CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Qiaorong Guo,Dongbin Wei,Chuanfang Zhao,Cuiping Wang,Haijun Ma,Yuguo Du
Physical UV-blocker TiO 2 nanocomposites and chemical sunscreen benzophenones (BPs) have been frequently detected in the aquatic environment, their combined fates and potential risk should be concerned. In this study, the typical cosmetic grade UV-blocker TiO 2 nanocomposites (labeled as CG-TiO 2 ) and 2,4-dihydroxy benzophenone (BP-1) were targeted, and the effects of CG-TiO 2 on the transformation of BP-1 during UV irradiation were explored. It was found that CG-TiO 2 destruction did not form toxic products, while they could promote the chemical reactions of BP-1 that will lead to highly toxic products during UV irradiation. More importantly, UV irradiation could break the organic coatings on CG-TiO 2 , the broken CG-TiO 2 exhibited stronger catalytic activity on BP-1 and form highly toxic products during UV irradiation. Total of 24 transformation products were tentatively identified, including hydroxyl BPs, hydroxyl dibenzo-p-dioxins, hydroxyl benzoyl benzoquinones, etc. The main transforamtion mechanisms of BP-1 included hydroxylation, radical coupling, oxidation, decarboxylation, Norrish type I reaction, and ring closure through electrophilic substitution. This study highlighted that physical UV-blocker CG-TiO 2 promoted the transformation of chemical sunscreen BP-1 and generated higher toxicity during UV irradiation. It was expected that these results would provide scientific data for evaluating the fates and potential risk of sunscreens in the environment.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Siying Du,Liuyun Chen,Chengzheng Men,Hongbing Ji,Tongming Su,Zuzeng Qin
Photocatalytic H 2 production using solar energy has received great attention, but suffers from low photocatalytic efficiency. Herein, Zn (1−x) Cd x S solid solution with different Zn/Cd molar ratio was synthesized by a solvothermal method, and tested for photocatalytic H 2 production from water. The bandgap, charge carrier separation efficiency and surface defect states of the Zn (1−x) Cd x S can be adjusted by altering the Zn/Cd molar ratio. The separation efficiency of photogenerated electrons and holes was greatly enhanced with the Zn/Cd molar ratio of 0.8:0.2. Moreover, the Zn 0.8 Cd 0.2 S exposed most surface defect states compared to those of other Zn (1−x) Cd x S, which can be act as electron pools and active sites for improving photocatalytic H 2 production. Therefore, when the molar ratio of Zn/Cd is 0.8:0.2, the Zn 0.8 Cd 0.2 S exhibited the best performance for photocatalytic H 2 production with the H 2 production rate of 7.71 mmol·g -1 ·h -1 , which is much higher than that of ZnS (17 μmol·g -1 ·h -1 ) and CdS (5.37 μmol·g -1 ·h -1 ). This work provides an in-depth understanding of the surface defect states for enhancing the photocatalytic H 2 production.
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CANCER BIOLOGY & THERAPY
·
2023
·
IF 3.6
Xiaojing Xing,Xuguang Wang,Meichen Liu,Qianxue Guo,Hongyue Wang
A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its role in lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated in diffuse large B-cell lymphoma (DLBCL) specimens. In this article, we demonstrated that RASIP1 is highly expressed in DLBCL cell lines, compared with primary B cells. The gain- and loss-of-function experiments were performed to investigate the effects of RASIP1 on DLBCL cells. CCK-8, flow cytometry, western blot, and transwell assays demonstrated that silence of RASIP1 inhibited proliferation, cell cycle transition, and invasion and induced significant apoptosis in DLBCL cells, and ectopic expression of RASIP1 played opposite roles. Xenograft results revealed that RASIP1 facilitated the growth of DLBCL cells in vivo. These findings suggest that RASIP1 may be required for malignancy of DLBCL cells. In addition, we also found that the expression of RASIP1 was negatively regulated by forkhead box O3 (FOXO3), which has been reported to suppress the proliferation of DLBCL cells. Our results indicate that FOXO3 is bound to the promoter sequence of RASIP1 and inhibits its transcription. The suppressive effects of FOXO3 on proliferation and invasion of DLBCL cells were neutralized by RASIP1. In conclusion, we demonstrate that FOXO3 negatively regulated RASIP1 facilitates growth and invasion of DLBCL cells, provides novel diagnostic markers and therapeutic targets for DLBCL in clinic.
