ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 14
·21632-21645
·
IF 0
He Yuanzhen,Zhong Dengjie,Xu Yunlan,Zhang Jiayou,Jiang Ran,Liao Pengfei
In this paper, La-doped Ti/SnO 2 -Sb 2 O 4 electrode was prepared by electrodeposition and used for electrochemical degradation of rhodamine B. The optimum preparation conditions of the electrode were optimized as deposition time of 15 min and calcination at 500 ℃ for 2 h. The water treatment conditions were selected as initial pH 3.0, electrolyte Na 2 SO 4 concentration 0.1 M, current density 30 mA cm −2 , and initial rhodamine B concentration 20 mg L −1 ; the color and TOC removal of RhB reached 99.78% and 82.41% within 30 min. The FESEM, XRD, XPS, CV, LSV, and EIS characterization studies demonstrated that Ti/SnO 2 -Sb 2 O 4 -1%La electrode had a dense structure and the highest oxygen evolution potential (2.14 V) and lowest charge transfer resistance (0.198 Ω cm −2 ), indicating that doped La has lower energy consumption. Moreover, La doping can expand the specific surface area, active site, performance of pollutant degradation, and service life of the electrode. Especially, the service life of Ti/SnO 2 -Sb 2 O 4 -1%La is increased by three times, and the maximum life span reaches 90 min (1000 mA cm −2 , 1 M H 2 SO 4 ). Free radical quenching experiments show that ·OH plays a major role in the degradation of RhB. The Ti/SnO 2 -Sb 2 O 4 -1%La electrode prepared in this paper and its results will provide data support and reference for the design of efficient electrocatalytic electrode. Graphical
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Polymer Chemistry
·
2019
·Vol. 10
·期 34
·4718-4731
·
IF 4.76
Xian Yang,Junyi Ruan,Chen Ma,Bingjie Hao,Xiaoyu Huang,Guolin Lu,Chun Feng
Self-seeding of living crystallization-driven self-assembly (CDSA) has been considered to be one of the most attractive strategies to fabricate well-defined fiber-like nanostructures with excellent control over their length and composition. To extend the scope of self-seeding of oligo(p-phenylene vinylene) (OPV)-based copolymers, the poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) segment with proven biocompatibility, synthetic flexibility and well-developed conjugation chemistry, which was synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization using an azide-containing chain transfer agent, was coupled with the alkyne-terminated OPV block by a copper-catalyzed alkyne–azide cycloaddition reaction. All OPV5-b-PHPMA (OPV5-b-PHPMA36, OPV5-b-PHPMA71 and OPV5-b-PHPMA100, the subscripts represent the number of repeat units of each block) with the same crystallizable core-forming OPV segment but different corona-forming PHPMA blocks of various chain lengths can self-assemble in ethanol to form fiber-like micelles with a length of several micrometers by a direct heating and cooling process. Uniform fiber-like micelles with a length up to ∼1 μm can be easily prepared by temperature-induced self-seeding of OPV5-b-PHPMA71. However, for self-seeding of OPV5-b-PHPMA36, ribbon-like nanostructures with a uniform and controllable length were formed, whereas relatively short fiber-like micelles with broad length distributions were formed under similar conditions for OPV5-b-PHPMA100. These results indicated that the length of the PHPMA segment played an important role in determining the self-seeding behavior of OPV5-b-PHPMA.
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Soft Matter
·
2014
·Vol. 10
·期 20
·3578-3586
·
IF 4.151
Lei Hou,Peiyi Wu
The self-aggregation behavior of poly(N-isopropylacrylamide)-b-poly(N-vinylcaprolactam) (PNIPAM-b-PVCL) during the thermal-induced phase transition in water was explored by a combination of calorimetric, turbidity, dynamic light scattering (DLS) and FTIR measurements. Only one transition can be observed via all detecting methods, revealing the cooperative aggregation of the two distinct temperature-sensitive segments. What is more, the combination of strong hydrophobic interactions among the entire polymer chains and hydrogen bonds of CO…H–N within PNIPAM segments results in the sharp variations at the LCST and gradual variations above the LCST during the phase transition of PNIPAM-b-PVCL aqueous solution upon heating. Additional analysis by perturbation correlation moving window (PCMW) and two-dimensional correlation spectroscopy (2Dcos) indicates that the hydrophobic C–H groups have an earlier response than the relatively hydrophilic CO groups during the LCST transition.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2025
·
IF 4.9
Wang Chiyuan,Long Xin,Shao Changwei,Huang Jiawei,Ren Jiaqi
Si–B–N–O ceramics are promising materials for wave-transparent windows of hypersonic vehicles due to the excellent thermal stability and low dielectric constant. The polymer-derived ceramics (PDC) route is widely adopted for flexible compositional control of the Si–B–N–O covalent ceramics. In this study, a novel borazine-modified polysilazoxane (RBOSZ) was synthesized using trichlorosilane, tert -butanol, trichloroborazine, and ammonia as starting materials. RBOSZ features a Si–N–Si backbone and borazine rings. The Si–B–N–O ceramic was derived from RBOSZ with a ceramic yield of 61 wt% after pyrolysis under nitrogen atmosphere. Boron facilitates the formation of Si 2 N 2 O nanograins at elevated temperatures and enhances the ceramic’s high-temperature stability. By switching nitrogen to ammonia during organic-inorganic transformation, a low-carbon Si–B–N–O ceramic was obtained and retained its amorphous structure up to 1400 °C. After annealing at 1600 °C, Si 2 N 2 O/β-Si 3 N 4 nanocrystals participated in the Si–B–N–O matrix. This work establishes a facile precursor for high-performance Si–B–N–O ceramics to meet the application demands of heat-resistant wave-transparent windows.
