SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yunheng Wang,Hengle Wang,Tiantian She,Renjie Wang,Zhe Xu,Qiuyi Ji,Shaogui Yang,Limin Zhang,Huan He
Transition metals (TMs) are widely employed to improve poor intrinsic activity of biochar for peroxymonosulfate (PMS) activation towards water purification. However, the mechanistic effects of TMs on carbon substrates requires further understanding. Herein, we constructed TM-modified C-Ni and C-Ni-Co catalysts via simple pyrolysis of rice husk precursor, optimizing carbonaceous morphologic and electronic structures. The Co-Ni-Co (0.013 min −1 ) exhibited over 10 times higher performance than pristine biochar for iohexol (IOH) removal. Systemic spectroscopic and electrochemical measurements indicate that embedded Ni increases graphitization degree facilitating IOH adsorption by π-π conjugated attraction. And, the anchored Co enhances work function promoting electron extraction for selective generation of 1 O 2 . The interfacial d-p orbital hybridization increases the acidic degree on biochar for PMS adsorption, accelerating electron exchange for PMS activation. Our work attempts to study the complex interaction between carbon and metal sites by orbital hybridization to design efficient PMS activators for Fenton-like decontamination.
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Food Science and Human Wellness
·
2024
·
IF 5.6
Lan Li,Shengye Yang,Xinyu Liang,Yameng Liu,Hualing Xu,Xiaozhen Guo,Cen Xie,Xiaojun Xu
Non-alcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide. Bupleurum is widely used in the treatment of non-alcoholic fatty liver, and saikosaponin D (SSD) is one of the main active components of Bupleurum. The purpose of this study was to investigate the efficacy of SSD in the treatment of NAFLD and to explore the mechanism of SSD in the improvement of NAFLD based on “gut-liver axis”. Our results showed that SSD dose-dependently alleviated high fat diet-induced weight gain in mice, improved insulin sensitivity, and also reduced liver lipid accumulation and injury-related biomarkers aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Further exploration found that SSD inhibited the mRNA expression levels of farnesoid X receptor ( Fxr ), small heterodimer partner ( Shp ), recombinant fibroblast growth factor 15 ( Fgf15 ) and apical sodium dependent bile acid transporter ( Asbt ) in the intestine, suggesting that SSD improved liver lipid metabolism by inhibiting intestinal FXR signaling. SSD can significantly reduce the gut microbiota associated with bile salt hydrolase (BSH) expression, such as Clostridium . Decreased BSH expression reduced the ratio of unconjugated to conjugated bile acids, thereby inhibiting the intestinal FXR. These data demonstrated that SSD ameliorated NAFLD potentially through the gut microbiota-bile acid-intestinal FXR pathway and suggested that SSD is a promising therapeutic agent for the treatment of NAFLD.
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JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Xiaoju Yan,Shirong Cheng,Cong Ma,Junyu Li,Guodong Wang,Chengyu Yang
Sodium tetraborate pentahydrate (STB) was intercalated into graphene oxide (GO) nanosheets to form a nanocomposite (STB@GO). Subsequently, it was self-assembled on a substrate membrane to prepare STB@GO nanofiltration membrane. The properties of the STB@GO powder samples and the nanofiltration membrane were studied using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), contact angle (CA), and zeta potential . When the STB concentration was 1.0 g/L in the cross-linking reaction, the membrane was described as the STB 2 @GO membrane and exhibited a large interlayer space ( d -spacing = 1.347 nm), high hydrophilicity (CA = 22.2 ° ), and high negative potential (zeta = −18.0 mV). Meanwhile, the pure water flux of the membrane was significantly increased by 56.60% than that of the GO membrane. In addition, the STB 2 @GO membrane exhibited a favorable capability for dye rejection,98.52% for Evans blue (EB), 99.26% for Victoria blue B (VB), 91.94% for Alizarin yellow (AY), and 93.21% for Neutral red (NR). Furthermore, the STB 2 @GO membrane performed better in dye separation under various types and concentrations of dye, pH values, and ions in solution. Thus, this study provides a promising method for preparing laminated GO nanofiltration membranes for dye wastewater treatment .
