ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Ding Wang,Lifeng Deng,Haijie Cai,Jialin Yang,Liping Bao,Yongheng Zhu,Xianying Wang
As a foodborne bacterium, Listeria monocytogenes (LM) can cause serious diseases and even death to weak people. 3-Hydroxy-2-butanone (3H-2B) has been proven to be a biomarker for exhalation of LM. Detection of 3H-2B is a fast and effective method for determining whether the food is infected. Herein, we present an excellent 3H-2B gas sensor based on bimetallic PtCu nanocrystal modified WO3 hollow spheres. The structure and morphology of the PtCu/WO3 were characterized, and their gas sensitivities were measured by a static testing method. The results showed that the sensor response of WO3 hollow spheres was enhanced by about 15 times after modification with bimetallic PtCu nanocrystal. The maximum response value of the PtCu/WO3 sensor to 10 ppm 3H-2B is as high as 221.2 at 110 °C. In addition, the PtCu/WO3 sensor also exhibited good selectivity to 3H-2B, fast response/recovery time (9 s/28 s), and low limit of detection (LOD < 0.5 ppm). Furthermore, the sensitivity mechanism was studied by monitoring the reaction products by gas chromatography–mass spectrometry. The excellent gas-sensing performance can be attributed to the synergy between PtCu and WO3, including the unique spillover effect of O2 on PtCu nanoparticles, the regulated depletion layer by p-type CuxO to n-type WO3, and their selective catalysis to 3H-2B. Hence, this work offers the rational design and synthesis of highly efficient sensitive materials for the detection of LM for food security.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2020
·
IF 4.192
Jianxia Sun,Xinghua Li,Haixia Luo,Lijun Ding,Xinwei Jiang,Xusheng Li,Rui Jiao,Weibin Bai
Pyranoanthocyanins are the important color and functional compounds in red wine. Six common kinds of pyranoanthocyanins were synthesized through the reaction of malvidin-3-O-glucoside (Mv-3-gluc) with acetone, pyruvic acid, p-cumaric acid, caffeic acid, ferulic acid, and sinapid acid, respectively, and their pH (1.0–11.0), SO2 (0–250 ppm), and thermo (50–98 °C) stabilities and antioxidant activities were comparatively studied. Results showed that the six pyranoanthocyanins all exhibited higher pH and SO2 color stability than Mv-3-gluc, especially vitisin-A with a carboxy group on the D ring. The six pyranoanthocyanins also showed much more thermostability than Mv-3-gluc, especially methylpyranomv-3-gluc. The degradation kinetics of Mv-3-gluc and its derivatives all fitted to a first-order reaction. Moreover, pinotin-A with the o-dihydroxyl group on the E ring presented the strongest antioxidant capability, as evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric ion reducing power (FRAP) assays. Additionally, the increase in the number of rings is beneficial to the improvement of the DPPH radical scavenging ability of anthocyanins.
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POLYMER BULLETIN
·
2020
·Vol. 78
·期 2
·753-768
·
IF 2.014
Wu Jie,Zhai Wentao,Gao Xue,Liu Bingxin,Zhang Ruling,Yu Yueqin
Well-defined triblock copolymers poly( N -isopropylacrylamide)-b-poly(3-methacryloxypropyltrimethoxysilane)-b-poly( N -isopropylacrylamide) (PNIPAM-b-PMEMO-b-PNIPAM) with varying block ratios were successfully synthesized via reversible addition–fragmentation chain transfer polymerization. The amphiphilic triblock copolymers showed surfactant-like behavior in aqueous solution and could easily self-assemble into dendritic micelles with hydrophobic PMEMO as the core and hydrophilic PNIPAM as the shell when the copolymer concentration exceeded the critical micelle concentration (CMC). Transmittance measurements showed the triblock copolymers were thermosensitive, and it was worth noting that the lower critical solution temperature (LCST) values of copolymers exceeded pure PNIPAM to about 35.3 °C, which was very close to physiological temperature of human body. This was attributed to the effect of Si–O–CH 3 hydrolysis in polymers. The effect of a series of inorganic salts on thermosensitivity of PNIPAM-b-PMEMO-b-PNIPAM was investigated, and our results suggested that the block copolymers maintained good thermosensitivity in all salt solutions. The LCST did not change significantly in different concentrations of NaCl, CaCl 2 and MgCl 2 solutions, which proved the polymer had good salt resistance. Dynamic light scattering experiments showed that the micelles were well dispersed at about 120 nm below LCST with a small polydispersity index. In addition, the drug-loading experiments of micelles showed high drug encapsulation efficiency indicating their potential as drug carriers.
