CHEMISTRY-A EUROPEAN JOURNAL
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2026
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IF 3.6
Peng Yang,Xiquan Chen,Hualei Hu,Soliman I. El-Hout,Guojun Lan,Yong Yang,Guowen Lu,Qianquan Fang,Jian Zhang,Chunlin Chen
Mesoporous copper oxide (CuO) fabricated via mechanochemical milling was employed as a robust catalyst for the efficient synthesis of 2,5-furandicarboxylic acid (FDCA) in a sodium hypochlorite (NaClO) oxidation system. We demonstrate that introducing cetyltrimethylammonium bromide (CTAB) in the mechanochemical synthesis process successfully creates mesoporosity, reduces the size of CuO nanoparticles, and modulates the ratio between surface oxygen vacancies (O V ) and lattice oxygen (O L ). Owing to its minimized particle size, enlarged pore volume, and elevated O V /O L ratio, the CuO@0.4 CTAB catalyst delivers exceptional catalytic activity and reusability toward 5-hydroxymethylfurfural (HMF) oxidation, affording a maximum FDCA yield of 95.2% under optimal reaction conditions. Furthermore, maintaining the solution pH value above 12 greatly inhibits the over-oxidation of FDCA and slows the rapid consumption of NaClO during the reaction. Graphical The efficient synthesis of FDCA from HMF was achieved in the sodium hypochlorite (NaClO) system using mechanochemically synthesized mesoporous CuO. .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Ping Liang,Bingke Li,Guorui Liu,Junran Xu,Qingyue Zhang,Yuchao Chen,Xinling Wu,Haoming Zhang,Zhongyu Li,Zhihui Li
Pyridoxal 5′-phosphate (PLP) serves as a dual crosslinker forming Schiff bases and electrostatic interactions. • Nanogels show pH-triggered release: 88.5% at pH 5.0 vs. 23.5% at pH 7.0. • TMX@CS-PLP NGs improve foliar wettability, rainfastness, and insecticidal efficacy. • The biocompatible nanogel platform enables intelligent, eco-friendly pesticide delivery. Conventional pesticide formulations suffer from poor targeting and low active ingredient utilization due to their inability to respond to microenvironmental signals at pest feeding sites. Here, we developed pH-responsive nanogels by crosslinking chitosan with PLP via Schiff base formation and electrostatic interactions using an inverse emulsion method, and loaded them with the neonicotinoid insecticide thiamethoxam (TMX). The resulting TMX@CS-PLP nanogels exhibited spherical morphology with a hydrodynamic diameter of 428.1 nm, a loading capacity of 9.2%, and an encapsulation efficiency of 79.4%. The Schiff base crosslinks imparted pH-dependent degradability: at acidic pH (5.0, simulating pest gut or infection sites), the nanogels released 88.5% of encapsulated TMX over 72 h, whereas only 23.5% was released at neutral pH (7.0, mimicking leaf surface conditions). The nanogel formulation also improved foliar wettability (contact angle reduced from 84.5o to 68.1o) and enhanced rainfastness compared with the technical suspension. In laboratory bioassays against Myzus persicae , TMX@CS-PLP nanogels caused 76.0% mortality after 24 h, significantly higher than the technical suspension (46.7%), while the blank nanogel showed no phytotoxicity or inherent insecticidal activity. These results demonstrate that PLP-crosslinked chitosan nanogels offer a biocompatible, pH-responsive platform for precision pesticide delivery, with enhanced foliar deposition and improved efficacy. Download: Download high-res image (124KB) Download: Download full-size image
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Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 3
·122789
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IF 7.5
Dancheng Zhu,Caiyun Zhang,Jiabin Shen,Chao Shen,Chuanhong Jin,Hao Xu
Sulfamethoxazole (SMX), a widely used sulfonamide antibiotic, is a persistent aquatic pollutant due to its resistance to conventional treatment. Here, a Cu-ZSM-5/Ti 3 C 2 composite catalyst was fabricated by electrostatic self-assembly for peroxymonosulfate (PMS) activation. Characterization by XRD, SEM, TEM, XPS, and zeta potential analysis confirmed the successful integration of the components. The catalyst achieved 97.59% removal of 10 mg/L SMX within 30 min. Quenching and EPR results indicated that 1 O 2 was the major reactive species. The enhanced performance under alkaline conditions was associated with the negatively charged composite surface (-38.8 mV at pH 9), the deprotonated state of SMX, and favorable interfacial interactions that may promote preferential oxidation of the isoxazole moiety. Control experiments using a physically mixed sample showed markedly lower activity, especially at pH 11, highlighting the importance of the intimate heterointerface created by self-assembly. The superior activity was attributed to the synergistic interaction between Cu species in Cu-ZSM-5 and Ti-based sites in Ti 3 C 2 . This work provides insight into designing selective PMS activation catalysts for antibiotic-contaminated water treatment.
