MICROCHIMICA ACTA
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2025
·Vol. 192
·期 11
·1-16
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IF 5.3
Zhuang Dengke,Guo Hao,Wei Yuli,Yu Zhiguo,Peng Liping,Ma Yanyan,Hui Yingfei,Yan Yu,Yang Wu
A sensitive and accurate ratiometric fluorescent sensor (RhB@UIO-67) is constructed by simply encapsulating rhodamine B (RhB) within a zirconium-based metal–organic framework (UIO-67). Based on the inhibition effect of ligand–to-metal charge transfer, adenosine triphosphate ATP induces a significant enhancement in the MOF centre emission, but does not affect the fluorescence of RhB in the probe material at all, which are respectively employed as detection signal and reference signal to realize sensitive ratiometric fluorescence detection of ATP in human serum and urine with a detection limit (LOD) of 0.45 μM. In particular, since the introduction of the target molecules does not cause any structural degradation, the sensor can be reused. Additionally, due to fluorescence resonance energy transfer between the probe components and malachite green (MG), addition of MG results in different degrees of quenching of the fluorescence emissions of UIO-67 and RhB in the RhB@UIO-67 and thus the probe material can simultaneously serve as a sensitive ratiometric sensing platform for MG detection in aquatic products including fish and shrimp with a low LOD of 0.03 μM. Benefited from its simplicity, sensitivity, and reusability, the sensing material has a wide application potential. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Yue Yuxue,Yu Mingde,Yao Zhangyi,Fang Guangzong,Wang Bolin,Wang Saisai,Jin Chunxiao,Chang Renqin,Sun Tulai,Pan Zhiyan,Zhu Yihan,Wang Feng Ryan,Li Xiaonian,Zhao Jia
Achieving specific orbital activation of C ≡ C by controlling the precise atomic architecture of supported metals is crucial for the selective transformation of alkynes. However, its physical mechanism remains a subject of debate. Herein, we construct a well-defined O-bridged CuN 3 -O-CuN 3 integrative catalytic pairs (Cu ICPs) based on Kirkendall effect. As a result, Cu ICPs with mixed Cu 2+ -Cu 3+ species demonstrate >99% conversion and >550 h stability in acetylene hydrochlorination (simulated industrial reaction conditions), showcasing unparalleled performance in the liquid-phase hydrochlorination of five alkynes as well. A combined experimental and theoretical analyses reveal selective coupling between the d xz / d yz orbitals of Cu ICPs and the σ orbitals of C ≡ C in C 2 H 2 , leading to the formation of highly reactive di- σ -HC = CH intermediate. Additionally, the presence of the bridged-O species promotes HCl dissociation, altering the addition pathway from the classical Eley-Rideal (E-R) mechanism to a Cl•-trigged Langmuir-Hinshelwood (L-H) mechanism, ultimately reducing the intrinsic energy barrier for addition, and breaking the universal standard electrode potential linear scaling relations.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Gu Jianfeng,Li Donghui,Ren Yichen,Li JiaHao,Ji Xinyi,Liu Xue,Zhan Weiqing,Zhao Xialian,Wang Quan,Liu Xiewen,Wang Huihui,Zhang Xinmin,Zhu YinBo,Yue Zhao,Wu Heng-An,Chen Yongsheng,Liang Jiajie
Despite high porosity, deer antlers exhibit high strength and toughness from synergistic hierarchical structures. MXene fibers offer promising applications but suffer from poor mechanical properties due to internal voids and weak interfaces. Conventional strengthening removes voids and enhances interlayer interactions, but yields rigid, brittle fibers. Here, we tackle this trade-off by constructing strong and slidable double-interfaces that can cooperate with internal micropores in MXene fibers to mimic the delicate structure of deer antlers. These voids, typically considered defects, instead enhance load-bearing and energy dissipation. At an optimal porosity of ~21%, the MXene fibers achieve high tensile strength, ductility, and toughness of 1060.1 ± 33.5 MPa, 34.2 ± 1.8%, and 136.1 ± 6.5 MJ m - 3 , respectively. Notably, this MXene-matrixed fiber shows elasticity and high durability and is even softer than polymer fibers, while maintaining an electrical conductivity of over 10500 S cm -1 after being coated with silver nanowires. This biomimetic approach enables robust, multifunctional fibers for smart textiles.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2025
