Journal of Environmental Sciences
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2013
·
IF 1.773
Liping Hao,Fan Lü,Lei Li,Liming Shao,Pinjing He
To use the selective inhibition method for quantitative analysis of acetate metabolism in methanogenic systems, the responses of microbial communities and metabolic activities, which were involved in anaerobic degradation of acetate, to the addition of methyl fluoride (CH 3 F), 2-bromoethanesulfonate (BES) and hydrogen were investigated in a thermophilic batch experiment. Both the methanogenic inhibitors, i.e., CH 3 F and BES, showed their effectiveness on inhibiting CH 4 production, whereas acetate metabolism other than acetoclastic methanogenesis was stimulated by BES, as reflected by the fluctuated acetate concentration. Syntrophic acetate oxidation was thermodynamically blocked by hydrogen (H 2 ), while H 2 -utilizing reactions as hydrogenotrophic methanogenesis and homoacetogenesis were correspondingly promoted. Results of PCR-DGGE fingerprinting showed that, CH 3 F did not influence the microbial populations significantly. However, the BES and hydrogen notably altered the bacterial community structures and increased the diversity. BES gradually changed the methanogenic community structure by affecting the existence of different populations to different levels, whilst H 2 greatly changed the abundance of different methanogenic populations, and induced growth of new species.
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HETEROATOM CHEMISTRY
·
2014
·Vol. 26
·期 2
·142-149
·
IF 1.257
Xuefang Shang,Wanli Li,Xiaofang Wei,Huanle Zhang,Zhiyuan Fu,Jinlian Zhang,Xiufang Xu
Two new compounds ( 1 and 2 ) containing 2-sulfydryl-1,3,4-thiodiazole have been synthesized and optimized. They both showed wide antibacterial activity for colon bacillus, Staphylococcus aureus , S. albus , dysentery bacillus and inferior activity for Bacillus subtilis . In addition, their binding properties were evaluated for biologically important anions (F – , Cl – , Br – , I – , AcO – , and H 2 PO 4 – ) by theoretical investigation, UV–vis, fluorescence, and 1 H NMR titration experiments, and they displayed strong binding ability for H 2 PO 4 – without the interference of other anions tested. Especially the binding ability of compound 2 containing anthracene with H 2 PO 4 – was 1000 times stronger than that of compound 1 containing nitrobenzene. Two compounds based on 2-sulfydryl-1,3,4-thiodiazole have both properties of anion recognition and antibacterial activity.
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ACS Applied Materials & Interfaces
·
2013
·
IF 5.008
Chaoran Li,Zanyong Zhuang,Feng Huang,Zhicheng Wu,Yangping Hong,Zhang Lin
Treatment of wastewater containing low-concentration yet highly-expensive rare earth elements (REEs) is one of the vital issues in the REEs separation and refining industry. In this work, the interaction and related mechanism between self-supported flowerlike nano-Mg(OH)2 and low-concentration REEs wastewater were investigated. More than 99% REEs were successfully taken up by nano-Mg(OH)2. Further analysis revealed that the REEs could be collected on the surface of Mg(OH)2 as metal hydroxide nanoparticles (<5 nm). An ion-exchange model was proposed as a critical factor for both guaranteeing the reaction speed and maintaining the self-supported structure of the materials. In addition, a method was developed to further separate the immobilized REEs and the residual magnesium hydroxide by varying the solution pH. In a pilot-scale experiment, the REEs from practical wastewater were immobilized effectively at a high flow rate. We anticipate this work can provide a good example for the recycling of valuable REEs in practical industrial applications.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2015
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IF 7.435
Dongting Yue,Taiyang Zhang,Miao Kan,Xufang Qian,Yixin Zhao
The sulfur tolerant Mo 3 S 13 2− /BiOBr nanocomposite photocatalysts were facilely fabricated by a hydrothermal method. The characterizations including X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectrometry (EDS), UV–vis diffuse reflection spectroscopy (DRS) and photoluminescence (PL) investigate the structures, elemental composition, morphologies and photocatalytic activities of Mo 3 S 13 2− /BiOBr nanocomposite. The 5.0 wt% Mo 3 S 13 2− /BiOBr composite sample showed highest visible-light-driven photocatalytic activity for decolorization of organic dyes including Rhodamine B (RhB) and sulfure containing methylene blue (MB). The decolorization of RhB was dominated by the direct hole and the generated O 2 − radicals oxidation process . Our 5.0 wt% Mo 3 S 13 2− /BiOBr nanocomposite exhibited comparable photocatalytic activity as the state of art 1 wt% BiOBr/Pt composite for photocatalytic decolorization of RhB. The 5.0 wt% Mo 3 S 13 2− /BiOBr composite possessed better sulfur resistance than 1.0 wt% Pt/BiOBr composite.
