MOLECULAR AND CELLULAR BIOCHEMISTRY
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2026
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IF 4.7
Li Sijie,Huang Huanhuan,Feng Jiahui,Gu Qiang,Sun Daquan
Hepatocellular carcinoma (HCC) ranks among the most lethal cancers, and its dismal prognosis underscores the urgent need to elucidate the underlying carcinogenic mechanisms. Endoplasmic reticulum lipid rafts associated protein 2 (ERLIN2), an endoplasmic reticulum protein, has been implicated in various malignant tumors. However, its functional role in HCC remains poorly understood. Here, we found elevated ERLIN2 expression and N-glycosylation modification at asparagine 106 (N106) in HCC. We identify site-specific N-glycosylation as a crucial advantage of ERLIN2 that may result in aberrant cancer cell growth. Overexpression of either N-glycosylated ERLIN2 (wild-type, WT) or an asparagine-to-glutamine mutant (N106Q) in HCC cell lines indicated that N106 N-glycosylation of ERLIN2 acts as an important advantage in the tumorigenesis and triggers aberrant cell proliferation, migration, and invasion. Furthermore, we found that E3 ubiquitin ligase membrane-associated ring-CH-type finger protein 6 (MARCHF6) can mediate the ubiquitination degradation of ERLIN2, and this effect is more significant after the N-glycosylation at the N106 site is inhibited. In addition, excessive N-glycosylation at this site enhanced the interaction between ERLIN2 and cyclin B1 (CCNB1), leading to dysregulated CCNB1 expression and further accelerating the progression of HCC. Comprehensive studies confirm that N-glycosylation is a significant post-translational modification of ERLIN2 in HCC, and elucidating this mechanism may pave the way for the development of novel therapeutic strategies in the future.
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高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
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2011
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IF 3.603
Shengtong Sun,Peiyi Wu
IR spectroscopy in combination with two-dimensional correlation spectroscopy (2DCOS) and the perturbation correlation moving window (PCMW) technique is employed to illustrate the dynamic hydration behavior of poly(N-vinylcaprolactam) (PVCL) in water, which exhibits a typical type I continuous lower critical solution temperature (LCST) behavior. PCMW easily determined the transition temperature to be ca. 43.5 °C during heating and ca. 42.5 °C during cooling and the transition temperature range to be 39.5–45 °C. On the other hand, 2DCOS was used to discern the sequence order of different species in PVCL and concluded that hydrogen bonding transformation predominates at the first stage below LCST while hydrophobic interaction predominates at the second stage above LCST. In combination with molecular dynamics simulation results, we find that there exists a distribution gradient of water molecules in PVCL mesoglobules ranging from a hydrophobic core to a hydrophilic surface. Due to the absence of self-associated hydrogen bonds and topological constraints, PVCL mesoglobules would form a “sponge-like” structure which can further continuously expel water molecules upon increasing temperature, while poly(N-isopropylacrylamide) (PNIPAM) with self-associated hydrogen bonds forms mesoglobules with a “cotton-ball-like” structure without an apparent distribution gradient of water molecules and does not change much upon increasing temperature.
研究领域:
高分子科学
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物理化学
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光谱学
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温敏性聚合物
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软物质物理
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ChemistrySelect
·
2022
·Vol. 7
·期 40
·e202203024
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IF 2.307
Xuehui You,Fang Liu,Guofei Jiang,Shuhua Chen,Beiya An,Rongli Cui
Graphical Degradation experiments of TC suggested that SCN/NT-2@PTFE composites showed the best photocatalytic performance under the optimal conditions, the degradation rate of tetracycline reached 99 % after 120 min of irradiation. The preparation of SCN/NT-2@PTFE composite membrane can solve the problem of difficult recovery and secondary contamination of powder catalysts. Herein we synthesized S-g-C 3 N 4 and N−TiO 2 catalysts by hydrothermal and calcination technologies and SCN/NT@PTFE membrane by a vacuum filtration method. The morphology and composition of the synthesized materials were analyzed by different characterization methods (SEM/HRTEM/XRD/XPS/UV-vis et.). The effects of different catalysts, pollutant concentrations, mass of catalyst and pH on the photo-degradation of tetracycline were investigated. The degradation rate of tetracycline by SCN/NT-2@PTFE membrane was as high as 99.9 % after 2 h of illumination. This was mainly because heterogeneous structure between S-g-C 3 N 4 and N−TiO 2 broadened the light absorption range and suppressed the carrier complex. Superoxide radicals (⋅O 2 − ) were proved to play a dominant role in the degradation reaction. After 20 days of stirring in water, the photocatalytic performance of membrane decreased slightly, demonstrating its good stability. The study of SCN/NT-2@PTFE membrane provides a new direction for the development of photocatalysis and membrane.