·
IF 3.1
Man Tian,Yu Huiyong,Li Lei,Nie Weicheng,Wang Chengxiang
Multidrug-resistant Klebsiella pneumoniae (MDR-KP) infections present a global health crisis, with escalating resistance to last-line antibiotics. Traditional Chinese medicines (TCMs) demonstrate multi-component synergy against resistant pathogens. This study deciphered the antibacterial mechanisms of bioactive TCM components targeting MDR-KP through integrative pharmacology and experimental validation. Four core TCMs ( Scutellaria baicalensis , Forsythia suspensa , Lonicera japonica , Aloe vera ) were screened via Chinese Pharmacopoeia and TCMSP database. Network pharmacology identified core components and enriched pathways. Clinically isolated MDR-KP strains (resistant to meropenem, polymyxin E, and tigecycline) were characterized. Synergistic effects were evaluated using checkerboard assays, biofilm quantification, and membrane permeability assays. Molecular docking and RT-qPCR analyzed target interactions, while ELISA and CCK-8 assessed anti-inflammatory activity and cytotoxicity. Consequently, luteolin, wogonin, and kaempferol were identified as key components targeting PI3K/AKT and MAPK pathways. Their triple combination (2/4/8 μg/mL) exhibited potent synergy (FIC = 0.38), reducing biofilm biomass by 68% (p < 0.001) and extracellular polysaccharide thickness from 15.1 μm to 3.1 μm (p < 0.001). Flow cytometry confirmed a 144.8% increase in membrane permeability. Molecular docking revealed high-affinity binding to PI3K (− 6.78 kcal/mol), AKT1 (− 6.60 kcal/mol), and MAPK1 (− 7.24 kcal/mol), with RT-qPCR showing significant downregulation of these genes (p < 0.001). The combination suppressed LPS-induced TNF-α and IL-6 release by 72% and 65%, respectively, while maintaining 95.5% cell viability at therapeutic concentrations. In Conclusion, this study unveils a triple-action mechanism of luteolin-wogonin-kaempferol against MDR-KP, simultaneously disrupting resistance pathways, biofilms, and hyperinflammation. The regimen offers a safe, multi-target therapeutic strategy for combating drug-resistant infections.
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JOURNAL OF MATERIALS SCIENCE
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2025
·
IF 3.9
Wen Jihai,Huang Gang,Sun Pengbo,Wang Xiaoling,Zhang Guizhen
As a critical component in lithium-ion batteries (LIBs), the separator significantly influences the electrochemical performance and safety of the batteries. However, conventional polyolefin separators suffer from poor ionic conductivity and limited thermal stability, hindering further improvements in battery charge–discharge property. This study introduces a poly(vinylidene fluoride)/nano-silica (PVDF/SiO 2 ) composite microporous membrane with interpenetrating dual-continuous pore structures, fabricated via a green and efficient thermally induced phase separation (TIPS) process using environmentally friendly diluents. The resulting membrane,with a thickness of 14 μm, incorporates uniformly dispersed nano-silica (nmSiO₂) particles, which significantly enhance electrolyte wettability and thermal stability. The composite membrane exhibits an impressive ionic conductivity of 1.35 mS/cm, thermal shrinkage of only 3.58% at 160 °C, and excellent structural integrity at 200 °C. Electrochemical tests using Li||LiFePO 4 (12 mg/cm −2 ) cells demonstrate that the PVDF/SiO 2 composite membrane delivers superior cycling stability (> 200 cycles) and a higher capacity retention rate (86.9%) compared to commercial polyolefin membranes. These findings underscore the developed membrane,s exceptional properties and highlight the success of a green and efficient process for fabricating PVDF/SiO 2 composite microporous membranes, paving the way for their application in high-performance LIBs. Graphical abstract