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ACTA PHARMACOLOGICA SINICA
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2026
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IF 10.4
Zhou Yan,Yang Yifan,Wang Yuehan,Cheang Wai San
YAP/TAZ and SMAD1/5 signaling modulate atherosclerosis. These involvements in diabetes-associated endothelial dysfunction remain unexplored, thereby being investigated from different endothelial cells and a total of 102 mice in the current study. Male C57BL/6 mice were fed a high-fat diet (45% kcal% fat, 15 weeks) and orally administered with endoplasmic reticulum (ER) stress alleviator 4-phenylbutyric acid (100 mg·kg –1 ·d –1 ) and jatrorrhizine (50 mg·kg –1 ·d –1 ) for 5 weeks. Endothelial cells were cultured with high glucose, ER stress inducer tunicamycin, ER stress alleviators, YAP inhibitor simvastatin, or jatrorrhizine. The mouse aorta was divided into the aortic arch and thoracic aorta regions to investigate the regional difference. Treatment with PBA and jatrorrhizine ameliorated endothelium-dependent relaxations as well as inhibited ER stress, YAP/TAZ-SMAD1/5 signaling and oxidative stress in aortas. Phosphorylation of YAP/TAZ was highly expressed in the thoracic aorta but low in the aortic arch. On the other hand, phosphorylation of SMAD1/5 was upregulated in the inner curvature of the aortic arch but downregulated in the thoracic aorta. In HUVECs, ER stress alleviators significantly inhibited YAP/TAZ-SMAD1/5 signaling and increased NO bioavailability, but the YAP inhibitor did not suppress ER stress. Inhibition of YAP/TAZ downregulated SMAD1/5 signaling under high glucose stimulation, followed by the Akt/eNOS pathway. YAP/TAZ directly interacts with SMAD1/5, and their binding is significantly enhanced under high-glucose conditions. A natural compound, jatrorrhizine, was identified to inhibit YAP/TAZ-SMAD1/5 signaling and protect vascular function in diabetes. To conclude, ER stress activates YAP/TAZ and SMAD1/5 signaling, resulting in endothelial dysfunction in diabetes. Inhibition of YAP/TAZ-SMAD1/5, such as by ER stress alleviators and natural product jatrorrhizine, ameliorates endothelial dysfunction associated with diabetes. These findings support the cross-talk between ER stress and YAP/TAZ-SMAD1/5 as well as their potential as therapeutic targets.
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CHEMICAL ENGINEERING SCIENCE
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2026
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IF 5.1
Benhuan Xu,Xuexue Dong,Yikun Zhou,Jiahao Wu,Bin Chen,Jian Tian,Guowu Zhan
This study presents a high-performance catalyst for sustainable biofuel production, synthesizing NiFe bimetallic catalyst on hierarchical ZSM-5 (NiFe-RH-Z5) using rice husk as a green silicon source and structural template. The resulting material features a multi-scale porous architecture that enhances mass transport and active site accessibility. In the hydrodeoxygenation (HDO) of stearic acid, the optimized 7Ni3Fe-RH-Z5 catalyst achieves complete conversion with 92% selectivity to n-octadecane (C 18 alkane), significantly outperforming monometallic analogues. Comprehensive characterization reveals a synergistic mechanism: Fe species adsorb oxygenated intermediates, while Ni sites dissociate hydrogen, collectively steering the pathway toward selective C O bond cleavage and minimizing carbon loss. Furthermore, molecular dynamics simulations confirm a 3.75-fold increase in the diffusion coefficient of stearic acid within the bio-templated hierarchical pores compared to conventional ZSM-5 (Z5). The reaction mechanism, proceeding through an aldehyde intermediate to the C 18 alkane, is unequivocally verified by in-situ spectroscopic and isotopic experiments. This work provides a sustainable strategy for designing efficient catalysts by simultaneously engineering bimetallic synergy and hierarchical diffusion pathways for advanced biofuel production.