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Catalysts
·
2025
·Vol. 15
·期 3
·219
·
IF 4
Xuan Han,Chao Guo,Hui Wang,Weijuan Xu,Qinlian Liu,Qingshan Zhao,Mingbo Wu
Hydrogen production from water electrolysis offers a highly promising and sustainable route to solve the energy crisis. However, it is severely limited by the sluggish kinetics of the oxygen evolution reaction (OER) occurring on the anode. Herein, employing carbon dots functionalized with benzene sulfonate groups (BS-CDs) as a distinctive inductor, a Co(OH)2catalyst featuring abundant defects was synthesized for an enhanced OER. The highly hydrophilic nature of BS-CDs exerts a significant interfacial induction effect on the growth dynamics of Co(OH)2, fostering the formation of elevated crystal defects and a substantial quantity of oxygen vacancies. The resulting BS-CDs/Co(OH)2catalyst requires an overpotential of only 340 mV to achieve a current density of 10 mA cm−2in alkaline media, demonstrating markedly improved OER activity compared to pristine Co(OH)2and N-CDs/Co(OH)2induced by amine-modified CDs. Furthermore, the structural integrity of the catalyst is maintained, with a current retention rate of 92% observed following a 20 h stability assessment. This work provides a novel approach for developing cost-effective transition metal catalysts that exhibit exceptional catalytic efficiency and excellent stability for the OER.
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ACS Applied Nano Materials
·
2024
·
IF 5.3
Ke Ma,Meng Yin,Xiao-Xue Wang,Chen-Yu Wang,Ke-Zheng Chen,Sheng-Lin Qiao
There is an urgent need for efficient and convenient methods to detect SARS-CoV-2 as the global pandemic continues. Currently, detection of COVID-19 relies primarily on reverse transcription PCR (RT-PCR), a laboratory-based method that is time-consuming. To tackle this challenge, the study proposes an immediate high-throughput detection platform for SARS-CoV-2. The platform uses a gold nanoenzymatic colorimetric assay that focuses on the specific detection of 3CLpro in SARS-CoV-2. The platform has been extensively characterized for stability, sensitivity, detection range, and response time. The colorimetric detection method not only provides easy-to-read results but also allows color readings to be taken using a smartphone, with accuracy comparable to that of large instruments such as a microplate reader. The innovation of this technology lies in the ability to achieve instant high-throughput detection, which makes rapid detection of SARS-CoV-2 feasible. The proposed detection platform has a wide range of potential applications, particularly in the field of virus detection, providing an efficient and reliable solution for managing current pandemics and future disease prevention and control.