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-15
·
IF 3.9
Yin Shize,Cao Guangsheng,Lin Yuxin,He Tairan
To mitigate problems such as injection water channeling, abrupt water breakthrough, rapid decline in oil production accompanied by an abrupt rise in water cut, and poor mobilization of matrix oil that commonly arise in low-permeability fractured reservoirs after conventional water flooding, many Chinese oilfields have implemented chemical profile modification. However, the produced water used to prepare these chemicals contains high concentrations of divalent metal cations especially Fe 2+ which dramatically reduce the gel viscosity and thus degrade the conformance control performance. To address this issue, we developed a deep profile conformance control system tailored to the produced water from the Xingshugang block. We optimized both the type and concentration of each component in the formulation: a polymer concentration of 1000 mg/L TS1600; a chromium-based crosslinker at 130 mg/L; thiourea as an oxygen scavenger at 1000 mg/L; 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) as a metal ion chelating agent at 60 mg/L; and formaldehyde as a biocide at 100 mg/L. Laboratory tests demonstrated that, when prepared with produced water, the system forms a gel with a viscosity of 3704 mPa·s, achieves a plugging rate of 86.0%, and contributes to an enhanced oil recovery (EOR) of 17.82%. These results indicate that the proposed deep profile conformance control system exhibits excellent salt tolerance and enhanced profile modification performance in the presence of divalent metal ions.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Sun Qian,Dou Pengjia,Du Jingcheng,Yao Ayan,Cao Dong,Ma Ji,Hassan Shabi Ul,Guan Jian,Liu Jiangtao
Highly permeable and selective biomimetic membranes that can feel and recognize valuable ion species have attracted enthusiastic interest due to their analogous behavior with biological ion channels and potential applications in rigorous ion sieving. However, designing and developing single-species selective membranes that can isolate monovalent cations such as K + /Na + remains a tremendous challenge due to the sub-nanometer ion size, as well as the angstrom-sized difference. Considering the non-homogeneous heterostructure of KcsA channels and -COOH groups generally showing lower K + affinity, we propose the 1D MOF (rich in -COOH groups)-in-2D COF concept, aiming to enhance K + /Na + separation through strategic construction of heterogeneous ion transport channels, therefore narrowing the pore size of pristine COF membrane, and weakening the K + -channel wall interactions. Concretely, by interlocking and in situ immobilized growth, the pristine COF membrane is capable of capturing MOF ligands and metal ions in sequence to form 1D MOF-in-2D COF hetero-structured composite membranes. Benefiting from the molecular-level interlinked hybridization of covalent and metal organic hetero-frameworks induced by the coordination interaction between the -NH groups in COFs and the Cu centers from MOFs, the composite membrane enables rapid diffusion of K + in confined heterogeneous channels, thus leading to unprecedented cation sieving performance with K + /Na + selectivity approaching 10 2 and K + /Mg 2+ selectivity exceeding 10 3 . This membrane design concept exploits a viable avenue for developing single-species selective biomimetic membranes to achieve ultrahigh separation performance.
