ACS Omega
·
2019
·
IF 2.584
Ling Cai,Xijiang Qin,Zhihui Xu,Yiyan Song,Huijun Jiang,Yuan Wu,Hongjie Ruan,Jin Chen
Critical cytotoxicity evaluation of pharmaceuticals is necessary for the clinical practice of chemotherapy. To quantitatively evaluate cell viability, currently there are two main types of sensitive methods including real-time cell analysis (RTCA) and CCK-8 assay, in which RTCA records electrochemical signal changes around an incubated cell, whereas CCK-8 is based on the colorimetric method. Despite the different detection principles adopted for the cytotoxicity assessment, the comparison of the two methods in terms of the application scope is lacking. In this study, comparison studies were conducted between the RTCA and CCK-8 assays using anticancer drugs including doxorubicin hydrochloride, curcumin, irinotecan (CPT-11), taxol, and oxaliplatin, which are classified into two groups of drug molecules in the absence and presence of additives. The cytotoxicity evaluation of these drugs on cancer cells revealed that the physicochemical properties of drug formulations such as optical and electrochemical properties are closely linked with the readout of cytotoxic methods. The experimental results suggested that the preselection of cytotoxic assay is critical for the quantitative measurement of cytotoxicity of anticancer drugs, which is of clinical importance for their therapeutic usage.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2017
·Vol. 314
·期 1
·59-67
·
IF 1.282
Liu Zhanxiang,Dong Yang,Liao Jiali,Li Xingliang,Yang Jijun,Yang Yuanyou,Luo Shunzhong,Liu Ning
A novel extractant, 5-octyloxymethyl-7-bromo-8-quinolinol (HBrO 8 Q), was employed to extract Pd(II) from low-acidity aqueous solution. The extraction behaviors indicated that HBrO 8 Q had high extraction efficiency and selectivity for Pd(II) under the experimental conditions, and the stoichiometry of Pd(II) with HBrO 8 Q was found to be 1:1 by means of mole ratio method and Job’s method. The thermodynamic study indicated that the extraction process was endothermic and spontaneous. Additionally, complete back extraction of palladium could be achieved by using acidic thiourea solution.
✓ 已验证
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 48
·2204926
·
IF 15.153
Shuaijun Lu,Hailong Tian,Lei Li,Bowen Li,Mei Yang,Li Zhou,Hao Jiang,Qiong Li,Weihua Wang,Edouard C. Nice,Na Xie,Canhua Huang,Lin Liu
Chemo-phototherapy has emerged as a promising approach to complement traditional cancer treatment and enhance therapeutic effects. However, it still faces the challenges of drug efflux transporter-mediated chemoresistance and heat shock proteins (HSPs)-mediated phototherapy tolerance, which both depend on an excessive supply of adenosine triphosphate. Therefore, manipulating energy metabolism to impair the expression or function of P-glycoprotein (P-gp) and HSPs may be a prospective strategy to reverse cancer therapeutic resistance. Herein, a chondroitin sulfate (CS)-functionalized zeolitic imidazolate framework-8 (ZIF-8) chemo-phototherapy nanoplatform (CS/ZIF-8@A780/DOX NPs) is rationally designed that is capable of manipulating energy metabolism against cancer therapeutic resistance by integrating the photosensitizer IR780 iodide (IR780)-conjugated atovaquone (ATO) (A780) and the chemotherapeutic agent doxorubicin (DOX). Mechanistically, ATO and zinc ions that are released in the acidic tumor microenvironment can lead to systematic energy exhaustion through disturbing mitochondrial electron transport and the glycolysis process, thus suppressing the activity of P-gp and HSP70, respectively. In addition, CS is used on the surface of ZIF-8@A780/DOX NPs to improve the targeting capability to tumor tissues. These data provide an efficient strategy for manipulating energy metabolism for cancer treatment, especially for overcoming cancer chemo-phototherapy resistance.
