JOURNAL OF THE ELECTROCHEMICAL SOCIETY
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2025
·Vol. 172
·期 3
·036503
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IF 3.3
Xiaoyan Wang,Hao Zheng,Huiling Chen,Bin Qiu,Yunliang Liu,Qing Ye
Interleukin-6 (IL-6) is a common proinflammatory cytokine and can be adopted as an important biomarker for several diseases including nasopharynx cancer, pancreatitis, infections, and cardiovascular. It is thus necessary to design an effective method for monitoring IL-6. Herein, by preparing gold nanoparticles/graphdiyne (Au/GRD) nanohybrid with simple electroless deposition as the sensing substrate and UiO-66 metal–organic frameworks/ferrocene (UiO/Fc) as the signaling-amplifier, a highly efficient sandwich-type electrochemical immunosensing (SEI) platform was proposed for IL-6 determination. The superior electrical properties, easy preparation, high surface area, and stability of Au/GRD make it a desirable substrate to immobilize the primary antibody of IL-6. Meanwhile, the unique structure of UiO-66 is beneficial to immobilizing the Fc probe and the secondary antibody. By optimizing experimental conditions, the Fc current obtained at the as-designed SEI platform increases along with IL-6 increase, and the related linearity is 0.5 pg ml−1–1200.0 pg ml−1 coupled with a low detection limit of 0.2 pg ml−1. It is expected the as-designed SEI platform based on Au/GRD and UiO/Fc shows potential applications for IL-6 analysis.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Rui Fan,Jingjing Dong,Xiaoxiao Li,Ying Chen,Zhengyu Jin,Yuxiang Bai
Reuteran is a functional homopolysaccharide comprising major (α1 → 4) and interspersed (α1 → 6) linkages whose properties and functions are directly associated with the structure. In order to enrich the structural variety and application prospects of reuteran, a GtfB-type 4,6-α-glucanotransferase from Limosilactobacillus mucosae L24-B (LmGtfB), which can synthesize reuteran with high-content linear (α1 → 6) linkages, was screened. LmGtfB exhibited 4,6-α-glucanotransferase activity against starch or dextrin and can synthesize both linear and branching (α1 → 6) linkages, which offered advantages in terms of source and cost. The as-produced reuteran had the highest content of linear (α1 → 6) linkages (19% in the methylation result) among the reuterans synthesized by other GtfB-type 4,6-α-glucanotransferases. A purification method was established and applied to the extraction of the core structure of the LmGtfB products. 1H NMR and enzymatic hydrolysis revealed that the core structure contains 46.24% (α1 → 6) linkages and alternating (α1 → 4)/(α1 → 6) linkages, which was formed by enzymatic transfer of maltose.
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POLYMER COMPOSITES
·
2024
·
IF 4.8
Haoqiang Du,Guijun Xian,Jingwei Tian,Zirong Ma,Chenggao Li,Meiyin Xin,Yunfeng Zhang
The mechanical properties of carbon fiber (CF) reinforced thermoplastic polymer composites are primarily governed by the interphase between CFs and matrix. However, the inherent inertness of CF surfaces combined with the high viscosity and processing temperatures of thermoplastic resin often result in relatively weak interfacial bonding. This study aims to enhance the interfacial adhesion of carbon fiber reinforced polyamide 6 composites to improve their mechanical properties. CFs were de-sized and oxidized, followed by re-sizing with silanized carbon nanotubes. Fracture morphology and composition analysis of the fibers were conducted, and the fibers were subsequently incorporated into composites for mechanical testing. Results revealed a 20.0% increase in tensile strength, a 25.11% increase in flexural strength, and a 24.88% increase in interlaminar shear strength for the resized-carbon fiber reinforced polyamide 6 composites compared to the pristine-carbon fiber reinforced polyamide composites. The cross-sectional morphology of the modified composites exhibited a zig-zag fracture pattern. Dynamic mechanical analysis indicated that the modified fibers required higher activation energy for the free movement of the polyamide 6 molecular chain. These findings suggest that surface treatment enhances the interfacial adhesive between CF and resin, thereby significantly improving the mechanical properties of carbon fiber reinforced polyamide 6 composites. Highlights An efficient and reliable carbon fiber surface treatment method is proposed. Surface modification improves surface chemical activity of carbon fibers. Composites show substantial improvements in mechanical properties. Interfacial performance enhancement mechanism of composite was revealed.