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Energy Sources Part A-Recovery Utilization and Environmental Effects
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2018
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IF 0.555
Hongguo Wu,Yancai Liu,Hu Li,Song Yang
A series of low-cost and sustainable amino-acid derived catalysts including glutamic acid hydrochlorate (GluCl), glycine hydrochlorate (GlyCl), alanine hydrochlorate (AlaCl) and valine hydrochlorate (ValCl) were prepared by using a simple assembly method and characterized by 1H/13C NMR (nuclear magnetic resonance) and FT-IR (Fourier transform infrared) techniques. These amino-acid based catalysts were highly efficient for the production of an important platform molecule 5-hydroxymethylfurfural (HMF) from biomass-derived sugars under oil-heating conditions. A high HMF yield of 83.7% at fructose conversion of 99.3% was achieved in merely 15 min at 120ºC. The catalyst could be reused for four times with no significant loss of its catalytic activity.
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Desalination and Water Treatment
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2024
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IF 1
Pingping Cheng,Fangyuan Sun,Wei Wang,Jingwei Feng,Zhen-Hu Hu,Shoujun Yuan,Qiquan Wang
5-Fluorouracil (5-FU) and cytarabine (Ara-C) are two commonly used antineoplastic drugs, which are ecotoxic and genotoxic and frequently detected in hospital wastewater. Potassium permanganate (KMnO 4 ) has been widely used to remove organic pollutants from wastewater. The oxidative deg- radation of 5-FU and Ara-C in aqueous solution by KMnO 4 has not been reported. In this study, the oxidative degradation of 5-FU and Ara-C with KMnO 4 in aqueous solution was investigated. 5-FU was oxidized rapidly by KMnO 4 due to the olefinic group in the central heterocyclic ring. The degradation kinetics of 5-FU was well described by the equation of –d[5-FU]/dt = k app [5-FU] t 0.77 [KMnO 4 ] t 0.86 . The degradation kinetics of Ara-C followed a generalized second-order rate law. The apparent rate constant (k app ) of these two target compounds was strongly depended on the reaction temperature, pH, humic acid (HA) and water quality. The apparent activation energies (E a ) of 5-FU and Ara-C were 32 and 40 kJ·mol –1 , respectively, indicating that 5-FU was more easily decomposed by KMnO 4 as compared with Ara-C. The maximum values of k app for 5-FU and Ara-C were 1.73 × 10 –4 μM –0.63 ·s –1 at pH 7.4 and 1.52 M –1 ·s –1 at pH 3.5, respectively. The oxidative degradation of 5-FU was inhibited by HA, while the oxidation of Ara-C was enhanced by HA. Reaction of both 5-FU and Ara-C was influenced by water quality. Thus, this study provides new insights into the degradation of antineoplastic drugs.
研究领域:
环境化学
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药物污染
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水处理
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降解动力学
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抗肿瘤药物
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ACS Applied Energy Materials
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2018
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IF 0
Lin Long,Zhenzhong Lan,Zhixiong Han,Yunfeng Qiu,Weixing Zhou
Endothermic hydrocarbon fuel has many advantages as a cooling medium in hypersonic aircraft; however substantial application has been greatly hindered due to easy coking, uncontrollable gas products, and low heat sink issues. Catalytic cracking of hydrocarbon fuel has been regarded as one of the most effective ways to improve the heat sink via modulating the cracking pathway. The incipient-wetness impregnation method was selected to load Co salts in commercial ZSM-5 in a large-scale manner; subsequent calcination in Ar gas resulted in Co3O4 nanosheet wrapped HZSM-5 composites. Salinization treatment was adopted to facilitate the dispersion of catalyst in a nonpolar solvent. The ratio of Brönsted/Lewis acidity decreased from 8.00 to 2.79 after modification by Co3O4 nanosheets. The synergistically catalytic effect between Co3O4 nanosheets and ZSM-5 was beneficial to the generation of a larger gas production rate with higher content of alkene, and thus resulting in a higher heat sink than benchmarked fuels. Catalytic cracking of n-decane (C10) in the presence of 0.1 wt % Co3O4 nanosheets@ZSM-5 could yield a heat sink as high as 4.64 MJ/kg at 758 °C, much higher than those of bare ZSM-5 (2.99 MJ/kg at 687 °C) and thermal cracking of C10 (3.77 MJ/kg at 728 °C). Meanwhile, the smart combination of Co3O4 nanosheets and commercial ZSM-5 could effectively suppress the coke deposition on the external surface of composites, thus resulting in efficient catalytic cracking at elevated temperatures for obtaining a higher heat sink.
