Foods
·
2026
·Vol. 15
·期 11
·1888
·
IF 6
Ning Su,Huiliang Yang,Qiyun Zheng,Fei Lin,Taosheng Xu
Fatty acid abundance is a key parameter for evaluating the quality of edible oils. This study developed a rapid and non-destructive method for predicting palmitic acid content in edible oils by combining visible-near-infrared (Vis-NIR) reflectance spectroscopy with deep learning models. A total of 1740 reflectance spectra in the range of 350–2500 nm were collected from 87 brands of edible oils, including peanut, soybean, corn, sunflower, rapeseed, sesame, and olive oils. Reference values of palmitic acid content were determined via gas chromatography–mass spectrometry (GC-MS). Two conventional machine learning models (SVR and KNN) and four deep learning models (1D-CNN, 1D-ResNet, 1D-Inception, and 1D-Inception-ResNet) were developed and compared using both full-spectrum data and CARS selected characteristic wavelengths. Among the full-spectrum models, the designed 1D-ResNet model achieved the best performance, with the determination coefficient of prediction (Rp2
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Materials Today Bio
·
2026
·
IF 11
Jin Zhang,Jiuling Liao,Dong Han,Xingsheng Ren,Dehong Hu,Duyang Gao,Pengfei Zhang,Shengnan Yuan,Wei Zheng,Christopher J. Butch,Bo Dai,Huiming Cai,Yiqing Wang,Hairong Zheng,Zonghai Sheng
Accurate intraoperative delineation of tumor margins remains a major clinical challenge because conventional fluorescence imaging is strongly influenced by probe concentration, tissue heterogeneity, and imaging conditions. Here, we report a renally clearable, tumor-targeted molecular probe, NY-07, for quantitative tumor-margin delineation using second near-infrared (NIR-II) fluorescence lifetime (FLT) imaging. NY-07 is constructed by conjugating a cyanine-based fluorophore with pemetrexed as an active targeting ligand, yielding a clinically compatible probe with excellent solubility, high optical stability, and efficient renal clearance. NY-07 exhibits tail emission in the NIR-II window with a stable fluorescence lifetime of 480 ± 0.6 ps and NIR-II brightness approximately twice that of indocyanine green (ICG) at the same concentration, while retaining ∼70% of its NIR-II signal after 7 days of storage. In vivo imaging demonstrates rapid renal excretion, with strong kidney and bladder signals within seconds after injection and minimal hepatic accumulation. Using cell models, tumor-bearing mice, and patient-derived tissues, we show that NY-07 enables target-specific NIR-II FLT imaging and achieves quantitative discrimination between tumor, inflammation, and normal tissues based on distinct lifetime signatures, enabling precise visualization of tumor margins independent of probe concentration and imaging parameters. Compared with conventional NIR-II fluorescence intensity (FLI) imaging, FLT imaging significantly reduces false-positive signals and improves boundary definition in complex biological environments. This work establishes a clinically translatable strategy that integrates renal clearance, active tumor targeting, and lifetime-resolved imaging for functional tumor-margin delineation, providing a robust platform for improving surgical precision and advancing next-generation image-guided oncologic surgery.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Arsalan Ahmed,Mehar Muhammad Hamza Maqbool,Weiping Zhou,Nosherwan Adil,Anam Zulfiqar,Yanjie Zhu,Di He,Yongjian Zhuang,Oleg G. Sinyashin,Asiya R. Mustafina,Rustem R. Zairov,Naeem Akhtar,Cong Yu
Machine learning optimized nanocrystals with narrow band in the NIR-I region were synthesized. • DBT-F 4 TCNQ derive nanocrystals offer excellent photothermal and sensing performance. • Designed theranostic platform integrates cancer therapy with precise electrochemical sensing. • DBT-F 4 TCNQ derive nanocrystals demonstrated effective glutathione depletion. Despite significant advances in near-infrared (NIR) photothermal agents, most current systems face challenges including large band gaps and poorly defined crystalline morphology, compromised responsiveness in the tumor microenvironment due to inefficient and time-consuming optimization, and dependence on separate, cancer type-specific diagnostic platforms for effective treatment. To overcome these challenges, we rationally synthesized a novel class of charge transfer complex-derived nanocrystals (CTNs) with well-defined morphology and a significantly reduced band gap in the NIR-I region, achieved for the first time through the unique combination of DBT as the electron donor with F 4 TCNQ, TCNB, and DTTCNQ as