF 5.4
Jinbiao Jia,Beibei Shi,Jia Dong,Xu Feng,Yangqing Wu,Bingqiang Cao
Although perovskite solar cells have made remarkable progress, the record device efficiency still lags far behind the theoretical limit efficiency. In this work, the ionic liquid, 1-ethyl-3-methylimidazolium chloride, is introduced into the triple-cation perovskite light absorption layer. The perovskite film with optimal amount of 1-ethyl-3-methylimidazolium chloride increases crystallinity, decreases pinholes and reduces defects density. As a result, the nonradiative recombination loss is efficiently restrained, accelerating the carrier extraction. The device modified with 1-ethyl-3-methylimidazolium chloride acquires a power conversion efficiency of 21.54%, which is considerably higher than that of the control device (18.12%). This work demonstrates that 1-ethyl-3-methylimidazolium chloride is a promising ionic liquid additive for high-performance perovskite solar cells.
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IET Nanobiotechnology
·
2023
·Vol. 17
·期 4
·387-395
·
IF 2.3
Wei Li,Chang Liu,Sichuan Wang,Naifeng Liu
Atherosclerosis is a progressive inflammatory disease characterised by excessive lipid accumulation and inflammatory cell infiltration and is the basis of most cardiovascular diseases and peripheral arterial diseases. Therefore, an effectively targeted delivery system is urgently needed to deliver ferroptosis-specific inhibitors to the site of arterial plaque and the inflammatory microenvironment. Inspired by the fact that neutrophils can be recruited to arterial plaques under the action of adhesion molecules and chemokines, the authors developed a neutrophil membrane hybrid liposome nano-mimetic system (Ptdser-NM-Lipo/Fer-1) that delivers Ferrostatin-1 (Fer-1) to the atherosclerotic plaque effectively, which is composed of Fer-1-loaded Ptdser-modified liposomes core and neutrophils shell. Fer-1 was released at the AS plaque site to remove reactive oxygen species (ROS) and improve the inflammatory microenvironment. In vitro ROS clearance experiments have shown that 50 μmol/ml Fer-1 can significantly remove ROS produced by H 2 O 2 -induced MOVAS cells and Ptdser-NM-Lipo/Fer-1 revealed a 3-fold increase in the inhibition rate of ROS than free Fer-1 in induced-RAW264.7, demonstrating its superior ROS-cleaning effect. Based on the interaction of adhesion molecules, such as vascular cell adhesion molecule 1, ICAM-1, P-selectin, E-selectin, and chemokines released in the inflamed site, the aorta in NM-Lipo-treated mice displayed 1.3-fold greater radiant efficiency than platelet membrane-Lipo-treated mice. Meanwhile, due to the modification of the Ptdser, the aorta in Ptdser-NM-Lipo/Fer-1-treated mice exhibited the highest fluorescence intensity, demonstrating its excellent targeting ability for atherosclerosis. Therefore, we present a specific formulation for the treatment of atherosclerosis with the potential for novel therapeutic uses.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Huahao Wang,Yaping Ding,Mengjia Ning,Miao Yu,Wenji Zheng,Xuehua Ruan,Yuan Xi,Yan Dai,Hongjing Liu,Gaohong He
Metal organic frameworks (MOFs) with appropriate pore size and sufficient CO 2 -philic groups are required to improve the mixed matrix membranes (MMMs)-based CO 2 capture. Herein, NH 2 -CPL-1 is designed for capture by utilizing amino pyrazine instead of pyrazine in CPL-1. The introduced CO 2 -philic amino groups together with rich hydroxyl and carboxyl groups in CPL-1 could improve the selective adsorption of CO 2 , enhancing the solubility selectivity. At the meantime, after the introduction of amino-functional, the pore size of NH 2 -CPL-1 is decreased from 0.93 nm of CPL-1 to 0.85 nm, which is beneficial for the screening of CO 2 over N 2 . As a result, the CO 2 separation performances of MMMs could be promoted greatly under the action of NH 2 -CPL-1. MMM with NH 2 -CPL-1 of 10 wt.% exhibited the best CO 2 separation performance, with CO 2 /N 2 selectivity of 85 and CO 2 permeability of 104 Barrer at 25 °C and 0.4 MPa. Compared with the CPL-1/Pebax-10 wt.% MMM, it was increased by 9.5 % and 13.3 %, respectively. This satisfactory CO 2 separation performance surpasses those of most reported other MOFs based MMMs, which is attributed to the facilitated CO 2 transport and pore size screening from the introduced amino groups. This is also confirmed by the improvement of diffusion selectivity and solution selectivity. The proposed NH 2 -CPL-1 shows great prospect as filler for enhanced MMMs-based CO 2 capture.
