APPLIED SURFACE SCIENCE
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2019
·
IF 5.155
Junjie Yang,Lei Liu
The friction influence of 2-D molybdenum disulfide (MoS 2 ) films deposited on different substrates (Si, SiO 2 and Al 2 O 3 ) by atomic layer deposition (ALD) has been investigated. All of the three substrates showed a trend of decreasing friction with increasing number of layers of MoS 2 , but the friction leveled off for more than 6 layers samples. Comparing these 2-D MoS 2 films with each other, MoS 2 on the Al 2 O 3 possesses the lowest friction, while MoS 2 on the Si possesses the highest one, owing to effect of substrate on the specific self-limiting reaction in ALD process. At the same time, the friction of the monolayer MoS 2 is strongest affected by sulfur deficient. As the number of layers increases, the influence of the substrate on the friction of MoS 2 can be approximately characterized by the work of adhesion. Greater work of adhesion corresponds to a higher friction force. When the thickness is more than 6 layers, the substrate effect disappears gradually. Moreover, the friction of 2-D MoS 2 could be controlled near linearly by changing plasma treatment time within the range from 1 to 20 s, which suggests a possible way for the friction control of 2-D MoS 2 on different substrate quasi-qualitatively or even qualitatively.
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Food Science and Human Wellness
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2024
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IF 5.6
Lan Li,Shengye Yang,Xinyu Liang,Yameng Liu,Hualing Xu,Xiaozhen Guo,Cen Xie,Xiaojun Xu
Non-alcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide. Bupleurum is widely used in the treatment of non-alcoholic fatty liver, and saikosaponin D (SSD) is one of the main active components of Bupleurum. The purpose of this study was to investigate the efficacy of SSD in the treatment of NAFLD and to explore the mechanism of SSD in the improvement of NAFLD based on “gut-liver axis”. Our results showed that SSD dose-dependently alleviated high fat diet-induced weight gain in mice, improved insulin sensitivity, and also reduced liver lipid accumulation and injury-related biomarkers aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Further exploration found that SSD inhibited the mRNA expression levels of farnesoid X receptor ( Fxr ), small heterodimer partner ( Shp ), recombinant fibroblast growth factor 15 ( Fgf15 ) and apical sodium dependent bile acid transporter ( Asbt ) in the intestine, suggesting that SSD improved liver lipid metabolism by inhibiting intestinal FXR signaling. SSD can significantly reduce the gut microbiota associated with bile salt hydrolase (BSH) expression, such as Clostridium . Decreased BSH expression reduced the ratio of unconjugated to conjugated bile acids, thereby inhibiting the intestinal FXR. These data demonstrated that SSD ameliorated NAFLD potentially through the gut microbiota-bile acid-intestinal FXR pathway and suggested that SSD is a promising therapeutic agent for the treatment of NAFLD.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Yunheng Wang,Hengle Wang,Tiantian She,Renjie Wang,Zhe Xu,Qiuyi Ji,Shaogui Yang,Limin Zhang,Huan He
Transition metals (TMs) are widely employed to improve poor intrinsic activity of biochar for peroxymonosulfate (PMS) activation towards water purification. However, the mechanistic effects of TMs on carbon substrates requires further understanding. Herein, we constructed TM-modified C-Ni and C-Ni-Co catalysts via simple pyrolysis of rice husk precursor, optimizing carbonaceous morphologic and electronic structures. The Co-Ni-Co (0.013 min −1 ) exhibited over 10 times higher performance than pristine biochar for iohexol (IOH) removal. Systemic spectroscopic and electrochemical measurements indicate that embedded Ni increases graphitization degree facilitating IOH adsorption by π-π conjugated attraction. And, the anchored Co enhances work function promoting electron extraction for selective generation of 1 O 2 . The interfacial d-p orbital hybridization increases the acidic degree on biochar for PMS adsorption, accelerating electron exchange for PMS activation. Our work attempts to study the complex interaction between carbon and metal sites by orbital hybridization to design efficient PMS activators for Fenton-like decontamination.