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高影响因子
ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Qi Huang,Xiaohu Jin,Zirui Hu,Ziwen Zhong,Yitao Cai,Qian Yao,Xiaofei Li,Xueqin Tao,Zhi Dang,Guining Lu
Antimony (Sb) pollution is becoming a non-negligible issue due to its toxic and carcinogenic properties. In mining areas, jarosite is a main host mineral for Sb(V), and its transformation may seriously influence the fate of Sb. In this study, we examined the transformation of Sb(V)-coprecipitated jarosite in the presence of oxalic acid (OA) and Desferrioxamine B (DFOB), and explored the resulting repartition of Sb. Results showed that OA and DFOB retarded jarosite dissolution but promoted Fe(III) and Sb(V) release, playing a combined role in this retardation and promotion. In treatment without OA or DFOB, jarosite transformed into hematite and goethite. In DFOB-only systems, DFOB did not change the jarosite transformation pathway; goethite and hematite were still the dominant products, and aqueous Fe(III)-DFOB complexes were formed. In OA-only systems, the re-adsorption of aqueous Fe(III)-OA complexes on the mineral surface may result in another recrystallization pathway, forming goethite. In OA-DFOB systems, DFOB competed with OA for Fe(III), forming Fe(III)-DFOB complexes and delayed OA-induced jarosite transformation into goethite. By the end of all reactions, more than 99.94 % of total Sb was retained by neo-formed secondary Fe(III) minerals. OA drove more Sb to become phosphate-extractable, and DFOB drove the above phosphate-extractable Sb into poorly crystalline phases or residual phases.
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PubMed
高影响因子
ORAL DISEASES
·
2024
·
IF 2.9
Qin Jiang,Fang Wang,Gang Zhou
Objective Oral lichen planus (OLP) is a chronic inflammatory disease characterized by a dense T-cell infiltration and the degeneration of basal keratinocytes. The potential functions of mucosal associated invariant T (MAIT) cells in OLP have been analyzed in our previous study. Keratinocytes under proinflammatory conditions have been demonstrated to activate T cells. This study was aimed to investigate how keratinocytes stimulate MAIT cells in OLP, and to explore the role of activated MAIT cells on keratinocytes. Methods and Results Increased MAIT cells and higher activation marker CD69 were detected in OLP lesions by flow cytometry. The enhanced expression of MHC class I-like molecule (MR1) required for MAIT cell activation in the epithelial layer of OLP lesions was determined by immunohistochemistry. Keratinocytes treated by 5-A-RU prodrug and lipopolysaccharide, respectively, exhibited higher expression of MR1 and secretion of IL-18. In direct coculture systems consisting of keratinocytes and peripheral blood mononuclear cells, both 5-A-RU prodrug-pretreated keratinocytes and lipopolysaccharide-pretreated keratinocytes activated MAIT cells to secrete granzyme B, contributing to elevated keratinocyte apoptosis. Conclusions Keratinocytes were capable to activate MAIT cells via MR1 and cytokines in OLP, and granzyme B produced by activated MAIT cells intensified keratinocyte apoptosis, engaging in the pathogenesis of OLP.
