COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Long Li,Yuyang Zhang,Yujie Liu,Zetao Wang,Luyao Cheng,Yuhan Du,Yangyi Nie,Jing Long,Cairong Li,Yuanchi Zhang,Wei Zhang,Lin Yang,Yuxiao Lai
Background Bone defects pose a significant clinical challenge due to their high morbidity and long-term disability. Simultaneous enhancement of osteogenesis and angiogenesis holds promise for accelerating bone regeneration. MicroRNAs (miRNAs), particularly miR-126, are critical regulators of angiogenesis; however, their therapeutic application requires efficient delivery systems. Designing miRNA carriers with intrinsic osteogenic activity remains a pivotal yet underexplored strategy. Methods Zeolitic imidazolate framework-8 (ZIF-8) was developed as a nanocarrier to deliver proangiogenic miR-126. The miR-126@ZIF-8 nanocomposites were synthesized via a one-pot method, and their physicochemical properties, miRNA loading efficiency, and cytotoxicity were systematically characterized. Cellular uptake, miR-126 release kinetics, and Zn 2 + dissolution was evaluated in vitro . Angiogenic and osteogenic effects were assessed through gene expression analysis, capillary-like tube formation assays, and mineralization studies. Results and discussion The miR-126@ZIF-8 nanoparticles exhibited a high miRNA loading capacity, efficient cellular internalization, and minimal cytotoxicity. Upon intracellular delivery, the nanoparticles decomposed to release miR-126 and Zn 2+ , synergistically enhancing angiogenic (e.g., VEGF, HIF-1α) and osteogenic (e.g., RUNX2, OCN) gene expression. Functional assays demonstrated significant improvements in endothelial cell tube formation and osteoblast mineralization compared to controls. Conclusion Our work presents miR-126@ZIF-8 as a novel dual-functional platform that simultaneously promotes angiogenesis and osteogenesis. By combining the proangiogenic action of miR-126 with the osteoinductive potential of Zn 2+ , our nanocomposite offers a promising strategy for vascularized bone regeneration for the repair of bone defects.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yuewen Chen,Tao Zheng,Hai Liu,Weidong Xie,Jiali Huang,Yimin Wang,Xiya Zhang,Zhen Yuan,Zhile Xiong
The electrocatalytic reduction of CO 2 to CO represents an important approach for carbon resource utilization. However, most existing catalysts still suffer from low activity and poor selectivity. In this work, a novel “domain-confined interface” synergistic catalytic system was constructed by integrating ionic liquid [BMIM][BF 4 ] with zeolitic imidazolate framework-8 (ZIF-8) to enhance the CO 2 reduction reaction (CO 2 RR) performance. The high specific surface area and microporous structure of ZIF-8 provide an ideal platform for CO 2 adsorption and activation, while [BMIM][BF 4 ] improves the local microenvironment of the catalytic interface, thereby boosting the catalytic activity. Experimental results indicate that the incorporation of the ionic liquid significantly enhances the CO 2 RR performance of ZIF-8 at low potentials. The Faradaic efficiency for CO (FE CO ) increases from 38.98 % to 75.25 % at −0.8 V versus the reversible hydrogen electrode (RHE). Moreover, at the optimal potential of −1.2 V (vs. RHE), FE CO reaches 96 % and remains stable during an 8-hour durability test, outperforming most reported ZIF-8-based catalysts. This work may provide useful insights for the design of efficient CO 2 RR electrocatalysts.