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CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Yanlin Wang,Xi Wang,Jingjing Mu,Hairong Yu,Xingbin Lv,Ting Liang,Changjing Cheng
Barium ions (Ba 2+ ) contamination is a serious environmental problem worldwide. The currently existing Ba 2+ -detection techniques are generally expensive, time-consuming, and complicated. Therefore, the development of a simple, inexpensive, rapid, and effective strategy to detect Ba 2+ in water is of great importance. Herein, we first report a smart photonic crystal hydrogel (PCH) sensor for simple, highly selective, and naked-eye detection of Ba 2+ in water based on 18-crown-6/Ba 2+ host–guest interactions. This sensor was composed of a poly(benzo-18-crown-6-acrylamide- co - N -isopropylacrylamide- co -acrylamide) (PBCNA) intelligent hydrogel with embedding Fe 3 O 4 @SiO 2 colloidal photonic crystals (CPCs). The prepared PBCNA PCH sensor demonstrated pH and temperature-dependent Ba 2+ -detection performances. Besides, the Ba 2+ -responded PCH sensor could be easily regenerated via simple washing using hot/cold water at least 20 times without compromising its detection performance. Such a PCH sensor with obvious advantages of portability, ease of operation, cost-effectiveness, high selectivity and excellent regenerability, provides a simple and effective strategy to monitor Ba 2+ in contaminated water.
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MOLECULAR NUTRITION & FOOD RESEARCH
·
2025
·
IF 4.2
Xin Li,Bohan Sun,Yanting Qin,Fangfang Yue,Xin Lü
Fecal microbiota transplantation (FMT) could significantly alter the recipient's gut bacteria composition and attenuate obesity and obesity-related metabolic syndromes. DL-norvaline is a nonproteinogenic amino acid and possesses anti-obesity potential. However, the specific mechanisms by which gut microbiota might mediate beneficial effects of DL-norvaline have not been completely elucidated. In this study, DL-norvaline-mediated FMT upregulated the beneficial bacteria ( Clostridia_UCG_014 , Christensenellales , Bacilli , Ileibacterium , Dubosiella , Lactobacillus , Muribaculaceae , and Bacteroidaceae ) and downregulated the harmful bacteria ( Tuzzerella and Marinifilaceae ), further intestinal inflammation, oxidative stress, and intestinal barrier were alleviated as well as short chain fatty acids levels were increased, thus alleviating glucose and insulin metabolism, improving biochemical indexes and energy metabolism and decreasing body weight gain and tissue weight. However, heat-inactivated FMT did not demonstrate any of those improvements in obese mice. Notably, both DL-norvaline-mediated FMT and heat-inactivated FMT increased Bacteroidaceae and Muribaculaceae , this being a signature of alterations to the gut microbiota marker caused by DL-norvaline. Therefore, the beneficial effects of DL-norvaline were transmissible via FMT. This study highlighted the pivotal involvement of the gut microbiota in the development of obesity and provided a novel insight into the underlying mechanisms of FMT, thereby potentially enhancing the efficacy and refinement of FMT utilization.
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2017
·
IF 4.159
Jinyu Li,Guoxin Tan,Bingchao Cheng,Dandan Liu,Weisan Pan
To facilitate the hydrophobic drugs modeled by coumarin-6 (Cou-6) acrossing the cornea to the anterior chamber of the rabbit eye, chitosan (CS) derivatives including chitosan-N-acetyl- l -cysteine (CS-NAC), chitosan oligosaccharides (COS) and carboxymethyl chitosan (CMCS) modified nanostructured lipid carriers (NLCs) were designed and characterized. We found that, with similar size distribution and positive charges, different CS derivatives based on NLCs led to distinctive delivery performance. In vivo precorneal retention study on rabbits revealed that these CS derivatives coating exhibited a stronger resistant effect than Cou-6 eye drops and Cou-6-NLC (P < 0.05), moreover, the AUC (0−∞) , C max and MRT (0−∞) of them followed the sequence of CMCS-Cou-6-NLC < COS-Cou-6-NLC < CS-NAC-Cou-6-NLC. Confocal laser fluorescence microscopy (CLSM) for in vitro corneal penetration study showed that COS-, and CS-NAC-coated NLCs penetrated through the whole corneal epithelium barrier (about 40 μm), while CMCS failed to significantly enhance the intraocular drug penetration as expected, displayed a negligible fluorescence at 30 μm deep. In addition, penetration through the intact cornea was achieved and the penetration levels through the ocular tissues were increased thoroughly for the COS and CS-NAC coating ones compared with CMCS-NLC (P < 0.05), and successfully reduced the conjunctival-to-corneal permeability ratio (ratio (C - S/C) ) thus resulted in a higher bioavailability, which was confirmed by ex vivo fluorescence imaging on ocular tissues. In summary, CS-NAC-NLC and COS-NLC are promising ocular drug delivery systems to achieve prolonged precorneal retention, higher corneal permeability and enhanced ocular bioavailability. And comparatively speaking, CS-NAC-NLC possesses the highest potential for ocular drug delivery.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jiancheng Sun,Chi Zhang,Rubing Zhang