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高影响因子
Materials
·
2023
·Vol. 16
·期 4
·1435
·
IF 3.4
Rui Liu,Shouguang Yao,Yan Shen,Yu Tian,Qiqi Zhang
In this study, N-doped layered porous carbon prepared by the high-temperature solid-state method is used as electrode material. Nano calcium carbonate (CaCO3) (40 nm diameter) is used as the hard template, sucrose (C12H22O11) as the carbon source, and melamine (C3H6N6) as the nitrogen source. The materials prepared at 850 °C, 750 °C, and 650 °C are compared with YP-50F commercial super-activated carbon from Japan Kuraray Company. The electrode material at 850 °C pyrolysis temperature has a higher specific surface area and more pores suitable for ion adsorption. Due to these advantages, the salt adsorption capacity (SAC) of the N-doped layered porous carbon at 850 °C reached 12.56 mg/g at 1.2 V applied DC voltage, 500 mg/L initial solution concentration, and 15 mL/min inlet solution flow rate, which is better than the commercial super activated carbon as a comparison. In addition, it will be demonstrated that the N-doped layered porous carbon at 850 °C has a high salt adsorption capacity CDI performance than YP-50F by studying parameters with different applied voltages and flow rates as well as solution concentrations.Keywords:capacitive deionization;N-doped layered porous carbon;salt adsorption capacity
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高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Bin Wang,Shu-han Lu,Shi-yuan Wang,Pei-ya Li,Tao Fang
N -ethylcarbazole (NEC) is a widely studied liquid organic hydrogen carrier, and a large number of catalysts with excellent reactivity has been designed and developed thus far. However, the phenomenon of isomeric transformation of 12H-NEC products during the reaction was not explained. Here, we studied the process based on three different Ru catalysts supported on zirconium-based supports, and based on the experimental results, we identified that supported metal-support strong interaction (SMSI), metal-support anion interaction (MSAI) and hydrogen spillover will have coupling effect on the hydrogenation reaction path and the occurrence of isomerization in 12H-NEC product. Higher 12 [H] B content in 12H-NEC under Ru/ZrN catalyst was caused by the large number of secondary active centers on the surface of the support reacting in the hydrogenation reaction. The active site for the isomerization of 12 [H] B to 12 [H] A may be the electronegativity interface formed by Ru and the support, while the electroneutral or electropositive interface rich in hydrogen is not conducive to the catalytic conversion. To sum up, an image model for the isomeric transformation of 12H-NEC products was proposed.