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Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2017
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IF 0.963
Ranhong Li,Ling Li,Xiaotong Sun,Yan Wang
Dummy-template molecularly imprinted microspheres were synthesized via precipitation polymerization employing 2,4-D isooctyl ester as the template molecule instead of 2,4-D butyl ester, while methacrylic acid and divinylbenzene were used as functional monomer and cross-linker in acetonitrile or a mixture of acetonitrile and toluene. The microspheres were characterized by scanning electron microscopy, laser particle size analyzer and fourier transform infrared spectrometry. Binding capacity experiment showed that the molecularly imprinted polymers prepared in a mixture of acetonitrile and toluene had a high binding capacity. The performance of microspheres was further assessed by equilibrium binding and kinetic adsorption experiments. The results showed that the apparent maximum adsorption reached up to 1.35 mg·g−1 within 10 min. Based on the dummy-template microspheres, a molecularly imprinted solid phase extraction-gas chromatography method was developed for the selective analysis of 2,4-D butyl ester in soil samples. The mean recoveries of 2,4-D butyl ester from blank soil samples ranged from 85.9 to 99.3% with relative standard deviations of 4.5–14.3% (n = 5). The limit of detection and the limit of quantification of 2,4-D butyl ester were 0.8 μg·kg−1 and 2.3 μg·kg−1, respectively.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2019
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IF 2.931
Xiaojuan Zhou,Chunli Xu,Yan Jin,Baoxin Li
Chiral recognition of enantiomers is fundamentally important. In this work, an effective and simple chiral sensing strategy for discrimination of leucine (Leu) enantiomers was constructed. In this chiral sensing, cube-shaped gold nanoparticles (AuNCs) as colorimetric probes are used to recognize Leu enantiomers . L-Leu can induce rapidly the aggregation of AuNCs, leading to change of AuNCs solution from red to colorless, while D-Leu cannot induce the color change. This distinct color changes allow naked-eye to distinguish chiral isomers of Leu. The chiral sensing was applied to measure the enantiometric excess of L-Leu in the whole range (from −100% to 100%). This chiral analysis can be performed by naked eye or simple ultraviolet-visible spectrometer. In addition, the mechanism of chiral recognition has been studied with circular dichroism (CD) spectra, UV–vis absorption spectra and zeta potential . In this method, the chiral recognition is due to the intrinsic chirality of AuNCs, and the AuNCs don't need any chiral labeling or modification. This chiral sensing method is simple, cheap, rapid and easy to operate. Furthermore, this work provides one experimental evidence for intrinsic chirality of nanoparticles , and helps people understand the chirality of nanostructures .
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ChemSusChem
·
2019
·Vol. 12
·期 24
·5274-5281
·
IF 7.804
Lulu Jia,Hao Wan,Xiaohe Liu,Gen Chen,Ning Zhang,Junhui Li,Wei Zhou,Yijun Cao,Renzhi Ma,Guanzhou Qiu
Morphology and composition tuning of layered materials is evaluated to influence their electrochemical performance for energy storage and conversion applications. Layered Co 1− x Ni x hydroxides ( x= 0, 1/2, 1/3, 1/4, 1) of three different morphologies—nanocones, 2 D nanosheets obtained by the rapid exfoliation of nanoconical counterparts, and 2 D superlattice-like nanostructures alternately restacked by the oppositely charged hydroxide and graphene oxide (GO) nanosheets—have been systematically investigated for electrocatalytic oxygen oxidation. High activity is obtained with the 2 D Co 2/3 Ni 1/3 hydroxide nanosheets/GO superlattice (Co 2/3 Ni 1/3 NS–GO), achieving a current density of 10 mA cm −2 at a low overpotential of 259 mV accompanied by a small Tafel slope of 35.7 mV dec −1 , surpassing nanocones and 2 D nanosheets, as well as the congeneric heterostructured Co 1− x Ni x hydroxide nanosheets/GO nanoarchitectures (Co 1− x Ni x NS–GO; x= 0, 1/2, 1/4, 1) and the commercial RuO 2 electrocatalyst. The outstanding activity of Co 2/3 Ni 1/3 NS–GO superlattice uncovers the combined merits of 2 D superlattice-like structure and composition optimization for electrocatalysis, providing a strategy for developing high-performance electrochemical materials by rational morphology and composition design. Graphical A super lattice : Composition and morphology optimization was used to develop a 2 D Co 2/3 Ni 1/3 hydroxide/graphene oxide superlattice with high activity for oxygen evolution, achieving a current density of 10 mA cm −2 at a low overpotential of 259 mV accompanied by a small Tafel slope of 35.7 mV dec −1 . The outstanding activity of the superlattice highlights the importance of morphology and composition optimization for electrocatalysis.