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PubMed
高影响因子
Annals of Translational Medicine
·
2020
·
IF 3.297
Shuang Chen,Mengzhen Li,Wei Jiang,Hao Zheng,Lian-Wen Qi,Shujun Jiang
Background Pharmacological induction of autophagy can protect against acetaminophen (APAP) induced acute liver failure (ALF) by removing APAP adducts (APAP-AD), but its mechanism is not well understood. Hepatoprotective effect of saponins from traditional Chinese medicine has attracted widespread attention from all over the world. The content of saponins in Lonicerae Flos (Shanyinhua in Chinese) is up to 15–25%. Dipsacoside B (DB) is a common bioactive ingredient of different Shanyinhua, but its hepatoprotective effect and mechanism are still unknown. The present investigation aimed to study the benefit of DB in APAP-induced hepatotoxicity mouse model and different cell model. Methods Mice were treated with DB by intraperitoneal injection 1 h before treated with 500 mg/kg APAP, which caused ALF after 4 h. HepG2 cells were treated with DB for 1 h before treated with 10 mM APAP for 12 h. Hepatotoxicity was assessed via ALT and AST. Neuraminidase 1 (Neu1), lysosomal autophagy marker LC3 and P62 were examined by western blot. Neu1 activity was assayed using its substrate 2-(4-methylumbelliferyl)-D-N-acetylneuraminic acid. Apoptosis level was examined by TUNEL and caspase 3 activity. Molecular docking was used to predict the interaction between DB and protein Neu1. Results Our results demonstrated that pretreatment with 0.5 μM DB ( in vitro ) and 50 mg/kg DB ( in vivo ) respectively reversed increased level of AST and ALT induced by APAP. Histopathological examinations showed reduced necrosis and apoptosis in the liver of DB-treated APAP mice. DB promoted the removal of APAP-AD by lysosomal autophagy. These effects were associated with significant decrease in the level of Neuraminidase 1 (Neu1), a negative regulator of lysosomal exocytosis. Molecular docking results showed that DB could bind to Neu1 protein (binding energy =−7.86 kcal/mol). Akt/mTOR-mediated autophagy and inhibition of apoptosis may be the main mechanisms for the hepatoprotective effects of DB in acetaminophen-induced liver injury. Conclusions These data indicate that DB alleviated hepatotoxicity caused by APAP at least in part via Neu1 inhibition, Akt/mTOR pathway is involved in the detoxification effect of DB on acetaminophen-induced hepatotoxicity.
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PubMed
高影响因子
FUNDAMENTAL & CLINICAL PHARMACOLOGY
·
2016
·Vol. 31
·期 1
·54-63
·
IF 2.156
Xiaolei Hu,Xiaomei Zhang,Guoxi Jin,Zhaoming Shi,Weihua Sun,Fengling Chen
Renal pathology was a commonly seen complication in patients with diabetes. Geniposide (GPO) was previously demonstrated to modulate glucose metabolism in diabetes. This study was to investigate effects of GPO in streptozotocin-induced diabetic rats and its underlying mechanism. Renal function in diabetic rats was evaluated by levels of serum creatinine (Scr), blood urea nitrogen (BUN), and urinary albumin. Renal inflammation was appraised by inflammatory cells infiltration and pro-inflammatory cytokines production. Renal monocytes, T lymphocytes infiltration, and intercellular adhesion molecule-1 (ICAM-1) expression were quantitated by immunohistochemistry. Moreover, renal nuclear factor-kappa B (NF-κB) was assayed by Western blotting. Diabetic rats showed renal dysfunction as evidenced by increased levels of Scr, BUN, urinary albumin, and elevator renal index. Histological examination revealed significant glomerular basement membrane (GBM) thickening. However, GPO notably improved renal function and diabetes-induced GBM changes. Additionally, diabetic rats showed noteworthy renal inflammation,as reflected by enhancement of monocytes and T lymphocytes infiltration, increased expression of ICAM-1, tumor necrosis factor-α, interleukin-1 (IL-1), and IL-6. Interestingly, the level of monocytes infiltration positively correlated with the severity of GBM. Further study indicated diabetic rats displayed increased activation of NF-κB, indicated by increased expression of NF-κB p65, IKKα, and p-IκBα in renal tissue. However, all the changes in renal inflammation and NF-κB pathway were obviously reversed in GPO-treated diabetic rats. Our works indicate GPO ameliorates structural and functional abnormalities of kidney in diabetic rats, which is associated with its suppression of NF-κB-mediated inflammatory response.