Conventional rigid patch antennas, constrained by high-permittivity substrates ( ε r > 3.0) with severe dielectric loss ( tanδ > 0.02), suffer from catastrophic performance degradation at elevated frequencies (>3 GHz) and inherent inflexibility that fundamentally prohibits their integration in wearable electronics. This work presents a breakthrough in synthesizing PMMA-reinforced polyimide aerogels (PIAs) via a 10-min ambient pressure drying (APD) strategy, enabling tunable porosity (>90%) and ultra-low dielectric constants ( ε r = 1.35, tanδ < 0.01). The incorporation of PMMA into the PI matrix endows the aerogel skeleton with outstanding mechanical resilience (tensile strength of 7.2 MPa and fracture energy of 45.8 kJ/m 2 ), while effectively suppressing capillary-induced shrinkage to below 2.1% during solvent evaporation. The synergistic interplay between PMMA encapsulation and APD-optimized solvent exchange yields a hierarchical nanoporous structure (30 nm average pore size) with exceptional thermal insulation (0.036 W/m·K). When deployed as a substrate for flexible Sub-6 GHz patch antennas, the aerogel exhibits 106% gain enhancement (9.92 dBi) and broad impedance bandwidth (3.862–3.941 GHz), outperforming conventional FR-4 substrates. This work establishes a scalable, low-cost paradigm for multifunctional aerogels in wearable electronics and high-frequency communication systems.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yuanyan Luo,Tao Zhou,Costas Molochas,Yongkang Tan,Xiaoting Huang,Zhenyu Chen,Jinliang Zhu,Panagiotis Tsiakaras,Peikang Shen
Pt-Pd-Ni polyhedral nanobelt (PNBs) composite catalysts are synthesized in presence of tungsten hexacarbonyl [W(CO) 6 ] by a simple solvothermal method, combining both higher specific surface area and more index active site than the corresponding single-structure catalysts. The thermal decomposition of W(CO) 6 plays a crucial role in the morphology formation. The tenuous composite with a moderate nanobelt width of 7.46 nm formed after heating for 6 h (Pt-Pd-Ni PNBs2) shows better ORR performance and durability than the ternary (Pt-Pd-Ni) and binary (Pt-Pd) single structures. It exhibits a mass activity of 1.49 (A mg Pt −1 ), which only degrades by about 10.63 % after 50,000 durability cycles. The metal regulatory effects induced by the carbonyl compounds cause the contraction of the Pt-Pt bonds. Density functional theory calculations indicate that the compressive strain of Pt-Pd-Ni PNBs2 leads to a decrease in the d-band center and overpotential negatively shifted, thus provide a more sufficient and faster ORR proceeding process in thermodynamics, facilitating a higher energy conversion efficiency.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Zhang Shirong,Tan Yuxin,Liu Yilei,Li Yafei,Li Jishun,Zhang Shenglan,Pan Hongcheng
Quantum dots (QDs) have emerged as highly sensitive fluorescent markers for lateral flow immunoassays (LFIAs) due to their excellent fluorescence brightness and photostability. The incorporation of multiple QDs onto a carrier can further enhance detection sensitivity. However, traditional carriers such as polystyrene, while commercially successful, involve complex preparation processes and rely on organic solvents, which can lead to fluorescence quenching and adversely affect detection performance. In this study, we selected isoreticular metal–organic framework-3 (IRMOF-3), characterized by its porous structure, high surface area, and abundant amine functional groups, as the carrier. We synthesized IRMOF-3@CdSe/ZnS composite nanoparticles with an average diameter of 378 ± 46 nm by coupling carboxyl-modified CdSe/ZnS QDs to the IRMOF-3 surface through an aqueous synthesis method. These nanocomposites efficiently loaded a high density of QDs without aggregation, thereby maintaining strong fluorescence intensity. Moreover, the abundant amino and carboxyl groups on their surfaces facilitate efficient antibody conjugation, and the nanoparticles retain excellent water dispersibility after labeling. Utilizing IRMOF-3@CdSe/ZnS composite nanoparticles as immunomarkers, we developed a novel fluorescent LFIA for the detection of interleukin-6 (IL-6), a biomarker associated with various inflammatory and autoimmune diseases. The method achieved a limit of detection for IL-6 as low as 8.6 pg/mL, with relative standard deviations ranging from 2.73% to 6.14% and spiking recoveries between 96.4% and 110.8%. Passing-Bablok regression analysis demonstrated good consistency between our method and commercially available immunochromatography assays. The IRMOF-3@CdSe/ZnS composite nanoparticles, as a novel fluorescent label, exhibit considerable potential for applications in biomedical detection. Graphical abstract
