Evidence-based Complementary and Alternative Medicine
·
2019
·Vol. 2019
·期 1
·2969364
·
IF 1.984
Zi-cong Wu,Qiang Xue,Zhen-ling Zhao,Peng-jun Zhou,Qun Zhou,Zhen Zhang,Jian-ping Deng,Ke Yang,Hua Fan,Yi-fei Wang,Zhi-ping Wang
Background . Huzhentongfeng (HZTF) is an extract from four Chinese medical herbs for treating gout. This study aims to evaluate its antigout activity and preliminary explore its mechanism in vivo and in vitro . Methods . The rats were intragastrically administered with HZTF for 5 days and then injected 0.1 ml (10 mg) of MSU crystals to their joints for generating a gout model to analyze the paw volume and histopathology of joint synovial tissues of rats with different doses. We also investigated the antioxidant capacity of HZTF in vitro using indication including lipid peroxidation, DPPH · , and ABTS + radical-scavenging capacity; besides, we used qRT-PCR to measure the effect of HZTF on interleukin (IL)-1 β , caspase-1, NLRP3, and NQO1 expression in hydrogen peroxide-stimulated RAW264.7 macrophages and IL-1 β , IL-6, and tumor necrosis factor (TNF)- α in MSU crystal-induced THP-1 monocytes. Confocal microscopy analysis was used to observe the dimerization of ASC adapter proteins. In addition, we also established quality standard of HZTF by using the high-performance liquid chromatography (HPLC) method. Results . HZTF could significantly suppress the paw swelling and neutrophil infiltration induced by MSU intra-articular injection in rats compared with the control group. HZTF also showed inhibition effects of inflammatory cytokines (IL-1 β , IL-6, and TNF- α ) secretion at 25.00 and 50.00 μ g/ml in MSU-induced THP-1 cells but showed no effects of IL-1 β , IL-6, and TNF- α mRNA expression in MSU-induced THP-1 cells. Furthermore, confocal microscopy analysis showed that HZTF could prevent the oligomerization of ASC. Moreover, HZTF also showed effects in cell-free and cell-base tests of antioxidant capacity. Conclusion . The results prove that HZTF possessed the potential preventive effect against gout arthritis, and the effect may be attributed to its preventing effect on neutrophil infiltration and proinflammatory cytokines secretion such as IL-1 β , IL-6, and TNF- α which were caused by the activation of inflammasome.
研究领域:
药理学
·
免疫学
·
风湿病学
·
中医药学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Wenjing Yang,Xuan Chen,Xun Yuan,Jia Yao,Weiliang Cai,Shuping Peng,Cijun Shuai
A novel design of antibacterial and magnetic halloysite nanotubes loaded with Ag and Fe 3 O 4 was reported. In detail, magnetic nanoparticles (Fe 3 O 4 ) were immobilized on the surface of halloysite nanotubes (HNTs) via electrostatic adsorption (termed as HNTs/Fe 3 O 4 ). The magnetic HNTs/Fe 3 O 4 was then modified by polydopamine to in-situ grow Ag nanoparticles by a redox reaction , forming a composite nanostructure of HNTs/Fe 3 O 4 @Ag. The HNTs/Fe 3 O 4 @Ag was incorporated into poly- l -lactic acid (PLLA) scaffold fabricated via selective laser sintering , with the intent to endow the scaffold with robust antibacterial function and favorable cell activity. The results showed that the released Ag + from the scaffold significantly against E. coli activity, with bacterial inhibition rate above 99%. Moreover, ion release behavior showed a scaffold enable to sustain release Ag + over 28 days. Furthermore, Fe 3 O 4 nanoparticles constructed magnetic microenvironment greatly enhanced cell activity and promoted cell proliferation . In addition, tensile strength of the scaffold increased by 52.9% compared with PLLA scaffold. These positive results suggested that the HNTs/Fe 3 O 4 @Ag nanostructure possessed potential in facilitating bone repair.