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2019
·
IF 3.782
Liu Lijuan,Yang Weiting,Gu Dongxu,Zhao Xiaojun,Pan Qinhe
With the rapid growth of nuclear power generation and fuel processing, the treatment of nuclear industry wastewater has become a major problem, and if not handled properly, it will pose a potential threat to the ecological environment and human health. Herein, a chitosan (CS)/ZIF-8 composite monolithic beads with ZIF-8 loading up to 60 wt% for U(VI) removal was prepared, which can be easily removed after use. It possesses a very high adsorption capacity of 629 mg•g−1 at pH = 3 for U(VI) and a well recyclability is demonstrated for at least four adsorption/desorption cycles. X-ray photoelectron spectroscopy (XPS) was carried out to study the adsorption mechanism between uranium and adsorbent, and the chelation of U(VI) ions with imidazole, hydroxyl, and amino groups was revealed. This work shows that CS/ZIF-8 composite can be used as an effective adsorbent for uranium extraction from aqueous solution, and has a potential application value in wastewater treatment.
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Ying Zhang,Ting-Ting Li,Li Sun,Bing-Chiuan Shiu,Lu Zhang,Jia-Horng Lin,Ching-Wen Lou
Nowadays, the hydrogen dressing and electrostatic spun films widely used on wounds do not facilitate the permeability of the wound area and fail to achieve controlled drug delivery. Therefore, finding a wound dressing with both breathability and targeted drug delivery has remained an unmet challenge. Here, an oriented microstructure membrane with sustained drug release and robust antibacterial performance was constructed through the microfluidic spinning method. The multifunctional oriented membrane was prepared by loading ascorbic acid onto the zeolitic metal-organic framework-8 to develop drug delivery nanomaterial zeolitic metal-organic framework-8 @ascorbic acid (ZIF-8 @AA) and then mixing ZIF-8 @AA with polyvinyl pyrrolidone (PVP) solution via microfluidic technology, which produced an oriented microfiber member. In addition, the spinning parameters, including the fluid content, rotation speed, and flow rate , on microfiber diameter were evaluated. The constructed oriented membrane had bactericidal efficiencies of 82.94% ± 2.79% and 95.96% ± 1.54% against E. coli and S. aureus , respectively. After five days, the membrane still has a sustained release. Moreover, the fabricated membrane also has good biocompatibility and hemocompatibility in vitro. The oriented arrangement strategy provides a promising approach for wound healing materials in targeted drug delivery. Furthermore, this strategy offers a feasible idea for loading active materials into substrates for disease treatment in the biomedical field.
✓ 已验证
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2021
·Vol. 9
·期 1
·165-178
·
IF 6.569
Ning Yang,Linjie Lu,Linhua Zhu,Peiwen Wu,Duanjian Tao,Xiaowei Li,Jiahong Gong,Linlin Chen,Yanhong Chao,Wenshuai Zhu
Porous ionic liquids (PILs), with permanent porosity and fluidity, have been drawing great attention in theoretical research and application. Herein, a novel PIL (HPMo@ZIF-8-PIL) was fabricated by dispersing a phosphomolybdic acid-modified zeolitic imidazolate framework-8 (ZIF-8) into an ionic liquid for deep reactive extraction desulfurization. Size calculation results show that 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonylimide) ([Emim][NTf2]) with larger ion sizes cannot occupy pores of ZIF-8. In detail, the structure along with permanent porosity was well characterized by gas absorption and molecule displacement experiments, and it was found that HPMo@ZIF-8-PIL can not only promote the dispersion of the catalytically active sites but also retain the good liquidity and excellent extraction ability of ionic liquids. At room temperature, 100% removal of dibenzothiophene sulfur in a model oil could be achieved within 2 h using HPMo@ZIF-8-PIL and hydrogen peroxide as the catalyst and oxidant, respectively. Besides, the successful preservation of porosity increases the probability of contact between the oxidant and active sites, which is also in favor of the promotion of desulfurization performance. This work offers a new method for the modification of porous frameworks to construct PIL catalysts, which will provide a new insight into the application of PILs.