acceptors. Additionally, we employed machine learning (ML) to systematically optimize donor-to-acceptor ratios in CTNs, ultimately identifying DBT-F 4 TCNQ as the most effective formulation, with strong NIR absorption, excellent photothermal conversion, and superior electrocatalytic efficiency. Interestingly, ML-optimized DBT-F 4 TCNQ derived from CTNs demonstrated effective cysteine-triggered intracellular depletion of glutathione (GSH), thereby promoting reactive oxygen species (ROS) accumulation and inducing ferroptosis. Additionally, the in vivo antitumor efficacy was validated through NIR-triggered photothermal therapy combined with ROS-mediated ferroptosis, while the diagnostic potential of the designed CTNs was demonstrated via in-direct electrochemical monitoring of choline released from 4T1 cancer cells. Thus, the designed ML-optimized CTNs derived from the novel DBT-F 4 TCNQ combination hold great promise as a next-generation theranostic platform by integrating therapeutic efficacy with diagnostic precision.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Zengyue Li,Nan Kang,Yixun Jin,Weiyan Yao,Jin Cheng,Zimei Liu,Xiaoqing Qian,Qian Zhang
Accurate diagnosis and effective treatment of pancreatic cancer are essential to improving survival rates, yet current strategies are highly limited by toxicity of therapeutic drugs and efficacy challenges. Herein, we proposed a biodegradable nanosystem (denoted as MnCO3–BSA@DOX/IR820) based on manganese carbonate (MnCO3) loaded with doxorubicin (DOX) and photothermal agent IR820. This platform integrates chemotherapy with photothermal/photodynamic therapy (PTT/PDT) under 808 nm laser irradiation, achieving synergistic antitumor efficacy against pancreatic cancer. Specifically, the MnCO3-based nanosystem can enhance tumor accumulation, while the hydrogen peroxide (H2O2)-enriched acidic tumor microenvironment (TME) triggers oxidative stress pathways to generate reactive oxygen species (ROS). Upon 808 nm laser irradiation, IR820 is activated to exert a combined therapeutic effect. It mediates PDT to generate ROS, while the localized hyperthermia induced by PTT causes direct cellular apoptosis and facilitates DOX release, thereby enhancing therapeutic efficacy. Additionally, the nanosystems integrate magnetic resonance imaging (MRI) and near-infrared fluorescence (NIR) imaging capabilities, enabling real-time treatment monitoring and precise diagnosis. In vivo studies demonstrated that MnCO3–BSA@DOX/IR820 nanosystems effectively inhibit tumor growth without causing notable damage to normal tissues. Therefore, this pH-responsive and MRI/NIR imaging-guided nanoplatform represents a targeted theranostic system for pancreatic cancer, enabling chemo-PTT/PDT synergy.
研究领域:
纳米医学
·
癌症诊疗一体化
·
生物医学成像
·
光热治疗
·
光动力治疗
·
药物递送
·
活性氧
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肿瘤微环境
·
分子成像
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yixin Wang,Ye Zhang,Mengshu Xu,Zhuoran Yang,Wei Guo,Chunyu Yang
Breast cancer is one of the most prevalent malignant tumors worldwide and a leading cause of cancer-related mortality, underscoring the urgent need for innovative therapeutic strategies. In this study, we developed an injectable hydrogel-based system, in which polyvinylpyrrolidone (PVP)-modified NiS 2-x @PVP nanospheres were incorporated with metformin hydrochloride (MH) and dispersed in a hyaluronic acid (HA) hydrogel matrix to form the NiS 2-x @PVP@HA tumor treatment platform. This system exhibits excellent photothermal performance under near-infrared (NIR) light irradiation and can be employed for tumor photothermal therapy (PTT). The Ni 2+ released from the degradation of NiS 2-x @PVP nanospheres can catalyze the decomposition of endogenous hydrogen peroxide in tumor cells, thereby generating toxic hydroxyl radicals for chemodynamic therapy (CDT). By altering the HA concentration, the internal pore structure, mechanical properties, drug release behavior, and swelling capacity of the hydrogel can be modulated. The loaded antitumor drug MH further enhances the therapeutic efficacy. Under NIR and ultrasound stimulation, this platform enables controlled drug release. In vitro and in vivo experiments have demonstrated that the NiS 2-x @PVP@HA hydrogel achieves the synergistic treatment of PTT/CDT/chemotherapy for tumor tissues. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that activation of the MAPK signaling pathway was a key mechanism underlying tumor cell death. This work presents a rational design strategy that addresses the related challenges in breast cancer and promotes precise cancer therapy.