研究领域:
生物材料学
·
纳米医学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Yan Li,Jipeng Xu,Huibin Liu,Xuewen Hu,Qicheng Zhang,Wenchao Peng,Yang Li,Fengbao Zhang,You Han,Xiaobin Fan
Low-cost sodium-ion-based electrochemical energy storage devices, especially vanadium-based sodium-ion pseudocapacitors, are receiving increasing attention. However, the inevitable dissolution of vanadium in aqueous electrolytes usually leads to poor cycling stability and a narrow electrochemical stability window (ESW). In this study, we prepared layered (NH4)2V10O25·8H2O with a hierarchical flower-like structure and an ultralarge layer spacing and evaluated its potential as a sodium-ion pseudocapacitive material. Ex situ X-ray diffraction (XRD) measurement and kinetic analysis demonstrate the reversible intercalation and deintercalation of Na+ in (NH4)2V10O25·8H2O in NaClO4 electrolytes. Significantly improved durability and a large voltage window of 3.2 V are achieved in the high-concentration NaClO4 electrolyte. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) analysis and molecular dynamics (MD) simulations reveal that the dissolution of vanadium in the high-concentration NaClO4 electrolyte can be effectively suppressed. An asymmetric sodium-ion capacitor with a wide voltage window of 3.2 V was successfully assembled, and it delivered a high energy density of 53.1 Wh kg–1 at a power density of 3.2 kW kg–1.
研究领域:
材料科学
·
电化学储能
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DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 91
·88701-88706
·
IF 3.289
B. J. Liu,W. T. Meng,M. Y. Zhang,H. X. Zhang
Fabricating monodispersed polymer latex particles with ∼300 nm size at high monomer concentrations by batch macroemulsion polymerization remains significantly challenging because of latex stability. In this study, we developed a novel approach based on in situ charge neutralization to prepare 40 wt% solid content latex containing monodispersed sub-300 nm latex particles. The cationic initiator 2,2′-azobis(2-methylpropionamidine)dihydrochloride (AIBA) was used to induce in situ charge neutralization in the particle nucleation period and shield the negative charges of surfactant sodium dodecyl sulfate molecules to further reduce the electrostatic repulsion between primary particles, resulting in primary particle coagulation nucleation. The primary particle coagulation promoted particle number decreased to ∼1016 L−1, and the average particle size increased to ∼100 nm at a very low monomer conversion (<0.12). With increasing AIBA concentrations from 0.6 and 0.8 to 1.0 wt% (the molar ratio of AIBA/SDS is 0.64, 0.85 and 1.06, respective), the average particle size of the latex ultimately attained from 170.6 and 221.7 to 288.0 nm, respectively. Moreover, the addition of an electrolyte and copolymerization composition also governed the particle coagulation extent and affected the particle size distribution of the ultimate latex particles. To the best of our knowledge, this is the simplest, most efficient, and inexpensive approach to prepare large sized, monodispersed latex particles.
研究领域:
化学工程
·
材料科学
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DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Yuntao Wang,Shasha Wang,Rui Li,Yu Wang,Qisen Xiang,Si Qiu,Wei Xu,Yanhong Bai
In recent years, emulsions stabilized by natural substances have attracted great interests of scientists. As both the emulsifying properties of chitosan (CH) and corn fiber gum (CFG) are poor, the different complex of CH and CFG were used to stabilize emulsion. It was found that the CH-CFG complex had significantly better emulsifying properties than CH or CFG at the same concentration, indicating they played a synergistic role in stabilizing oil in water emulsion. Cryo-SEM results showed that the CH-CFG complex formed a dense interfacial film on the surface of the oil droplets, forming a barrier that effectively prevented the flocculation of droplets, thus improving the stability of the emulsion. The changed surface zeta potential, interfacial activity and viscosity of CH-CFG complex compared with CH or CFG due to the interaction of CH and CFG contributed to the improved emulsifying properties of CH-CFG complex.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
ChemistryOpen
·
2020
·Vol. 9
·期 10
·996-1000
·
IF 2.37
Fangjun He,Rumeng Qu,Jie Su,Muyao Du,Junqiang Liu,Yiping Chen,Bo Wang
Graphical Solving the puzzle : The role of the amine in direct amidation of aromatic ketones has been investigated. Amines act as both the reactant and catalyst, as such the excess amount (two or more equivalents) of amines are required to afford reasonable conversions/yields in the classical amidation. The direct amidation of aromatic ketones has been achieved at mild reaction conditions. In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for a long time. In this work, we disclosed that the amine acts as both reactant and catalyst. Specifically, the determination of reaction intermediates revealed the full mechanism, based on which, the introduction of one equivalent base in the amidation is showcased here that a high yield (∼95 %) can be afforded using only 1.1 equiv. of amine.