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MICROCHEMICAL JOURNAL
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2020
·
IF 3.594
Lianjing Zhao,Dehao Kong,Zepei Wu,Guannan Liu,Yuan Gao,Xu Yan,Fangmeng Liu,Xiaomin Liu,Chenguang Wang,Jiuwei Cui,Geyu Lu
The combination of nanomaterials and DNA has captured extensive attention in the fields of sensor, catalysis, biomedicine and material science. The applications of DNA functionalized MoS 2 nanosheets (NSs) in biosensor and biomedicine in turn present an fascinating topic about biointerface science between DNA and MoS 2 NSs. The surface interaction between DNA and MoS 2 NSs was explored by adsorption and desorption experiments. The results indicated that van der waals force played an crucial role in DNA adsorption by MoS 2 NSs. Additionally, it was proved that the quenching of dye labelled DNA probe by MoS 2 NSs was attributed to fluorescence resonance energy transfer. Based on the extraordinarily high quenching efficiency of MoS 2 NSs and different adsorption affinity of MoS 2 NSs toward aptamer and aptamer-targeted protein, an aptameric biosensor was fabricated to detect carbohydrate antigen 15–3. The fabricated biosensor not only displayed high sensitivity with the detection limit of 0.0039 U/mL (S/N = 3), but also exhibited good stability and selectivity. The proposed sensing platform provided an easy-constructed and cost-effective protocol to detect other aptamer targeted biomolecules. The fundamental study of biointerface science on DNA and MoS 2 NSs will facilitate their potential applications in various fields.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2020
·
IF 2.627
Xiujuan Li,Le Chen,Dandan Zhu,Song Yang,Zhong Wu,Mingyang He,Zhihui Zhang,Qun Chen
A novel ZIF-8-CMC hybrid material was fabricated from the hybridization of ZIF-8 and carboxymethylcellulose (CMC) by impregnation method for n -hexane/3-methylpentane separation. The surface properties of ZIF-8 were tailored by introducing CMC into ZIF-8 nanoparticles . In this work, adsorption separation of n -hexane ( n HEX) and 3-methylpentane (3MP) on ZIF-8-CMC were investigated by batch vapor-phase adsorption and liquid-phase breakthrough adsorption. The adsorption selectivity of n HEX/3MP reversed from preferable adsorption of n HEX to preferable adsorption of 3MP upon the increasing of CMC containing in the hybrid materials. As the temperature increases, the adsorption amounts of n HEX and 3MP decrease. With the increasing of CMC contents, the n HEX uptake decreased, the uptake capacity of 3MP increased gradually. For liquid-phase breakthrough adsorption, the dynamic adsorption capacity of n HEX also decreased with the increasing of temperature.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2020
·Vol. 137
·期 47
·49559
·
IF 2.52
Yifan Wang,Ming Duan,Xiujun Wang,Bo Jing,Fei Wang,Yan Xiong,Shenwen Fang
Gas flotation is one of the important technologies for oily wastewater treatment and the surface-active polymer is an important kind of developing flotation agents. In this article, the flotation performance, polymerization kinetics, and copolymerization behavior of surface-active copolymer of N -[3-(dimethylamino) propyl] methacrylamide (DMAPMA) and dodecyl dimethyl propenyl ammonium chloride (C 12 DM) and copolymer of DMAPMA and decyl dimethyl vinylbenzyl ammonium chloride(C 10 MVBA) were investigated. The flotation experiment showed that both copolymers had an oil removal of 97% at the concentration of 30 mg/L. The result of polymerization kinetics showed that the polymerization initiation rate was influenced by the monomer concentration and the polymerization termination was dominated by bimolecular termination and accompanied by unimolecular termination. The activation energy of DMAPMA-C 12 DM copolymerization (89.64 kJ/mol) was smaller than that of DMAPMA-C 10 MVBA (91.65 kJ/mol) copolymerization. The reactivity ratios of DMAPMA and C 12 DM were 0.46 and 15.52, respectively, as well as the reactivity ratios of DMAPMA and C 10 MVBA were 1.19 and 35.77, respectively. These results are meaningful for the oily wastewater flotation and the copolymerization mechanism of DMAPMA-based copolymer.