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Research
·
2026
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IF 12.9
Ting Xu,Xiaoting Yan,Tingting Wang,Liping Cui,Shangshang Qin,Ruige Yang,Hong Yao,Yong Guo
The rise of multidrug-resistant bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA), poses a serious threat to human health, necessitating an urgent need to develop innovative antibacterials with multifunctions for this. Here, focusing on integrating multi-antimicrobial mechanisms with visual monitoring, we report a novel phenanthro[9,10-d]imidazole fluorogen 9b, outstanding for its antibacterial effects against S. aureus and various clinical MRSA isolates (minimum inhibitory concentration = 0.5 to 1 μg/ml) with rapid bactericidal activity, high membrane selectivity, and low susceptibility to drug resistance. Further investigation revealed its dual antimicrobial mechanisms of action by concurrently disrupting bacterial cell membranes and inducing bacterial DNA degradation to accelerate bacterial death. Ultraviolet–visible and fluorescence spectroscopy studies showed that the fluorescence intensity of 9b was dramatically enhanced when it interacted with S. aureus. Notably, in vivo studies demonstrated that 9b effectively treated both skin and thigh MRSA infections, showing a favorable safety profile and superior efficacy compared to the first-line antibiotic vancomycin. The “dual-mechanism” fluorescent phenanthro[9,10-d]imidazole fluorogen 9b holds promise as a candidate for developing innovative antibacterial agents that enable simultaneous real-time diagnosis and treatment.
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BIOORGANIC CHEMISTRY
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2026
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IF 5.1
Qian Zhang,Wenyu Wang,Chenhan Wu,Qingting Du,Weili Yin,Jiaheng Chen,Jian Ma,Chong Li,Shaojie Zhang
Ulcerative colitis (UC) is characterized by recurrent inflammation of the gastrointestinal tract, and currently available treatment drugs are limited. Plant-derived polysaccharides hold promise for UC prevention. A water-soluble α -D-glucan (CLP80–1) with a molecular weight of 8.17 × 10 5 Da was isolated and characterized from the roots of traditional Chinese medicinal plant Crepis lignea . Structural analysis revealed that its repeating units comprise →6)- α -D-Glc p -(1 → and →3,6)- α -D-Glc p- (1 → residues as the backbone, with α -D-Glc p -(1 → as side chains substituted at C-3. The protective effects of CLP80–1 on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in Drosophila melanogaster were investigated. Our results demonstrated that treatment with 1% CLP80–1 significantly improved survival rates, attenuated gut atrophy, reduced intestinal permeability, enhanced intestinal barrier function, suppressed excessive proliferation of intestinal stem cells (ISCs) and enteroblasts (EBs), and inhibited the death of intestinal epithelial cells (IECs). Metabolomic and transcriptomic analyses revealed that CLP80–1 mainly affected amino acid metabolism, TCA cycle, oxidative phosphorylation and JAK/STAT signaling pathway. Furthermore, CLP80–1 reduced reactive oxygen species (ROS) levels, suppressed the expression of pro-inflammatory factors, and downregulated the JAK-STAT signaling pathway, thereby mitigating oxidative stress and inflammatory responses. These findings suggest that CLP80–1 is effective in alleviating intestinal inflammation and may serve as a promising therapeutic candidate for addressing gut inflammatory conditions.
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TALANTA
·
2026
·
IF 6.7
Dan Wang,Panpan Chen,Qin Huang,Yan Ma,Xueping Tao,Yuanmin Gong,Jiaping Cui,Yang Zhou,Zhining Xia,Qifeng Fu
The inherently low phase ratio and limited surface capacity of open-tubular capillary electrochromatography (OT-CEC) significantly restrict its efficiency in enantioseparation. To overcome this limitation, we developed a rigid-flexible composite interface strategy to construct a high-efficiency chiral ligand-exchange CEC (CLE-CEC) column. A uniform nanocrystalline UiO-66-NH 2 layer was in situ grown on the capillary inner wall to serve as a high-surface-area rigid scaffold, followed by the covalent immobilization of L-arginine (L-Arg) as a flexible chiral ligand. This composite architecture combines the structural stability of metal-organic frameworks (MOFs) with the stereochemical selectivity of amino acid ligands. The dense MOF scaffold effectively increases the specific surface area and ligand loading capacity of the stationary phase, thereby facilitating efficient Zn(II)-mediated ternary complexation for chiral recognition. Validating this design, the UiO-66-NH-L-Arg@capillary column achieved baseline separation for seven pairs of Dns-D,L-AAs, with resolution factors reaching up to 2.56. The column exhibited satisfactory repeatability and good operational stability. Furthermore, the practicability of this method was demonstrated by its successful application in the kinetic monitoring of L-alanine dehydrogenase, providing a robust micro-separation tool for precise bioanalysis.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
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IF 5.895
Ziyan Wang,Heping Cui,Mengyu Ma,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The effect of ellagic acid on the formation of pyrazine, methylpyrazine, 2,3-methylpyrazine, 2,6-methylpyrazine, 2,5-methylpyrazine, and trimethylpyrazine in the xylose–glycine Maillard reaction model was researched. Ellagic acid could either inhibit or promote pyrazine formation, depending on its addition time point and the pH of the system. The addition of ellagic acid during the accumulation period of an Amadori compound inhibited pyrazine formation by capturing the Amadori compound in the xylose–glycine Maillard system and decreasing the pyrazine precursors. The inhibitory effect of ellagic acid on pyrazine formation got more obvious with an increase in the pH of the system. However, when ellagic acid was added at the beginning of the xylose and glycine Maillard system and when the oxidizing substances such as glyoxal and methylglyoxal were significantly formed in the Maillard system, its oxidation could promote the formation of pyrazines.