✓ 已验证
产品关联
DOI
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2024
·
IF 4.2
Chaojin Si,Hongjun Yang,Xiaoyan Wang,Qiaoxin Wang,Min Feng,Huayue Li,Yuqi Feng,Jiayuan Zhao,Ying Liao
Beta-cypermethrin (β-CYP) consists of four chiral isomers, acting as an environmental estrogen and causing reproductive toxicity, neurotoxicity, and dysfunctions in multiple organ systems. This study investigated the toxic effects of β-CYP, its isomers, metabolite 3-phenoxybenzoic acid (3-PBA), and 17β-estradiol (E2) on HTR-8/SVneo cells. We focused on the toxic mechanisms of β-CYP and its specific isomers. Our results showed that β-CYP and its isomers inhibit HTR-8/SVneo cell proliferation similarly to E2, with 100 μM 1S-trans-αR displaying significant toxicity after 48 h. Notably, 1S-trans-αR, 1R-trans-αS, and β-CYP were more potent in inducing apoptosis and cell cycle arrest than 1R-cis-αS and 1S-cis-αR at 48 h. AO/EB staining and flow cytometry indicated dose-dependent apoptosis in HTR-8/SVneo cells, particularly at 100 μM 1R-trans-αS. Scratch assays revealed that β-CYP and its isomers variably reduced cell migration. Receptor inhibition assays demonstrated that post-ICI 182780 treatment, which inhibits estrogen receptor α (ERα) or estrogen receptor β (ERβ), β-CYP, its isomers, and E2 reduced HTR-8/SVneo cell viability, whereas milrinone, a phosphodiesterase 3 A (PDE3A) inhibitor, increased viability. Molecular docking studies indicated a higher affinity of β-CYP, its isomers, and E2 for PDE3A than for ERα or ERβ. Consequently, β-CYP, its isomers, and E2 consistently led to decreased cell viability. Transcriptomics and RT-qPCR analyses showed differential expression in treated cells: up-regulation of Il24 and Ptgs2 , and down-regulation of Myo7a and Pdgfrb , suggesting the PI3K-AKT signaling pathway as a potential route for toxicity. This study aims to provide a comprehensive evaluation of the cytotoxicity of chiral pesticides and their mechanisms.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Shaorong An,Lina Wang,Qiang Jin
The Fe-N-C catalysts featuring abundant FeNx sites activating peroxymonosulfate (PMS) have been considered an attractive approach to water treatment and purification. It was reported that the coordination numbers of FeNx could be precisely controlled by varying the pyrolysis temperature, thereby affecting the catalytic activity . However, almost all Fe-N-C catalysts were prepared through energy-consuming high-temperature pyrolysis strategies, the activation performance and mechanism under low-temperature pyrolysis conditions are still unclear. In this work, three single-atom Fe catalysts (Fe SA -NC-300/500/1000) based on ZIF-8 were synthesized at different pyrolysis temperatures. Results showed that the degradation efficiency of sulfamethoxazole (SMX) in the Fe SA -NC-500/PMS and Fe SA -NC-1000/PMS systems could reach 100 % within 30 min, while only 91.9 % in the Fe SA -NC-300/PMS system. Combined with the turnover frequency (TOF) of the catalysts, it was found that the catalytic activity of Fe SA -NC-500 prepared by low-temperature pyrolysis was close to that of Fe SA -NC-1000, which was superior to many reported Fenton-like catalysts. Mechanism analysis manifested that both radical (·OH, SO 4 − ·, and ·O 2 − ) and nonradical ( 1 O 2 , high-valent Fe-oxo species, and electron transfer) pathways coexisted in the Fe SA -NC/PMS systems. Impressively, the larger production intensity of reactive species occurred in Fe SA -NC-500/PMS and Fe SA -NC-1000/PMS systems. The difference between these Fe SA -NC catalysts in actual printing and dyeing wastewater treatment offered some guidance for wider environmental applications. This work also provided a direction on the design and understanding of green and energy-saving Fe-N-C catalysts.
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Mimi Sun,Jiahui He,Wanting Xiang,Wei Zou,Wenfei Song,Yating Xi,Jun Yan,Meimei Zhou,Pingping Luo
The design and construction of diverse heterojunction architectures have emerged as an effective strategy for enhancing the photocatalytic performance of semiconductors. In this study, ZIF-8/TiO 2 composite nanofibers were successfully fabricated by combining electrospinning technology with a facile in-situ solvothermal method, followed by ZIF-8 sulfurization to form ZnS/TiO 2 nanofiber heterostructures. Comprehensive characterization confirmed that ZIF-8 on the surface of TiO 2 nanofibers was completely converted into ZnS, establishing a robust and intimate interface with TiO 2 . The resulting ZnS/TiO 2 heterojunction exhibited remarkable photocatalytic reduction activity for Cr(VI), achieving 100% removal efficiency within 20 min under visible light irradiation. The photocatalytic reaction rate constant of the ZnS@TiO 2 nanofibers was approximately 10 and 319.5 times higher than those of pristine ZnS and TiO 2 nanofibers, respectively. This enhanced photocatalytic performance is attributed to the formation of the heterojunction, which effectively narrows the bandgap of the composite, optimizes photogenerated charge transfer pathways and significantly improves electron-hole pairs separation. Furthermore, mechanistic studies identified photogenerated electrons (e − ) and superoxide radicals ( O 2 − ) as the dominant active species involved in the photocatalytic reduction process. This work provides both fundamental understanding and practical methodology for developing high-performance TiO 2 -based photocatalytic systems, highlighting their potential for advanced water purification technologies.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yuqin Chen,Benjian Sun,Zhouyu Yu,Zhen Cheng,Si Chen,Baisong Chang