研究领域:
肿瘤学
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纳米医学
·
生物材料
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药物递送
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癌症治疗
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Ranran Guo,Ruixun Chen,Zhenhang Rao,Lugui Wang,Jianing Xi,Yu Zhang,Weisheng Guo,Ye Tian
Immune checkpoint blockade therapy has revolutionized clinical oncotherapy by intercepting immunosuppressive pathways in tumor tissues. Nevertheless, the therapeutic efficacy is limited by a multidimensional immunosuppressive tumor microenvironment, which impedes the activity of tumor-infiltrating immune cells and undermines treatment outcomes. In this study, a zwitterionic polymer is designed for the conjugation and traceless release of a checkpoint inhibition antibody (Atezolizumab), while concurrently enabling the restoration of membrane redox homeostasis on T cell membranes within the oxidative tumor microenvironment. Contrast-enhanced fluorescence imaging in the near-infrared II spectral region with a deep learning network is employed to visualize in vivo dynamics of the antibody conjugates. The antibody conjugates demonstrate enhanced and accelerated tumor accumulation, thereby promoting T cell proliferation and augmenting the antitumor efficacy. Mechanistic investigations reveal that the conjugate-mediated regulation of the T cell surface redox state protects against damage induced by extracellular reactive oxygen species, subsequently mitigating ferroptosis of T cells. In murine models, the antibody conjugates effectively suppressed colorectal tumor growth and recurrence, leading to a significant extension of animal survival. This work thus realizes reversing suppressive immune microenvironment from multiple dimensions with a simple checkpoint inhibitor conjugate, promising for clinical translation and next-generation immune checkpoint blockade therapy.
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Materials Today Bio
·
2025
·
IF 10.2
Wenkang Liu,Tao Wu,Wenxuan Ye,Mingyang He,Jianfu Zhao,Wei Xue,Siming Yu
Currently, Pseudomonas aeruginosa ( P. aeruginosa ) infections pose a significant threat to public health, owing to the high morbidity, mortality and antibiotic resistance. Alkyl radical (AR)-based photodynamic therapy exhibits great potential in antibacterial applications due to its oxygen-independent advantage. Nevertheless, targeted delivery systems capable of precisely controlling AR release at bacterial infectious foci are still lacking. In the present work, a mesoporous gold nanorod (mGNR)-based multifunctional nanogenerator with P. aeruginosa -targeting and near infrared (NIR) laser-controlled AR release properties was fabricated for enhanced bacterial wound treatment. Herein, mGNR with mild-photothermal therapeutic (MPTT) effect was firstly synthesized and used as a carrier for effective loading of an AR initiator 2, 2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH). Then, cysteamine and polymer of HOOC-PEG 5000 -Mal were added in sequence to functionalize the nanosystem, obtaining nanogenerator of mGNR@AIPH@PEG-Mal. Due to the specific maleimide (Mal) and Type IV Pilus (T4P) reaction, mGNR@AIPH@PEG-Mal displayed high binding efficiency on P. aeruginosa . Upon NIR laser irradiation, mGNR@AIPH@PEG-Mal triggered AIPH cleavage to generate substantial amount of AR, which enabled high-efficient inhibition on P. aeruginosa and biofilms via the synergistic MPTT/AR antibacterial effect. Moreover, mGNR@AIPH@PEG-Mal exhibited excellent antibacterial and wound healing effect on P. aeruginosa infectious rats’ wounds. In-depth mechanism study revealed that the synergistic MPTT/AR therapeutic effect of mGNR@AIPH@PEG-Mal induced P. aeruginosa death by breaking bacterial membrane, triggering ROS boost, GSH depletion and DNA damage, as well as promoted wound healing by repolarizing M2-type macrophages and upregulating CD 31 and α-SMA expressions.