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JOURNAL OF HAZARDOUS MATERIALS
·
2026
·
IF 10.6
Yaxin Zheng,Zexiu An,Weihua Liu,Minghua Wang,Yichun Ren,Dongchen Yang,Wei Gao,Ningzhao Shang,Jinlin Zhang,Chun Wang,Shutao Gao
Nitrogen vacancy incorporation into Co 4 N-600 upshifts the D-band center and facilitates the generation of Co IV =O. • The Co 4 N-600/PMS system yields a modified kinetic rate constant of 300.6 min⁻ 1 M⁻ 1 . • Rapid degradation of different types of pollutants within Co 4 N-600/PMS system. High‑valent cobalt-oxo species (Co IV =O) have been demonstrated to exhibit efficient degradation capability toward emerging contaminants (ECs). However, the 3d 7 electronic configuration of Co(II) sites in Co‑based catalysts severely restricts their binding affinity to the terminal oxygen of peroxymonosulfate (PMS), which is unfavorable for the generation of Co IV =O. Herein, we report a nitrogen vacancy (Nv)‑rich cobalt nitride nanozyme Co 4 N-600. The introduction of Nv markedly reduces the d‑electron occupancy of Co, upshifts the d‑band center, and promotes the formation efficiency of Co IV =O. Remarkably, employing 150 mg L −1 peroxymonosulfate (PMS) as the oxidant, the Co 4 N-600 nanozyme achieves complete degradation of 10 mg L −1 imidacloprid within 10 min at an ultralow catalyst loading of 1 mg L −1 , yielding an excellent modified kinetic rate constant of 300.6 min −1 M −1 . These findings establish d -band center engineering as an effective strategy for boosting the catalytic performance of nanozymes by promoting the generation of high-valent metal-oxo (HVMO) species. Download: Download high-res image (179KB) Download: Download full-size image
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INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Wenxiu Jiang,Xuejun Yu,Yuan Hui,Bowei Shen,Zhang Farong,Zhiquan Pan,Hong Zhou
Diosgenin is an important intermediate of steroid hormone drugs, green production of diosgenin with high yield is a key research issue. In this study, a convenient, efficient, and eco-friendly approach was developed to produce diosgenin from saponins in D. zingiberensis C. H. Wright (Curcuma longa L) using a magnetic solid acid. Fe 3 O 4 @SiO 2 -Pr-S-SO 3 H is a heterogeneous catalyst and was obtained by loading 3-(mercaptopropyl) trimethoxysilane on the surface of Fe 3 O 4 @SiO 2 , followed by sulfonation with chlorosulfonic acid. The magnetic solid acid catalyst was fully characterized by Fourier Transform-Infrared (FT-IR) spectra, thermo gravimetric analysis (TGA), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), and X-ray photoelectron spectroscopy (XPS), scanning electron microscope(SEM), transmission electron microscope (TEM), NH 3 -TPD, elemental mapping analysis. The effects of single factors, such as the solid acid mass, alcoholysis temperature, extraction time, and solvent volume on the diosgenin yield were analyzed. The extraction parameters for diosgenin were optimized by response surface methodology (RSM). The optimized values for the solid acid mass, solvent volume, extraction time, and temperature were 0.22 g, 7.8 mL, 7.4 h, and 100 °C, respectively. Under the optimized conditions, the maximum yield of diosgenin was 19.15 %. The solid acid reported in this work exhibited higher catalytic activity at a smaller dosage than traditional sulfuric acid and other solid acids. The alcoholysis products were identified by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Alcoholysis catalysed by an as-prepared magnetic solid acid is clearly superior in terms of catalytic activity, dosage, and reusability. It is a promising strategy for the green production of diosgenin.
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