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Nanoscale
·
2025
·
IF 5.1
Guanjun Liu,Yan Liu,Meng Zhang,Danyang Zhao,Ping Liu,Lu Wang,Lizhi Li,Meiling Yan
The rise of hydrogen energy places stringent demands on the mechanical strength and thermal conductivity of polyamide 6 (PA6) liners used in hydrogen storage tanks. However, the presence of weak interfaces in PA6 composites significantly hinders the efficient transfer of the intrinsic mechanical and thermal conductivity properties of the reinforcing phases. In this work, hydroxyl-functionalized carbon nanotubes (CNT-OH) were covalently grafted onto graphene oxide (GO) to construct a hybrid nanofiller, which was subsequently surface-functionalized with hexamethylene diisocyanate (HDI), yielding a reactive nanofiller (fGO+CNT-OH+HDI) rich in isocyanate groups. This functionalized nanofiller served as an activator during the in situ anionic ring-opening polymerization of ε-caprolactam, enabling the fabrication of PA6 composites with strengthened nanofiller/nanofiller and nanofiller/matrix interfacial interactions. Owing to the synergistic reinforcement from the hybrid nanofiller and its uniform dispersion driven by in situ polymerization, the resulting composite containing only 0.2 wt% fGO+CNT-OH+HDI exhibited outstanding mechanical performance, with a 36.3% increase in tensile strength and an exceptional elongation at break of 130.86%. In addition, the thermal conductivity was improved by 46.3%. This interfacial engineering strategy provides a promising pathway toward the development of high-performance liner materials for reliable and safe hydrogen energy applications.
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POLYMER ENGINEERING AND SCIENCE
·
2025
·
IF 3.2
Yong Wang,Yanqin Shi,Haojie Li,Meng Ma,Si Chen,Yulu Zhu,Huiwen He,Xu Wang
Epoxy adhesive is becoming increasingly widely used in industry and daily life. There are many requirements to adhere to high and low polar interfaces simultaneously. In this work, a high polar epoxy resin, N , N -bis(4-(oxiran-2-ylmethoxy) phenyl) adipamide (BOYPA), was designed and prepared. The relationship between the curing temperature and the curing time and the curing reaction kinetics equations of BOYPA and Bisphenol A diglycidyl ether (DGEBA) with diethylenetriamine (DETA) was clarified by the study of the curing kinetics according to the Kissinger equation and the Crane equation. Compared with DGEBA, BOYPA required higher curing activation energy and had a lower curing reaction rate. The curing reaction of BOYPA and DGEBA was both a simple curing reaction. Moreover, the peel strength between the PP film and PA6 board bonded by the mixture of BOYPA and DGEBA could be obviously enhanced with the increase of BOYPA content due to the proper polarity and the formation of hydrogen bonds. Meanwhile, the impact strength of the mixture of BOYPA and DGEBA was significantly improved because of the good toughness of BOYPA. As a result, this work provided a simple method for regulating the bonding properties of epoxy adhesive for different adherent surfaces.
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JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Qiqi Wang,Mei Liu,Shuo Wang,Lulu Shi
A novel supramolecular framework [Cd(QDS) 2 ]·(CB[6]) 2 ( 1 ) based on cucurbit[6]uril (CB[6]) and 8-hydroxyquinoline-5-sulfonic acid ion (QDS − ) was successfully synthesized under solvothermal conditions. The single crystal X-ray diffraction analyses indicated that the construction of this supramolecular framework is attributed to the non-covalent interactions between the QDS − and the outer surface of CB[6]. The performance study demonstrates that 1 exhibits a remarkable sensitivity and selectivity in detecting anions Cr 2 O 7 2− , MnO 4 − , furan antibiotics nitrofurantoin (NFT) and nitrofurazone (NFZ) through fluorescence quenching with the limit of detection (LOD) were 95, 89, 132, and 113 ppb, respectively. Meanwhile, due to the remarkable fluorescent properties of 1 , anti-counterfeiting marks were incorporated into the positioning boxes of quick response (QR) codes. The anticounterfeiting signs appear yellow in daylight while exhibit bright green fluorescence when excited at 365 nm. Furthermore, 1 also have been successfully applied to real samples with satisfactory results. These remarkable findings suggest that 1 hold promise as an effective fluorescent sensor.
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