The tumor microenvironment (TME) poses significant challenges for achieving efficient cancer remission through monotherapy, making multimodal synergistic therapy a key strategy in tumor treatment. Here, we designed and constructed a hollow core–shell nanocage based on zeolitic imidazolate framework-8 (ZIF-8), zeolitic imidazolate framework-8@zinc sulfide@copper sulfide (ZIF-8@ZnS@CuS, denoted as ZZCS), for the combined application of chemodynamic therapy (CDT), photothermal therapy (PTT) and photocatalytic therapy (PCT). The Cu 2+ ions in ZZCS imparted peroxidase (POD)-like and catalase (CAT)-like activities, enabling the generation of toxic hydroxyl radicals ( OH) through POD-like catalysis to enhance CDT effect, while also reacting with overexpressed glutathione (GSH) to elevate intracellular reactive oxygen species (ROS) levels. To overcome the inhibitory effects of hypoxia on PCT in the TME, ZZCS catalyzed the production of O 2 from endogenous hydrogen peroxide (H 2 O 2 ) via CAT-like activity, alleviating hypoxia and enhancing the PCT effect. Furthermore, hollow core–shell heterojunction structure of ZZCS exhibited excellent near-infrared absorption and multiple light reflection effects. Under 808 nm laser irradiation, ZZCS showed a high photothermal conversion efficiency (η = 78.1 %) and generated significant amounts of ROS ( OH, O 2 − , 1 O 2 ), enabling the synergistic elimination of tumor cells via PTT and PCT. Benefiting from the combined CDT/PTT/PCT effects, ZZCS demonstrated excellent therapeutic efficacy in vivo, nearly eradicating tumors. This study may provide a promising foundation and potential direction for advancing multimodal tumor therapy. Future studies will focus on conducting long-term investigations to systematically evaluate the efficacy of ZZCS core–shell nanocages in achieving durable tumor eradication.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Ying Yang,Wenqi Zhang,Lu Zhang,Ziyan Shi,Dexiang Wei,Weiwei Xia,Xiaoguang Xu
Ochratoxin A (OTA) is a highly toxic and bioaccumulative mycotoxin found in grains, threatening food safety. Surface-enhanced Raman spectroscopy (SERS) combined with immunochromatography enables rapid and sensitive detection of OTA. This study aimed to develop a novel core-shell-satellite SERS probe (Au@Ag@(Cu-ZIF-8)-AuNPs) for OTA detection. The structure comprised an Au@Ag nanoparticle core, coated with Cu-doped ZIF-8 and gold nanosatellites. This design generated dense electromagnetic “hot spots” through plasmonic coupling between the core and satellites. Simultaneously, Cu doping reduced the bandgap of ZIF-8, thus enhancing charge transfer efficiency for chemical signal amplification. The dual electromagnetic-chemical enhancement achieved a detection range of 0.1 fg/mL–1.0 μg/mL and an ultralow detection limit of 0.057 fg/mL, thereby surpassing the detection limits of conventional methods. This innovative probe, with its high sensitivity and wide dynamic range, offers a powerful platform for mycotoxin monitoring, hence advancing SERS-based rapid detection technologies crucial for food safety.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2019
·Vol. 25
·期 1
·124
·
IF 3.06
Sufeng Zhang,Yongshe Xu,Dongyan Zhao,Wenqiang Chen,Hao Li,Chen Hou
A facile approach was successfully developed for synthesis of cellulose nanocrystals (CNC)-supported magnetic CuFe2O4@Ag@ZIF-8 nanospheres which consist of a paramagnetic CuFe2O4@Ag core and porous ZIF-8 shell. The CuFe2O4nanoparticles (NPs) were first prepared in the presence of CNC and dispersant. Ag NPs were then deposited on the CuFe2O4/CNC composites via an in situ reduction directed by dopamine polymerization (PDA). The CuFe2O4/CNC@Ag@ZIF-8 nanocomposite was characterized by TEM, FTIR, XRD, N2adsorption-desorption isotherms, VSM, and XPS. Catalytic studies showed that the CuFe2O4/CNC@Ag@ZIF-8 catalyst had much higher catalytic activity than CuFe2O4@Ag catalyst with the rate constant of 0.64 min−1. Because of the integration of ZIF-8 with CuFe2O4/CNC@Ag that combines the advantaged of each component, the nanocomposites were demonstrated to have an enhanced catalytic activity in heterogeneous catalysis. Therefore, these results demonstrate a new method for the fabrication of CNC-supported magnetic core-shell catalysts, which display great potential for application in biocatalysis and environmental chemistry.Keywords:CuFe2O4nanoparticles;cellulose nanocrystals;Ag nanoparticles;ZIF-8 catalysis;4-nitrophenol reduction
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Battery Energy
·
2025
·
IF 9.9
Yuzhen Zhao,Dongliang Yang,Yinfu Lu,Kexuan Li,Zhun Guo,Jianjing Gao,Ruijuan Yao,Dong Wang,Yi Luan,Hong Gao
Cholesteric liquid crystal (CLC) materials with broadband reflective properties have garnered much attention because of their light-selective reflective properties. In this study, broadband reflective films were prepared by doping a novel UV absorber, ZIF-8, into a CLC system to take advantage of the formation of a UV intensity gradient. The effects of ZIF-8 content, C6M content, UV intensity, UV irradiation time, and diffusion temperature on the reflection bandwidth of the samples were systematically investigated. The reflection bandwidth was expanded from 277 to 429 nm under optimum conditions. In addition, the ZIF-8-doped broadband reflective films not only have IR thermal control and UV shielding capabilities but also have the optical property of third-order nonlinear saturable absorption, which makes the preparation of multifunctional broadband reflective films possible. The above results show that the developed thin films have a broad application prospect in building energy saving, UV protection, and laser protection.