研究领域:
催化化学
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能源材料
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化学工程
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石油炼制
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航空航天推进
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Nature Communications
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2026
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IF 15.7
Lai Dingbo,Yu Jia,Ma Zi-Ang,Ye Xiaolin,Wang Chaoxi,Zhang Junqing,Wang Tuo,Zhao Zhi-Jian,Zhang Peng,Gong Jinlong
The electrochemical C–N coupling of biomass-derived 5-hydroxymethylfurfural (HMF) with methylamine offers a promising sustainable route to value-added amines. However, achieving high selectivity remains challenging due to competing side reactions, including C = O hydrogenation and C–C dimerization. This paper describes tailoring the surface structure of Ag catalysts to modulate HMF adsorption and intermediate hydrogenation behavior and thus enhancing C–N coupling selectivity. Ag nanoparticles, predominantly exposing the (111) facet, exhibit higher selectivity compared with Ag nanocubes mainly enclosed by (100) planes. The Ag(111) facet favors the C–N coupling pathway by regulating both adsorption geometry and hydrogenation ability. In-situ Raman spectroscopy and density functional theory (DFT) calculations reveal that an η 1 (C)-aldehyde adsorption configuration, dominant on Ag(111), enhances carbonyl electrophilicity and facilitates C = O polarization, promoting nucleophilic attack by methylamine. In contrast, the η 2 (C,O)–aldehyde configuration, more common on Ag (100), stabilizes the C = O bond, limiting its reactivity. Moreover, Ag(111) shows enhanced imine hydrogenation activity, further improving amine selectivity. This study highlights the significance of facet-dependent adsorption modulation in steering reaction pathways and advancing sustainable electrochemical synthesis.
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JOURNAL OF ETHNOPHARMACOLOGY
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2026
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IF 5.4
Meiyu Wan,Tiexin Sun,Yuying Diao,Saijin Huang,Yingying Tong,Ying Liu,Weijie Liu,Meijuan Liu,Shu Jiang,Erxin Shang,Jinao Duan
Ethnopharmacological relevance Dachengqi decoction (DCQ), a well-known Traditional Chinese Medicine (TCM) formula, has been widely applied for anti-constipation in clinical practice for thousands of years. Nevertheless, its pharmacological mechanisms remain not fully elucidated. Aim of the study This research employed a comprehensive approach integrating network pharmacology and metabolomics, supplemented with molecular docking techniques and both in vitro and in vivo experimental validation, to systematically elucidate the bioactive constituents, critical targets, and underlying mechanisms of DCQ in alleviating constipation. Materials and methods This investigation utilized a comprehensive pharmacology integration strategy to forecast the principal therapeutic pathways through which DCQ alleviates constipation. The establishment of a loperamide-induced constipation model in rats served to evaluate the interventive effects of orally administered DCQ. In addition, ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) was used to detect the changes of metabolites in plasma and urine of rats, and the metabolic related targets were analyzed. Combined with network pharmacology, the potential mechanism of DCQ in ameliorating constipation was revealed and further verified by molecular docking. According to the results of joint analysis, the intervention of DCQ mainly involved the serotonin (5-HT) pathway, including the inflammatory pathways of arachidonic acid and cAMP downstream of 5-HT. Therefore, the mRNA and protein expression levels of key factors associated with the 5-HT pathway, including phospholipaseA2 (PLA2), cAMP/PKA/AQPs, and PANoptosis, were detected. Furthermore, an inflammatory model of Caco-2 cells was induced to investigate the effect of DCQ on the 5-HT pathway. The expression of related targets (PLA2, PKA and ZBP1) was detected by reverse transcription quantitative PCR and immunofluorescence to further verify the molecular mechanism of DCQ. Results DCQ demonstrated efficacy in ameliorating constipation symptoms induced by loperamide in rats and reducing inflammatory responses in Caco-2 cells, while normalizing aberrant plasma and urinary