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PubMed
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2023
·Vol. 21
·期 16
·3417-3422
·
IF 3.2
Yuyan Zhao,Xu Jiang,Shihuan Zhou,Jin Tian,Piao Yang,Yanli Chen,Quan Zhang,Xianlin Xu,Yongzheng Chen,Jiawei Yang
Optically pure sulfoxides are noteworthy compounds that find wide applications in various industrial fields. Here, we report a methionine sulfoxide reductase B (MsrB) homologue that exhibits high enantioselectivity and broad substrate scope for the kinetic resolution of racemic (rac) sulfoxides. This MsrB homologue, named liMsrB, was identified from Limnohabitans sp. 103DPR2 and showed good activity together with enantioselectivity towards a series of aromatic, heteroaromatic, alkyl and thioalkyl sulfoxides. Chiral sulfoxides in the S configuration were prepared in approximately 50% yield and 92–99% enantiomeric excess through kinetic resolution at an initial substrate concentration of up to 90 mM (11.2 g L−1). This study presents an efficient route for the enzymatic preparation of (S)-sulfoxides through kinetic resolution.
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PubMed
高影响因子
CATALYSIS COMMUNICATIONS
·
2019
·
IF 3.674
Yuanmei Wen,Liaotian Peng,Yang Zhou,Tao Peng,Yu Chen,Xiaoling Cheng,Yongzheng Chen,Jiawei Yang
Here we report a methionine sulfoxide reductase B (MsrB) enzymatic system for the preparation of ( S )-sulfoxides through kinetic resolution of racemic ( rac ) sulfoxides. Eight MsrB homologue recombinant proteins were expressed and their activities on asymmetric reduction of rac -sulfoxides were analyzed. Among these MsrB homologue proteins, one protein from Acidovorax species showed good activity and enantioselectivity towards several aryl-alkyl sulfoxides. The ( S )-sulfoxides were prepared with 93–98% enantiomeric excess through kinetic resolution at initial substrate concentration up to 50 mM. The establishment of MsrB catalytic kinetic resolution system provides a new efficient green strategy for preparation of ( S )-sulfoxides.
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高影响因子
Oxidative Medicine and Cellular Longevity
·
2022
·
IF 7.31
Tingting Zhang,Chenxin Xu,Peisen Zheng,Xiaoxian Zhang,Chenyu Qiu,Fengjiao Wu,Jundixia Chen,Zhongxiang Xiao,Jiandong Zhu,Jingjing Zhang,Peng Zou,Daoyong Ni
Ovarian cancer is one of the fatal gynecological cancers around the world. Cisplatin is the first-line chemotherapy drug for the clinical treatment of ovarian cancer. However, many patients with ovarian cancer are still suffering from resistance to cisplatin. Therefore, the new drug combinations or treatment strategies for ovarian cancer are urgently needed. Glaucocalyxin B (GLB), a diterpenoid isolated from the aerial parts of Rabdosia japonica, has shown antitumor activity in some tumors. However, the mechanisms by which GLB inhibits ovarian cancer remain unclear. In the present study, we showed that GLB potently inhibits ovarian cancer cell growth in a dose-dependent manner. Furthermore, we found that GLB has a notably synergistic antitumor effect with cisplatin. Mechanistically, we found that GLB enhances the sensitivity of ovarian cancer cells to cisplatin via increasing reactive oxygen species (ROS) levels, the phosphorylation of c-Jun N-terminal kinase (JNK), and DNA damage. Interestingly, a synergistic inhibitory effect of GLB with cisplatin was also observed in the cells which were resistance to cisplatin. Together, these data suggest that GLB can sensitize ovarian cancer cells to cisplatin by increasing ROS levels.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yibo Gao,Chengxin Xu,Xiaoyan Yang,Wen Yin,Shulin Liu,Xiaojun Kuang
Twinned hexagonal perovskite Ba 8 ZnTa 6 O 24 exhibits partially B-cation order but exceptionally low microwave dielectric loss, surpassing those of its fully ordered shifted hexagonal perovskite counterparts, on which the underlying structural origin has not been fully understood. This study employs neutron pair distribution function (nPDF) analysis combined with reverse Monte Carlo (RMC) modeling to elucidate the local B-site cation and vacancy ordering in Ba 8 ZnTa 6 O 24 . Refinements against nPDF data, utilizing both small unit cell and large supercell (8 ×8 ×4) models, consistently confirm that corner-sharing octahedral (CSO) sites are exclusively fully occupied by Ta 5 + cations and face-sharing octahedral (FSO) sites are partially occupied by both Zn 2+ and Ta 5+ cations, accommodating the B-site vacancies. The large supercell RMC simulations confirm the specific B-site atomic and vacancy arrangement avoiding strong electrostatic repulsion by preventing high-charge Ta 5+ -Ta 5+ pairs in the FSO layers and establishes charge neutrality over short ranges, which consequently could account for the observed ultra-low dielectric loss. This work provides atomic-scale cation-ordering insights into the low microwave loss of twinned hexagonal perovskites, offering guidance for designing high-performance microwave dielectrics.
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