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Jiangnan Wang,Long Li,Jinli Zhang,Xueqin Li
The construction on the interconnected network can be considered as a potential strategy for boosting CO 2 transport in mixed matrix membranes (MMMs). In this study, poly (ionic liquids)/ZIF-8 (PIL/ZIF-8) was synthesized and incorporated into sulfonated poly (ether ether ketone) (SPEEK) matrix to fabricate MMMs for rapid CO 2 transport. Wherein, ZIF-8 with a highly porous framework within PIL/ZIF-8 can efficiently capture CO 2 and allow CO 2 simultaneously transport in multi routes, thus improving CO 2 separation performance of SPEEK/PIL/ZIF-8 MMMs. PIL in PIL/ZIF-8 can guide the rapid transport of CO 2 in an orderly manner with the help of the anion CO 2 carriers (Cl − ) on the PIL chains, accelerating CO 2 transport in the MMMs. And the interconnected network was constructed by incorporating PIL/ZIF-8 in MMMs, which was endowed with the excellent CO 2 separation performance. And the CO 2 permeability and CO 2 /CH 4 selectivity of SPEEK/PIL/ZIF-8-7 MMM were 1641 ± 41 Barrer and 32 ± 0.9, respectively, approaching the 2019 upper bound. It implied that the construction on the interconnected network in MMMs had great potential for rapid CO 2 transport.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Wei Wan,Meijia Liu,Xiangling Ren,Longfei Tan,Changhui Fu,Qiong Wu,Jun Ren,Hongbo Li,Zhongbing Huang,Xianwei Meng
Adenosine triphosphate (ATP) actively involve into cellular processes. Abnormal levels of ATP related to a variety of diseases, therefore determining the ATP level is of pivotal significance for diagnoses. Here, a highly sensitive fluorescence probe based on gold nanoclusters (Au NCs) was constructed for the detection of ATP, and an expanded detection range and low limit of detection (LOD) were realized in our work. Zeolitic imidazolate framework-8 (ZIF-8) enhanced the fluorescence intensity of Au NCs by the encapsulation and less ATP cause to a stronger fluorescence change, which guaranteed detection reproducibility and facilitated lower LOD. The LOD of Au NCs encapsulated ZIF-8 (AZ) for ATP detection was expanded to 2 μM, which was only 0.05 % of sole Au NCs (4000 μM). Significantly, ATP of high concentration quenched AZ by disrupting the structure of ZIF-8 which expanded the detection range. Moreover, the linear range of high concentration ATP detection in serum was 600–4000 μM, which was closed to the normal level of ATP in physiological. Therefore, due to its low LOD and high sensitivity, AZ can be applied for fluorescence detection and initial diagnosis of disease related to ATP.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2025
·
IF 6.3
Tian Li,Dongxue Liu,Sainan Ma,Gang Xu,Buyi Yan,Xiaoyue Hao,Likun Wang,Yong Liu,Gaorong Han
As an indispensable and crucial component in electrochromic devices, transparent gel electrolyte has a significant impact on optical contrast, switching speed, cycling stability, and mechanical robustness. In this study, an engineering by grafting polar bimolecular groups of Terephthalic Dihydrazide (TPHD) onto the surface of ZIF-8 nanoparticles and polymer to enhance performance of gel electrolyte was proposed. Benefiting from the stable pore structure and high dispersion of TPHD modified ZIF-8 (TPHD@ZIF-8), the gel electrolyte doped with 6 wt% TPHD@ ZIF-8 (TGPL-6 %) achieves high initial transmittance of 82 % at 633 nm, representing a 23 % enhancement over the 6 wt% unmodified ZIF-8 doped gel polymer electrolyte layer (ZGPL-6 %). A high ionic conductivity of 1.73 mS/cm was obtained, which was 30 % higher than that of ZGPL-6 % (1.33 mS/cm) and more than four times that of pure GPL (0.37 mS/cm). Young's modulus and tensile strength of TGPL-6 % are 0.0064 and 0.179 MPa, respectively. The TGPL-6 % has been successfully applied in electrochromic devices, achieving a high optical modulation of 38 % and excellent durability. This work provides valuable insights into the rational design of high-performance transparent gel electrolytes for advanced electrochromic devices.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）