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RARE METALS
·
2023
·Vol. 42
·期 4
·1195-1204
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IF 8.8
Dong Wei,Zhou Shi-An,Ma Yan,Chi Dian-Jun,Chen Rong,Long Hong-Ming,Chun Tie-Jun,Liu Sheng-Jun,Qian Fu-Ping,Zhang Kui
Designing a heterojunction photocatalyst to improve the separation efficiency of photogenerated electrons and holes is of great significance to improve the hydrogen production efficiency. In this work, we report a rational design to grow ZnIn 2 S 4 on Mo-MOF-derived N-doped C-coated MoO 2 (MOZIS), and it has excellent photocatalytic hydrogen production with triethanolamine (TEOA) as sacrificial agent. N-doped C improves the electron transport efficiency between MoO 2 and ZnIn 2 S 4 . The systematic study shows that MOZIS has good properties to promote the effective separation and transfer of photocatalytic charges, which is attributed to the tight contact interface and good energy band structure between MoO 2 and ZnIn 2 S 4 . The optimized nanocomposites have a high hydrogen production efficiency of 10.89 mmol·g −1 (4 h) under visible light. MOF-derived N-doped C-coated MoO 2 is an effective strategy to improve the photocatalytic hydrogen production efficiency of ZnIn 2 S 4 . Graphical abstract
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2023
·Vol. 24
·期 3
·2445
·
IF 5.6
Nan Wang,Xiaofan Zhai,Fang Guan,Ruiyong Zhang,Baorong Hou,Jizhou Duan
Exploring new and high efficiency mimic enzymes is a vital and novel strategy for antibacterial application. Haloperoxidase-like enzymes have attracted wide attention thanks to their amazing catalytic property for hypohalous acid generation from hydrogen peroxide and halides. However, few materials have displayed halogenating catalytic performance until now. Herein, we synthesized N-doped C/CeO2(N-C/CeO2) composite materials by a combination of the liquid and solid-state method. N-C/CeO2can possess haloperoxidase-like catalytic activity by catalyzing the bromination of organic signaling compounds (phenol red) with H2O2at a wide range of temperatures (20 °C to 55 °C), with a solution color changing from yellow to blue. Meanwhile, it exhibits high catalytic stability/recyclability in the catalytic reaction. The synthesized N-C/CeO2composite can effectively catalyze the oxidation of Br−with H2O2to produce HBrO without the presence of phenol red. The produced HBrO can resist typical marine bacteria likePseudomonas aeruginosa. This study provides an efficient biomimetic haloperoxidase and a novel sustainable method for antibacterial application.Keywords:N-C/CeO2composite;catalytic materials;biomimetic catalyst;haloperoxidase-like enzyme;antibacterial
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高影响因子
Frontiers of Optoelectronics
·
2022
·Vol. 15
·期 1
·1-10
·
IF 0
Jiang Mengjia,Li Shuyu,Zhen Chun,Wang Lingsong,Li Fei,Zhang Yihan,Dong Weibing,Zhang Xiaotao,Hu Wenping
Simultaneously realizing the optical and electrical properties of organic materials is always challenging. Herein, a convenient and promising strategy for designing organic materials with integrated optoelectronic properties based on cocrystal engineering has been put forward. By selecting the fluorene (Flu) and the 7,7′,8,8′-tetracyanoquinodimethane (TCNQ) as functional constituents, the Flu-TCNQ cocrystal prepared shows deep red emission at 702 nm, which is comparable to the commercialized red quantum dot. The highest electron mobility of organic field-effect transistor (OFET) based on Flu-TCNQ is 0.32 cm 2 V −1 s −1 . Spectroscopic analysis indicates that the intermolecular driving force contributing to the co-assembly of Flu-TCNQ is mainly charge transfer (CT) interaction, which leads to its different optoelectronic properties from constituents. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 6
·3237-3249
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IF 2.779
Wang Siyu,Guo Jiaxiong,Lin Zhidong,Liu Liming,Hui Yuchong,Zhang Xiaowen
A series of very small grain Au/SnO 2 composites were synthesized by a facile hydrothermal method. The microstructure of the Au/SnO 2 composites were characterized by X-ray diffraction, scanning electron microscope, transmission electron microscopy, and nitrogen adsorption–desorption experiment. The composites were composed of 20–30 nm spherical nanoparticles, which are hierarchical structure composed of 8 nm Au cores and 5 nm SnO 2 nanograins. The composites were porous material with large specific surface area. The sensors based on the Au/SnO 2 composites showed high sensitivities and selectivity to n -butanol at low working temperature with fast response. Among these sensors, the 1.5 wt% Au/SnO 2 -based sensor shows the highest response (2662.8) to 100 ppm n -butanol with the response time of 35 s at 80 °C. The excellent low-temperature gas-sensing properties of the Au/SnO 2 sensors can be ascribed to the synergetic effect of high surface energy of small SnO 2 nanograins and catalysis of gold nanoparticles. Our study demonstrates that controlling the grain size of SnO 2 and Au nanoparticle-assisted gas sensing are effective methods to improve the sensing properties of SnO 2 at low working temperature. The 1.5 wt% Au/SnO 2 composite is a potential low-temperature gas-sensing material for n -butanol detection.