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AQUATIC TOXICOLOGY
·
2020
·
IF 4.346
Lei Peng,Chang Wang,Pingdeng Li,Bo Cheng,Yeli Hu,Yang Cheng,Qi Zheng
Halogenated dipeptides, 3, 5-di-I-tyrosylalanine (DIYA), have been identified as novel disinfection byproducts (DBPs), following chloramination of authentic water. However, little is known about their toxicity. Zebrafish embryos were used to assess the toxicity of novel iodinated DBPs (I-DBPs). Although DIYA did not exhibit high acute toxicity to embryonic zebrafish (LC 50 > 2 mM), it significantly inhibited pigmentation of melanophores and xanthophores on head, trunk and tail at 500 μM as determined by photographic analysis. Whereas N-phenylthiourea (PTU) as a pigment inhibitor did not inhibit development of yellow pigments. Colorimetric detection of melanin further confirmed these results. Quantitative real time polymerase chain reaction (qRT-PCR) measurements indicated that genes ( dct , slc24a5 , tyr , tyrp1a , tyrp1b , silva ) associated with the melanogenesis pathway were dramatically down-regulated following exposure to 500 μM DIYA. In addition, enzymatic activity of tyrosinase (TYR) decreased, also demonstrating that the underlying mechanism of hypopigmentation was attributed to the disruption of melanogenesis pathway. Transcription levels of xanthophore genes ( gch2 , bnc2 , csf1a , csf1b , pax7a and pax7b ) were also monitored by qRT-PCR assay. DIYA exposure up-regulated expression of gch2 and bnc2 , but not csf1 and pax7 . Tested DIYA analogues, brominated tyrosine was unlikely to inhibit pigmentation, indicating that the iodine substitution and dipeptides structure are of important structural feature for the inhibition of pigmentation. In this study, we observed that DIYA inhibited melanogenesis related genes, which might contribute to pigmentation defects. Moreover, as an emerging I-DBPs, the developmental toxicity of aromatic dipeptides should be further studied.
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CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Ihtisham Ul Haq,Shen Hui Li,Hong-Gang Zhen,Rehan Khan,Ao-Shuai Zhang,Zhi-Ping Zhao
For separating 1, 3-butadiene (BD) from BD/N 2 mixture, among numerous studied metal–organic frameworks-based adsorbents, Ni-ZIF-8 was comparatively selected here based on intelligent gravimetric analysis, simulation studies, facile synthesis, and very good IAST selectivity. Experimental results showed good butadiene uptake capacity of Ni-ZIF-8 of 7.41 mol/kg, which is 42% higher than pure ZIF-8. Additionally, Ni-ZIF-8 exhibits IAST selectivities of 2826 and 3302 at 0.1 bar, at 25 and 45 °C respectively, for 20% BD/N 2 adsorption. The molecular simulation results showed that Ni-ZIF-8 has binding energies of 65.25, 9.54 kJ/mol, while ZIF-8 has 56.07, 15.03 kJ/mol for butadiene, and nitrogen, respectively. This strongly supported the experimental results. To the best of our knowledge, Ni-ZIF-8 showed the best working capacity of 5.91 mol/kg for butadiene among all the reported adsorbents. Moreover, dynamic adsorption experiments revealed that butadiene could be recovered from BD/N 2 mixtures at room temperature, suggesting great potential for industrial BD/N 2 separation.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2019
·
IF 3.571
Xiumei Wang,Xiaoli Qin,Xiuting Li,Zexin Zhao,Bo Yang,Yonghua Wang
n-3 polyunsaturated fatty acid (PUFA)-rich lysophosphatidylcholine (LPC) with many beneficial effects was effectively synthesized by immobilized MAS1 lipase-catalyzed esterification of n-3 PUFA with sn-glycero-3-phosphatidylcholine (GPC) under vacuum in a solvent-free system. Immobilized MAS1 lipase was found to be a more suitable catalyst for the production of n-3 PUFA-rich LPC when compared with Novozym 435. The maximal GPC conversion and LPC content (93.12% and 90.77 mol %) were obtained under the optimized conditions (enzyme loading of 300 U/g substrate, temperature of 55 °C, and n-3 PUFA/GPC molar ratio of 20:1). Moreover, it was observed that 1-acyl-sn-glycero-3-lysophosphatidylcholine (sn-1 acyl LPC) was the main reaction product, as demonstrated by molecular docking. These results showed that immobilized MAS1 lipase had high phospholipase activity with a predominant specificity for the sn-1 hydroxyl position of GPC to efficiently synthesize highly pure n-3 PUFA-rich LPC from GPC for industrial application.