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Reaction Kinetics Mechanisms and Catalysis
·
2025
·
IF 1.7
Guo Lirong,Yang Xiaodie,Shao Huijuan,Zhang Xuzhi,Wang Yating,Jiang Tao
We have investigated the effect of different impurities (CO, CO 2 , CS 2 , CH 3 OH, H 2 O, C 4 H 4 S) on the silicon-bridged diphosphine(PNSiP)/CrCl 3 (C 4 H 8 O) 3 /modified methylaluminoxane ethylene tri-/tetramerization system. The results showed that the addition of trace impurities has a certain inhibitory effect on catalytic activity. The influence of impurities on the catalytic activity of the catalyst system was as follows: CO > CO 2 > CS 2 > CH 3 OH > H 2 O > C 4 H 4 S. CO showed the most significant inhibitory effect in reducing activity from 1.75 × 10 6 g/(mol Cr h) to 0.74 × 10 6 g/(mol Cr h) at an addition of 0.2 ppm. Through the analysis of nuclear magnetic resonance (NMR) and ultraviolet–visible spectrophotometry (UV–vis), we found that carbon monoxide mainly inactivates the catalytic system by coordinating with chromium active sites, while methanol and water reduce the catalytic activity by destroying the structure of modified methylaluminoxane. Furthermore, we also proposed a possible reaction path between carbon monoxide and the chromium active center. Graphical abstract
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BIOLOGICAL TRACE ELEMENT RESEARCH
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2025
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IF 3.6
Cai ZhaoLong,Wang HongRu,Han Fuxin,Wang JingJing,LV Hongli,Gao Xue-jiao,Guo Meng-yao
Zinc deficiency is closely related to oxidative stress, inflammation, and programmed cell death. In this study, mouse models with normal zinc (Con), zinc deficiency (L-Zn), and high zinc (H-Zn) and an in vitro model of AML-12 hepatocytes were established to systematically explore the effects of zinc deficiency on hepatic oxidative stress, inflammation, and programmed cell death. In vivo experiments showed that zinc deficiency significantly increased the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in the liver ( P < 0.05), inhibited the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), and induced hepatocyte edema, inflammatory infiltration, and an increase in the number of TUNEL-positive apoptotic cells. Using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot, it was found that zinc deficiency activated the NF-κB pathway (increased expression of p-IκB α and p-NF κB p65), significantly increased the expression of pro-inflammatory factors (TNF-α, IL-6, IL-1β, IL-18), and decreased the anti-inflammatory factor IL-10. In addition, zinc deficiency upregulated apoptosis-related genes (Cyt-C, Bax, Bcl-2, Caspase-3/9), necroptosis marker indicators (RIPK1, RIPK3, MLKL), and key molecules of pyroptosis (NLRP3, ASC, GSDMD, Caspase-1), indicating the programmed cell death is activated in a number of ways. In vitro experiments further verified the above experimental results. Flow cytometry showed that the apoptosis rate of AML-12 cells in the L-Zn group (17.20%) was significantly higher than that in the Con group (4.75%) and the H-Zn group (2.55%). The experiment concluded that zinc supplementation could effectively alleviate oxidative damage, inhibit the inflammatory pathway, and reduce the expression of programmed cell death–related factors. This study confirms that zinc deficiency activates programmed cell death through a multimodal pattern and provides a theoretical basis for studies related to zinc intake imbalance leading to liver injury. Graphical This graphical abstract succinctly illustrates the mechanism of zinc deficiency in liver injury in mice.
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ACTA PHARMACOLOGICA SINICA
·
2025
·
IF 8.4
Yang Huan-xin,Wang Bing-xin,Dong Xiao-liang,Sun Jia,Miao Zeng-li,Pan Li-long