✓ 已验证
DOI
高影响因子
POLYHEDRON
·
2015
·
IF 2.011
Jiangjiao Shi,Chunhua Gong,Xianghua Zeng,Junyong Zhang,Chengfeng Zhu,Jingli Xie
By taking advantage of the synthetic 8-hydroxyquinoline derivative, (E)-2-[2-(4-chlorophenyl)vinyl]-8-hydroxyquinoline ( HL ), three new metal–organic coordination compounds [Zn 3 L 6 ] ( 1 ), [Cd 3 L 6 ] ( 2 ) and [Cu 2 L 4 ] ( 3 ) have been obtained by solvothermal or solution processing methods and structurally characterized. Single crystal X-ray diffraction analysis revealed that complexes 1 and 2 have similar ‘V’-type trinuclear structures. Different from complexes 1 and 2 (trinuclear structure), complex 3 displays dinuclear structure. The effects of central metals and reaction solvents on the structures of complexes 1 – 3 have been discussed. Furthermore, thermogravimetric analysis and solid state fluorescence of ligand HL , 1 – 3 were investigated.
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Libo Shi,Xiang Zhu,Tingting Liu,Hongli Zhao,Minbo Lan
In this work, we applied metal-organic frameworks (MOFs) as a porous matrix to encapsulate Cu nanoparticles (NPs) for nonenzymatic glucose sensing in alkaline media . SEM and TEM confirmed that the size of the encapsulated Cu NPs ranges from 2.5 to 5 nm. The hybrid of Cu NPs encapsulated in ZIF-8 (Cu-in-ZIF-8) was further modified onto screen-printed electrodes for nonenzymatic sensing of glucose in alkaline medium. The porous structure of ZIF-8 are beneficial for the unimpeded diffusion of glucose and reaction product. And as a matrix for encapsulating Cu NPs, ZIF-8 also protect the Cu NPs from dissolution and agglomeration during the electrocatalytic process. For comparison, the electrochemical performance of Cu NPs loaded on ZIF-8 (Cu-on-ZIF-8) was also investigated and it is found that Cu-in-ZIF-8 exhibited higher activity and better stability for cyclic test toward the oxidation of glucose in alkaline media. Additionally, Cu-in-ZIF-8 based glucose sensor also shows a favorable sensitivity and selectivity.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2024
·
IF 2.5
Lin Zhan,Xuelian Yin,Li Qiu,Chenchen Li,Yanli Wang
The nanomedicine system based on dual drug delivery systems (DDDs) can significantly enhance the efficacy of tumor treatment. Herein, a metal-organic framework, Zeolite imidazole salt frames 8 (ZIF-8), was successfully utilized as a carrier to load the dual chemotherapeutic drugs doxorubicin (DOX) and camptothecin (CPT), named DOX/CPT@ZIF-8 (denoted as DCZ), and their inhibitory effects on 4T1 breast cancer cells were evaluated. The study experimentally demonstrated the synergistic effects of the dual chemotherapeutic drugs within the ZIF-8 carrier and showed that the ZIF-8 nano-carrier loaded with the dual drugs exhibited stronger cytotoxicity and inhibitory effects on 4T1 breast cancer cells compared to single-drug treatment. The use of a ZIF-8-based dual chemotherapeutic drug carrier system highlighted its potential advantages in suppressing 4T1 breast cancer cells.