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JOURNAL OF POLYMER RESEARCH
·
2019
·Vol. 26
·期 12
·1-12
·
IF 1.53
Jiao Yang,Chen Guofei,Zhou Haijun,Zhang Feng,Chen Xiaoqi,Li Yantao,Xiao Xueshan,Fang Xingzhong
A series of poly(benzimidazole-imide)s (PBIPIs) derived from different dianhydrides and 2-(3-aminophenyl)-5-aminobenzimidazole ( m -BIA) were synthesized via thermal imidization to form flexible films. This series of PBIPIs showed great T g s ranging from 296 to 484 °C, excellent thermal stability performed in 5% weight loss temperatures ( T d5% s) of 502–529 °C in N 2 and good mechanical properties (tensile strengths of 89–127 MPa, tensile moduli of 2.9–4.1 GPa and elongations at break of 3.9–6.9%). Compared with PIs derived from 6-amino-2-(4-(4-aminophenoxy)phenyl)-1H-benzimidazole ( p -BIODA), m -BIA based PBIPI films exhibited higher T g , and better solubility. Besides, the thermoplastic PBIPI resin (PI-6-PA) derived from 2,2-bis[4-(3,4-dicarboxyphenoxy)phenyl]propane dianhydride (BPADA) and m -BIA exhibited good melt processability with high T g of 273 °C, melt flow index (MFI) of 7.76 g/10 min, minimum complex viscosity of 11.9 × 10 3 Pa·s at 402 °C and low melt viscosity ratio of 2.46 at 400 °C.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2019
·Vol. 31
·期 2
·338-349
·
IF 2.162
Lei Yang,He-qing Fu
Based on the strong adsorption of the diphosphate group to Fe and Al ions, first, the Fe 3 O 4 and Al (OH) 3 nanoparticles were modified by alendronate sodium (ALN), and organic phosphorus coated nanoparticles (Fe 3 O 4 -ALN and Al (OH) 3 -ALN) with the active group ─NH 2 were prepared. Novel [ x Fe 3 O 4 –2 x Al(OH) 3 ]/waterborne polyurethane nanocomposite with superparamagnetism and excellent flame retardancy were prepared by in situ polymerization. The experimental results showed that when the content of Fe 3 O 4 -ALN increased, the M s increased. And the saturation magnetization reached 14.35 emu/g when the Fe 3 O 4 -ALN content was 10 wt%. The nanoparticle network formed by Fe 3 O 4 and Al (OH) 3 can prevent the melting deformation of waterborne polyurethane (WPU) composite film and reduce the burning area. And the dual physical protective layer formed by nanoparticle network and char layer can prevent the combustible gas contacting with oxygen and giving off combustion heat, which effectively reduced the heat and smoke gas release. When the content of x Fe 3 O 4 –2 x Al(OH) 3 was 20 wt%, the oxygen index of the composite was 28.4%, and the flame retardancy of nanocomposite was classified as V-0 rating in the UL-94 test.
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Journal of Functional Biomaterials
·
2023
·Vol. 14
·期 11
·546
·
IF 4.8
Qingfeng Guo,Jie Li,Jing Mao,Weijun Chen,Meiyang Yang,Yang Yang,Yuming Hua,Lipeng Qiu
Multidrug resistance (MDR) is a key factor in chemotherapy failure and tumor recurrence. The inhibition of drug efflux and autophagy play important roles in MDR therapy. Herein, a multifunctional delivery system (HA-MIL-125@DVMA) was prepared for synergistically reverse tumor MDR. Tumor-targeted hollow MIL-125-Ti nanoparticles were used to load the doxorubicin–vitamin E succinate (DV) prodrug and 3-methyladenine (3-MA) to enhance reverse MDR effects. The pH-sensitive DV can kill tumor cells and inhibit P-gp-mediated drug efflux, and 3-MA can inhibit autophagy. HA-MIL-125@DVMA had uniformly distributed particle size and high drug-load content. The nanoparticles could effectively release the drugs into tumor microenvironment due to the rapid hydrazone bond-breaking under low pH conditions, resulting in a high cumulative release rate. In in vitro cellular experiments, the accumulation of HA-MIL-125@DVMA and HA-MIL-125@DV in MCF-7/ADR cells was significantly higher than that in the control groups. Moreover, the nanoparticles significantly inhibited drug efflux in the cells, ensuring the accumulation of the drugs in cell cytoplasm and causing drug-resistant cells’ death. Importantly, HA-MIL-125@DVMA effectively inhibited tumor growth without changes in body weight in tumor-bearing mice. In summary, the combination of the acid-sensitive prodrug DV and autophagy inhibitor 3-MA in a HA-MIL-125 nanocarrier can enhance the antitumor effect and reverse tumor MDR.Keywords:hyaluronic acid;metal-organic framework;multidrug resistance;doxorubicin;3-methyladenine
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