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高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 3.978
Yiwei Dai,Chenchen Li,Luhua Zheng,Bo Jiang,Tao Zhang,Jingjing Chen
In our previous study, a whole-cell biocatalytic system involving α-glucan phosphorylase , phosphoglucomutase , glucose 6-phosphate isomerase, tagatose 1,6-bisphosphate aldolase , and phosphoglycolate phosphatase , was constructed to produce d -tagatose from maltodextrin . However, the biotransformation efficiency of this whole-cell catalyst was low because of the unbalanced ratio of each enzyme and metabolic flux of the intermediates. Therefore, in this study, the biosynthesis of d -tagatose was enhanced by optimizing vectors and improving the expression of rate-limiting enzymes through the construction of multi-copy genes to regulate expression levels. The conversion rate increased from 20.8% after 24 h to 25.2% after 3 h using 10 g/L maltodextrin as the substrate. Furthermore, the genes in the bypass pathways in Escherichia coli , pfka and zwf , were deleted to increase the accumulation of intermediates. The strain ER-2GatZ (Δ p Δ z ) produced 3.383 g/L d -tagatose using 10 g/L substrate after 3 h, which was 1.34 times that of the wild strain. This work exemplifies the use of modular engineering to enhance d -tagatose production using whole-cell catalysts.
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GREEN CHEMISTRY
·
2018
·Vol. 20
·期 10
·2320-2327
·
IF 8.586
Alei Zhang,Guoguang Wei,Xiaofang Mo,Ning Zhou,Kequan Chen,Pingkai Ouyang
In this study, we propose a novel biological fermentation method to process chitin powder utilizing the bacteria Chitinolyticbacter meiyuanensis SYBC-H1. The chitin obtained from this process is called CBF, and it was further investigated for N-acetyl-D-glucosamine (GlcNAc) enzymatic production. This fermentative treatment caused chitin powder to acquire a visible fleecy structure, and scanning electron microscopy showed that the surface of the CBF was a fiber-like structure with a diameter ranging from 10 nm to 200 nm. Moreover, Fourier transform infrared spectrometry, X-ray diffraction and gel permeation chromatography revealed that the crystallinity and average molecular weight of the chitin clearly decreased in the absence of deacetylation following bacterial fermentation treatment. The optimal conditions for bacterial treatment of chitin were determined at 25 °C, 200 rpm, and an initial pH of 7.5 for 12 h. Additionally, 19.2 g L−1 of GlcNAc could be obtained with a yield of 96% from 20 g L−1 of CBF in a batch enzymatic reaction within 6 h. This new approach provided an environmentally friendly and mild method for reducing the crystallinity of chitin and enhancing GlcNAc conversion without the use of oxidants, acids, or other environment unfriendly reagents.
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RSC Advances
·
2015
·Vol. 5
·期 47
·37574-37580
·
IF 3.84
Chao-Feng Du,Lei Jiang,Lei Sun,Nian-Yu Huang,Wei-Qiao Deng
We synthesized a D–π–A–π–A type dye and demonstrated its application in dye-sensitized solar cells (DSSCs). This D–π–A–π–A type dye, named C321, consisted of a triphenylamine as a donor, a 3,4-ethylenedioxythiophene (EDOT) as a π-bridge, and a benzothiazole (BTDA)–phenyl-cyanoacrylic acid as an A–π–A group. Compared with DSSCs based on a traditional D–π–A type dye C311, the DSSCs based on C321 exhibited a significant enhancement of cell performance. A power conversion efficiency of 8.2% was achieved for DSSCs based on C321, which was 9 times higher than that for DSSCs based on C311 (0.9%). The theoretical calculations and electrochemical impedance spectroscopy investigations revealed the mechanism of the enhancement of cell performance.