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Brain Sciences
·
2024
·Vol. 14
·期 4
·327
·
IF 2.7
Yuhan Wu,Hui Hu,Weiwei Liu,Yun Zhao,Fang Xie,Zhaowei Sun,Ling Zhang,Huafeng Dong,Xue Wang,Lingjia Qian
Lactate has emerged as a key player in regulating neural functions and cognitive processes. Beyond its function as an energy substrate and signal molecule, recent research has revealed lactate to serve as an epigenetic regulator in the brain. However, the molecular mechanisms by which lactate regulates spatial memory and its role in the prevention of cognitive disorders remain unclear. Herein, we injected L-lactate (10 μmol/kg/d for 6 d) into the mouse’s hippocampus, followed by the Morris water maze (MWM) test and molecular analyses. Improved spatial memory performances were observed in mice injected with lactate. Besides, lactate upregulated the expression of synaptic proteins post-synaptic density 95 (PSD95), synaptophysin (SYP), and growth associated protein 43 (GAP43) in hippocampal tissues and HT22 cells, suggesting a potential role in synaptic transmission and memory formation. The facilitative role of monocarboxylate transporter 2 (MCT2), a neuron-specific lactate transporter, in this process was confirmed, as MCT2 antagonists attenuated the lactate-induced upregulation of synaptic proteins. Moreover, lactate induced protein lactylation, a post-translational modification, which could be suppressed by MCT2 inhibition. RNA sequencing of lactated-injected hippocampal tissues revealed a comprehensive gene expression profile influenced by lactate, with significant changes in genes associated with transcriptional progress. These data demonstrate that hippocampal lactate injection enhances spatial memory in mice, potentially through the upregulation of synaptic proteins and induction of protein lactylation, with MCT2 playing a crucial role in these processes. Our findings shed light on the multi-faceted role of lactate in neural function and memory regulation, opening new avenues for therapeutic interventions targeting cognitive disorders.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yuping Wang,Yiting Lei,Nan Wang,Jun Zhang,Wenguo Cui,Xiaoji Luo
The challenge of achieving graded regeneration of adjacent tissues remains significant in tissue repair and regeneration. For instance, the disruption of the microenvironment caused by “osteogenesis mobilization” often results in fibrosis of the regenerated cartilage, ultimately leading to osteoarthritis. Inspired by the utilization of activated carbon for adsorbing and filtering small particles in air purification and water treatment, we have designed an integrated hydrogel scaffold capable of absorbing the endogenous BMP-2 produced by “osteogenesis mobilization”, confining it to the bone defect area, and preventing its diffusion into the cartilage region, thereby facilitating physiological osteochondral gradient regeneration. The osteogenic layer of this integrated scaffold is NHAP-AHAMA-B2A, which captures the BMP-2 produced by “osteogenesis mobilization” and amplifies its osteogenic effect through the grafted peptide B2A. This upregulation enhances the expression of ALP, OCN, and OPN in MSCs within the osteogenic layer, promoting osteogenic differentiation. The chondrogenic layer, HAMA-B2A, utilizes the peptide B2A to upregulate the expression of COL II and ACAN in MSCs, fostering chondrogenic differentiation. This integrated HAMA-B2A/NHAP-AHAMA-B2A hydrogel scaffold confines the BMP-2 produced by “osteogenesis mobilization” to the bone defect area, prevents its diffusion into the cartilage defect area, and effectively utilizes it to induce stem cell osteogenic differentiation. Simultaneously, it induces stem cell chondrogenic differentiation in the cartilage defect area, achieving transparent cartilage regeneration. In summary, the osteogenic and chondrogenic layers of this integrated scaffold collaborate to achieve a physicochemical gradient regeneration of bone-cartilage.
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Food & Function
·
2024
·
IF 5.1
Li Fan,Lijuan Zhao,Yangbo Zhu,Lin Li,Xueping Yang,Ping Ma,Jian Liu,Qingwei Zhao,Xiaobo Li
Hydroxytyrosol (HT), a phenolic extra–virgin olive oil compound used as a food supplement, has been recognized to protect liver function and alleviate stress–induced depressive–like behaviors. However, its protective effects against stress–induced liver injury (SLI) remain unknown. Here, the anti–SLI effect of HT was evaluated in mice with chronic unpredictable mild stress–induced SLI. Network pharmacology combined with molecular docking was used to clarify the underlying mechanism of action of HT against SLI, followed by experimental verification. The results showed that accompanying with the alleviation of HT on stress–induced depressive–like behaviors, HT was confirmed to exert the protective effects against SLI, as represented by reduced serum corticosterone (CORT), aspartate aminotransferase and alanine aminotransferase activities, as well as repair of liver structure, inhibition of oxidative homeostasis collapse, and inflammation reaction in the liver. Furthermore, core genes including histone deacetylase 1 and 2 (HDAC1/2), were identified as potential targets of HT in SLI based on bioinformatic screening and simulation. Consistently, HT significantly inhibited HDAC1/2 expression to maintain mitochondrial dysfunction in an autophagy–dependent manner, which was confirmed in a CORT–induced AML–12 cell injury and SLI mice models combined with small molecule inhibitors. We provide the first evidence that HT inhibits HDAC1/2 to induce autophagy in hepatocytes for maintaining mitochondrial dysfunction, thus preventing inflammation and oxidative stress for exerting an anti‒SLI effect. This constitutes a novel therapeutic modality to synchronously prevent stress‒induced depression‒like behaviors and liver injury, supporting the advantaged therapeutic potential of HT.