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MATERIALS RESEARCH BULLETIN
·
2026
·
IF 5.7
Hui Zeng,Xiaolang Fan,Yangbo Wang,Huaiyong Li
Lanthanide NIR-II luminescence free from thermal quenching is attractive for various applications at elevated temperatures. Here, we present a thermal enhancement of Er 3+ NIR-II luminescence based on the synergy of phonon assisted Er 3+ -Er 3+ cross relaxations and controllable Er 3+ -Ho 3+ energy transfer. The lattice expansion of NaYGeO 4 olivine phosphor upon heating (298–823 K) suppresses the Er 3+ -Ho 3+ energy transfer and leads up to 46.1 times enhancement of Er 3+ NIR-II luminescence under 379 nm excitation. The NIR-II luminescence evolution as increasing temperature allows dual-mode ratiometric thermometry, i.e., luminescence intensity ratios (LIRs) based on Er 3+ 4 I 13/2 Stark sublevels and on Er 3+ 4 I 13/2 and Ho 3+ 5 I 6 levels. Obtained relative sensitivities above 0.46% K ‒1 over a broad temperature range of 298–673 K with a maximum of 2.32% K -1 suggest NaYGeO 4 :Er 3+ /Ho 3+ phosphor as a promising NIR-II luminescence thermometer. Moreover, this research offers an available perspective for designing thermal-enhanced NIR luminescence in ordinary thermal expansion materials.
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RSC Advances
·
2026
·Vol. 16
·期 6
·5168-5178
·
IF 4.6
Xiaotao Wang,Zhihao Bi,Yonggui Liao,Chak-Yin Tang,Xuefeng Li,Wing-Cheung Law
We report the synthesis of an organic/inorganic architecture, a rare-earth upconversion nanoparticle (UCNP)-based core with organic porous silicon shell nanocapsules, that enables visible and ultraviolet light emission under 980 nm near-infrared (NIR) irradiation for photodegradation. A mesoporous organosilica shell containing disulfide bonds was uniformly coated onto UCNP cores via a combined sol–gel and hard-template strategy. Glutathione (GSH) – triggered degradation of the nanocarriers was quantified using the molybdenum blue method. A photoresponsive azobenzene derivative, activatable by both UV and visible light, was synthesized and grafted onto the nanocarrier surface. Doxorubicin (DOX) was loaded into the nanocapsules, achieving a drug-loading capacity of 12.2 wt%. At neutral pH, minimal DOX leakage occurred; maximal release was observed under a composite stimulus environment. The Baker-Lonsdale model was employed to calculate diffusion coefficients under varying release conditions, providing quantitative guidance for designing multi-responsive drug-release systems. In vitro cellular assays showed that synergistic stimuli—NIR irradiation combined with an acidic, GSH-rich microenvironment—trigger controllable DOX release, enabling efficient tumor cell ablation. This work demonstrates a versatile, multi-responsive delivery platform combining UCNP-based photoreactivity, GSH-triggered degradation, and photoactive surface gating to achieve targeted, low-toxicity, on-demand chemotherapy.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Yongjie Wang,Dongshuo Li,Yingju Yan,Li Li,Guotao Xiang,Sha Jiang,Ruiheng Pan,Xiantong Tang,Chuan Jing,Xianju Zhou,Yaroslav Zhydachevskyy,Andrzej Suchocki
Broadband shortwave infrared (SWIR) light-emitting diodes (LEDs) have attracted significant attention due to their widespread applications in spectroscopy, food industry, agriculture, optical communications, night vision, and biomedical technologies. Nevertheless, their performance remains limited by the critical phosphor layer's low quantum efficiency and narrow emission bandwidth. This work presents a series of Ni 2+ -doped spinel phosphors emitting in the SWIR range with high efficiency and tunable broadband emission. Upon UV illumination, normal spinel MgAl 2 O 4 :Ni 2+ phosphors exhibit an emission range of 1100–1600 nm and an internal quantum efficiency (IQE) of 5.2 %. By contrast, the inverse spinel MgGa 2 O 4 :0.02Ni 2+ demonstrates a significantly improved IQE of 77.2 % and excellent thermal stability (62.9 %@423 K), achieved by cation substitution. Furthermore, the significant spectral tuning over a broad range of 405 nm is realized through In 3+ cation- and F − anion-substitution in MgGa 2 O 4 :0.02Ni 2+ . Finally, SWIR pc-LEDs incorporating MgGa 2 O 4 :Ni 2+ phosphors were fabricated, and its potential applications in night vision, high-penetrating imaging, and non-destructive detection were evaluated. This work offers a promising pathway for developing tunable near-infrared light sources, thereby expanding their applicability across a range of advanced technologies.