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JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
·
2017
·Vol. 50
·期 9
·748-753
·
IF 0.629
Zhaoyu Wang,Rongling Yang,Jizhong Wang,Yanhong Bi,Chun Zhu,Xiangjie Zhao,Linghong Nie,Wenqian Li
Regioselective enzymatic glycosylation of D-glucose and various structural alcohols for synthesizing β-D-glucopyranosides was successfully conducted. Among the β-glycosidases from seven potential plant seeds, the low-cost β-glycosidase from Prunus persica seed displayed excellent activity for salidroside preparation. Several crucial parameters, such as the solvent, buffer pH, buffer content, substrate molar ratio, enzyme dosage, and temperature were examined for yield optimization. Under the optimal conditions, the initial reaction rate and yield of salidroside were as high as 3.04 mM/h and 18.90%, respectively. Moreover, the alcohol acceptor recognition of the enzyme in synthesizing β-D-glucopyranosides was also investigated. The experimental data indicated that β-glycosidase activity and yield varied widely among all the tested alcohols due to the specific spatial structures of various acceptors.
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APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Junjie Yang,Lei Liu
The friction influence of 2-D molybdenum disulfide (MoS 2 ) films deposited on different substrates (Si, SiO 2 and Al 2 O 3 ) by atomic layer deposition (ALD) has been investigated. All of the three substrates showed a trend of decreasing friction with increasing number of layers of MoS 2 , but the friction leveled off for more than 6 layers samples. Comparing these 2-D MoS 2 films with each other, MoS 2 on the Al 2 O 3 possesses the lowest friction, while MoS 2 on the Si possesses the highest one, owing to effect of substrate on the specific self-limiting reaction in ALD process. At the same time, the friction of the monolayer MoS 2 is strongest affected by sulfur deficient. As the number of layers increases, the influence of the substrate on the friction of MoS 2 can be approximately characterized by the work of adhesion. Greater work of adhesion corresponds to a higher friction force. When the thickness is more than 6 layers, the substrate effect disappears gradually. Moreover, the friction of 2-D MoS 2 could be controlled near linearly by changing plasma treatment time within the range from 1 to 20 s, which suggests a possible way for the friction control of 2-D MoS 2 on different substrate quasi-qualitatively or even qualitatively.
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ChemistrySelect
·
2022
·Vol. 7
·期 36
·e202202508
·
IF 2.307
Meifeng Wang,Liyin Zhang,Yiqun Li,Liuqun Gu
Graphical An unprecedent “mixing and stand” anomerization of D-glucose pentaacetate in solid state was discovered after simple premixing in solvent and then removal of solvent, and the reaction proceeded continuously to full conversion without stirring or mechanomixing. Gram scale reaction was demonstrated and a new mechanism was also proposed. Anomerization of glycosides was rarely performed under basic condition. Here, an imidazole promoted anomerization of β-D-glucose pentaacetate in solid state at room temperature was discovered. This unprecedent anomerization occurred after simple premixing and reaction proceeded continuously in solid state to full conversion without stirring or mechanomixing. Full conversion of all β-forms in the mixture (α:β=2.2 : 1) into α-forms only was demonstrated at 1 gram scale. A proposed mechanism involved with inter/intramolecular acyl transfer promoted by imidazoles in a concerted manner may promote the discovery of more new transformations in solid state.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Chu Juan,Liu Zhaoli,Yu Jie,Wang Heng-Guo,Cui Fengchao,Zhu Guangshan
Two-dimensional conjugated metal organic frameworks (2D c-MOFs) hold significant promise as electrode materials for alkali metal ion batteries while their electrochemical properties still lack reasonable and effective regulation. Here, two representative 2D c-MOFs (M-HHTQ/M-HHTP, M=Cu or Ni) as positive electrodes are used as models to explore the basic/microscopic principles of their complex storage mechanism in sodium ion batteries (SIBs). It is demonstrated that the energy storage mechanism of 2D c-MOFs is determined by the interaction between coordination covalent bonds and organic linkers. Theoretical calculations and experiment results have jointly demonstrated that the redox potential and theoretical capacity can be regulated based on the valence of M-O bond and the utilization of anions and cations, respectively. As a result, Cu-HHTQ achieves a high discharge voltage at 2.55 V (vs. Na + /Na), a higher stable specific capacity of 208 mAh g −1 at 0.05 A g −1 , and long cyclability with the capacity retention rate of 100% at 1 A g −1 after 2000 cycles.