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers of Environmental Science & Engineering
·
2015
·Vol. 10
·期 3
·438-446
·
IF 1.357
Xu Minhui,Gu Xiaogang,Lu Shuguang,Miao Zhouwei,Zang Xueke,Wu Xiaoliang,Qiu Zhaofu,Sui Qian
The thermally activated persulfate (PS) degradation of carbon tetrachloride (CT) in the presence of formic acid (FA) was investigated. The results indicated that CT degradation followed a zero order kinetic model, and CO
– 2
· was responsible for the degradation of CT confirmed by radical scavenger tests. CT degradation rate increased with increasing PS or FA dosage, and the initial CT had no effect on CT degradation rate. However, the initial solution pH had effect on the degradation of CT, and the best CT degradation occurred at initial pH 6. Cl – had a negative effect on CT degradation, and high concentration of Cl – displayed much strong inhibition. Ten mmol·L –1 HCO
– 3
promoted CT degradation, while 100 mmol·L – 1NO
– 3
inhibited the degradation of CT, but SO
2– 4
promoted CT degradation in the presence of FA. The measured Cl–concentration released into solution along with CT degradation was 75.8% of the total theoretical dechlorination yield, but no chlorinated intermediates were detected. The split of C-Cl was proposed as the possible reaction pathways in CT degradation. In conclusion, this study strongly demonstrated that the thermally activated PS system in the presence of FA is a promising technique in in situ chemical oxidation (ISCO) remediation for CT contaminated site.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Inventions
·
2021
·Vol. 6
·期 2
·29
·
IF 0
Bhuwan Kashyap,Ratnesh Kumar
Reducing agricultural losses is an effective way to sustainably increase agricultural output efficiency to meet our present and future needs for food, fiber, fodder, and fuel. Our ever-improving understanding of the ways in which plants respond to stress, biotic and abiotic, has led to the development of innovative sensing technologies for detecting crop stresses/stressors and deploying efficient measures. This article aims to present the current state of the methodologies applied in the field of agriculture towards the detection of biotic stress in crops. Key sensing methodologies for plant pathogen (or phytopathogen), as well as herbivorous insects/pests are presented, where the working principles are described, and key recent works discussed. The detection methods overviewed for phytopathogen-related stress identification include nucleic acid-based methods, immunological methods, imaging-based techniques, spectroscopic methods, phytohormone biosensing methods, monitoring methods for plant volatiles, and active remote sensing technologies. Whereas the pest-related sensing techniques include machine-vision-based methods, pest acoustic-emission sensors, and volatile organic compound-based stress monitoring methods. Additionally, Comparisons have been made between different sensing techniques as well as recently reported works, where the strengths and limitations are identified. Finally, the prospective future directions for monitoring biotic stress in crops are discussed.Keywords:biosensors;hyperspectral;thermography;electrochemical;hormones;fluorescence;acoustic;spectroscopy;remote sensing;volatile organic compounds
研究领域:
农业
·
植物病理学
·
昆虫学
·
传感技术
·
生物技术
✓ 已验证
DOI
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Yifan Rao,Min Yuan,Feng Luo,Hui Li,Jiabing Yu,Xianping Chen
Transition metal nanoparticles-graphene nanocomposites incorporate the advantages of graphene and metal nanoparticles, which arouse extensive attention. Here, we design a novel, facile and versatile method for in-situ synthesis of laser-induced porous graphene (LIG) decorated with cobalt particles (Co). The LIG/Co nanocomposites are fabricated through one-step laser direct scribing on a customized film composed of polyimide (PI) powder, polyvinyl alcohol (PVA), and cobalt chloride (CoCl 2 ·6H 2 O) precursors. Benefiting from the unique properties of Co nanoparticles embedded LIG, the obtained optimal in-plane micro-supercapacitors (IMSC) based on LIG/Co-1.5 possesses an excellent areal capacitance of 110.11 mF cm −2 and a superior energy density of 9.79 μWh cm −2 , which are about 79 times that of pure LIG-based IMSCs. Simultaneously, the LIG/Co-1.5 MSCs also present good cycling stability, remarkable modular integration capability, and outstanding mechanical flexibility, showing potential for practical applications. Additionally, the density functional theory (DFT) calculations indicate that the decorating of cobalt particles elevates electron transfer. Moreover, the interaction between electrolyte and electrodes is also improved with the introduction of cobalt particles. Therefore, this strategy offers a new avenue for facile and large-scale manufacturing of various metallic atoms in-situ decorating in porous graphene.