研究领域:
纳米医学
·
肿瘤学
·
药物递送
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2019
·
IF 3.372
Donghui Liu,Long Xiang,Hao Chang,Ke Chen,Chongqing Wang,Yichang Pan,Yanshuo Li,Zhongyi Jiang
Mixed matrix membranes (MMMs) have attracted tremendous attention in the field of gas separation, which adopts the synergistic advantages of the polymer and inorganic phase. However, the MMMs rarely generate sufficient selectivity for energy-efficient gas separation, even if the dispersed molecular sieve is highly selective. Here, an unprecedented improvement (∼4.5-fold) of both C 3 H 6 /C 3 H 8 permeability and selectivity on the crosslinked poly(ethylene oxide) (XLPEO) membranes containing ZIF-8 nanocrystals. When the ratio of polymer-to-sieve permeability ( R c/d ) is in the range of 0.004–0.36, both C 3 H 6 /C 3 H 8 permeability and selectivity increases with the ZIF-8 loading, and the separation performance on MMMs can approach and surpass the-state-of-the-art polymer upper bound. Besides C 3 H 6 /C 3 H 8 separation, the universality of this proposed polymer-sieve matching law is suitable for other gas-pairs on MOF-based MMMs.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2012
·
IF 3.07
Jie Zhao,Baocun Zhu,Haiqin Yu,Liangguo Yan,Qin Wei,Bin Du
On the basis of high selective and sensitive interaction of 1,8-naphthalimide with Hg 2+ and the formation of stable neutral imide-Hg-imide complexes, we designed and synthesized a novel magnetic fluorescent sensor ( S1 ) employed Fe 3 O 4 magnetic nanoparticles and 1,8-naphthalimide fluorescent sensor. Under optimum conditions, S1 exhibits the high selectivity toward Hg 2+ over other metal ions, with the detection limit of 1.03 × 10 −8 M. We demonstrated that a reliable fluorescence response of S1 toward Hg 2+ over a broad pH range (pH = 5.0–9.0) could be reused at least four cycles. The maximum sorption capacity of S1 was about 5.6 mg g −1 . In addition, the removal of Hg 2+ in water was achieved by the aggregation-induced sedimentation (AIS) strategy. Moreover, the suspended magnetic nanoparticles could be removed by external magnetic field , and the secondary pollution was avoided. The above-mentioned results indicate that this approach may serve as a foundation of the preparation of the multifunctional magnetic fluorescent sensor for simple, rapid, and simultaneous determination and removal of trace Hg 2+ and other pollutants in environmental samples.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2026
·
IF 4.2
Fuxin Li,Jingxian Ye,Jianjun Hao,Zexiao Liu,Dongyin Yi,Gaoming Zhang,Xinyu Luo,Yang Bi
BACKGROUND Prochloraz (Pro) is a broad-spectrum fungicide that is effective against various plant pathogens, including Colletotrichum fructicola , the causal agent of strawberry anthracnose. However, its limited absorption restricts its effectiveness. In this study, zeolitic imidazolate framework-8 (ZIF-8) was utilized as a nanocarrier and combined with the fungicide prochloraz (Pro) to develop an effective delivery system (Pro@ZIF-8), improving the fungicidal activity of prochloraz. RESULTS Characterization confirmed that Pro@ZIF-8 possesses a distinct dodecahedral crystal structure with an average particle size of 139.6 nm. The system exhibited pH-sensitive release, with 89.8% of the prochloraz released within 24 h at pH 5.0, while remaining stable at pH 7.4. Antifungal assays demonstrated that Pro@ZIF-8 had an EC 50 of 0.0150 mg L −1 against C. fructicola , which was significantly lower than that of free prochloraz (0.0429 mg L −1 ). Pro@ZIF-8 effectively delayed disease lesion development on strawberry leaves and fruits inoculated with C. fructicola . Under storage conditions, Pro@ZIF-8 prevented pathogen infection and kept the fruit fresh for an extended period. Additionally, by tracking fluorescein isothiocyanate (FITC)-labeled ZIF-8 after foliar and root applications, it was confirmed that it was systemically transported within strawberry plants. CONCLUSION These findings highlight the potential of Pro@ZIF-8 as a smart fungicide delivery system, offering a promising strategy for improving disease management in strawberries. © 2026 Society of Chemical Industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）