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高影响因子
Frontiers in Pharmacology
·
2018
·
IF 3.831
Mao Jingxin,Yi Man,Wang Rui,Huang Yuanshe,Chen Min
Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed to investigate the hepatoprotective effects of costunolide against lipopolysaccharide (LPS) and D-galactosamine-induced acute liver injury (ALI) in mice. The results indicated that costunolide (40 mg/kg) could significantly improve the pathological changes of hepatic tissue, and reduced the LPS and D-galactosamine-induced increases of alanine aminotransferase (from 887.24 ± 21.72 to 121.67 ± 6.56 IU/L) and aspartate aminotransferase (from 891.01 ± 45.24 to 199.94 ± 11.53 IU/L) activities in serum. Further research indicated that costunolide significantly reduced malondialdehyde content (from 24.56 ± 1.39 to 9.17 ± 0.25 nmol/ml) and reactive oxygen species (from 203.34 ± 7.68 to 144.23 ± 7.12%), increased the activity of anti-oxidant enzymes superoxide dismutase (from 153.74 ± 10.33 to 262.27 ± 8.39 U/ml), catalase (from 6.12 ± 0.30 to 12.44 ± 0.57 U/ml), and total anti-oxidant capacity (from 0.64 ± 0.06 to 6.29 ± 0.11 U/ml) in hepatic tissues. Western blot results revealed that costunolide may trigger the anti-oxidative defense system by inhibiting kelch-like ECH-associated protein 1 and nuclear factor-related factor 2 (cytosol), increasing nuclear factor-related factor 2 (nucleus), heme oxygenase-1 and NAD (P) H quinone oxidoreductase 1 activity. Moreover, costunolide significantly decreased the protein expression of proinflammatory cytokines including interleukin 1β, interleukin 6, and tumor necrosis factor. Pretreatment with costunolide could reduce the expression of toll-like receptor 4, myeloid differentiation factor 88, p65 (Nucleus), phosphorylated IκB kinase α/β, inhibitor of nuclear factor kappa-B kinase, inhibitor kappa Bα and prevent the expression of phosphorylated inhibitor kappa B kinase which repressed translocation of p65 from cytoplasm to nucleus. In addition, pretreatment with costunolide also inhibited hepatocyte apoptosis by reducing the expression of B-cell lymphoma 2 associated X, cytochrome C, cysteinyl aspartate specific proteinase 3, cysteinyl aspartate specific proteinase 8 and cysteinyl aspartate specific proteinase 9, and by increasing B-cell lymphoma 2. From the above analysis, the protective effects of costunolide against LPS and D-galactosamine-induced ALI in mice may be attributed to its anti-oxidative activity in nuclear factor-related factor 2 signaling pathways, anti-inflammatory suppression in nuclear factor-kappa B signaling pathways, and inhibition of hepatocyte apoptosis. Thus, costunolide may be a potential therapeutic agent in attenuating LPS and D-galactosamine -induced ALI in the future.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yan Liu,Ling Zhang,Kaiyang Guo,Jingyuan Zhao,Yonglei Xing,Zhuosen Wang,Yapeng Tian,Xinwei Cui
Intercalation pseudocapacitance is the key point to achieving the balance between the volumetric capacitance and the rate performance of energy storage. However, the low pseudocapacitive reactivity of the active center still limits the energy density of the pseudocapacitance devices. Herein, we propose a strategy that regulates the p - d hybridization of confined MXene via the co-doping of B and O atoms (BO-MXene) for outstanding electrochemical performance. Both experiments and density functional theory (DFT) reveal that the inner doped O atoms in low 2 p orbital energy strengthen the hybridization of Ti and electron-deficient B in MXene for high retention of B atoms, weaken the Ti-O covalency in MXene. As a result, the weakened p - d hybridization of Ti and O for the outer surface and strengthened p - d hybridization of Ti and B for the inner, promote the adsorption of protons and electron transfer, respectively. Further, the BO-MXene-based hybrid supercapacitors achieve a significant volumetric energy density of 56.86 Wh L -1 at 25.6 kW L -1 . This electronic structure via tuning the p - d hybridization in MXene proposes a new path for designing proton-confined intercalation pseudocapacitance.
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