metabolic profiles and regulating arachidonic acid metabolism in constipated rats. Integrated metabolomics and network pharmacology analyses revealed that DCQ mainly alleviated constipation via the 5-HT pathway, markedly suppressing the PLA2-mediated inflammation and PANoptosis while concurrently activating the cAMP-PKA-AQPs cascade to notably increase the expression of aquaporins (AQPs). Conclusions DCQ could restore the homeostasis of metabolic profiles in plasma and urine in model rats, activate the 5-HT pathway to alleviate inflammation, and may be involved in the regulation of PANoptosis-related mechanisms in intestinal epithelial cells, providing a new perspective for constipation treatment.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Akkammagari Putta Rangappa,Wei Xiong,Wenhua Xue,Xinxin Lu,Yiqi Geng,Yuchao Shao,Guohan Sun,Jun Zhao
Activation of molecular O 2 on catalytic surfaces to form reactive oxygen species (ROS) is a pivotal step in catalytic reactions. In this study, we synthesized a bimetallic Zn 3 In 2 S₆ (ZIS) catalyst enriched with Pd S interfaces via a straightforward cation exchange process between Pd 2+ and Zn 2+ . These interfaces function as electron reservoirs, and Pd incorporation significantly enhances photocatalytic performance by reorganizing the electronic structure of the ZIS matrix, thereby improving charge carrier dynamics and reaction kinetics. Additionally, Pd modification optimizes O 2 adsorption strength, preventing excessive population of the π* antibonding orbital that can lead to O O bond cleavage and reduce ROS generation. Theoretical calculations reveal that monodentate adsorption of O 2 on Pd-ZIS surfaces promotes efficient photo induced electron transfer across all excited states, enabling effective ROS activation. The combination of experimental findings and theoretical analysis identified the mechanisms underlying the improved selectivity of Pd-modified ZIS catalysts. As a result, the optimized Pd-ZIS-5 photocatalyst demonstrates a high photo-oxidation performance for HMF oxidation, achieving 92.4 % conversion, 86.3 % yield, and 93.4 % selectivity–representing a 1.7-fold improvement over prismatic ZIS. Overall, this work demonstrates how Pd doping and tailored O 2 adsorption strength enhance photocatalytic processes, offering valuable insights for advanced biomass conversion and sustainable chemical production.
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Carbon Resources Conversion
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2026
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IF 10.9
Zhixing Li,Fei Wang,Yanchao Liu,Jinghong Ma,Kai Bian,Xinwei Zhang,Yanze Du,Ruifeng Li
The efficient conversion of C 9 heavy aromatics into high-value benzene, toluene, and xylenes (BTX) products is essential for optimizing petroleum refining. This process often depends on both diffusion and the unresolved relationship among structure, acidity, and reactivity of zeolite catalysts. This study focuses on the intracrystalline micro-/ meso -pores in ZSM-5 and decouples the interdependent effects of crystalline morphology and Al distribution of Brønsted acid sites (BAS) in ZSM-5 on C 9 aromatic conversion pathways. The hierarchical ZSM-5 catalysts have the identical SiO 2 /Al 2 O 3 ratios (SAR) and the different distribution of framework Al-species. This dominates the acid distribution of the zeolites and catalytic performances of the catalysts in C 9 aromatic reaction. In toluene/trimethylbenzene (TMB) transalkylation, the hierarchical porosity coupled with reduced crystallite size of the ZSM-5 enhances 1,2,4-TMB conversion by 24.4% and xylene selectivity by 17.9% versus conventional microporous ZSM-5. The product distribution is positively correlated to the concentration of Al atoms localized at channel intersections of the ZSM-5. Diffusion-decoupled experiments demonstrated acid site spatial configuration in the ZSM-5 governs the reaction pathway selection, with aluminum enrichment at channel intersections favoring transalkylation over disproportionation. The hierarchical ZSM-5 in submicron with intracrystalline mesopores and enriched intersection-channel aluminum favors transalkylation of C 9 aromatics to BTX. The hierarchical ZSM-5, with submicron crystallites, intracrystalline mesopores, and enriched intersection-channel aluminum, enhances transalkylation of C 9 aromatics to BTX.
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