Aortic dissection (AD) is a life-threatening condition with high morbidity. Its underlying pathogenesis remains poorly understood, yielding limited therapeutic options. In this study, we investigated the role of gut microbiota and its metabolite, butyrate, in AD development. Experimental AD was established in 3-week-old mice by administering of β-aminopropionitrile monofumarate (BAPN, 1 g·kg -1 ·d -1 ) in drinking water for 4 weeks. Microbiota composition analysis was conducted on fecal samples from of the mice. AD mice exhibited significant alterations in gut microbiota composition in particular a decrease in butyrate-producing bacteria, accompanied by markedly reduced serum and fecal butyrate levels. Supplementation with exogenous butyrate (200 mg·kg -1 ·d -1 , i.g., for 4 weeks) significantly attenuated the progression of AD by enhancing the expression of vascular smooth muscle cell (SMC) contractile markers. Moreover, butyrate alleviated AD-associated SMC phenotypic switching by suppressing NADPH oxidase 4 expression, thereby reducing reactive oxygen species production. Notably, the protective effects of butyrate were abolished in G-protein-coupled receptor 41 (GPR41) knockout mice, but not in GPR109A knockout mice, highlighting the critical role of GPR41 in mediating its therapeutic effects. These results provide new insights into the pathogenesis of AD and suggest that targeting gut microbiota and its metabolites, such as butyrate, may offer a promising strategy.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 17
·1-11
·
IF 2.8
Li Zhenwei,Yan Mi,Su Xu,Lei Wenyang,Han Jinming,Huang Qiushi,Liao Hongxin,Hu Xuebu
The sluggish lithium-ion diffusion kinetics and severe lithium plating under fast charging conditions significantly impair the fast charging ability of graphite anode. Herein, water-soluble polyelectrolyte binder cellulose sulfate lithium (CSL) is employed as a multifunctional binder to enhance the extremely fast charging (> 4C) ability of the graphite anode. The CSL binder contributes to forming a uniform and thin solid electrolyte interphase layer, greatly reducing surface layer resistance. The –SO 4 Li groups also provide additional lithium ions, which prominently promote the diffusion of lithium ions. Furthermore, a number of –SO 4 Li and –OH groups in the binder can form robust hydrogen bonds with oxygen-containing groups from the graphite and collector, ensuring the cycling stability of graphite anode. Consequently, at 1C, the discharge specific capacity of the graphite anode using CSL (Gr-CSL) reaches 346.9 mAh g −1 , and it still has a specific capacity of 335.5 mAh g −1 with a retention rate of 96.7% (vs. 100 cycles) after 1000 cycles. At 5C, the Gr-CSL anode displays a reversible capacity of 147.3 mAh g −1 , much higher than 111.4 and 50.3 mAh g −1 using polyvinylidene fluoride and sodium carboxymethyl cellulose. Even after 1200 cycles, it still maintains a capacity of 132.8 mAh g −1 and an average coulombic efficiency of 99.89%. These results offer novel perspectives into the reasonable design of binders for the graphite anode with fast charging capability.
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Biochar
·
2025
·Vol. 7
·期 1
·1-15
·
IF 13.5
Xu Xiuzhen,Jiang Zhicheng,Xu Shuguang,Shi Bi
The efficient conversion of distiller’s grains (DGs) into high-value products will promote the sustainable development of the Chinese spirit industry and reduce related environmental issues. Herein, a composite adsorbent material (AC-SiO 2 ) composed of activated carbon (AC) and silica (SiO 2 ) was prepared from DGs via sequential pyrolysis, KOH etching, and steam activation processes. AC-SiO 2 was used to remove benzaldehyde from the Chinese spirit to improve the aroma and quality of the spirit. The experiment results showed that, KOH etching effectively removed SiO 2 from DGs and exposing the carbon substrate for further steam activation, then the specific surface area of AC-SiO 2 extremely increased to 1213.0 m 2 g –1 . Steam activation introduced Si–OH/Si–H bonds on SiO 2 and –OH/–COOH groups on the carbon surface and increased the graphitization degree of the materials. After optimization of the AC-SiO 2 preparation processes, the obtained AC-SiO 2 removed 68.7% of benzaldehyde from the spirit. The high benzaldehyde removal rate of AC-SiO 2 was attributed to the synergistic effect of AC and SiO 2 components (binding energy up to − 15.45 kcal mol –1 ), where benzaldehyde was preferentially adsorbed on the AC-SiO 2 interface. Specifically, highly graphitized AC promoted the planar adsorption of the benzene ring in benzaldehyde via π-π stacking, and the Si–OH/Si–H bonds on SiO 2 adsorbed the aldehyde group of benzaldehyde via hydrogen bonding. This study not only presents a novel approach to DGs resource utilization, but also provides theoretical underpinnings and technical support for the spirit quality enhancement, significantly promoting the green and sustainable development of the spirit industry. Graphic
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