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PubMed
高影响因子
POLYMER
·
2023
·
IF 4.6
Yuhui Xie,Xue Lv,Xinyi Sui,Song Tian,Li'an Jiang,Shulin Sun
In this paper, the physicochemical double cross-linking nanocomposite hydrogels were prepared. Due to the addition of ionic liquid (1-butyl-3-methylimidazolium chloride salt), Laponite cannot spontaneously form a high thixotropic gel in water. The homogeneously dispersed Laponite nanosheets act as dynamic physical crosslinking sites, which cooperate with the chemical crosslinking center of MBA in the polymer chain segments and build a super-strong and super-tough hydrogel network structure. The PAM/Laponite/IL nanocomposite hydrogel achieves excellent tensile strength up to 1191 Kpa, a high tensile strain of 6842%, and a very high toughness of 26.62 MJ/m 3 . In this paper, an effective mechanism to enhance the mechanical properties of the hydrogel is proposed based on the structural evolution of Laponite. This highly flexible nanocomposite hydrogel shows excellent potential as a load-bearing material.
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Food Science and Human Wellness
·
2023
·
IF 7
Linglin Fu,Rongrong Wang,Jinru Zhou,Chong Wang,Yanbo Wang
N -glycans in many proteins are of great concern because of their strong association with food allergies. Triticum aestivum (bread wheat), a major food crop, is known as one of the “Big Eight” allergenic groups. However, little research has been done about N -glycans in wheat glycoproteins. In this study, a soluble wheat glycoprotein was purified from wheat and further identified as globulin-1 S allele (GSA). The wheat GSA displayed significant IgE-binding activity. Moreover, one N -glycosylation site and 6 kinds of N -glycans were identified by mass spectrometry, including 3 high mannose types and 3 complex types. Furthermore, the IgE-binding activity of wheat GSA is proved to be reduced by the removal of N -glycan, thermal treatment (temperatures > 80 °C), and strong acidic treatment (pH 3.0). These findings would provide a better understanding of the effects of N -glycosylation, thermal treatment, and acidic treatment on the molecular characteristics of GSA, and further provide new insights into the development of hypoallergenic wheat products.
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AICHE JOURNAL
·
2019
·Vol. 65
·期 6
·e16605
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IF 3.463
Min Xiao,Wenchao Zheng,Helei Liu,Paitoon Tontiwachwuthikul,Zhiwu Liang
1-(2-Hydoxyethyl)-piperidine (1-(2HE)-PP) is a new tertiary amine with desirable properties and can be potentially used to formulate superior absorbents for CO 2 capture. The equilibrium CO 2 solubility of 1-(2HE)-PP solution is measured over temperatures from 298 to 333 K, CO 2 partial pressures from 8.1 to 101.3 kPa and initial amine concentrations from 1 to 5 M. Two thermodynamic models, namely semiempirical model and activity coefficient model are developed for the system. The activity coefficient model shows better estimation solubility with an absolute average relative deviation (AARD) of 7.6%. In the comparison between the two models, a comprehensive analysis is presented. Some suggestions are provided for the similar model development. In addition, the speciation plot of CO 2 loaded 1-(2HE)-PP solution is predicted based on the activity coefficient model. The predictive pH values agree well with experimental data with AARD of 1.0%. Finally, the potential of 1-(2-HE)PP to be an alternative amine in CO 2 capture is evaluated.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2019
·
IF 2.298
Lemeng Wang,Xiangfeng Tian,Chi Fang,Hao Huang,Dong Fu,Yuheng Quan
In this work, the surface tensions (γ) of the aqueous blends of 1-dimethylamino-2-propanol (DMA2P) + amino acid ionic liquids (AAILs) were studied using the Wilhelmy plate method at temperatures from 303.2 to 323.2 K and atmospheric pressure. The AAILs include tetramethylammoniumglycinate ([N1111][Gly]), 1-butyl-3-methylimidazolium glycinate ([Bmim][Gly]), and 1-butyl-3-methylimidazolium-l-lysinate ([Bmim][Lys]). The concentrations of DMA2P and AAILs were varied between 0.300 and 0.500 wt % and 0.025 and 0.075 wt %, respectively. A thermodynamic correlation approach with respect to the mass fraction and temperature was employed to correlate the surface tension of DMA2P–AAILs aqueous solutions. The surface entropy (SS) and surface enthalpy (HS) were calculated from the analytical formulation, and their variation with mass fraction and temperature was demonstrated. The effects of the types of AAILs on the surface properties were also analyzed and compared.