研究领域:
材料科学
·
光学工程
·
纳米技术
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.7
Yehui Kang,Yahui Zhang,Weijiao Fan,Liya Yu,Mengdie Yu,Yuejia Ding,Yu Cai,Aihong Jiao,Jiajie Xu
Head and neck squamous cell carcinoma (HNSCC) remains a clinically challenging malignancy due to limited therapeutic options and considerable treatment-related toxicity. In this study, we present an innovative nanotherapeutic platform—monocarboxylate transporter 1 (MCT1) antibody-targeted nanoparticles co-loaded with a second near-infrared window (NIR-II, 1000–1700 nm) absorbing conjugated polymer (PDTP-TBZ-OD, denoted as PTO) and emodin (MCT@PTO-Em NPs) —that synergistically integrates emodin-induced pyroptosis with NIR-II mediated mild photothermal therapy (MPTT) to address critical limitations of current HNSCC treatments strategies. The synthesized NIR-II-absorbing conjugated polymer PTO exhibits strong absorption at 1064 nm and a high photothermal conversion efficiency (39 %), enabling deeptissue penetration and precise hyperthermia control. Accordingly, MCT@PTO-Em NPs implement a dual-modal therapeutic strategy that triggers pyroptosis through NLRP3 inflammasome activation while simultaneously enhancing tumor cell death via mild hyperthermia. Moreover, emodin encapsulated within the nanoparticles (NPs) inhibits heat-shock protein 70 (HSP70), thereby disrupting cellular thermoresistance mechanisms and sensitizing cancer cells to MPTT. Additionally, surface functionalization of the nanoparticles with MCT1-targeting antibodies enhances tumor-specific delivery and intracellular accumulation, thereby minimizing off-target effects. Both in vitro and in vivo studies demonstrate that MCT@PTO-Em NPs achieve superior tumor suppression through the synergistic interplay between pyroptosis and MPTT, while exhibiting excellent biocompatibility. This work presents a precision nanomedicine strategy that integrates molecular targeting, pyroptosis-mediated immune activation, and MPTT, offering a transformative therapeutic paradigm for HNSCC and other solid tumors.
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CERAMICS INTERNATIONAL
·
2024
·Vol. 50
·期 18
·32662-32669
·
IF 5.1
Li Li,Haoliang Yang,Yongjie Wang,Xianju Zhou,Faling Ling,Huajing Gao,Zhiyu Yang,Xiantong Tang,Yongbin Hua
The development of medical, military, and other fields has greatly increased the demand for broadband near-infrared light sources . This article reports that Sr 3 Sc 2 Ge 3 O 12 : Cr 3+ (SSGO: Cr 3+ ), a broadband near-infrared phosphor with 850 nm as the luminescence center, has an emission spectrum covering 700–1200 nm and a full width at half maximum (FWHM) of 125 nm under 490 nm excitation. To further increase the FWHM value, Yb 3+ is introduced into the phosphor of SSGO: Cr 3+ to enable energy transfer from Cr 3+ to Yb 3+ . After doping 1 % of Yb 3+ onto the Sr 2+ site, the near-infrared emission generated by the 4 A 2 → 4 T 1 (4P) transition of Cr 3+ and the near-infrared emission generated by the 2 F 5/2 → 2 F 7/2 transition of Yb 3+ work so that the FWHM increases to 220 nm. In addition, the thermal stability of the phosphor after co-doping with Yb 3+ is also greatly enhanced from 61.6 % to 75.1 % by comparing it to the Cr 3+ single-doped sample. In addition, SSGO:0.08Cr 3+ , 0.01 Yb 3+ was combined with a commercial 490 nm chip to prepare a broadband near-infrared light-emitting diode (pc-LED).
研究领域:
材料科学
·
光学材料
·
光子学
·
固态照明
·
能量传递
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