研究领域:
材料科学
·
能源存储
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
·
2023
·
IF 3.9
Celebı Demet,Celebı Ozgur,Aydin Elif,Baser Sumeyye,Güler Mustafa Can,Yildirim Serkan,Taghizadehghalehjoughi Ali
Multidrug-resistant bacteria is one of the most important public health problems. Increasing rates of antibacterial resistance also affect the outcomes of medical approaches. Cancer treatment because of immune system deficiency (chemotherapy or steroids usage) commonly can cause infection. Lung cancer is the dominant cause of cancer-related deaths, and infection is the most common cause of death among those patients. In this study, it was aimed to determine the antimicrobial, antibiofilm, and anticancer activity of boron compounds. A549 lung cancer cell line was infected with Acinetobacter baumannii (ATCC 19606), Klebsiella pneumoniae (ATCC 700603), and Pseudomonas aeruginosa (ATCC 27853). In order to determine the fractional inhibitory concentration (FIC) index, antibiotics and boron compound concentrations prepared according to the minimum inhibitory concentration (MIC) values were determined by the checkerboard method. In our study results, the antibiofilm activity was an average of 46% in A. baumannii +boron compounds, 45% in P. aeruginosa +boron compounds, and 43% in K. pneumoniae . Cell culture analysis results show a decrease in viability and antioxidant capacity and an increase in total oxidant status after adding boron compounds to the culture. Immunofluorescence results show a correlation with MTT, and boron compounds increased 8-OHdG expression in comparison to antibiotic administration. In conclusion, boron compounds have promising effects on bacteria, especially in resistant bacteria spp.
研究领域:
医学
·
微生物学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Hantao Li,Xuefei Wang,Guoqiang Luo,Chen Chen,Ming Gao,Qiang Shen
Silicon anodes offer very high theoretical capacity, but their low ionic conductivity and the development of an unstable solid electrolyte interphase (SEI) lead to fast capacity loss and restricted rate performance. In this work, we present a novel surface engineering approach using liquid nitrogen-assisted cryomilling to form an ultrathin silicon nitride (Si N) layer in situ on nano‑silicon particles. The resulting Si@Si-N composite has a dual-phase coating composed of electrochemically inert Si 3 N 4 and active, non-stoichiometric SiN x . These phases synergistically stabilize the electrode/electrolyte interface and enhance Li-ion transport. TEM, XPS, and EDS analysis confirm the formation of a uniform amorphous Si N layer. Electrochemical tests show outstanding performance: after 500 cycles at 1 A g −1 , the Si@Si-N anode delivers a high reversible capacity of 1152 mAh g −1 , with an initial coulombic efficiency of 82.8 %. In rate capability tests, it delivers 759 mAh g −1 at 5 A g −1 and recovers 98.49 % of its capacity when the current returns to 0.2 A g −1 . GITT and EIS analyses reveal significantly improved Li + diffusion kinetics, which can be attributed to the formation of a highly conductive Li 3 N-rich interphase during lithiation, along with the mechanically robust Si 3 N 4 framework that collectively mitigate SEI degradation. This work provides a scalable, cost-effective strategy for stabilizing silicon anodes, representing a significant advancement toward their commercial use in high-energy-density lithium-ion batteries.
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DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 237
·期 1
·9
·
IF 3
Liu Yiqing,Hu Hong,Chen Chuanzeng,Xu Linghan
Generally, Fe(II) has an efficiently catalytic activity toward peroxymonosulfate (PMS), but the slow conversion of Fe(III) to Fe(II) and production of iron sludge impede the practical application of Fe(II)/PMS system. In this work, ascorbic acid (AA), a complexing agent and reductant, was introduced to Fe(III)/PMS process to facilitate the Fe(III) reduction. The decoloration of rhodamine B (RhB) was obviously enhanced in Fe(III)/PMS process with the addition of AA. Fe(III)-AA complex was firstly generated in Fe(III)/AA/PMS process via the complexation and then was reduced to Fe(II), which could catalyze PMS to yield oxidative species. Fe(IV), sulfate radical (SO 4 •− ) and hydroxyl radical ( • OH) were the working oxidants for RhB decoloration in this system, and SO 4 •− played a major role. Increasing Fe(III), AA or PMS dosage was beneficial to RhB decoloration, but their excessive concentration would hinder RhB decoloration. The existence of HCO 3 − , SO 4 2− or FA in this system showed an inhibition effect on RhB decoloration, while a facilitation effect was obtained when the high concentration of Cl − was present. This research offers a way to improve PMS activation by Fe(III) and a technology for eliminating the refractory organic pollutants from the contaminated water.
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高影响因子
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