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高影响因子
ACS Applied Nano Materials
·
2019
·
IF 0
Yanan Sun,Yuwei Wu,Chaoran Yu,Li Zhang,Gang Song,Zhiyi Yao
We report nanoscale pyrenyl excimers induced by the self-assembly of a pyrene-based fluorescent probe, 12-pyren-1-yldodecanoic acid (PyDA), for rapid detection of 2,4,6-trinitrotoluene (TNT) in aqueous media. Under the optimized conditions, the sensing nanosystem exhibited fast response and high selectivity and sensitivity for the detection of TNT. Especially, it could distinguish TNT from TNP, which is the major interferent in most circumstances. The detection limit is as low as 5.0 × 10–9 M. It also can be used for qualitatively and quantitatively monitoring TNT in real samples.
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ORGANIC & BIOMOLECULAR CHEMISTRY
·
2019
·Vol. 17
·期 21
·5381-5391
·
IF 3.49
Chunfeng Jiang,Quan Liu,Jiaming Liu,Kaixuan Liu,Liangliang Tian,Mingfei Duan,Ying Wang,Zhufang Shen,Youjun Xu
A convenient synthesis of novel 3-deoxy-5-hydroxy-1-aminocarbasugars was developed here. The benzyl-protected glucose-derived ketone 12 was selectively converted in high yield to enone 13via retro-Michael elimination of BnOH. The double bond of 13 was regio- and stereo-selectively reduced by the induction of C4-α-OBn to the multi-functionalized 15. 15 contained all the functionalities with similar configurations to carbasugars but with 3-H and 5-OH in the ring, and it would be a very interesting building block for organic synthesis or for bioactive compounds. As one application, 15 was further transformed into 1-amino-carbasugars by the reductive amination and final deprotection of benzyls. The targets were subjected to the in vitro inhibitory activity test against sucrase or maltase. The inhibitory activity of 17b, 17h or 17j against sucrase was nearly similar to that of voglibose. In comparison with voglibose, in vivo results similarly showed that 17b, 17h or 17j could lower the post-prandial blood glucose level after sucrose loading in healthy male ICR mice, while miglitol or acarbose was less effective. The molecular modeling study of some targets or voglibose with human sucrase could explain the inhibiting action.