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高影响因子
Materials Today Energy
·
2022
·
IF 9.257
Luyao Zheng,Cong Liu,Sinong Wang,Boxu Gao,Xueliang Fan,Shuyu Xu,Yingshuai Jia,Yahong Zhang,Qingsheng Gao,Xiaoming Cao,Yi Tang
Transition metal carbides (TMCs) are regarded as cost-efficient and stable electrocatalysts for hydrogen evolution reaction (HER). Nitrogen doping into nanosized TMCs in a control manner (e.g. doping amount and site) is one of the most effective routes to intrinsically enhance the activity and durability owing to the ameliorated Mo–H strength and amplified active sites. Herein, an approach based on reticular chemistry is developed to synthesize nanosized N-doped Mo 2 C embedded in porous carbon (N–Mo 2 C/PC), via pyrolyzing a hybrid precursor consisting of highly-dispersed molybdates within melamine-benzenetricarboxylic acid supermolecule networks. With optimal N-doping, the N–Mo 2 C/PC electrocatalyst exhibits an excellent HER stability and activity with overpotential of 109 mV at 10 mA cm −2 in 0.5 M H 2 SO 4 , as well as 100 mV at 10 mA cm −2 in 1.0 M KOH. Density functional theory calculations confirm that the appropriate N doping on the surface of Mo 2 C nanoparticles would accelerate the HER process via weakening the Mo–H bond strength and lowering the H–H coupling barrier. Furthermore, Mo 2 C nanoparticles loaded on carbon cloth with high HER activity can also be successfully achieved by this strategy. This work paves a universal way to design active sites-enriched TMCs with high performance in energy conversion and storages.
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高影响因子
CHEMOSPHERE
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2022
·
IF 8.943
Jian Zhao,Shangbiao Fang,Weixiao Qi,Huijuan Liu,Jiuhui Qu
Biodegradation is regarding as the most important organic micro-pollutants (OMPs) removal mechanism during riverbank filtration (RBF), but the OMPs co-metabolism mechanism and the role of NH 4 + -N during this process are not well understood. Here, we selected atenolol as a typical OMP to explore the effect of NH 4 + -N concentration on atenolol removal and the role of ammonia oxidizing bacteria (AOB) in atenolol biodegradation. The results showed that RBF is an effective barrier for atenolol mainly by biodegradation and adsorption. The ratio of biodegradation and adsorption to atenolol removal was dependent on atenolol concentration. Specifically, atenolol with low concentration (500 ng/L) is almost completely removed by adsorption, while atenolol with higher concentration (100 μg/L) is removed by biodegradation (51.7%) and adsorption (30.8%). Long-term difference in influent NH 4 + -N concentrations did not show significant impact on atenolol (500 ng/L) removal, which was mainly dominated by adsorption. Besides, AOB enhanced the removal of atenolol (100 μg/L) as biodegradation played a more crucial role in removing atenolol under this concentration. Both AOB and heterotrophic bacteria can degrade atenolol during RBF, but the degree of AOB's contribution may be related to the concentration of atenolol exposure. The main reactions occurred during atenolol biodegradation possibly includes primary amide hydrolysis, hydroxylation and secondary amine depropylation. About 90% of the bio-transformed atenolol was produced as atenolol acid. AOB could transform atenolol to atenolol acid by inducing primary amide hydrolysis but failed to degrade atenolol acid further under the conditions of this paper. This study provides novel insights regarding the roles played by AOB in OMPs biotransformation during RBF.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Fangfei Meng,Ying Xu,Zhaoqiang Wu,Hong Chen
A simple and convenient strategy for fabricating superhydrophilic antifogging coatings was developed by poly( N -hydroxyethyl acrylamide) (PHEAA) composites enhanced by zwitterionic sulfobetaine silane (SBSi)-modified SiO 2 nanoparticles . These antifogging coatings can be easily obtained by coating PHEAA composites on substrates at room temperature and then cured by thermal treatment. Such transparent coatings exhibited excellent antifogging performance under both hot and cold fogging conditions. Additionally, the coatings have good adhesion against the cross-cut test and thermal stability in the hot water resistance test. The present PHEAA composite coatings are promising for real-world antifogging applications.
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高影响因子
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