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Applied Materials Today
·
2023
·
IF 8.3
Mingming Song,Bin Zhu,Shuang Qiu,Jiameng Tian,Jianning Li,Daling Chen,Chang Liu
Melanoma is one of the most aggressive and deadly forms of skin cancer, and effective treatments need to be developed. The combination of chemoimmunotherapy has emerged as a promising strategy for treating cancer. However, this strategy still has several limitations, including the inability of more than two drugs to reach tumor tissue simultaneously and the risk of serious adverse effects. The use of nanodrug delivery systems is an effective method to successfully combine these therapies, as they reduce side effects and improve bioavailability. In this study, we developed IL4RPep-1-targeting peptide nanoparticles (IPP NPs) for the codelivery of afuresertib and celecoxib for melanoma treatment by taking advantage of the high drug loading capacity and favorable pharmacokinetic profile of the poly(lactide-co-glycolide) nanoparticle platform. IPP NPs efficiently target three different types of melanoma cells in vitro and significantly accumulate at the tumor site in vivo . In both ectopic and pulmonary metastatic melanoma models, targeted codelivery of afuresertib and celecoxib not only promotes melanoma cell apoptosis but also reprograms M2-type macrophages into M1-type macrophages, reconstructing the tumor immune microenvironment and activating the immune response against cancer cells. In addition, this highly coordinated precise delivery of the drug to tumor cells significantly reduces adverse reactions associated with the combination of afuresertib and celecoxib. In summary, IPP NPs exhibit an accurate pH response and ideal targeted drug delivery capabilities for combination chemotherapy and immunotherapy, offering therapeutic potential for this combination in melanoma.
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Analytical Methods
·
2023
·Vol. 15
·期 27
·3318-3324
·
IF 3.1
Hongyu Chen,Mingshuo Liu,Jianing Wang,Yunfei Wang,Yajuan Wang,Wenyan Liu
Due to their excellent optical and electrical properties, all-inorganic metal halide perovskite CsPbBr3 quantum dots (QDs) have become one of the most promising materials in the field of optoelectronics during recent years. However, the stability of CsPbBr3 QDs limits their practical application and further development to a certain extent. In order to improve their stability, CsPbBr3 QDs were modified with 2-n-octyl-1-dodecanol for the first time in this paper. The 2-n-octyl-1-dodecanol-modified CsPbBr3 QDs were prepared by the ligand-assisted reprecipitation (LARP) method at room temperature in an air environment. Then the stability of the samples was tested at different temperatures and humidity. When the humidity was 80%, the photoluminescence (PL) intensity of both unmodified and modified CsPbBr3 QDs increased to different degrees because the appropriate amount of water changed the crystallization environment. The PL intensity of the modified QDs increased, and the peak positions were basically not shifted, proving that they did not agglomerate. Thermal stability test results showed that the PL intensity of the 2-n-octyl-1-dodecanol-modified QDs could still maintain 65% of the original intensity at 90 °C, which is 4.6 times that of the unmodified CsPbBr3 QDs. Experimental results show that the stability of CsPbBr3 QDs is significantly improved after 2-n-octyl-1-dodecanol modification, which demonstrates the excellent surface passivation of CsPbBr3 QDs by 2-n-octyl-1-dodecanol.
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