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DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
·
2019
·
IF 3.119
Liting Wu,Enxu Zhou,Along Gao,Linghe Kong,Siwei Wu,Xia Bian,Yuan Li,Bingxi Li,Shengli Fu,Zheng Guo,Jianmin Ye
B lymphocyte-induced maturation protein 1 (Blimp-1), a transcription factor containing zinc finger , is required and sufficient to trigger terminal differentiation of B cells in mammals. The Blimp-1 ( OnBlimp-1 ) from Nile tilapia ( Oreochromis niloticus ) was identified and characterized its expression pattern during B cell activation and maturation. The cDNA of OnBlimp-1 open reading frame is 2547 bp encoding a protein of 848 amino acids and the predicted molecular weight is 93.36 kDa. OnBlimp-1 contains a SET domain and five ZnF_C2H2 domains, which shares high homology with that of other species. OnBlimp-1 transcription was detected in all examined tissues with high expression in the spleen (SPL). Analysis of sorted lymphocyte populations , including IgM + and IgM − cells from peripheral blood (PBL), SPL and anterior kidney (AK), indicated that the OnBlimp-1 transcription was highly expressed in the IgM + B cells. Upon LPS stimulation, OnBlimp-1 expression was up-regulated in tissues of PBL, SPL and AK significantly. The expression of OnBlimp-1 , as well as the secreted IgM , was significantly up-regulated in the SPL and AK leukocytes stimulated with anti-OnIgM monoclonal antibody and LPS in vitro , respectively. Above results suggest that OnBlimp-1, a cytokine regulating the terminal differentiation of activated B cells to antibody-secreting cells, is likely to play important roles in B cell activation and maturation in Nile tilapia.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Jingcheng Du,Changyuan Zhang,Hong Pu,Yufeng Li,Saimeng Jin,Luxi Tan,Cailong Zhou,Lichun Dong
Oil/water separation is an urgent topic because the frequently occurred oil leakages and increasing discharge of oily wastewater. The 3D metal foams with special wettabilities are promising oil/water separation materials owing to their outstanding properties. Herein, we fabricated a HKUST-1 MOFs decorated copper foam using a facile template-sacrificial method for oil/water separation. The as-prepared copper foam possessed good superhydrophobicity under broad pH and saline conditions. Its oil adsorption capability was larger than 150% for all the chosen oils and the oil/water separation efficiency of the foam for various oil/water mixture was larger than 96%. Furthermore, although the wettability decreased to hydrophobic state after 30 cycles of mechanical abrasion, the separation efficiency of the foam kept above 97%, showing good repeatability. Results demonstrated that the distinctive 3D structure of copper foam contributed the excellent durability to mechanical abrasion.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Hai-Bin Qiu,Yi Hu,Han-Juan Chong,Li Yuan,Guo-Ping Sheng
Ionic liquids (ILs) have been widely applied in chemical industry due to their unique properties. There is mounting evidence that they are toxic to various living organisms. Thus, it is crucial to develop methods to efficiently degrade and mineralize ILs to reduce their potential risks to the environment. In this work, the degradation of 1-butyl-3-methylimidazolium bromide ([C 4 MIM]Br), an imidazolium-based IL, was investigated in aqueous solution via 60 Co γ-ray irradiation. Results show that [C 4 MIM]Br could be effectively degraded by γ-ray irradiation. The irradiation-induced degradation of [C 4 MIM]Br fitted well to the pseudo-first-order kinetics model. The kinetic constant ( k ) increased linearly with the increase of irradiation dose rate (R 2 = 0.942) and solution pH value (R 2 = 0.974), and decreased with the increase of [C 4 MIM]Br concentration. Fourteen intermediates were detected using a liquid chromatography-mass spectrometry analysis. Based on these intermediate products, the degradation pathways and mechanisms of [C 4 MIM]Br were proposed. The free radicals (e.g., aqueous electron (e aq – ), hydroxyl radical ( OH), and hydrogen atom (H )) generated by γ-ray irradiation showed synergistic effects in the degradation and mineralization of [C 4 MIM]Br. Moreover, the toxicity assessment using C. elegans and Chlorella pyrenoidosa as model organisms demonstrates that sufficient γ-ray irradiation could effectively reduce the potential risks of [C 4 MIM]Br and its intermediates to the environment. These findings of this study may offer an efficient and environmentally friendly approach for effectively removing ILs and other persistent organic pollutants.
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