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Journal of Materials Chemistry C
·
2025
·
IF 5.1
Zuhuan Lu,Yukun Wang,Jing Zhang,Xujianeng Du,Wenhong Sun
Tin dioxide (SnO2) is a widely used electron transport layer (ETL) in perovskite detectors, and optimizing the ETL is a common strategy to enhance detector performance. However, SnO2 films prepared via solution methods exhibit numerous defects, which degrade device performance. In this study, 2-fluoroethylamine hydrochloride (2-FN), containing both fluorine (F) and chlorine (Cl), was incorporated into SnO2 films. The incorporation of 2-FN effectively reduced oxygen vacancies in SnO2, passivated defects, and enhanced electrical conductivity. Additionally, the presence of 2-FN in the SnO2 film facilitated the growth and crystallization of the perovskite film, increased the size of perovskite grains, and improved crystallinity. Consequently, the external quantum efficiency (EQE) of the perovskite detector improved from 86.92% to 91.11%. Simultaneously, the dark current density decreased from 2.47 × 10−9 to 1.26 × 10−10 A cm−2, and the linear dynamic range (LDR) increased from 93.62 to 117.85 dB. The device stability was also enhanced due to the reduction of oxygen vacancies, with the 2-FN-doped perovskite detector maintaining 72.66% of its initial EQE after 32 days in a dark environment at 25 °C and 20–30% relative humidity.
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Nature Chemistry
·
2024
·Vol. 16
·期 6
·893-900
·
IF 19.2
Zhang Lei,Bai Rui,Lin Jin,Bu Jun,Liu Zhenpeng,An Siying,Wei Zhihong,Zhang Jian
Metal-free catalysts offer a desirable alternative to traditional metal-based electrocatalysts. However, metal-free catalysts, featuring defined active sites, rarely show activities as promising as metal-based materials. Here we report 2-thiolimidazole as an efficient metal-free catalyst for selective electrocatalytic hydrogenation of acetylene into ethylene. Under alkaline conditions, the sulfhydryl and imino groups of 2-thiolimidazole are spontaneously deprotonated into dianions. Deprotonation thus enriches the negative charges of pyridinic N sites in 2-thiolimidazole to enhance the adsorption of electrophilic acetylene through the σ -configuration. Ethylene partial current densities show a volcano relationship with the negative charges of the pyridinic N sites in various imidazole derivatives. Consequently, the deprotonated 2-thiolimidazole exhibits an ethylene partial current density and faradaic efficiency competitive with metal-based catalysts like Cu and Pd. This work highlights the tunability and promising potential of metal-free molecules in electrocatalysis.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Yu Zhu,Xiang-Yu Ma,Ling-Ge Cui,Ya-Ru Xu,Chen-Xi Li,Milton Talukder,Xue-Nan Li,Jin-Long Li
Di(2-ethylhexyl) phthalate (DEHP) is a synthetic chemical applied as a plasticizer. As an environmental toxicant, DEHP poses a serious health threat. Many studies have revealed that DEHP can cause lead to various degrees of damage to the kidney. However, the evidence of DEHP-induced renal ferroptosis has not been reported. The purpose of this work was to probe the specific role of lipophagy in DEHP-induced renal injury and to investigate the relationship between lipophagy and ferroptosis. Quail were treated with DEHP (250 mg/kg BW/day, 500 mg/kg BW/day and 750 mg/kg BW/day) for 45 days. Microstructural and ultrastructural observations showed that DEHP caused damage to glomerular and tubular cells, and autophagy with multilayer structures were observed, suggesting that DEHP can induce lipophagy. The results indicated that the iron homeostasis was abnormal and the lipid peroxidation was increased. SLC7A11 and SLC3A2 were down-regulated. PTGS2, ACSL4 and LPCAT3 were elevated. In conclusion, DEHP could induce lipid peroxidation, lead to ferroptosis, and damage renal cells. Therefore, the relationship between lipophagy and ferroptosis was elucidated, which provided a new basis for intervention and prevention of DEHP increased diseases.
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